Current Approaches to Surface Modification and Target Tactics for Oral Administration of Liposomes: An Overview

Published: 20210507

Authors

  • Printy Dhadwal
  • Adeeba Zahoor
  • Nirmala
  • Gurfateh Singh
Keywords
Gastrointestinal Tract, Oral Drug Delivery, Permeability

Abstract

Background: The future researcher will be able to improve on present platform and address the current translational and it is aware of liposomal technology advancement to obstacle that still need to resolve. Liposomes imitate natural cell membranes and have long been analyze as drug delivery carriers due to magnificent entrapment capacity, bio-compatibility and safety. Oral drug delivery via the gastrointestinal tract is the dominant route for drug administration. Liposomes carriers can increase the drug bioavailability, solubility and protect the encapsulated therapeutic
agents from the extreme condition found in Gastrointestinal tract. Orally delivered liposomal carriers can enhance drug solubility and protect the encapsulated therapeutic agents from the extreme conditions found in GI tract. Liposomes, with their fluid lipid bilayer membranes and their
nanoscale size, can significantly improve oral absorption. Unfortunately, the clinical application of conventional liposomes has been hindered due to their poor stability and availability under the harsh conditions typically presented in the GI tract.

Purpose: The purpose of this study is know the surface modification and target tactics for oral medication administration using liposomes. Despite the success of parenteral the liposomes oral delivery is blocked by various barriers such as instability in gastrointestinal tract difficulties in across. Perhaps substantially enhanced oral medication delivery by rectification of liposome bilayers and addition of polymers or ligands while accounting for liposome stability and permeability. To overcome this problem, the surface modification of liposomes has been investigated. Although liposomes surface modification has been extensively studied for oral drug delivery, so far no correction has been adequately integument in that topic.

Conclusion: The conclusion of overall study to overcome this problem, the surface modification of liposomes has been extensively studied for oral drug delivery.

References

Agrawal, A. K., Harde, H., Thanki, K., & Jain, S. (2014). Improved stability and antidiabetic potential of insulin containing folic acid functionalized polymer stabilized multilayered liposomes following oral administration. Biomacromolecules15(1), 350–360. https://doi.org/10.1021/bm401580k Alpes,H.,Allmann,K.,Plattner,H.,Reichert,J.,Rick,R.and Schulz, S., (1986). Formation of large unilamellarvesicles using alkyl maltoside detergents.BiochimicaetBiophysicaActa(BBA)-Biomembranes,862(2),294-302. Barea, M. J., Jenkins, M. J.et al.,(2010). Evaluation of liposomes coated with a pH responsive polymer. International journal of pharmaceutics402(1-2), 89–94. https://doi.org/10.1016/j.ijpharm.2010.09.028 Barea, M. J., Jenkins,et al., (2012). Encapsulation of Liposomes within pH Responsive Microspheres for Oral Colonic Drug Delivery. International journal of biomaterials2012, 458712. https://doi.org/10.1155/2012/458712 Barea, M. J., Jenkins, M. J., Gaber, M. H., &Bridson, R. H. (2010). Evaluation of liposomes coated with a pH responsive polymer. International journal of pharmaceutics402(1-2), 89–94. https://doi.org/10.1016/j.ijpharm.2010.09.028  Batzri, S., &Korn, E. D. (1973). Single bilayer liposomes prepared without sonication. Biochimicaetbiophysicaacta298(4), 1015–1019. https://doi.org/10.1016/0005-2736(73)90408-2 Chandranmp,S.,andP.Vp.(2016).“Formulation and Evaluation of Glimepiride-Loaded LiposomesbyEthanolinjectionMethod”.AsianJournalofPharmaceuticalandClinicalResearch,9(4),192-5, Chen, C., Han, D., Cai,et al., (2010). An overview of liposome lyophilization and its future potential. Journal of controlled release : official journal of the Controlled Release Society142(3), 299–311. https://doi.org/10.1016/j.jconrel.2009.10.024 Chen, H., Wu, J.,et al., (2012). N-trimethyl chitosan chloride-coated liposomes for the oral delivery of curcumin. Journal of liposome research22(2), 100–109. https://doi.org/10.3109/08982104.2011.621127 Chen, H., Torchilin, V., & Langer, R. (1996).Lectin-bearing polymerized liposomes as potential oral vaccine carriers. Pharmaceutical research, 13(9), 1378–1383. https://doi.org/10.1023/a:1016030202104 Chen, W. L., Yuan, Z. Q.,et al.,(2016). Liposomes coated with N-trimethyl chitosan to improve the absorption of harmine in vivo and in vitro. International journal of nanomedicine11, 325–336. https://doi.org/10.2147/IJN.S95540 Chinnala, K. M. and Panigrahy, R., (2016). Formulationand Evaluation of Acyclovir Liposomes.InternationalResearchJofPharmaceuticalandBiosciences2017;4(1) Daemen, T., Hofstede, G., et al., (1995). Liposomal doxorubicin-induced toxicity: depletion and impairment of phagocytic activity of liver macrophages. International journal of cancer61(5), 716–721. https://doi.org/10.1002/ijc.2910610520 DeMiguel,I.,Ioualalena,K.,Bonnefous,M.,Peyrot,M.,Nguyen, F., Cervilla, M., Soulet, N., Dirson, R.,Rieumajou, V., Imbertie, L. and Solers, C., (1995).Synthesisandcharacterizationofsupramolecularbiovector(SMBV)specificallydesignedfortheentrapment of ionic molecules. BiochimicaetBiophysicaActa(BBA)-Biomembranes,1237(1),49-58. Deamer, D., & Bangham, A. D. (1976).Large volume liposomes by an ether vaporization method. Biochimicaetbiophysicaacta443(3), 629–634. https://doi.org/10.1016/0005-2736(76)90483-1 desRieux, A., Fievez, V.,et al., (2006). Nanoparticles as potential oral delivery systems of proteins and vaccines: a mechanistic approach. Journal of controlled release : official journal of the Controlled Release Society116(1), 1–27. https://doi.org/10.1016/j.jconrel.2006.08.013 Fan,Y.andZhang,Q.,(2013).Developmentofliposomalformulations: From concept to clinical investigations.AsianJournalofPharmaceuticalSciences,8(2),pp.81-87. Gradauer, K., Barthelmes,J.,et al.,(2013). Liposomes coated with thiolated chitosan enhance oral peptide delivery to rats. Journal of controlled release : official journal of the Controlled Release Society172(3), 872–878. https://doi.org/10.1016/j.jconrel.2013.10.011 Guan, P., Lu, Y., Qi, J., Niu, M., Lian, R., & Wu, W. (2015). Solidification of liposomes by freeze-drying: the importance of incorporating gelatin as interior support on enhanced physical stability. International journal of pharmaceutics478(2), 655–664. https://doi.org/10.1016/j.ijpharm.2014.12.016 Han, M., Watarai, S., Kobayashi, K., & Yasuda, T. (1997). Application of liposomes for development of oral vaccines: study of in vitro stability of liposomes and antibody response to antigen associated with liposomes after oral immunization. The Journal of veterinary medical science59(12), 1109–1114. https://doi.org/10.1292/jvms.59.1109. Handa, T., Sakano, M., Naito, S., Hiramatsu, M. andTsuboi, M., (2006). Thermal sio and h13co+ lineobservations of the dense molecular cloud g0. 11–0.11in the galactic center region.The Astrophysical Journal,636(1), 261. Hashimoto, A. and Kawada, J. U. N., (1979). Effects oforaladministrationofpositivelychargedinsulinliposomes on alloxan diabetic rats: preliminary study.Endocrinologiajaponica,26(3),pp.337-344. Hashimoto, A. and Kawada, J. U. N., (1979). Effects oforaladministrationofpositivelychargedinsulinliposomes on alloxan diabetic rats: preliminary study.Endocrinologiajaponica,26(3),337-344. Hashimoto, A., & Kawada, J. (1979). Effects of oral administration of positively charged insulin liposomes on alloxan diabetic rats: preliminary study. Endocrinologia japonica26(3), 337–344. https://doi.org/10.1507/endocrj1954.26.33 He, H., Lu, Y., Qi, J., Zhu, Q., Chen, Z., & Wu, W. (2019).Adapting liposomes for oral drug delivery. ActapharmaceuticaSinica. B9(1), 36–48. https://doi.org/10.1016/j.apsb.2018.06.005 Hillaireau, H., &Couvreur, P. (2009). Nanocarriers' entry into the cell: relevance to drug delivery. Cellular and molecular life sciences : CMLS66(17), 2873–2896. https://doi.org/10.1007/s00018-009-0053-z Himanshu,A.,Sitasharan,P.andSinghai,A.K.,(2011).Liposomesasdrugcarriers.IJPLS,2(7),945-951. Hosny, K. M., Ahmed, O. A., & Al-Abdali, R. T. (2013). Enteric-coated alendronate sodium nanoliposomes: a novel formula to overcome barriers for the treatment of osteoporosis. Expert opinion on drug delivery10(6), 741–746. https://doi.org/10.1517/17425247.2013.799136 Hu, S., Niu, M., Hu, F.,et al., (2013). Integrity and stability of oral liposomes containing bile salts studied in simulated and ex vivo gastrointestinal media. International journal of pharmaceutics441(1-2), 693–700. https://doi.org/10.1016/j.ijpharm.2012.10.025 Iwanaga, K., Ono, S.,et al.,(1999). Application of surface-coated liposomes for oral delivery of peptide: effects of coating the liposome's surface on the GI transit of insulin. Journal of pharmaceutical sciences88(2), 248–252. https://doi.org/10.1021/js980235x Kannan, V., Balabathula, P., Thoma, L. A., & Wood, G. C. (2015).Effect of sucrose as a lyoprotectant on the integrity of paclitaxel-loaded liposomes during lyophilization. Journal of liposome research25(4), 270–278. https://doi.org/10.3109/08982104.2014.992023 Kastner, E., Kaur, R., Lowry, D., Moghaddam, B., Wilkinson, A., &Perrie, Y. (2014). High-throughput manufacturing of size-tuned liposomes by a new microfluidics method using enhanced statistical tools for characterization. International journal of pharmaceutics477(1-2), 361–368. https://doi.org/10.1016/j.ijpharm.2014.10.030 Kataria, S., Sandhu, P., Bilandi, A., Akanksha, M. andKapoor,B.,(2011).Stealthliposomes:areview.Internationaljournal ofresearchinayurveda&pharmacy,2(5). Katayama, K., Kato, Y., Onishi, H., Nagai, T., & Machida, Y. (2003). Double liposomes: hypoglycemic effects of liposomal insulin on normal rats. Drug development and industrial pharmacy29(7), 725–731. https://doi.org/10.1081/ddc-120021771 Kazakov, S., &Levon, K. (2006). Liposome-nanogel structures for future pharmaceutical applications. Current pharmaceutical design12(36), 4713–4728. https://doi.org/10.2174/138161206779026281 Li, K., Chen, D., Zhao, X., Hu, H., Yang, C., & Pang, D. (2011).Preparation and investigation of Ulexeuropaeus agglutinin I-conjugated liposomes as potential oral vaccine carriers. Archives of pharmacal research34(11), 1899–1907. https://doi.org/10.1007/s12272-011-1110-3 Mayer, L. D., Bally, M. B., Hope, M. J., &Cullis, P. R. (1986).Techniques for encapsulating bioactive agents into liposomes. Chemistry and physics of lipids40(2-4), 333–345. https://doi.org/10.1016/0009-3084(86)90077-0 Miller,R.M.andBartha,R.,(1989).Evidencefromliposomeencapsulationfortransport-limitedmicrobial metabolism of solid alkanes.Applied andEnvironmentalMicrobiology,55(2),269-274. Moghimipour, E., Salami, A., &Monjezi, M. (2015).Formulation and Evaluation of Liposomes for Transdermal Delivery of Celecoxib. Jundishapur journal of natural pharmaceutical products10(1), e17653. https://doi.org/10.17795/jjnpp-17653 Niu, M., Lu, Y., Hovgaard,et al.,(2012). Hypoglycemic activity and oral bioavailability of insulin-loaded liposomes containing bile salts in rats: the effect of cholate type, particle size and administered dose. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur PharmazeutischeVerfahrenstechnike.V81(2), 265–272. https://doi.org/10.1016/j.ejpb.2012.02.009 Ohsawa, T., Miura, H., & Harada, K. (1985).Improvement of encapsulation efficiency of water-soluble drugs in liposomes formed by the freeze-thawing method. Chemical & pharmaceutical bulletin33(9), 3945–3952. https://doi.org/10.1248/cpb.33.3945 Parmentier,J.,Hartmann,F.J.andFricker,G.,(2010). Invitroevaluationofliposomescontainingbio-enhancersfor the oral delivery of macromolecules.Europeanjournal of pharmaceutics and biopharmaceutics, 76(3),394-403. Parmentier, J., Hartmann, F. J., &Fricker, G. (2010). In vitro evaluation of liposomes containing bio-enhancers for the oral delivery of macromolecules. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur PharmazeutischeVerfahrenstechnike.V76(3), 394–403. https://doi.org/10.1016/j.ejpb.2010.09.002 Parmentier, J., Hofhaus, G.et al.,(2014). Improved oral bioavailability of human growth hormone by a combination of liposomes containing bio-enhancers and tetraether lipids and omeprazole. Journal of pharmaceutical sciences103(12), 3985–3993. https://doi.org/10.1002/jps.24215       Patel, H. M. and Ryman, B. E., (1976).Oral administrationof insulin by encapsulation within liposomes.FEBSletters,62(1),pp.60-63.   Patil, Y. P. and Jadhav, S., (2014). Novel methods forliposome preparation.Chemistry and physics of lipids,177,8-18.   Pick U. (1981). Liposomes with a large trapping capacity prepared by freezing and thawing of sonicated phospholipid mixtures. Archives of biochemistry and biophysics212(1), 186–194. https://doi.org/10.1016/0003-9861(81)90358-1   Ramana,M.V.,Chaudhari,A.D.,Himaja,M.,Satyanarayana,D.andDua,K.,(2007).Anapproach to minimize pseudomembranous colitis caused byclindamycin through liposomal formulation.Indianjournalofpharmaceuticalsciences,69(3),390.   Richards, M. H., & Gardner, C. R. (1978).Effects of bile salts on the structural integrity of liposomes. Biochimicaetbiophysicaacta543(4), 508–522. https://doi.org/10.1016/0304-4165(78)90305-7   S.R.,Faizi,S.M.andDeshmuk,A.D.,(2012).Formulationand development of liposomal gel for topical drugdelivery system.International Journal of PharmaceuticalSciencesandResearch,3(11),4461.   Schieren, H., Rudolph, S., Finkelstein, M., Coleman, P., &Weissmann, G. (1978). Comparison of large unilamellar vesicles prepared by a petroleum ether vaporization method with multilamellar vesicles: ESR, diffusion and entrapment analyses. Biochimicaetbiophysicaacta542(1), 137–153. https://doi.org/10.1016/0304-4165(78)90240-4     Shaheen, S. M., Shakil Ahmed, F. R., Hossen, M. N.,Ahmed, M., Amran, M. S. and Ul-Islam, M. A.,(2006). Liposome as a carrier for advanced drugdelivery.PakJBiolSci,9(6),1181-1191.   Siler-Marinkovic, S., (2016). Liposomes as drug deliverysystems in dermal and transdermal drug delivery.Percutaneous penetration enhancers chemical methods inpenetrationenhancement,15-38.   Song, H., Geng, H.,et al., (2011). Development of Polysorbate 80/Phospholipid mixed micellar formation for docetaxel and assessment of its in vivo distribution in animal models. Nanoscale research letters6(1), 354. https://doi.org/10.1186/1556-276X-6-354     Srinivas, L., Tenneti, V. V. K. and Rajasri, A., (2015).Preparation and evaluation of liposome formulationsfor poorly soluble drug itraconazole by complexation.DerPharmaciaLettre,7(8),1-17.   Takeuchi, H., Matsui, Y., Yamamoto, H., & Kawashima, Y. (2003).Mucoadhesive properties of carbopol or chitosan-coated liposomes and their effectiveness in the oral administration of calcitonin to rats. Journal of controlled release : official journal of the Controlled Release Society86(2-3), 235–242. https://doi.org/10.1016/s0168-3659(02)00411-x     Thirawong, N., Thongborisute, J., Takeuchi, H., &Sriamornsak, P. (2008).Improved intestinal absorption of calcitonin by mucoadhesive delivery of novel pectin-liposome nanocomplexes. Journal of controlled release : official journal of the Controlled Release Society125(3), 236–245. https://doi.org/10.1016/j.jconrel.2007.10.023.       Tian, J. N., Ge, B. Q., Shen, Y. F., He, Y. X., & Chen, Z. X. (2016). Thermodynamics and Structural Evolution during a Reversible Vesicle-Micelle Transition of a Vitamin-Derived Bolaamphiphile Induced by Sodium Cholate. Journal of agricultural and food chemistry64(9), 1977–1988. https://doi.org/10.1021/acs.jafc.5b05547   Torchilin V. P. (2005). Recent advances with liposomes as pharmaceutical carriers. Nature reviews. Drug discovery4(2), 145–160. https://doi.org/10.1038/nrd1632   Wagner, A., Platzgummer, M., Kreismayr, G., Quendler, H., Stiegler, G., Ferko, B., Vecera, G., Vorauer-Uhl, K., &Katinger, H. (2006).GMP production of liposomes--a new industrial approach. Journal of liposome research16(3), 311–319. https://doi.org/10.1080/08982100600851086   Wasankar,S.R.,Faizi,S.M.andDeshmuk,A.D.,(2012).Formulation and development of liposomal gel fortopical drug delivery system.International Journal ofPharmaceuticalSciencesandResearch,3(11),4461.   Yamabe, K., Kato, Y., Onishi, H., & Machida, Y. (2003). Potentiality of double liposomes containing salmon calcitonin as an oral dosage form. Journal of Controlled Release, 89(3), 429–436. https://doi.org/10.1016/S0168-3659(03)00160-3    

How to Cite

Printy Dhadwal, Adeeba Zahoor, Nirmala, and Gurfateh Singh. Current Approaches to Surface Modification and Target Tactics for Oral Administration of Liposomes: An Overview. J. Pharm. Technol. Res. Manag.. 2021, 09, 29-41
Current Approaches to Surface Modification and Target Tactics for Oral Administration of Liposomes: An Overview

Current Issue

PeriodicityBiannually
Issue-1May
Issue-2November
ISSN Print2321-2217
ISSN Online2321-2225
RNI No.CHAENG/2013/50088
OA Policy

Publisher's policy of the journal at Sherpa UK for the submitted, accepted, and published articles. Click OAPolicy

Plan-S Compliance

To check compliance, one has to use the Journal Check Tool (JCT). This tool provided by cOAlition S (European funders) for the researchers (fundee) to check the compliance with the journal.

Recommend journal to your library

You can recommend the journal being a researcher or faculty member to your library. We will post a copy of the Journal to your library on your behalf at free of cost.
Click here: Recommend Journal

Preprint Arxiv Submission

The authors are encouraged to submit the author’s copy (preprint) to appropriate preprint archives e.g. https://arxiv.org and/or on https://indiarxiv.org or institutional repositories (e.g., D Space) before paper acceptance by the editor of Journal. After publications of the paper author(s) should mention the citation information, title and abstract along with DOI number of the publication carefully on the required page of the depository(ies).

Contact: Phone: +91-172-2741000, +91-172-4691800

Email : editor.jptrm@chitkara.edu.in;

Abstract and Indexing

Information

This work is licensed under a Creative Commons Attribution 4.0 International License.

Articles in Journal of Nuclear Physics, Material Sciences, Radiation and Applications (J. Nucl. Phy. Mat. Sci. Rad. A.) by Chitkara University Publications are Open Access articles that are published with licensed under a Creative Commons Attribution- CC-BY 4.0 International License. Based on a work at http://jnp.chitkara.edu.in. This license permits one to use, remix, tweak and reproduction in any medium, even commercially provided one give credit for the original creation.

View Legal Code of the above-mentioned license, https://creativecommons.org/licenses/by/4.0/legalcode

View Licence Deed here https://creativecommons.org/licenses/by/4.0/

Creative Commons License

Journal of Nuclear Physics, Material Sciences, Radiation and Applications by Chitkara University Publications is licensed under a Creative Commons Attribution 4.0 International License.
Based on a work at https://jnp.chitkara.edu.in/

Members