Standardization of Some Commercial Anti-diabetic Herbal Products containing Syzygiumcumini

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Published: May 5, 2017

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Authors

Jasmeen KaurDepartment of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala – 147001, Punjab, India
Munish SinglaDepartment of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala – 147001, Punjab, India
Balraj SainiDepartment of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala – 147001, Punjab, India
Gulshan BansalDepartment of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala – 147001, Punjab, India

DOI Number
https://doi.org/10.15415/jptrm.2017.51002

Keywords
Methylxanthoxylin, Syzygiumcumini, HPLC, stability testing, anti-diabetic

Abstract

An isocratic HPLC method was developed for standardization of five commercially available products containing S. cumini seeds (DIABECON, MADHULENE, HYPONIDD, D-FIT and DIABEGON)using methylxanthoxylin (MXX)as marker. The method was validated in accordance with ICH Q2(R1) guidelines. The chromatographic separation of MXX was achieved on a C18 column by mobile phase composed of methanol and water (60:40%v/v) at a flow rate 0.5 mL/min. The eluent was detected at 280 nm.
The method was linear over concentration of 1-200 μg/mL with correlation coefficient of 0.9999. The LOD and LOQ were 0.175 and 0.530 µg/mL, respectively. The method was precise (%RSD <0.31), accurate and robust for determination of MXX in herbal extracts. The content of MXX in the seed extract was found to be 0.0433%w/w while it was ranging from 0.026-
0.041%w/w in the products. The content of MXX was found to be equivalent to the pure seed extract only in DIABECON tablets and D-FIT soft gelatine capsules while it was found to be significantly less in the other formulations.

References

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How to Cite

Jasmeen Kaur, Munish Singla, Balraj Saini, Gulshan Bansal. Standardization of Some Commercial Anti-diabetic Herbal Products containing Syzygiumcumini. J. Pharm. Technol. Res. Manag.. 2017, 05, 21-30

Standardization of Some Commercial Anti-diabetic Herbal Products containing Syzygiumcumini

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