3a79e5121a0e547867b-517e 20260928051358513 chitu:chitu chitkarauniversitypublications@chitkara.edu.in WEB-FORM Journal of Pharmaceutical Technology, Research and Management JPTRM 23212217 23212225 10.15415/jptrm https://jptrm.chitkara.edu.in/ 09 11 2026 09 11 2026 14 1 10.15415/jptrm.2026.141 https://jptrm.chitkara.edu.in/2026/volume-14-and-issue-1/ Stem Cell-Derived Exosomal microRNAs: An Innovative Approach Towards Diabetes Mellitus Garima . Chitkara College of Pharmacy, Chitkara University, Punjab, India. Meenakshi Dhanawat Amity Institute of Pharmacy, Amity University Haryana, Gurugram-122413, India Neeraj Mittal Chitkara College of Pharmacy, Chitkara University, Punjab, India. https://orcid.org/0000-0002-3334-1712 Pramila Chaubey College of Pharmacy, Shaqra University, Dawadmi 11961, Kingdom of Saudi Arabia Background: Diabetes mellitus is described as a lifelong metabolic disorder where the body cannot regulate its blood sugar level. Despite advancement in the treatment modalities, one of the greatest challenges faced today remains early diagnosis and comprehending the pathophysiology of diabetes. Recent studies indicate that the use of exosomes, which contain proteins and microRNAs (miRNAs) isolated from various cells, is becoming increasingly common due to their significant role in cell-cell interactions. Purpose: This review aims to highlight the rising significance of exosomes and exosomal miRNAs as novel biomarkers and possible therapeutic targets for diabetes diagnosis and treatment. Methods: A comprehensive review of the recent literature was conducted on the subject of the biological function of exosomes, the diagnostic potential of exosomal miRNAs, and their implication in the development and severity of diabetes. Besides that, special focus was placed on identifying specific miRNA profiles connected to diabetic diseases. Results: Exosomal miRNAs have been considered highly promising non-invasive markers in the prognosis and early diagnosis of diabetes. Multiple studies show that changes in the expression of miRNAs are positively correlated with the progression of disease and the occurrence of its complications. Treatment using exosomes has shown great potential in the management of the molecular mechanisms of the disease. Conclusion: Exosomes, mainly the miRNAs contained by them, are recently discovered, fascinating tools that could be used for the diagnosis and treatment of diabetes. Actually, they can be used both as biomarkers and as drugs, which might dramatically change the way of patient care and disease control. 09 11 2026 09 11 2026 60 73 10.15415/jptrm.2026.141004 https://jptrm.chitkara.edu.in/2026/stem-cell-derived-exosomal-micrornas-an-innovative-approach-towards-diabetes-mellitus/