Synthesis, antimicrobial evaluation and QSAR studies of p-amino benzoic acid derivatives

Home > 2014, Vol. 2 No. 1 > Synthesis, antimicrobial evaluation and QSAR studies of p-amino benzoic acid derivatives

Published: May 20, 2014

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Authors

MeetaFaculty of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak-124001, India
Pradeep KumarFaculty of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak-124001, India
Balasubramanian NarasimhanFaculty of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak-124001, India

DOI Number
https://doi.org/10.15415/jptrm.2014.21007

Keywords
PABA, Synthesis, Antimicrobial, mt-QSAR, LOO method

Abstract

A series of Schiff bases (1-16) and esters (17-27) of p-amino benzoic acid (PABA) was synthesized and its in vitro antimicrobial potential was evaluated by using tube dilution method. Compound 11 was found to be most promising antibacterial agent (pMICbs = 2.11 Î¼M/ml) having antibacterial potential comparable to standard drug norfloxacin (pMICbs = 2.61 Î¼M/ml) and may be taken as a lead compound for the development of novel antibacterial agents. QSAR analysis indicated that electronic parameters, total energy (Te) and energy of lowest unoccupied molecular orbital (LUMO) were found dominant in explaining the antimicrobial activity of synthesized compounds.

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How to Cite

Meeta, Pradeep Kumar, Balasubramanian Narasimhan. Synthesis, antimicrobial evaluation and QSAR studies of p-amino benzoic acid derivatives. J. Pharm. Technol. Res. Manag.. 2014, 02, 87-104

Synthesis, antimicrobial evaluation and QSAR studies of p-amino benzoic acid derivatives

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