ba60f6118992d8a5a2-6f43 20230808044500516 chitu:chitu chitkarauniversitypublications@chitkara.edu.in WEB-FORM Journal of Pharmaceutical Technology, Research and Management JPTRM 23212217 23212225 10.15415/jptrm https://jptrm.chitkara.edu.in/ 05 20 2014 05 20 2014 2 1 10.15415/jptrm.2014.21 https://jptrm.chitkara.edu.in/2014/vol-2-no-1/ Synthesis, antimicrobial evaluation and QSAR studies of p-amino benzoic acid derivatives Faculty of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak-124001, India Pradeep Kumar Faculty of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak-124001, India Balasubramanian Narasimhan Faculty of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak-124001, India A series of Schiff bases (1-16) and esters (17-27) of p-amino benzoic acid (PABA) was synthesized and its in vitro antimicrobial potential was evaluated by using tube dilution method. Compound 11 was found to be most promising antibacterial agent (pMICbs = 2.11 μM/ml) having antibacterial potential comparable to standard drug norfloxacin (pMICbs = 2.61 μM/ml) and may be taken as a lead compound for the development of novel antibacterial agents. QSAR analysis indicated that electronic parameters, total energy (Te) and energy of lowest unoccupied molecular orbital (LUMO) were found dominant in explaining the antimicrobial activity of synthesized compounds. 05 20 2014 05 20 2014 87 104 10.15415/jptrm.2014.21007 https://jptrm.chitkara.edu.in/2014/synthesis-antimicrobial-evaluation-and-qsar-studies-of-p-amino-benzoic-acid-derivatives/