Importance of Pharmacovigilance in Ayurveda

Published: November 8, 2021

Authors

  • Susheel Kumar
  • Rashmi Arora
  • Ritchu Babbar
  • Rajwinder Kaur
Keywords
Phramacovigilance, Adverse drug reaction, ayurvedic medicines, Ayurveda formulations, Ayurveda.

Abstract

Introduction: Ayurveda has been introduced in India around 1500 BC. Ayurvedic medicines are more accepted these days as people are looking out for the natural medications. The major function of this system is to preserve the normal wellness of people and to cure the patient. These medicines, which are generally considered as safer, are now in the aura of doubt, due to some of the recent incidences of Adverse Drug Reaction (ADR), during their usage.

Objective: Pharmacovigilance is an important step in Ayurveda to overcome and continuously monitor the ADR. Pharmacovigilance is the law and regulations for pharma industries, which deal with the detection, assessment, monitoring, understanding, prevention and reporting of adverse effects of medicines. Thus, this is the recurrent theme of ayurvedic pharmacology (dravyagunavigyan) and healing (chikitsa). The most important aim of pharmacovigilance, that is to enhance patient care and safety of the drug use, and as a result elevate rational drug use are recurring premise of ayurvedic pharmacology cology (dravyagunavigyan) and therapeutics (chikitsa).

Methods: The data was collected from different websites and databases such as PubMed, Biomedical Sciences, Science Direct, Wiley Online Library, Google Scholar, WHO, Bentham science etc. A total of 80 articles were downloaded, studied, categorized and 52 were selected to write the manuscript.

Results and Conclusion: There is requirement of an appropriate post-clinical surveillance program for ayurvedic drugs based on its quality, safety, and efficacy, for public health and disease management, which is now accessible in National Pharmacovigilance Programme for ASU (Ayurveda, Siddha, Unani) drugs, Ayurveda has explained a broad hypothesis on homeopathy medicines, in relation with its usage, causal ADR, treatment and its prevention. Spontaneous reporting of ADR related to Ayurveda plays an essential role in the identification and detection of new signals and communicating novel research questions.

References

  • Ajanal, M., Nayak, S., Kadam, A., Prasad, B., 2015. Pharmacovigilance study of Ayurvedic medicine in Ayurvedic Teaching Hospital: A prospective survey study. AYU (An Int. Q. J. Res. Ayurveda) 36, 130. https://doi.org/10.4103/0974-8520.175539
  • Ajanal, M., Nayak, S., Prasad, B.S., Kadam, A., 2013a. Adverse drug reaction and concepts of drug safety in Ayurveda: An overview. J. Young Pharm. https://doi.org/10.1016/j.jyp.2013.10.001
  • Ajanal, M., Nayak, S., Prasad, B.S., Kadam, A., 2013b. Adverse drug reaction and concepts of drug safety in Ayurveda: An overview. J. Young Pharm. https://doi.org/10.1016/j.jyp.2013.10.001
  • Ajanal, M., Nayak, S., Prasad, B.S., Kadam, A., 2013c. Adverse drug reaction and concepts of drug safety in Ayurveda: An overview. J. Young Pharm. https://doi.org/10.1016/j.jyp.2013.10.001
  • Apte, A., 2016. Reporting of adverse events for marketed drugs: Need for strengthening safety database. Perspect. Clin. Res. 7, 111. https://doi.org/10.4103/2229-3485.184781
  • Ayurveda 2.0: Rediscovering Ancient Remedies for Modern Needs | by Dr Swati Subodh | The Startup | Medium [WWW Document], URL https://medium.com/swlh/ayurveda-2-0-rediscovering-ancient-remedies-for-modern-needs-b1a6c051eb7c (accessed 8.19.20).
  • Baghel, M., 2010. The national pharmacovigilance program for Ayurveda, Siddha and Unani drugs: Current status. Int. J. Ayurveda Res. 1, 197. https://doi.org/10.4103/0974-7788.76779
  • Chaudhary, A., Singh, N., Kumar, N., 2010. Pharmacovigilance: Boon for the safety and efficacy of ayuvedic formulations. J. Ayurveda Integr. Med. 1, 251–256. https://doi.org/10.4103/0975-9476.74427
  • Chaudhary, P., Lamba, N., Sharma, Y., 2014a. Pharmacovigilance and ayurveda. J. Biol. Sci. Opin. 2, 210–213. https://doi.org/10.7897/2321-6328.02246
  • Chaudhary, P., Lamba, N., Sharma, Y.K., 2014b. Pharmacovigilance and ayurveda. J. Biol. Sci. Opin. · 2. https://doi.org/10.7897/2321-6328.02246
  • Galib, Acharya, R., 2020. National Pharmacovigilance Programme for Ayurveda, Siddha and Unani Drugs. AYU (An Int. Q. J. Res. Ayurveda) 29, 195.
  • Goyal, M., 2018. Pharmacovigilance: An ayurvedic viewpoint. AYU (An Int. Q. J. Res. Ayurveda) 39, 197. https://doi.org/10.4103/ayu.ayu_82_19
  • Kales, S.N., Saper, R.B., 2009. Editorial ayurvedic lead poisoning: an under-recognized, international problem. Indian J. Med. Sci. 63. https://doi.org/10.4103/0019-5359.56108
  • Kashinath, S., Tasyasheetiyaadhyay, G.C., Bharati, C., 2005,  undefined, n.d. Charaka Samhita of Agnivesha elaborated Vidyotini Hindi commentary.
  • Krüth, P., Brosi, E., Fux, R., Mörike, K., Gleiter, C.H., 2004. Ginger-Associated Overanticoagulation by Phenprocoumon. Ann. Pharmacother. 38, 257–260. https://doi.org/10.1345/aph.1D225
  • Kubde, S., Renuka Vihar, M., 2016. Adverse drug reactions and pharmacovigilance of herbal medicines in India, International Journal of Green Pharmacy (IJGP). https://doi.org/10.22377/IJGP.V10I1.610
  • Kubde, S., Renuka Vihar, M.,  Adverse drug reactions and pharmacovigilance of herbal medicines in India.
  • Kumar Shukla, A., Bigoniya, P., Shukla, ;, Bigoniya, I., 2016. Herbal, Drug and Food Interaction. Int. J. Tradi-tional Complement. Med. 1, 33–0037.
  • Medicines Agency, E., 2017. Guideline on good pharmacovigilance practices (GVP) – Module VI – Collection, management and submission of reports of suspected adverse reactions to medicinal products (Rev 2).
  • Microsoft Word – Assessment of the Community System consultation final.doc | Enhanced Reader [WWW Document], URL moz-extension://fc05633c-6128-4b91-aefb-7556e2703879/enhanced-reader.html?openApp&pdf=https%3A%2F%2Fec.europa.eu%2Fhealth%2Fsites%2Fhealth%2Ffiles%2Ffiles%2Fpharmacovigilance%2Fdocs%2Facs_consultation_final_en.pdf (accessed 8.19.20).
  • Nishteswar, K., 2013. Institute for Post Graduate Teaching and Research in Ayurveda, Gujarat Ayurved University, Jamnagar – A WHO-recognized collaborating center for traditional medicine (Ayurveda). AYU (An Int. Q. J. Res. Ayurveda) 34, 133. https://doi.org/10.4103/0974-8520.119662
  • Nitin L, U.B., 2012. NEED FOR PHARMACOVIGILANCE IN ĀYURVEDA, Global Journal of Research on Medicinal Plants & Indigenous Medicine GJRMI.
  • orintalia, P.S.-V.C., 1979,  undefined,  Dhanvantari Nighantu of Dhanvantari. vol. 54.
  • Panda, A., Debnath, S., 2010. Overdose effect of aconite containing ayurvedic medicine (′Mahashankha Vati′). Int. J. Ayurveda Res. 1, 183. https://doi.org/10.4103/0974-7788.72493
  • Parab, S., Kulkarni, R., Thatte, U., 2003. Heavy metals in “herbal” medicines [3]. Indian J. Gastroenterol.
  • Parasuraman, S., Thing, G.S., Dhanaraj, S.A., 2014. Polyherbal formulation: Concept of ayurveda. Pharmacogn. Rev. https://doi.org/10.4103/0973-7847.134229
  • Patwardhan, B., Vaidya, A.D.B.,  Ayurveda: scientific research and publications. Curr. Sci. https://doi.org/10.2307/24111950
  • Pharmacovigilance of Ayurvedic medicines in India | Request PDF [WWW Document], n.d. URL https://www.researchgate.net/publication/50268272_Pharmacovigilance_of_Ayurvedic_medicines_in_India (accessed 8.20.20).
  • Pirmohamed, M., Breckenridge, A.M., Kitteringham, N.R., Park, K., 1998. Adverse drug reactions. BMJ 316, 1295. https://doi.org/10.1136/bmj.316.7140.1295
  • Ranade, A.V., Acharya, R., 2015. Influence of time factor on phytoconstituents in certain ayurvedic medicinal plants: a comprehensive review. J. Pharm. Sci. Innov. 4, 235–241. https://doi.org/10.7897/2277-4572.04553
  • Rastogi, S., 2011. Why and how? Addressing to the two most pertinent questions about pharmacovigilance in Ayurveda. Int. J. Ayurveda Res. https://doi.org/10.4103/0974-7788.83187
  • Rastogi, S., 2010. Identifying attitudes about drug safety: A sample survey of ayurvedic physicians. Int. J. Risk Saf. Med. 22, 93–101. https://doi.org/10.3233/JRS-2010-0493
  • Rastogi, S., 2009. Poor quality and improper use: A review of common reasons of possible adversity in Ayurvedic practice COVID-19 and Ayurveda View project Workshop on Scientific Writing for Ayurveda Scholars View project Poor quality and improper use: A review of common reasons of possible adversity in Ayurvedic practice. Int. J. Risk Saf. Med. 00, 1–10. https://doi.org/10.3233/JRS-2009-0470
  • Rastogi, S., Rastogi, R., Singh, R.H., 2007. Adverse effects of Ayurvedic drugs: An overview of causes and possibilities in reference to a case of Vatsanabha (Aconite) overdosing.
  • Samal, J., 2018. Pharmacovigilance in Ayurveda – Concept and Regulations. Curr. Pharmacogenomics Person. Med. 16, 4–8. https://doi.org/10.2174/1875692116666180419153658
  • Saper, R., Kales, S., Paquin, J., Jama, M.B.-, 2004,  undefined, n.d. Heavy metal content of ayurvedic herbal medicine products. jamanetwork.com.
  • Saper, R., Kales, S., Paquin, J., Jama, M.B.-, 2004,  undefined, Heavy metal content of ayurvedic herbal medicine products. jamanetwork.com.
  • Sarkar, P.K., Chaudhari, S., Chattopadhyay, A., 2013. Concept of interactions between consumable substances in Ayurveda with special reference to foods and drugs. Drug Metabol. Drug Interact. https://doi.org/10.1515/dmdi-2013-0014
  • Sharma, R., Hazra, J., Prajapati, P., 2017. Knowledge and awareness of pharmacovigilance among ayurveda physicians in Himachal Pradesh. Anc. Sci. Life 36, 234. https://doi.org/10.4103/asl.asl_41_17
  • Sharma, R., Kellarai, A., 2014. Pharmacovigilance and adverse drug reaction reporting perspectives among interns and postgraduates of a teaching hospital. J. Pharmacol. Pharmacother. https://doi.org/10.4103/0976-500X.142436
  • Suke, S.G., Kosta, P., Negi, H., 2015. Role of Pharmacovigilance in India: An overview. Online J. Public Health Inform. 7. https://doi.org/10.5210/ojphi.v7i2.5595
  • Thatte, U., Bhalerao, S., 2008. Pharmacovigilance of ayurvedic medicines in India. Indian J. Pharmacol.
  • Thatte, U., Pharmacology, S.B.-I.J. of, 2008,   Pharmacovigilance of ayurvedic medicines in India. ncbi.nlm.nih.gov.
  • Tiwari, V., Tiwari, S., Rahim, A.. Need of Pharmacovigilance in Alternative Systems of Medicine, J. Pharm. Sci. Technol. Manag.
  • UMC | Uppsala Monitoring Centre [WWW Document],. URL https://www.who-umc.org/ (accessed 8.19.20).
  • Wal, P., Wal, A., Gupta, S., Sharma, G., Rai, A.K., 2011. Pharmacovigilance of herbal products in India. J. Young Pharm. 3, 256–258. https://doi.org/10.4103/0975-1483.83780
  • Who, n.d. Guidelines for the regulation of herbal medicines in the South-East Asia Region. https://pharmacy.utah.edu/ICBG/pdf/WebResources/TraditionalMedicines/WHO-TradMed-Safe-and-Effective.pdf
  • WHO | WHO traditional medicine strategy, 2005. WHO. https://apps.who.int/iris/bitstream/handle/10665/67163/WHO_EDM_TRM_2002.1.pdf;jsessionid=6FD671160190EB2AF989C18646C10640?sequence=1

How to Cite

Susheel Kumar, Rashmi Arora, Ritchu Babbar and Rajwinder Kaur. Importance of Pharmacovigilance in Ayurveda. J. Pharm. Technol. Res. Manag.. 2021, 09, 87-97
Importance of Pharmacovigilance in Ayurveda

Current Issue

PeriodicityBiannually
Issue-1May
Issue-2November
ISSN Print2321-2217
ISSN Online2321-2225
RNI No.CHAENG/2013/50088
OA Policy

Publisher's policy of the journal at Sherpa UK for the submitted, accepted, and published articles. Click OAPolicy

Plan-S Compliance

To check compliance, one has to use the Journal Check Tool (JCT). This tool provided by cOAlition S (European funders) for the researchers (fundee) to check the compliance with the journal.

Recommend journal to your library

You can recommend the journal being a researcher or faculty member to your library. We will post a copy of the Journal to your library on your behalf at free of cost.
Click here: Recommend Journal

Preprint Arxiv Submission

The authors are encouraged to submit the author’s copy (preprint) to appropriate preprint archives e.g. https://arxiv.org and/or on https://indiarxiv.org or institutional repositories (e.g., D Space) before paper acceptance by the editor of Journal. After publications of the paper author(s) should mention the citation information, title and abstract along with DOI number of the publication carefully on the required page of the depository(ies).

Contact: Phone: +91-172-2741000, +91-172-4691800

Email : editor.jptrm@chitkara.edu.in;

Abstract and Indexing

Information

This work is licensed under a Creative Commons Attribution 4.0 International License.

Articles in Journal of Pharmaceutical Technology, Research and Management (J. Pharm. Tech. Res. Management) by Chitkara University Publications are Open Access articles that are published with licensed under a Creative Commons Attribution- CC-BY 4.0 International License. Based on a work at https://jptrm.chitkara.edu.in/. This license permits one to use, remix, tweak and reproduction in any medium, even commercially provided one give credit for the original creation.

View Legal Code of the above-mentioned license, https://creativecommons.org/licenses/by/4.0/legalcode

View Licence Deed here https://creativecommons.org/licenses/by/4.0/

Creative Commons License

Journal of Pharmaceutical Technology, Research and Management by Chitkara University Publications is licensed under a Creative Commons Attribution 4.0 International License.
Based on a work at https://jptrm.chitkara.edu.in//

Members