Eco-Friendly Solvent-Free Infrared (IR) Spectroscopic Method for Voglibose Determination

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Published: April 20, 2024

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Authors

Kritika Verma, Shibam Das, Amit Sharma, and Rohit Bhatia

DOI Number
https://doi.org/10.15415/jprtm.2024.121007

Keywords
Voglibose, Analytical methods, Quality control, FTIR spectroscopy, Quantitative, Validation

Abstract

Background: Voglibose, an α-glucosidase inhibitor used in diabetes management, traditionally requires chromatographic or solvent-based methods for quantification. However, IR spectroscopy offers a rapid, non-destructive, and cost-effective alternative without chemical waste. This method enhances sustainability while maintaining accuracy and sensitivity in pharmaceutical analysis.

Purpose: To validate a method for quantifying voglibose using Fourier-transform infrared (FTIR) spectroscopy, emphasizing its environmental benefits and applicability in academic and industrial settings.

Methods: The FTIR spectroscopy method was developed without the use of organic solvents, requiring only grinding of powders for pellet preparation. Spectra were recorded in absorbance mode within the 868.47–829.40 cm⁻¹ region, based on Beer’s law, to construct a calibration model. Validation was performed according to International Council for Harmonization (ICH) guidelines.

Results: The method demonstrated linearity with a regression coefficient of 0.996. It was precise, accurate (average recovery of 98.68%), and robust across a concentration range of 0.5 to 5.0 mg. The method minimizes waste generation, offering an eco-friendly alternative to conventional techniques.

Conclusion: The validated FTIR spectroscopy method for voglibose quantification in raw materials is a reliable, accurate, and environmentally sustainable alternative for standard quality control processes in both academic and industrial applications.

References

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How to Cite

Kritika Verma, Shibam Das, Amit Sharma, and Rohit Bhatia. Eco-Friendly Solvent-Free Infrared (IR) Spectroscopic Method for Voglibose Determination. J. Pharm. Technol. Res. Manag.. 2024, 12, 84-90

Eco-Friendly Solvent-Free Infrared (IR) Spectroscopic Method for Voglibose Determination

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