Predicting The Potential of Convolvulus Pluricaulis Against Cognitive Dysfunction With The Help of Prediction of Activities Spectra of Substances Software
Home >
2022,
Vol. 10 No. 02 > Predicting The Potential of Convolvulus Pluricaulis Against Cognitive Dysfunction With The Help of Prediction of Activities Spectra of Substances Software
Published: November 10, 2022
Authors
- Vikas Sharma
- Navneet Khurana
- Sakshi Sharma
- Soumik Chaudhury
- Samriti, Talluri Sriram
- Neha Sharma
Keywords
CP, Cognitive dysfunction, Alzheimer’s disease, Curcumin, Rivastigmine, Donepezil, Memantine
Abstract
Objective: Cognitive dysfunction appertains to a loss in verbal, non-verbal learning, attention, working and short-term memory, motor functioning, problem-solving, and processing speed. The major objective of this study is to find out phytoconstituents obtained from Convolvulus Pluricaulis with the help of PASS software, which can be used in the treatment of cognitive dysfunction.
Methods: PASS is important software used in this study to find out biological activity spectra of phytoconstituents of Convolvulus Pluricaulis in the amelioration of cognitive dysfunction. The predicted biological activity was also compared with marketed compounds like Rivastigmine, donepezil, memantine, and curcumin.
Results: From the study, it was found that CP has great potential in the treatment of cognitive dysfunction. Many phytoconstituents of CP have free radical scavenging, antioxidant, and dementia treatment activity.
Conclusion: In this research work, information was compiled with the help of PASS software of phytoconstituents of Convolvulus Pluricaulis for its potential against cognitive dysfunction. Further research is required to explore the potential of CP phytoconstituents in the treatment of cognitive dysfunction.
References
- Angélica Maria, S.-G., Juan Ignacio, M.-M., Ramírez-Pineda Jose, R., Marisol, L.-R., Edison, O., Gloria Patricia, C.-G., & Patricia Cardona-Gómez, G. (2015). The flavonoid quercetin ameliorates Alzheimer’s disease pathology and protects cognitive and emotional function in aged triple transgenic Alzheimer’s disease model mice HHS Public Access. Neuropharmacology, 93, 134–145. https://doi.org/10.1016/j.neuropharm.2015.01.027
- Annicchiarico, R., Federici, A., Pettenati, C., & Caltagirone, C. (2007). Rivastigmine in Alzheimer’s disease: Cognitive function and quality of life. Therapeutics and Clinical Risk Management, 3(6), 1113–1123. https://moh-it.elsevierpure.com/en/publications/ rivastigmine-in-alzheimers-disease-cognitive- function-and-quality
- Bae, W. Y., Choi, J. S., & Jeong, J. W. (2018). The Neuroprotective Effects of Cinnamic Aldehyde in an MPTP Mouse Model of Parkinson’s Disease. International Journal of Molecular Sciences 2018, 19, 551, 19(2), 551. https://doi.org/10.3390/IJMS19020551
- Balkrishna, A., Thakur, P., & Varshney, A. (2020). Phytochemical Profile, Pharmacological Attributes and Medicinal Properties of Convolvulus prostrates – A Cognitive Enhancer Herb for the Management of Neurodegenerative Etiologies. Frontiers in Pharmacology, 11, 171. https://doi.org/10.3389/FPHAR.2020.00171/BIBTEX
- Bowman, G. L. (2012). Ascorbic acid, cognitive function, and Alzheimer’s disease: a current review and future direction NIH Public Access. Biofactors, 38(2), 114–122. https://doi.org/10.1002/biof.1002
- Chang, P., Augustin, K., Boddum, K., Williams, S., Sun, M., Terschak, J. A., Hardege, J. D., Chen, P. E., Walker, M. C., & Williams, R. S. B. (2016). Seizure control by decanoic acid through direct AMPA receptor inhibition. Brain, 139(2), 431. https://doi.org/10.1093/BRAIN/AWV325
- Fata, G. La, Weber, P., & Hasan Mohajeri, M. (2014). Effects of Vitamin E on Cognitive Performance during Ageing and in Alzheimer’s Disease. Nutrients, 6, 5453–5472. https://doi.org/10.3390/nu6125453
- Hornick, A., Lieb, A., Vo, N. P., Rollinger, J. M., Stuppner, H., & Prast, H. (2011). The coumarin scopoletin potentiates acetylcholine release from synaptosomes, amplifies hippocampal long-term potentiation and ameliorates anticholinergic- and age-impaired memory. Neuroscience, 197, 280–292. https://doi. org/10.1016/J.NEUROSCIENCE.2011.09.006
- Hornick, Ariane, Lieb, A., Vo, N. P., Rollinger, J., Stuppner, H., & Prast, H. (2008). Effects of the coumarin scopoletin on learning and memory, on release of acetylcholine from brain synaptosomes and on long-term potentiation in hippocampus. https://doi.org/10.1186/1471-2210-8-S1-A36
- Jayaraj, R. L., Beiram, R., Azimullah, S., Meeran, N. M.,Ojha, S. K., Adem, A., & Yousuf Jalal, F. (n.d.). Valeric Acid Protects Dopaminergic Neurons by Suppressing Oxidative Stress, Neuroinflammation and Modulating Autophagy Pathways. International Journal of Molecular Sciences Article. https://doi.org/10.3390/ijms21207670
- Kim, H. S., Sul, D., Lim, J. Y., Lee, D., Joo, S. S., Hwang,K. W., & Park, S. Y. (2009). Delphinidin Ameliorates Beta-Amyloid-Induced Neurotoxicity by Inhibiting Calcium Influx and Tau Hyperphosphorylation. Bioscience, Biotechnology, and Biochemistry, 73(7), 1685–1689. https://doi.org/10.1271/BBB.90032
- Lagunin, A., Stepanchikova, A., Filimonov, D., & Poroikov, V. (2000). PASS: prediction of activity spectra for biologically active substances. Bioinformatics, 16(8), 747–748. https://doi.org/10.1093/ BIOINFORMATICS/16.8.747
- Masheta, D. Q., & Al-Azzawi, S. K. (2018). Antioxidant and Anti-Inflammatory Effects of Delphinidin on Glial Cells and Lack of Effect on Secretase Enzyme. IOP Conference Series: Materials Science and Engineering, 454(1). https://doi.org/10.1088/1757-899X/454/1/012061
- Mehla, J., Gupta, P., Pahuja, M., Diwan, D., & Diksha, D. (2020). Indian medicinal herbs and formulations for Alzheimer’s disease, from traditional knowledge to scientific assessment. Brain Sciences, 10(12), 1–31. https://doi.org/10.3390/BRAINSCI10120964
- Mirzaev, Y. R., & Aripova, S. F. (1998). Neuro-and psychopharmacological investigation of the alkaloids convolvine and atropine. Chemistry of natural compounds, 34(1), 56–58 | 10.1007/ bf02249687. (n.d.). Retrieved April 6, 2023, from https://sci-hub.se/https://link.springer.com/ article/10.1007/BF02249687
- Parasuraman, S. (2011). Prediction of activity spectra for substances. Journal of Pharmacology & Pharmacotherapeutics, 2(1), 52–53. \ https://doi.org/10.4103/0976-500X.77119
- Ramaswamy, S., Madabushi, J., Hunziker, J., Bhatia, S. C., & Petty, F. (2015). Clinical Study An Open-Label Trial of Memantine for Cognitive Impairment in Patients with Posttraumatic Stress Disorder. https://doi.org/10.1155/2015/934162
- Ren, J., Lu, Y., Qian, Y., Chen, B., Wu, T., & Ji, G.(2019). Recent progress regarding kaempferol for the treatment of various diseases (Review). Experimental and Therapeutic Medicine, 18(4), 2759–2776. https://doi.org/10.3892/ETM.2019.7886
- Rogers, S. L., Doody, R. S., Mohs, R. C., Friedhoff, L. T., & Donepezil Study Group. (1998). Donepezil improves cognition and global function in Alzheimer disease: a 15-week, double-blind, placebo-controlled study. Archives of internal medicine, 158(9), 1021-1031. https://doi:10.1001/archinte.158.9.1021
- S, N., & Shivanandappa, T. (2018). Neuroprotective action of 4-Hydroxyisophthalic acid against paraquat- induced motor impairment involves amelioration of mitochondrial damage and neurodegeneration in Drosophila. NeuroToxicology, 66, 160–169. https://doi.org/10.1016/J.NEURO.2018.04.006
- Sasaki, K., Othman, M. Ben, Ferdousi, F., Yoshida, M., Watanabe, M., Tominaga, K., & Isoda, H. (2019). Modulation of the neurotransmitter systems through the anti-inflammatory and antidepressant-like effects of squalene from Aurantiochytrium sp. PLOS ONE, 14(6), e0218923. https://doi.org/10.1371/JOURNAL.PONE.0218923
- Shelke, S. A., & Jitendra Joshi, N. (2020). A Review on Medicinal Plants against Various Forms of Dementia. International Journal of Pharmaceutical Sciences Review and Research, 64(2), 171–182. https://doi.org/10.47583/IJPSRR.2020.V64I02.028
- Travica, N., Ried, K., Sali, A., Scholey, A., Hudson, I., & Pipingas, A. (2017). Vitamin C Status and Cognitive Function: A Systematic Review. https://doi.org/10.3390/nu9090960
- Umukoro, S., Adewole, F. A., Eduviere, A. T., Aderibigbe, A. O., & Onwuchekwa, C. (2014). Free radical scavenging effect of donepezil as the possible contribution to its memory enhancing activity in mice. Drug Research, 64(5), 236–239. https://doi. org/10.1055/S-0033-1357126/ID/R2013-08-0368- 0025.
- Voulgaropoulou, S. D., van Amelsvoort, T. A. M. J., Prickaerts, J., & Vingerhoets, C. (2019). The effect of curcumin on cognition in Alzheimer’s disease and healthy aging: A systematic review of pre-clinical and clinical studies. Brain Research, 1725. https://doi.org/10.1016/J.BRAINRES.2019.146476
- Wang, D., & Mitchell, E. S. (2016). Cognition and Synaptic-Plasticity Related Changes in Aged Rats Supplemented with 8- and 10-Carbon Medium Chain Triglycerides. PLOS ONE, 11(8), e0160159. https:// doi.org/10.1371/JOURNAL.PONE.0160159
- Wu, Z., Li, X., Li, F., Yue, H., He, C., Xie, F., & Wang, Z. (2014). Enantioselective transesterification of (R,S)-2-pentanol catalyzed by a new flower-like nanobioreactor. RSC Advances, 4(64), 33998–34002. https://doi.org/10.1039/C4RA04431B
- Zhao, Q., Zhou, B., Ding, D., Teramukai, S., Guo, Q., Fukushima, M., & Hong, Z. (2014). Cognitive Decline in Patients with Alzheimer’s Disease and Its Related Factors in a Memory Clinic Setting, Shanghai, China. PLOS ONE, 9(4), e95755. https://doi.org/10.1371/JOURNAL.PONE.0095755
How to Cite
Vikas Sharma, Navneet Khurana, Sakshi Sharma, Soumik Chaudhury, Samriti, Talluri Sriram, and Neha Sharma. Predicting The Potential of Convolvulus Pluricaulis Against Cognitive Dysfunction With The Help of Prediction of Activities Spectra of Substances Software.
J. Pharm. Technol. Res. Manag.. 2022, 10, 171-180