Stem Cell-Derived Exosomal microRNAs: An Innovative Approach Towards Diabetes Mellitus
Published: September 11, 2026
Authors
Garima, Ritamay Sau, Meenakshi Dhanawat, Neeraj Mittal, and Pramila Chaubey
Keywords
Diabetes mellitus, Exosomes, Insulin resistance, microRNA, Stem cells
Abstract
Background: Diabetes mellitus is described as a lifelong metabolic disorder where the body cannot regulate its blood sugar level. Despite advancement in the treatment modalities, one of the greatest challenges faced today remains early diagnosis and comprehending the pathophysiology of diabetes. Recent studies indicate that the use of exosomes, which contain proteins and microRNAs (miRNAs) isolated from various cells, is becoming increasingly common due to their significant role in cell-cell interactions.
Purpose: This review aims to highlight the rising significance of exosomes and exosomal miRNAs as novel biomarkers and possible therapeutic targets for diabetes diagnosis and treatment.
Methods: A comprehensive review of the recent literature was conducted on the subject of the biological function of exosomes, the diagnostic potential of exosomal miRNAs, and their implication in the development and severity of diabetes. Besides that, special focus was placed on identifying specific miRNA profiles connected to diabetic diseases.
Results: Exosomal miRNAs have been considered highly promising non-invasive markers in the prognosis and early diagnosis of diabetes. Multiple studies show that changes in the expression of miRNAs are positively correlated with the progression of disease and the occurrence of its complications. Treatment using exosomes has shown great potential in the management of the molecular mechanisms of the disease.
Conclusion: Exosomes, mainly the miRNAs contained by them, are recently discovered, fascinating tools that could be used for the diagnosis and treatment of diabetes. Actually, they can be used both as biomarkers and as drugs, which might dramatically change the way of patient care and disease control.
References
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How to Cite
Garima, Ritamay Sau, Meenakshi Dhanawat, Neeraj Mittal, and Pramila Chaubey. Stem Cell-Derived Exosomal microRNAs: An Innovative Approach Towards Diabetes Mellitus.
J. Pharm. Technol. Res. Manag.. 2026, 14, 60-73
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