UV-Spectrophotometry – Multicomponent Mode of Analysis for Simultaneous Estimation of Brinzolamide and Brimonidine Tartrate in Bulk and Ophthalmic Formulation

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Published: May 10, 2019

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Authors

Vikram L. Jadhav Department of Pharmaceutical Chemistry, R. C. Patel Institute of Pharmaceutical Education and Research, Shirpur, Dist.: Dhule (M.S.) India 425 405
Amod S. Patil Department of Pharmaceutical Chemistry, R. C. Patel Institute of Pharmaceutical Education and Research, Shirpur, Dist.: Dhule (M.S.) India 425 405
Suraj R. Chaudhari Department of Pharmaceutical Chemistry, R. C. Patel Institute of Pharmaceutical Education and Research, Shirpur, Dist.: Dhule (M.S.) India 425 405
Atul A. Shirkhedkar Department of Pharmaceutical Chemistry, R. C. Patel Institute of Pharmaceutical Education and Research, Shirpur, Dist.: Dhule (M.S.) India 425 405

DOI Number
https://doi.org/https://doi.org/10.15415/jptrm.2019.71005

Keywords
Brinzolamide, Brimonidine tartrate, UV-Spectrophotometry, Multicomponent mode of analysis, Validation

Abstract

Brinzolamide (BRZ) and Brimonidine Tartrate (BT) in combination are available as an ophthalmic suspension in the ratio of 5:1. A simple, reproducible and efficient method for the simultaneous determination of BRZ and BT in Bulk and Ophthalmic formulation has been developed. The absorbance was assessed at two wavelengths i.e. 252.40 nm (λ max of BRZ) and 246 nm (λmax of BT) in methanol. In this method, BRZ and BT executed linearity in the concentration range of 5-35 μg/mL and 3-18 μg/mL, respectively at their respective λ max. The developed method was found to be accurate, precise and rugged as marked by small values of % RSD according to ICH guidelines.

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How to Cite

Vikram L. Jadhav, Amod S. Patil, Suraj R. Chaudhari , Atul A. Shirkhedkar . UV-Spectrophotometry – Multicomponent Mode of Analysis for Simultaneous Estimation of Brinzolamide and Brimonidine Tartrate in Bulk and Ophthalmic Formulation. J. Pharm. Technol. Res. Manag.. 2019, 07, 31-35

UV-Spectrophotometry – Multicomponent Mode of Analysis for Simultaneous Estimation of Brinzolamide and Brimonidine Tartrate in Bulk and Ophthalmic Formulation

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