Dementia: An Overview
Authors
- Nitin BansalDepartment of Pharmacology, ASBASJSM College of Pharmacy, BELA (Ropar) Punjab-140111, India
- Milind ParleDepartment of Pharmaceutical Sciences, Guru Jambhwshawar University of Science & Technology, Hisar, Haryana-125001, India
Keywords
Amnesia, Alzheimer’s disease, Cognition, Dementia, Memory
Abstract
Dementia is a neurodegenerative disorder characterized by progressive and continuous loss of cognitive functions. The neuropsychiatric symptoms include apathy; agitation and depression. As the disorder progresses, the patient gradually becomes dependent on others to perform routine daily activities. Various underlying diseases or disorders are the root cause of the syndrome of dementia. Each of these disorder or disease is characterized by a specific signs and symptoms in combination with a presumed underlying neuropathology. Alzheimer’s disease is the most prevalent cause of dementia. The second most prevalent cause is vascular dementia. In this review, the clinical types, pathophysiology and pharmacotherapy is summarized.
References
- Anand, A., Saraf, M. K., Prabhakar, S. (2007). Sustained inhibition of brotizolam induced anterograde amnesia by norharmane and retrograde amnesia by l-glutamic acid in mice. Behavioural Brain Research, 182, 12-20. https://doi.org/10.1016/j.bbr.2007.04.022
- Bassil, N., Morley, J.E. (2010). Endocrine aspects of healthy brain aging. Clinics in Geriatric Medicine, 26, 57-74. https://doi.org/10.1016/j.cger.2009.12.004
- Budson, A. E., Price, B. H. (2005). Memory Dysfunction. New England Journal of Medicine, 352, 692-699. https://doi.org/10.1056/NEJMra041071
- Caccamo, A., Fisher, A., LaFerla, F. M. (2009). M1 agonists as a potential disease-modifying therapy for Alzheimer’s disease. Current Alzheimer Research, 6, 112-117. https://doi.org/10.2174/156720509787602915
- Carrera, E., Michel, P., Bogousslavsky, J. (2004). Anteromedian, central, and posterolateral infarcts of the thalamus: three variant types. Stroke, 35, 2826-2831. https://doi.org/10.1161/01.STR.0000147039.49252.2f
- Chun, M. M. (2005). Drug-induced amnesia impairs implicit relational memory. Trends in Cognitive Sciences, 9, 355-357. https://doi.org/10.1016/j.tics.2005.06.015
- Cipolotti, L., Shallice, T., Chan, D., Fox, N., Scahill, R., Harrison, G., Stevens, J., Rudge, P. (2001). Long-term retrograde amnesia the crucial role of the hippocampus. Neuropsychologia, 39, 151-172. https://doi.org/10.1016/S0028-3932(00)00103-2
- Craft, S. (2009). The role of metabolic disorders in Alzheimer disease and vascular dementia: two roads converged. Archives of Neurology, 66, 300-305. https://doi.org/10.1001/archneurol.2009.27
- Cummings, J. L. (2004). Alzheimer’s disease. New England Journal of Medicine, 351, 56 67. https://doi.org/10.1056/NEJMra040223
- Cyngiser, T. A. (2008). Creutzfeldt-Jakob disease: a disease overview. American Journal of Electroneurodiagnostic Technology, 48, 199-208. PubMed ID-18998478
- Deadwyler, S. A., Hampson, K. E. (1999). Anatomical model of hippocampal encoding of spatialinformation. Hippocampus, 9, 397-421.
- DeKosky, S. T., Ikonomovic, M. D., Gandy, S. (2010). Traumatic brain injury–football, warfare, and long-term effects. New England Journal of Medicine, 363, 1293-1296. https://doi.org/10.1056/NEJMp1007051
- Di Gennaro, G., Grammaldo, L. G., Quarato. P. P., Esposito, V., Mascia, A., Sparano, A., Meldolesi, G. N., Picardi, A. (2006). Severe amnesia following bilateral medial temporal lobe damage occurring on two distinct occasions. Journal of Neurological Sciences, 27, 129-133. https://doi.org/10.1007/s10072-006-0614-y
- Dupiereux, I., Zorzi, W., Quadrio, I., Perret-Liaudet, A., Kovacs, G. G., Heinen, E., Elmoualij, B., Creutzfeldt-jakob. (2009). Parkinson, lewy body dementia and Alzheimer diseases: from diagnosis to therapy Central Nervous System Agents in Medicinal Chemistry, 9, 2-11. https://doi.org/10.2174/187152409787601950
- Ellis, K. A., Nathan, P. J. (2001). Pharmacology of human working memory. The International Journal of Neuropsychophrmacology, 4, 299-313. https://doi.org/10.1017/S1461145701002541
- Esbenshade, T. A., Browman, K. E., Bitner, R. S., Strakhova, M., Cowart, M. D., Brioni, J. D. (2008). The histamine H3 receptor: an attractive target for the treatment of cognitive disorders. British Journal of Pharmacology, 154, 1166-81. https://doi.org/10.1038/bjp.2008.147
- Fama, R., Marsh, L., Sullivan, E. V. (2004). Dissociation of remote and anterograde memory impairment and neural correlates in alcoholic Korsakoff syndrome. Journal of the International Neuropsychological Society, 10, 427-441. https://doi.org/10.1017/S135561770410310X
- Farlow, M. R. (2009). Treatment of mild cognitive impairment (MCI). Current Alzheimer Research, 6, 362-367. https://doi.org/10.2174/156720509788929282
- Fratiglioni, L., Winblad, B., Strauss, E. V. (2007). Prevention of Alzheimer’s disease and dementia. Major findings from the Kungsholmen Project. Physiology & Behaviour, 92, 98–104. https://doi.org/10.1016/j.physbeh.2007.05.059
- Gilbert, M. E. (2000). In-vitro system as stimulation of in-vitro conditions: The study of cognition and synaptic plasticity in neurotoxicology. Annals of the New York Academy of Sciences, 919, 119-132. https://doi.org/10.1111/j.1749-6632.2000.tb06874.x
- Herta, K. D., Sturzenegger, M., Berkhoff, M. (2005). Human immunodeficiency virus associated tuberculous meningoencephalitis causing abnormal behaviour in a prisoner. Der Nervenarzt, 76, 68-71. https://doi.org/10.1007/s00115-004-1702-y
- Hillbom, M., Marttila, M. (2010). Encephalopathies due to vitamin deficiency. Duodecim, 126, 2132- 2138. PMID:21072960
- Hindle, J. V. (2010). Ageing, neurodegeneration and Parkinson’s disease Age and Ageing, 39, 156-161. https://doi.org/10.1093/ageing/afp223
- Hulse, G. K., Lautenschllger, N. T., Tait, R. J., Almeida, O. P. (2005). Dementia associated with alcohol and other drug use. International Psychogeriatrics, 17, S109-S127. https://doi.org/10.1017/S1041610205001985
- Husband, A., Worsley, A. (2006). Different types of dementia. The Pharmaceutical Journal, 277, 579-582.
- Kamphuis, P. J., Wurtman, R. J. (2009). Nutrition and Alzheimer’s disease: Preclinical concepts. European Journal of Neurology, 16, 12-18. https://doi.org/10.1111/j.14681331.2009.02737.x
- Kazui, H. (2008). Cognitive impairment in patients with idiopathic normal pressure hydrocephalus. Brain and Nerve, 60, 225-231.
- Korczyn, A. D., Halperin, I. (2009). Depression and dementia. Journal of Neurological Sciences, 283, 139-142. https://doi.org/10.1016/j.jns.2009.02.346
- Krobitsch, S., Kazantsev, A. G. (2011). Huntington’s disease: From molecular basis to therapeutic advances. International Journal of Biochemestry & Cell Biology, 43, 20-24. https://doi.org/10.1016/j.biocel.2010.10.014
- Kulisevsky. J., Pagonabarraga. J. (2009). Cognitive impairment in Parkinson’s disease: tools for diagnosis and assessment. Movement Disorders, 24, 1103-1110. https://doi.org/10.1002/mds.22506
- Kupers, R. C., Fortin. A., Astrup, J., Gjedde, A., Ptito, M. (2004). Recovery of anterograde amnesia in a case of craniopharyngioma. Archives of Neurology, 61, 1948-1952. https://doi.org/10.1001/archneur.61.12.1948
- Lillo, P., Hodges, J. R. (2009). Frontotemporal dementia and motor neuron disease: Overlappingclinicpathological disorders. Journal of Clinical Neuroscience, 16, 1131-1135. https://doi.org/10.1016/j.jocn.2009.03.005
- Lindebooma, J., Weinstein, H. (2004). Neuropsychology of cognitive ageing, minimal cognitive impairment, Alzheimer’s disease, and vascular cognitive impairment. European Journal of Pharmacology, 490, 83-86. https://doi.org/10.1016/j.ejphar.2004.02.046
- Liu, L., Groen, T. V., Kadish, I., Tollefsbo, T. O. (2009). DNA methylation impacts on learning and memory in aging. Neurobiology of Aging, 30, 549-60. https://doi.org/10.1016/j.neurobiolaging.2007.07.020
- Lobo, A., Saz, P. (2005). Dementia. In: Textbook of psychosomatic medicine. Ed. Levenson, J. L. American Psychiatric Publishing Inc. pp. 131-169.
- McIntosh, C., Chick, J. (2004). Alcohol and the nervous system. Journal of Neurology Neurosurgery & Psychiatry, 75, 16-21. https://doi.org/10.1136/jnnp.2004.045708
- Nader, K., Scafe, G. E., LeDoux, J. E. (2000). The labile nature of consolidation theory. Nature Reviews Neuroscience, 1, 216-219. https://doi.org/10.1038/35044580
- Nagano, I., Abe, K. (2004). Neurosyphilis. Nihon Rinsho, 62, 231-234.
- Nalecz, K. A., Miecz, D., Berezowski, V., Cecchelli, R. (2004). Carnitine: transport and physiological functions in the brain. Molecular Aspects of Medicine, 25, 551-567. https://doi.org/10.1016/j.mam.2004.06.001
- Neary, D., Snowden, J., Mann, D. (2005). Frontotemporal dementia. The Lancet Neurology, 4, 771-780. https://doi.org/10.1016/S1474-4422(05)70223-4
- Okano, H., Hirano, T., Balaban, E. (2000). Learning and memory. Proceedings of the National Academy of Sciences, 97, 12403-12404. https://doi.org/10.1073/pnas.210381897
- Olin, J., Schneider, L., Novit, A., Luczak, S. (2001). Hydergine for dementia Cochrane Database of Systemic Reviews, 2, CD000359. https://doi.org/10.1002/14651858.CD000359
- Osimani, A., Berger, A., Friedman, J., Porat-Katz, B. S., Abarbanel, J. M. (2005). Neuropsychology of vitamin B12 deficiency in elderly dementia patients and control subjects. Journal of Geriatric Psychiatry and Neurology, 18, 33-38.
- Parigi, A. D., Panza, F., Capurso, C., Solfrizzi, V. (2006). Nutritional factors, cognitive decline and dementia. Brain Research Bulletin, 69, 1-19. https://doi.org/10.1016/j.brainresbull.2005.09.020
- Park, K. W., Seo, J. H., Yoon, G. U. (2007). Selective anterograde amnesia with thalamus andhippocampal lesions in neuro-Behcet’s disease. Clinical Neurology and
- Neurosurgery, 109, 470-473. https://doi.org/10.1016/j.clineuro.2007.02.016
- Parle, M., Singh, N., Vasudevan, M. (2006). Regular rehearsal helps in consolidation of Long term Memory. Journal of Sports Science and Medicine, 5, 80-88.
- Phaf, H. R., Geurts, H., Eling, P. A. (2000). Word frequency and word stem completion in Korsakoff patients. Journal of Clinical and Experimental Neuropsychology, 22, 817-
- https://doi.org/10.1076/jcen.22.6.817.956
- Pike, C. J., Carroll, J. C., Rosario, E. R., Barron, A. M.(2009). Protective action of sex steroidhormones in alzheimer’s disease. Frontiers in Neuroendocrinology, 30, 239-258. https://doi.org/10.1016/j.yfrne.2009.04.015
- Poreh, A., Winocur, G., Moscovitch, M., Backon, M., Goshen, E., Ram, Z., Feldman, Z.(2006). Anterograde and retrograde amnesia in a person with bilateral fornix lesions following removal of a colloid cyst. Neuropsychologia, 44, 2241-2248. https://doi.org/10.1016/j.neuropsychologia.2006.05.020
- Ramirez-Amaya, V., Escoban, M. L., Chao, V., Bermudez-Rattoni, F. (1999). Synaptogenesis of mossy fibers induced by spatial water maze over training. Hippocampus, 9, 631-636.
- Ratnavalli, E., Brayne, C., Dawson, K., Hodges, J. R. (2002). The prevalence of frontotemporal dementia. Neurology, 58, 1615-1621.
- Robbins, T. W., Murphy, E. R. (2006). Behavioural pharmacology: 40+ years of progress, with a focus on glutamate receptors and cognition. Trends Pharmacological Sciences, 27, 141-148. https://doi.org/10.1016/j.tips.2006.01.009
- Roman, G. C. (2002). Vascular dementia may be the most common form of dementia in the elderly. Journal of Neurological Sciences, 203–204, 7-10. https://doi.org/10.1016/S0022-510X(02)00252-6
- Román, G. C. (2005). Vascular dementia prevention: a risk factor analysis. Cerebrovascular Diseases, 20, 91-100. https://doi.org/10.1159/000089361
- Roze, E., Bonnet, C., Betuing, S., Caboche, J. (2010). Huntington’s disease Advences in experimental medicine and biology, 685, 45-63. https://doi.org/10.1007/978-1-4419-
- -9_5
- Scarpini, E., Scheltens, P., Feldman, H. (2003). Treatment of Alzheimer’s disease: current status and new perspectives. The Lancet Neurology, 2, 539-547. https://doi.org/10.1016/S1474-4422(03)00502-7
- Schreurs, B. G. (2010). The effect of cholesterol on learning and memory. Neuroscience & Biobehavioral Reviews, 34, 1366-1379. https://doi.org/10.1016/j.neubiorev.2010.04.010
- Schweickert, R. A. (1993). Multinomial processing tree model for degradation and redintegration in immediate recall. Memory & Cognition, 21, 168-175. https://doi.org/10.3758/BF03202729
- Shah, R. S., Lee, H. G., Xiongwei, Z., Perry, G., Smith, M. A., Castellani, R. J. (2008). Current approaches in the treatment of Alzheimer’s disease. Biomedicine &
- Pharmacotherapy, 62, 199-207. https://doi.org/10.1016/j.biopha.2008.02.005
- Shaprine, M. L., Eichenbaum, H. (2000). Hippocampus is a memory map: synaptic plasticity andmemory encoding by hippocampus neuron. Hippocampus, 9, 365-384. https://doi.org/10.1002/(SICI)1098-1063(1999)9:4<365::AID-HIPO4>3.0.CO;2-T
- Sharma, D. Bhattacharya, J. (2009). Cellular & molecular basis of HIV-associated neuropathogenesis. Indian Journal of Medical Research, 129, 637-651.
- Shimizu, N. (2004). Wilson disease. Nihon Rinsho, 62, 399-403.
- Silvestrelli, G., Lanari, A., Parnetti, L., Tomassoni, D., Amenta, F. (2006). Treatment of Alzheimer’s disease: From pharmacology to a better understanding of disease pathophysiology. Mechanisms of Ageing and Development, 127, 148–157.
- Sjögren, M., Andersen, C. (2006). Frontotemporal dementia-a brief review. Mechanisms of Ageing and development, 127, 180-187.
- Solntseva, E. I., Bukanova, Iu. V., Skrebitskii, V. G. (2003). Memory and potassium channels. Usp Fiziol Nauk 34, 16-25.
- Staropoli, J. F. (2008). Tumorigenesis and neurodegeneration: two sides of the same coin? BioEssays, 30, 719-727. https://doi.org/10.1002/bies.20784
- Stewart, W. F., Kawas, C., Corrada, M., Metter, E. J. (1997). Risk of Alzheimer’s disease and duration of NSAID use. Neurology, 48, 626-632. https://doi.org/10.1212/WNL.48.3.626
- Summers, M. J. (2002). Neuropsychological consequences of right thalamic haemorrhage: case study and review. Brain and Cognition, 50, 129-138. https://doi.org/10.1016/S0278-2626(02)00017-9
- Tampi, R. R., Williamson, D., Muralee, S., Mittal, V., McEnerney, N., Thomas, J., Cash, M. (2011). Behavioral and psychological symptoms of dementia: Part I- epidemiology,
- neurobiology, heritability and evaluation. Clinical Geriatrics, 19, 1-6.
- Thomas, S. J., Grossberg, G. T. (2009). Memantine: a review of studies into its safety and efficacy in treating Alzheimer’s disease and other dementias.Clinical Interventions in Aging, 4, 367-377. https://doi.org/10.2147/CIA.S6666
- Tomassoni, D., Lanari, A., Silvestrelli, G., Traini, E., Amenta, F. (2008). Nimodipine and its use in cerebrovascular disease: evidence from recent preclinical and controlled clinical studies. Clinical and Experimental Hypertension, 30, 744-766. https://doi.org/10.1080/10641960802580232
- Trinh, N. H., Hoblyn, J., Mohanty, S., Yaffe, K. (2003). Efficacy of cholinesterase inhibitors in the treatment of neuropsychiatric symptoms and functional impairment in Alzheimer disease: ameta-analysis. Journal of the American Medical Association, 280, 210-216. https://doi.org/10.1136/ebmh.6.3.94
- Tuszynski, M. H. (2007). Nerve growth factor gene therapy in Alzheimer disease. Alzheimer Disease and Associated Disorders, 21, 179-189. https://doi.org/10.1097/WAD.0b013e318068d6d2
- Vik, P.W., Cellucci, T., Jarchow, A., Hedt, J. (2004). Cognitive impairment in substance abuse. Psychiatric Clinicis of North America, 27, 97-109. https://doi.org/10.1016/S0193-953X(03)00110-2
- Winnicka, K., Tomasiak, M., Bielawska, A. (2005). Piracetam- an old drug with novel properties? Acta Poloniae Pharmceutica, 62, 405-409.
- Yaffe, K., Kanaya, A., Lindquist, K. et al. (2004). The metabolic syndrome, inflammation and risk of cognitive decline. Journal of the American Medical Association, 242, 2237-2242. https://doi.org/10.1001/jama.292.18.2237
- Zandi, P.P., Anthony, J. C., Khachaturian, A. S., Stone, S. V., Gustafson, D., Tschanz, J. T., Norton, M. C., Welsh-Bohmer, K. A., Breitner, J. C. (2004). Cache County Study Group. Reduced risk of Alzheimer disease in users of antioxidant vitamin supplements: the Cache County Study. Archives of Neurology, 61, 82-88.
How to Cite
Nitin Bansal, Milind Parle. Dementia: An Overview.
J. Pharm. Technol. Res. Manag.. 2014, 02, 29-45
