Antianxiety Activity Evaluation of Hibiscus Sabdariffa Linn. Calyces

Home > 2022, Vol. 10 No. 02 > Antianxiety Activity Evaluation of Hibiscus Sabdariffa Linn. Calyces

Published: November 10, 2022

Download PDF

Download XML | Download HTML

Authors

Gulsheen
Anupam Sharma

DOI Number
https://doi.org/10.15415/jptrm.2022.102001

Keywords
Calyces; Elevated plus maze;Hibiscus sabdariffa; Extracts; Anxiety

Abstract

Background: Anxiety is one of the most commonly prevailing psychiatric and behavioural disorders. Evolutionarily, it is regarded as a healthy emotion or behavioural repertoire, which is the outcome of a stressful situation, thereby, helping an individual to cope with a possible risk or a novel situation by increasing awareness and responsiveness. Benzodiazepines, barbiturates, SRIs etc., are used as first line drugs for the management of anxiety, but due to myriad of adverse effects associated with these conventional drugs, inclination of patients towards complementary and alternative medicines (CAMs) has tremendously risen. CAM interventions mainly include herbal remedies.Different parts of Hibiscus sabdariffa have been used traditionally for treating several ailments including mental disorders.

Purpose: Keeping in mind the traditional use of H. sabdariffacalyces,the present study was designed to evaluate their antianxiety potential.

Methods: Petroleum ether (60-80°C), chloroform, ethanol, and water extracts were prepared using successive Soxhlet extraction and evaluated using elevated plus-maze model.

Results: Among all the extracts, ethanol extract showed significant antianxiety activity at a dose of 400 mg/kg.

Conclusion: Thus, the study establishes antianxiety activity of H. sabdariffa calyces and also validates their traditional use.

References

Chatterjee, M., Verma, P., Maurya, R., &Palit, G. (2011). Evaluation of ethanol leaf extract of Ocimum sanctum in experimental models of anxiety and depression. Pharmaceutical Biology, 49(5), 477-483. https://doi.org/10.3109/13880209.2010.523832
Christine, M., Henry, L., Bendantunguka, T., Simeon, W., Daphrose, G., &Bellancile, U. (2017). Evaluation of the storage stability of pineapple products processed by small and medium scale processing enterprises in Rwanda. African Journal of Food Science, 11(6), 146-159. https://doi.org/10.5897/AJFS2016.1547
Lister, R. G. (1990). Ethologically-based animal models of anxiety disorders. Pharmacology & Therapeutics, 46(3), 321-340. https://doi.org/10.1016/0163-7258(90)90021-s
Mak, Y. W., Chuah, L. O., Ahmad, R., & Bhat, R. (2013). Antioxidant and antibacterial activities of hibiscus (Hibiscus rosa-sinensis L.) and Cassia (Senna bicapsularis L.) flower extracts. Journal of King Saud University-Science, 25(4), 275-282. https://doi.org/10.1016/j.jksus.2012.12.003
OECD 2001. OECD Guidelines for testing of chemicals: Acute oral toxicity – Acute toxic class method. Test no. 423, adopted 22^nd March 1996, and revised method adopted 17^th December 2001, OECD, Paris.https://doi.org/10.1787/9789264071001-en
Pellow, S., Chopin, P., File, S. E., & Briley, M. (1985). Validation of open: closed arm entries in an elevated plus-maze as a measure of anxiety in the rat. Journal of Neuroscience Methods, 14(3), 149-167. https://doi.org/10.1016/0165-0270(85)90031-7
Qi, Y., Chin, K.L., Malekian, F., Berhane, M., & Gager, J. (2005). Biological characteristics, nutritional and medicinal value of roselle, Hibiscus sabdariffa. Circular-Urban Forestry Natural Resources and Environment, 604, 1-2. https://doi.org/10.15237/gida.GD21075
World Health Organization. 2017. Depression and other common mental disorders: global health estimates (No. WHO/MSD/MER/2017.2). Retrieved from https://apps.who.int/iris/handle/10665/254610

How to Cite

Gulsheen and Anupam Sharma. Antianxiety Activity Evaluation of Hibiscus Sabdariffa Linn. Calyces. J. Pharm. Technol. Res. Manag.. 2022, 10, 119-122

Antianxiety Activity Evaluation of Hibiscus Sabdariffa Linn. Calyces

Current Issue

Periodicity	Biannually
Issue-1	May
Issue-2	November
ISSN Print	2321-2217
ISSN Online	2321-2225
RNI No.	CHAENG/2013/50088

OA Policy

Publisher's policy of the journal at Sherpa UK for the submitted, accepted, and published articles. Click OAPolicy

Plan-S Compliance

To check compliance, one has to use the Journal Check Tool (JCT). This tool provided by cOAlition S (European funders) for the researchers (fundee) to check the compliance with the journal.

Recommend journal to your library

You can recommend the journal being a researcher or faculty member to your library. We will post a copy of the Journal to your library on your behalf at free of cost.
Click here: Recommend Journal

Preprint Arxiv Submission

The authors are encouraged to submit the author’s copy (preprint) to appropriate preprint archives e.g. https://arxiv.org and/or on https://indiarxiv.org or institutional repositories (e.g., D Space) before paper acceptance by the editor of Journal. After publications of the paper author(s) should mention the citation information, title and abstract along with DOI number of the publication carefully on the required page of the depository(ies).

Contact: Phone: +91-172-2741000, +91-172-4691800

Email : editor.jptrm@chitkara.edu.in;

Abstract and Indexing

Information

This work is licensed under a Creative Commons Attribution 4.0 International License.

Articles in Journal of Pharmaceutical Technology, Research and Management (J. Pharm. Tech. Res. Management) by Chitkara University Publications are Open Access articles that are published with licensed under a Creative Commons Attribution- CC-BY 4.0 International License. Based on a work at https://jptrm.chitkara.edu.in/. This license permits one to use, remix, tweak and reproduction in any medium, even commercially provided one give credit for the original creation.

View Legal Code of the above-mentioned license, https://creativecommons.org/licenses/by/4.0/legalcode

View Licence Deed here https://creativecommons.org/licenses/by/4.0/