Application of Microcrystalline Cellulose Powders Obtained from Gossypiumherbaceum As Dry Binder in the Formulation of Diazepam Tablets
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2022,
Vol. 10 No. 01 > Application of Microcrystalline Cellulose Powders Obtained from Gossypiumherbaceum As Dry Binder in the Formulation of Diazepam Tablets
Authors
- Nkemakolam Nwachukwu
- SabinusIfeanyi Ofoefule
Keywords
Tableting, in-vitro release, diazepam, Gossypiumherbaceum, microcrystalline cellulose.
Abstract
Background: Microcrystalline cellulose (MCC) is a popular dry binder in tablet formulation. Differences in its processing methods can significantly affect its tableting properties.
Aim Assessment of the tableting and in-vitro release properties of diazepam tablets formulated with Gossypiumherbaceum (GH) derived MCC that was dried by two different methods.
Methods: G.herbaceum bolls were de-lignified in sodium hydroxide solutions to obtain α- cellulose which was hydrolyzed with 2.0 N hydrochloric acid to obtain MCC. The neutralized damp MCC was separated into two portions. One portion was fluid bed dried (MCC-GossF) while the other portion was lyophilized (MCC-GossL). Diazepam tablets were prepared with 20, 30 and 40%w/w of MCC-GossF and MCC-GossL..Avicel PH 102 (AVH-102) served as comparing standard. The formulations were evaluated using standard methods.
Results: The powders flowed well and the tablets met with British Pharmacopoiea specifications. Diazepam tablets containing MCC-GossL (DGL) were stronger than those of MCC-GossF (DCF) (p<0.05). The disintegration times were < 2 min and friability ≤ 1%. The strength of tablets containing AVH-102 (DAV) compared well with those of DGL tablets. More than 80% of diazepam was released from the tablets.
Conclusion: The GH MCCs served as good dry binders in the formulation of diazepam tablets.
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How to Cite
Nkemakolam Nwachukwu and SabinusIfeanyi Ofoefule. Application of Microcrystalline Cellulose Powders Obtained from Gossypiumherbaceum As Dry Binder in the Formulation of Diazepam Tablets.
J. Pharm. Technol. Res. Manag.. 2022, 10, 75-86
