In-Vitro Anti-oxidant And Antimicrobial Study of Ficus Hispida

Home > 2015, Vol. 3 No. 2 > In-Vitro Anti-oxidant And Antimicrobial Study of Ficus Hispida
Published: November 17, 2015
Download PDF
Download XML | Download HTML

Authors

  • Atanu ChatterjeeBengal School of Technology (A College of Pharmacy), Sugandha, Delhi Road, Hooghly-712102, West Bengal, India
  • Jayita MondalBengal School of Technology (A College of Pharmacy), Sugandha, Delhi Road, Hooghly-712102, West Bengal, India
  • Rudranil BhowmikBengal School of Technology (A College of Pharmacy), Sugandha, Delhi Road, Hooghly-712102, West Bengal, India
  • Anshuman BhattachayraBengal School of Technology (A College of Pharmacy), Sugandha, Delhi Road, Hooghly-712102, West Bengal, India
  • Hirak RoyBengal School of Technology (A College of Pharmacy), Sugandha, Delhi Road, Hooghly-712102, West Bengal, India
  • Swarnendu KunduBengal School of Technology (A College of Pharmacy), Sugandha, Delhi Road, Hooghly-712102, West Bengal, India
DOI Number
https://doi.org/10.15415/jptrm.2015.32012
Keywords
Ficus hispida, Antioxidant activity, Minimum Inhibitory Concentration, Antimicrobial activity

Abstract

Ficus hispida L. belongs to the Moraceae family and is used by the maaiba trible (indigenous medicine – man of Manipur, India) as an indigenous traditional medicine. Present study deals with the successive extraction of the aerial parts of Ficus hispida and in-vitro screening of anti-oxidant and anti-microbial activity. The phytochemical screening of the methanol extract of Ficus hispida shows the presence of secondary metabolite groups like alkaloid, phenolic compounds, flavonoid, glycosides, protein etc. Phenolic compounds are commonly found in both edible and nonedible plants and are responsible for various medicinal activities of plants, so our study is based on determining antioxidant activity and anti-microbial activity. Beside these, we also measured the total flavonoid and total phenolic content of the respective sample to understand the effect of polyphenolic compound on different pathophysiological state associated with high free radical production. The in-vitro investigation proves the efficiency of this plant in various diseases states.

References

  • Arteel, G.E., (2009). Oxidants and antioxidants in alcohol-induced liver disease. Gastroenterology, 124: 778–790. http://dx.doi.org/10.1053/gast.2003.50087
  • Balasundram, S., Sundram, K., Sammar, S., (2006).Phenolic compounds of plants and agricultural by-products, antioxidant activity, Occurrence and potential uses. Journal of Food Chemistry, 68:191-203. http://dx.doi.org/10.1016/j.foodchem.2005.07.042
  • Blois, M.S., (1958). Antioxidant determinations by the use of a stable free radical, Nature. 29:1199 1200. http://dx.doi.org/10.1038/1811199a0
  • Davlo,s M., Rolnaldo, N., (1998).Alcoholic hepatitis. Review on Gastroenterology Peru, 18: 151–164. (1998).
  • Ghosh, R., Sharotchandra, RS., (2004) Hypo glycemic activity of Ficus hispida in normal and diabetic albino rats. Indian Journal of Pharmacology 36: 222-225
  • Gillman, B., Papachristodouluo, D.K., Thomas, J.H., Will’s Bio-chemical Basis of Medicine, 3rd Edition, Oxford. Butterworth Heinemann. p. 343
  • Green, LC., Wagner, DA., Glogowski, J., (1982). Analysis of nitrate, nitrite and nitrate in biological fluids. Analytical Biochemistry, 126: 131–138. http://dx.doi.org/10.1016/0003-2697(82)90118-X
  • Hatano, T., Edamaysu, R., Mori, A., Fujita, Y., Yasuhara, E., (1989). Chemistry and Pharmaceutical Bulletin, 37: 2016-2021. http://dx.doi.org/10.1248/cpb.37.2016
  • Hsu, C., (2006).Antioxidant activity of extract from Polygonum aviculare L, Biological Research, 39, 281-288. http://dx.doi.org/10.4067/S0716-97602006000200010
  • Hu, J., Lee, SO., Hendrich, S., Murphy, PA., (2002).Quantification of the group B soya saponins by high-performance liquid chromatography. Journal of Agricultural and Food Chemistry, 50: 2587–2594. http://dx.doi.org/10.1021/jf0114740
  • Kahkonen, MP., Hopia, AI., Vuorela, HJ., Rauha, JP., PIhlaja, K., Kulaja, TS., (1999). Antioxidant activity of plant extracts containing phenolic compounds, Journal of Food Chemistry, 47:3954-3962. http://dx.doi.org/10.1021/jf990146l
  • Khandelwal, K.R., (2012). Practical Pharmacognosy, 22nd edition, 23.10-23.11
  • Kokate, C.K., Purohit, A.P., Gokhale, S.B., Book of Pharmacognosy, 46th edition, 8.57-8.58
  • Kokate, C.K., Purohit, A.P., Gokhale, S.B., Book of Pharmacognosy, 46th edition, A.1-
  • Kone, WM., Kamanzi, K., Traore, DA., Terreaux, C., Hostettmann, K., Dosso, M., (2004). Traditional medicine in North Cote-d’Ivoire screening of 50 medicinal plants for antibacterial activity. Journal of Ethnopharmacology; 93:43-49. http://dx.doi.org/10.1016/j.jep.2004.03.006
  • Mandal, S.C., Ashok Kumar, C.K., (2002) Studies on anti-diarrhoeal activity of Ficus hispida leaf extract in rats. Fitoterapia, 73(7-8):663-7. http://dx.doi.org/10.1016/S0367-326X(02)00225-3
  • Mandal, SC., Saraswathi B, Kumar, CK., Mohana Lakshmi, S., Maiti, BC., (2000)Protective effect of leaf extract of Ficus hispida Linn. Against paracetamol-induced hepatotoxicity in rats. Phytotherapy Research, 14(6):457-9. http://dx.doi.org/10.1002/1099-1573(200009)14:6<457::AID-PTR610>3.0.CO;2-8
  • Marcocci, L., Maguire, JJ., Droy-Lefaix, MT., Packer, L., (1994a). The nitric oxide scavenging properties of Ginkgo biloba extract EGb 761. Biochemistry Biophysics Research Commuication, 15:748-755. http://dx.doi.org/10.1006/bbrc.1994.1764
  • Marcocci, L., Packer, L., Droy-Lefaix, MT., Packer, L., (1994b). Antioxidant action of Ginkgo biloba extract EGB 761, Methods Enzymology, 234: 462-475. http://dx.doi.org/10.1016/0076-6879(94)34117-6
  • Nadkarni, A. K., (1976). Materia Medica. (Pp.1031–1035). Popular Prakashan. Mumbai India.
  • Rastogi, Mehrotra, BN., (1993). Compendium of Indian Medicinal Plants, Central Drug Research Institute; (pp. 27–30). Publication and Information Directorate, II. Lucknow, New Delhi.
  • Ripu, M., Kunwar, I., Rainer, W. B., (2006) Ficus (Fig) species in Nepal a review of diversity and indigenous uses. Journal of Ecological Application,11:85–87.
  • Ruch, R.J., Cheng, S.J., Klaunig, J.E., (1989). Prevention of cytotoxicity and inhibition of intracellular communication by antioxidant catechins isolated from Chinese green tea. Carcinogenesis, 10, pp. 1003-1008. http://dx.doi.org/10.1093/carcin/10.6.1003
  • Salah, N., Miller, NJ., Paganga, J., Tijburg, L., Bolwell, GP., Rice-Evans, C., (1995). Polyphenolic flavonols as scavengers of aqueous phase radicals and chain-breaking antioxidants. Archives of Biochemistry and Biophysics; 322:339-346. http://dx.doi.org/10.1006/abbi.1995.1473
  • Sergio, R., Peraza, S., (2002)Constituents of leaves and twigs of Ficus hispida. Plant Med. 68: 186-188. http://dx.doi.org/10.1055/s-2002-20257
  • Shanmugarajan, TS., Arunsunda, MC., (2008).Cardio protective effect of Ficus hispida Linn on cyclophosphamide provoked oxidative myocardial injury in a rat model. International Journal of Pharmacology, 1-10.
  • Singh, H.K., Dhawan, B.N., (1997). Neuro-psychopharmacological effects of the Ayurvedic nootropic Bacopa monnieri Linn. (Brahmi). Indian Journal of Pharmacology, 29:S359- S365.
  • Singleton, V L., Orthofer, L., Lamuela, Raventos., Rosa, M., (1999) Analysis of total phenol and other oxidation substrate and antioxidant by means of folin-ciocalteu reagents, Methods in Enzymology, 299, 152-178. http://dx.doi.org/10.1016/S0076-6879(99)99017-1
  • Strube, M., Dragstedt, LO., Larsen, JC., (1993).Naturally occurring Anti-tumourigens, Plant Phenols, The Nordic Councils of Ministers, Copenhagen, 39-40.
  • Sun, J., Chu, Y. F., Wu, X. Z., Liu, R. H., (2002) Journal of Agriculture and Food Chemistry, 50:7449 -7454. http://dx.doi.org/10.1021/jf011617i
  • Tsao, R., Akhtar, M.H., (2005). Nutraceuticals and functional foods: I. Current trend in phytochemical antioxidant research. Journal of Food, Agriculture and Environment, 3(1): 10-17.
  • Vishnoi, SP., Jha, T., (2004) Evaluation of anti-inflammatory activity of leaf extracts of Ficus hispida. Indian Journal of Natural Product, 20:27–29.
  • Yoshiki, K., Kudou, S., Okubo, K., (1998).Relationship between chemical structures and biological activities of triterpinoid saponins from soyabean. Bioscience, Biotechnology, and Biochemistry, 62: 2291-2299. http://dx.doi.org/10.1271/bbb.62.2291
  • Yoshiki, Y., Okubo, K., (1995). Active oxygen scavenging activity of DDMP (2, 3-dihydro-2, 5-dihydrox saponin in soybean seed. Bioscience, Biotechnology, and Biochemistry, 59: 1556–1557. http://dx.doi.org/10.1271/bbb.59.1556
  • Zheng, W., Wang, S. Y., (2001) Journal of Agriculture and Food Chemistry, 49:5165-5170. http://dx.doi.org/10.1021/jf010697n

How to Cite

Atanu Chatterjee, Jayita Mondal, Rudranil Bhowmik, Anshuman Bhattachayra, Hirak Roy, Swarnendu Kundu. In-Vitro Anti-oxidant And Antimicrobial Study of Ficus Hispida. J. Pharm. Technol. Res. Manag.. 2015, 03, 153-166
In-Vitro Anti-oxidant And Antimicrobial Study of Ficus Hispida

Current Issue

PeriodicityBiannually
Issue-1May
Issue-2November
ISSN Print2321-2217
ISSN Online2321-2225
RNI No.CHAENG/2013/50088
OA Policy

Publisher's policy of the journal at Sherpa UK for the submitted, accepted, and published articles. Click OAPolicy

Plan-S Compliance

To check compliance, one has to use the Journal Check Tool (JCT). This tool provided by cOAlition S (European funders) for the researchers (fundee) to check the compliance with the journal.

Recommend journal to your library

You can recommend the journal being a researcher or faculty member to your library. We will post a copy of the Journal to your library on your behalf at free of cost.
Click here: Recommend Journal

Preprint Arxiv Submission

The authors are encouraged to submit the author’s copy (preprint) to appropriate preprint archives e.g. https://arxiv.org and/or on https://indiarxiv.org or institutional repositories (e.g., D Space) before paper acceptance by the editor of Journal. After publications of the paper author(s) should mention the citation information, title and abstract along with DOI number of the publication carefully on the required page of the depository(ies).

Contact: Phone: +91-172-2741000, +91-172-4691800

Email : editor.jptrm@chitkara.edu.in;

Abstract and Indexing

Information

This work is licensed under a Creative Commons Attribution 4.0 International License.

Articles in Journal of Pharmaceutical Technology, Research and Management (J. Pharm. Tech. Res. Management) by Chitkara University Publications are Open Access articles that are published with licensed under a Creative Commons Attribution- CC-BY 4.0 International License. Based on a work at https://jptrm.chitkara.edu.in/. This license permits one to use, remix, tweak and reproduction in any medium, even commercially provided one give credit for the original creation.

View Legal Code of the above-mentioned license, https://creativecommons.org/licenses/by/4.0/legalcode

View Licence Deed here https://creativecommons.org/licenses/by/4.0/

Creative Commons License

Journal of Pharmaceutical Technology, Research and Management by Chitkara University Publications is licensed under a Creative Commons Attribution 4.0 International License.
Based on a work at https://jptrm.chitkara.edu.in//

Members

Chitkara University

Chitkara University

India’s top rated university

Chandigarh-Patiala National Highway, Punjab 140 401

Chandigarh Information Center SCO 160-161, Sector 9-C, Chandigarh 160 009

Publisher

Chitkara University Publications,
Administrative Office, Saraswati Kendra, P.O. Box No. 70, SCO 160-161, Sector- 9C, Chandigarh-160009, India.
Phone: +91-172-2741000, +91-172-4691800;
Email: chitkarauniversitypublications@chitkara.edu.in;
For all journals, please visit the website: https://publications.chitkara.edu.in/

The Journal of Pharmaceutical Technology, Research and Management is a peer-reviewed, refereed, bi-annual open-access journal of "Chitkara University Publications".  ISSN (p):2321-2217, ISSN (e): 2321-2225, RNI No.: CHAENG/2013/50088, Journal's DOI: https://doi.org/10.15415/jptrm

Copyright ©2023 Chitkara Educational Trust | All rights reserved
Explore Your Potential

Chandigarh-Patiala National Highway, Punjab 140 401

Chandigarh Information Center SCO 160-161, Sector 9-C, Chandigarh 160 009