Molecular Docking Approach to Identify Potential AntiCandidal Potential of Curcumin.

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Published: November 17, 2020

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Authors

Nidhi Rani Chitkara College of Pharmacy, Chitkara University, Punjab, India.
Prerna Sharma Vikas Kumar Sharma, Guru Gobind Singh College of Pharmacy, Yamuna Nagar, 135001, Haryana, India.
Praveen Kuma SunPharma, Hill Top Area, Vill. Bhatolikalan, P.O.Barotiwala, Distt.Solan, Himachal Pardesh, India-174103.

DOI Number
https://doi.org/10.15415/jptrm.2020.82008

Keywords
Antifungal medications, Candida albicans, 14α-demethylase, Molecular docking, Molecular modeling

Abstract

Background: Candida albicans is a kind of fungus that can lead to mortality. In the presence of the enzyme Lanosterol-demethylase, Ergosterol, the major sterol in the fungal cell membrane, is the resulting product of Lanosterol (Cytochrome P450DM).

Purpose: Azole antifungal drugs target this enzyme as a target enzyme. The work included selecting and modelling the target enzyme. Cucumin’s inhibitory effect on Cytochrome P450 was tested utilising molecular docking experiments.

Methods: Chem sketch was used to create compound structures, and Molergo Virtual Docker was used to do molecular docking.

Results: All of the curcumin and conventional medicines, such as Ketoconazole, Clotrimazole, and Miconazole, have interaction with 14-demethylase amino acid residues, Haem and water molecules in the target site, as per the docking research.

References

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How to Cite

Nidhi Rani, Prerna Sharma, Vikas Kumar Sharma, Praveen Kumar. Molecular Docking Approach to Identify Potential AntiCandidal Potential of Curcumin.. J. Pharm. Technol. Res. Manag.. 2020, 08, 67–71

Molecular Docking Approach to Identify Potential AntiCandidal Potential of Curcumin.

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