Objective: Cognitive dysfunction appertains to a loss in verbal, non-verbal learning, attention, working and short-term memory, motor functioning, problem-solving, and processing speed. The major objective of this study is to find out phytoconstituents obtained from Convolvulus Pluricaulis with the help of PASS software, which can be used in the treatment of cognitive dysfunction.
Methods: PASS is important software used in this study to find out biological activity spectra of phytoconstituents of Convolvulus Pluricaulis in the amelioration of cognitive dysfunction. The predicted biological activity was also compared with marketed compounds like Rivastigmine, donepezil, memantine, and curcumin.
Results: From the study, it was found that CP has great potential in the treatment of cognitive dysfunction. Many phytoconstituents of CP have free radical scavenging, antioxidant, and dementia treatment activity.
Conclusion: In this research work, information was compiled with the help of PASS software of phytoconstituents of Convolvulus Pluricaulis for its potential against cognitive dysfunction. Further research is required to explore the potential of CP phytoconstituents in the treatment of cognitive dysfunction…
Angélica Maria, S.-G., Juan Ignacio, M.-M., Ramírez-Pineda Jose, R., Marisol, L.-R., Edison, O., Gloria Patricia, C.-G., & Patricia Cardona-Gómez, G. (2015). The flavonoid quercetin ameliorates Alzheimer’s disease pathology and protects cognitive and emotional function in aged triple transgenic Alzheimer’s disease model mice HHS Public Access. Neuropharmacology, 93, 134–145. https://doi.org/10.1016/j.neuropharm.2015.01.027
Annicchiarico, R., Federici, A., Pettenati, C., & Caltagirone, C. (2007). Rivastigmine in Alzheimer’s disease: Cognitive function and quality of life. Therapeutics and Clinical Risk Management, 3(6), 1113–1123. https://moh-it.elsevierpure.com/en/publications/ rivastigmine-in-alzheimers-disease-cognitive- function-and-quality
Bae, W. Y., Choi, J. S., & Jeong, J. W. (2018). The Neuroprotective Effects of Cinnamic Aldehyde in an MPTP Mouse Model of Parkinson’s Disease. International Journal of Molecular Sciences 2018, 19, 551, 19(2), 551. https://doi.org/10.3390/IJMS19020551
Balkrishna, A., Thakur, P., & Varshney, A. (2020). Phytochemical Profile, Pharmacological Attributes and Medicinal Properties of Convolvulus prostrates – A Cognitive Enhancer Herb for the Management of Neurodegenerative Etiologies. Frontiers in Pharmacology, 11, 171. https://doi.org/10.3389/FPHAR.2020.00171/BIBTEX
Bowman, G. L. (2012). Ascorbic acid, cognitive function, and Alzheimer’s disease: a current review and future direction NIH Public Access. Biofactors, 38(2), 114–122. https://doi.org/10.1002/biof.1002
Chang, P., Augustin, K., Boddum, K., Williams, S., Sun, M., Terschak, J. A., Hardege, J. D., Chen, P. E., Walker, M. C., & Williams, R. S. B. (2016). Seizure control by decanoic acid through direct AMPA receptor inhibition. Brain, 139(2), 431. https://doi.org/10.1093/BRAIN/AWV325
Fata, G. La, Weber, P., & Hasan Mohajeri, M. (2014). Effects of Vitamin E on Cognitive Performance during Ageing and in Alzheimer’s Disease. Nutrients, 6, 5453–5472. https://doi.org/10.3390/nu6125453
Hornick, A., Lieb, A., Vo, N. P., Rollinger, J. M., Stuppner, H., & Prast, H. (2011). The coumarin scopoletin potentiates acetylcholine release from synaptosomes, amplifies hippocampal long-term potentiation and ameliorates anticholinergic- and age-impaired memory. Neuroscience, 197, 280–292. https://doi. org/10.1016/J.NEUROSCIENCE.2011.09.006
Hornick, Ariane, Lieb, A., Vo, N. P., Rollinger, J., Stuppner, H., & Prast, H. (2008). Effects of the coumarin scopoletin on learning and memory, on release of acetylcholine from brain synaptosomes and on long-term potentiation in hippocampus. https://doi.org/10.1186/1471-2210-8-S1-A36
Jayaraj, R. L., Beiram, R., Azimullah, S., Meeran, N. M.,Ojha, S. K., Adem, A., & Yousuf Jalal, F. (n.d.). Valeric Acid Protects Dopaminergic Neurons by Suppressing Oxidative Stress, Neuroinflammation and Modulating Autophagy Pathways. International Journal of Molecular Sciences Article. https://doi.org/10.3390/ijms21207670
Kim, H. S., Sul, D., Lim, J. Y., Lee, D., Joo, S. S., Hwang,K. W., & Park, S. Y. (2009). Delphinidin Ameliorates Beta-Amyloid-Induced Neurotoxicity by Inhibiting Calcium Influx and Tau Hyperphosphorylation. Bioscience, Biotechnology, and Biochemistry, 73(7), 1685–1689. https://doi.org/10.1271/BBB.90032
Lagunin, A., Stepanchikova, A., Filimonov, D., & Poroikov, V. (2000). PASS: prediction of activity spectra for biologically active substances. Bioinformatics, 16(8), 747–748. https://doi.org/10.1093/ BIOINFORMATICS/16.8.747
Masheta, D. Q., & Al-Azzawi, S. K. (2018). Antioxidant and Anti-Inflammatory Effects of Delphinidin on Glial Cells and Lack of Effect on Secretase Enzyme. IOP Conference Series: Materials Science and Engineering, 454(1). https://doi.org/10.1088/1757-899X/454/1/012061
Mehla, J., Gupta, P., Pahuja, M., Diwan, D., & Diksha, D. (2020). Indian medicinal herbs and formulations for Alzheimer’s disease, from traditional knowledge to scientific assessment. Brain Sciences, 10(12), 1–31. https://doi.org/10.3390/BRAINSCI10120964
Mirzaev, Y. R., & Aripova, S. F. (1998). Neuro-and psychopharmacological investigation of the alkaloids convolvine and atropine. Chemistry of natural compounds, 34(1), 56–58 | 10.1007/ bf02249687. (n.d.). Retrieved April 6, 2023, from https://sci-hub.se/https://link.springer.com/ article/10.1007/BF02249687
Parasuraman, S. (2011). Prediction of activity spectra for substances. Journal of Pharmacology & Pharmacotherapeutics, 2(1), 52–53. \ https://doi.org/10.4103/0976-500X.77119
Ramaswamy, S., Madabushi, J., Hunziker, J., Bhatia, S. C., & Petty, F. (2015). Clinical Study An Open-Label Trial of Memantine for Cognitive Impairment in Patients with Posttraumatic Stress Disorder. https://doi.org/10.1155/2015/934162
Ren, J., Lu, Y., Qian, Y., Chen, B., Wu, T., & Ji, G.(2019). Recent progress regarding kaempferol for the treatment of various diseases (Review). Experimental and Therapeutic Medicine, 18(4), 2759–2776. https://doi.org/10.3892/ETM.2019.7886
Rogers, S. L., Doody, R. S., Mohs, R. C., Friedhoff, L. T., & Donepezil Study Group. (1998). Donepezil improves cognition and global function in Alzheimer disease: a 15-week, double-blind, placebo-controlled study. Archives of internal medicine, 158(9), 1021-1031. https://doi:10.1001/archinte.158.9.1021
S, N., & Shivanandappa, T. (2018). Neuroprotective action of 4-Hydroxyisophthalic acid against paraquat- induced motor impairment involves amelioration of mitochondrial damage and neurodegeneration in Drosophila. NeuroToxicology, 66, 160–169. https://doi.org/10.1016/J.NEURO.2018.04.006
Sasaki, K., Othman, M. Ben, Ferdousi, F., Yoshida, M., Watanabe, M., Tominaga, K., & Isoda, H. (2019). Modulation of the neurotransmitter systems through the anti-inflammatory and antidepressant-like effects of squalene from Aurantiochytrium sp. PLOS ONE, 14(6), e0218923. https://doi.org/10.1371/JOURNAL.PONE.0218923
Shelke, S. A., & Jitendra Joshi, N. (2020). A Review on Medicinal Plants against Various Forms of Dementia. International Journal of Pharmaceutical Sciences Review and Research, 64(2), 171–182. https://doi.org/10.47583/IJPSRR.2020.V64I02.028
Travica, N., Ried, K., Sali, A., Scholey, A., Hudson, I., & Pipingas, A. (2017). Vitamin C Status and Cognitive Function: A Systematic Review. https://doi.org/10.3390/nu9090960
Umukoro, S., Adewole, F. A., Eduviere, A. T., Aderibigbe, A. O., & Onwuchekwa, C. (2014). Free radical scavenging effect of donepezil as the possible contribution to its memory enhancing activity in mice. Drug Research, 64(5), 236–239. https://doi. org/10.1055/S-0033-1357126/ID/R2013-08-0368- 0025.
Voulgaropoulou, S. D., van Amelsvoort, T. A. M. J., Prickaerts, J., & Vingerhoets, C. (2019). The effect of curcumin on cognition in Alzheimer’s disease and healthy aging: A systematic review of pre-clinical and clinical studies. Brain Research, 1725. https://doi.org/10.1016/J.BRAINRES.2019.146476
Wang, D., & Mitchell, E. S. (2016). Cognition and Synaptic-Plasticity Related Changes in Aged Rats Supplemented with 8- and 10-Carbon Medium Chain Triglycerides. PLOS ONE, 11(8), e0160159. https:// doi.org/10.1371/JOURNAL.PONE.0160159
Wu, Z., Li, X., Li, F., Yue, H., He, C., Xie, F., & Wang, Z. (2014). Enantioselective transesterification of (R,S)-2-pentanol catalyzed by a new flower-like nanobioreactor. RSC Advances, 4(64), 33998–34002. https://doi.org/10.1039/C4RA04431B
Zhao, Q., Zhou, B., Ding, D., Teramukai, S., Guo, Q., Fukushima, M., & Hong, Z. (2014). Cognitive Decline in Patients with Alzheimer’s Disease and Its Related Factors in a Memory Clinic Setting, Shanghai, China. PLOS ONE, 9(4), e95755. https://doi.org/10.1371/JOURNAL.PONE.0095755