Dissolution Enhancement of Domperidone Fast Disintegrating Tablet Using Modified Locust Bean Gum by Solid Dispersion Technique
Home >
2016,
Vol. 4 No. 1 > Dissolution Enhancement of Domperidone Fast Disintegrating Tablet Using Modified Locust Bean Gum by Solid Dispersion Technique
Authors
- Manju Nagpal Chitkara College of Pharmacy, Chitkara University, Rajpura, Punjab-140401
- Loveleen Kaur Chitkara College of Pharmacy, Chitkara University, Rajpura, Punjab-140401
- Janita Chander Chitkara College of Pharmacy, Chitkara University, Rajpura, Punjab-140401
- Pratima Sharma Chitkara College of Pharmacy, Chitkara University, Rajpura, Punjab-140401
Keywords
Solubility, Natural carrier, Dissolution, Solid dispersions, Disintegration
Abstract
Enhancement of dissolution characteristics of poorly soluble drug Domperidone by solid dispersion technique using modified locust bean gum (MLBG) and further conversion into tablet dosage form with fast dissolving characteristics is being explored in current study. Solid dispersions (SD) were prepared by solvent evaporation technique. F1, F3, F5 and F7 batches of SD (1:1, 1:3, 1:5 and 1:7 ratio of drug to MLBG) were prepared. Maximum solubility was observed in 1:3 ratio (F3 batch) in comparison to pure drug. Fourier Transform Infrared spectroscopy studies revealed no interaction of drug to polymer MLBG. Transition from crystalline to amorphous state of drug was analyzed by X-RD studies. SEM studies revealed change in surface characteristics of drug in solid dispersions. In vitro release studies revealed maximum dissolution in F3 (93% in 30 min). Further solid dispersion batches F3 was compressed into tablets including other excipients and crosspovidone as superdisintegrant. The in vitro release from tablet batch revealed better dissolution characteristics (95% in 30 min) in comparison to marketed tablet (50% in 60 min). Therefore, MLBG solid dispersion tablets of domperidone can be a convenient dosage form with enhanced dissolution characteristics.
References
- Battu, S.K., Repka, M.A.,Majumdar, S., Madhusudan, R.Y. (2007). Formulation and evaluation of rapidly disintegrating tablet Fenoverine tablets: Effect of superdisintegrants. Drug Dev. Ind. Pharm., 33, 1225–32. http://dx.doi.org/10.1080/03639040701377888
- Essa, E.A., Balata, G.F (2012).Preparation and characterization of domperidone solid dispersions. Pak J Pharm Sci., 25(4), 783-91. http://www.drugbank.ca/drugs/DB01184
- Malik K, Arora G, Singh I (2011). Locust Bean gum as superdisintegrant – formulation and evaluation of Nimesulide Orodispersibile Tablets. Malik K, Arora G, Singh I (2011). Locust bean gum as superdisintegrant–formulation and evaluation of nimesulide orodispersible tablets. Polimery w medycynie 41 (1), 17-28.
- Panghal, D., Nagpal, M., Thakur, G.S., Arora, S. (2014). Dissolution improvement of atorvastatin calcium using modified locust bean gum by the solid dispersion technique, Sci. Pharm., 82, 177-191. http://dx.doi.org/10.3797/scipharm.1301-23
- Patel, D.M., Patel S. P., Patel, C.N. (2014). Formulation and evaluation of fast dissolving tablet containing domperidone ternary solid dispersion. Int. J. Pharm. Invest, 4(4), 174-182. http://dx.doi.org/10.4103/2230-973X.143116
- Poovi, G., Umamaheswari, M., Sharmila, S., Kumar, S. and Rajalakshmi, A.N. (2013). Development of Domperidone Solid Dispersion Powders Using Sodium Alginate as Carrier. European Journal of Applied Sciences, 5(2), 36-42.
- Serrajuddin, A.T.M. (1999). Solid dispersion of poorly soluble drugs-Early promises, subsequent problems, and recent breakthroughs. J. Pharm. Sci., 88(10), 1058–1066. http://dx.doi.org/10.1021/js980403l
- Sharma, D. K., and Joshi, S.B. (2007). Solubility enhancement strategies for poorly water soluble drugs in solid dispersion: A Review. Asian J. Pharm., 1, 9–19.
- Sharma, J., Nagpal, M., Arora, S. (2012).Glibenclamide Solubility Enhancement by Modified Natural Carriers Using the Solid Dispersion Technique Farmacia, 60(6), 822–839.
- Sharma, S., Sharma, N., Gupta, G.D. (2010). Formulation of fast dissolving tablets of Promethazine Theoclate. Trop J Pharm Res., 9(5), 489– 497. http://dx.doi.org/10.4314/tjpr.v9i5.61063
- Thapa, P., Thapa, R., Budhathoki, U., Thapa, P. (2014). Solubility Enhancement of Domperidone Fast Disintegrating Tablet Using Hydroxypropyl-β-Cyclodextrin by Inclusion Complexation Technique. Pharmacol & Pharm, 5, 238–249. http://dx.doi.org/10.4236/pp.2014.53031
How to Cite
Manju Nagpal, Loveleen Kaur, Janita Chander, Pratima Sharma. Dissolution Enhancement of Domperidone Fast Disintegrating Tablet Using Modified Locust Bean Gum by Solid Dispersion Technique.
J. Pharm. Technol. Res. Manag.. 2016, 04, 1-11
