Citrus Genus and its Pharmacological Activities: A Review

Authors

Parwinder Singh, Rahul Kumar Sharma, Ramandeep Kaur, Puskar Mehta1, Pankaj, Neelam Sharma, Shailesh Sharma

Abstract

References

Abdul, M., Shenoy, A., Hegde, K., Aamer, S., & Shabaraya, A. (2014). Evaluation of the anti-diabetic activity of ethanolic extract of Citrus maxima Stem Bark. IJPCS, 3, 642–650.

Al-Snafi, A. E. (2016). Nutritional value and pharmacological importance of citrus species grown in Iraq. IOSR Journal of Pharmacy, 6(8), 76–108.

Aranganathan, S., Selvam, J. P., & Nalini, N. (2008). Effect of hesperetin, a citrus flavonoid, on bacterial enzymes and carcinogen-induced aberrant crypt foci in colon cancer rats: a dose-dependent study. J Pharm Pharmacol, 60, 1385-1392.https://doi.org/10.1211/jpp/60.10.0015

Arias, B. A., & Ramon-Laca, L. (2005). Pharmacological properties of citrus and their ancient and medieval uses in the Mediterranean region. Journal of Ethnopharmacology, 97(1), 89–95.https://doi.org/10.1016/j.jep.2004.10.019

Bairagi, G., Kabra, A., & Mandade, R. (2011). Anthelmintic activity of Citrus medica L. leaves in Indian adult earthworm. Int J Pharm Technol Res, 3, 664–667.

Beecher, G. R. (1999). Phytonutrients’ role in metabolism: effects on resistance to degenerative processes. Nutrition Reviews, 57(9), 3-6.

Berk, Z. (2016). Miscellaneous citrus products. In Citrus Fruit Processing (pp. 235–249). Elsevier Science. https://doi.org/10.1016/B978-0-12-803133-9.00011-4

Bertuzzi, G., Tirillini, B., Angelini, P., & Venanzoni, R. (2013). Antioxidative action of Citrus limonum essential Oil on skin. Eur J Med Plants, 3, 1–9.

Bhavitavya, B., Asdaq, S., Asad, M., & Prasad, S. (2012). Antiulcer activity of Lemon (Citrus limon) fruit juice and its interaction with conventionally used antiulcer drugs in rats. Nat Prod J, 2, 61-68.

Bhavsar, S., Joshi, P., Shah, M., & Santani, D. (2007). Investigation into hepatoprotective activity of Citrus limon. Pharm Biol, 45, 303-311.

Bidkar, J., Bhujbal, M., Ghanwat, D., & Dama, G. (2011). Anthelmentic activity of Citrus aurantium Linn. IJPRD, 3, 69-72.

Bilal, H., Akram, W., & Ali-Hassan, S. (2012). Larvicidal Activity of citrus limonoids against Aedesalbopictus Larvae. J Arthropod Borne Dis, 6, 104-111.http://www.ncbi.nlm.nih.gov/pmc/articles/pmc3547300/

Breithaupt, D. E., & Bamedi, A. (2001). Carotenoid esters in vegetables and fruits: A screening with emphasis on β-cryptoxanthin esters. Journal of Agricultural and Food Chemistry, 49(4), 2064-2070. https://doi.org/10.1021/jf001276t

Campêlo, L. M., de Almeida, A. A., de Freitas, R. L., Cerqueira, G. S., de Sousa, G. F., Saldanha, G. B., et al. (2011). Antioxidant and antinociceptive effects of Citrus limon essential oil in mice. J Biomed Biotechnol, 2011, 678673.https://doi.org/10.1155/2011/678673

Campêlo, L. M., Gonçalves, F. C., Feitosa, C. M., & de Freitas, R. M. (2011). Antioxidant activity of Citrus limon essential oil in mouse hippocampus. Pharm Biol, 49, 709-715.https://doi.org/10.3109/13880209.2010.541924

Casimiro, M., Margarita, G., Danice, R., &Judilynn, N. (2010). Evaluation of the hepatoprotective activity of Citrus microcarpa Bunge (Family Rutaceae) fruit peel against acetaminophen-induced liver damage in male BFAD- Sprague Dawley rats. Int J Chem Environ Eng, 1, 127-132.

Dangl, J. L., & Jones, J. D. G. (2001). Plant pathogens and integrated defence responses to infection. Nature, 411(6839), 826-833.

Degirmenci, H., & Erkurt, H. (2019). Relationship between volatile components, antimicrobial and antioxidant properties of the essential oil, hydrosol and extracts of Citrus aurantium L. flowers. Journal of Infection and Public Health, 13(1), 58-67.https://doi.org/10.1016/j.jiph.2019.06.017

Deterre, S., Rega, B., Delarue, J., Decloux, M., Lebrun, M., &Giampaoli, P. (2011). Identification of key aroma compounds from bitter orange (Citrus aurantium L.) products: essential oil and macerate-distillate extract. Flavour Fragr J, 27(1), 77-88.

Dhiman, A., Nanda, A., Ahmad, S., & Narasimhan, B. (2012). In vitro antimicrobial status of methanolic extract of Citrus sinensis Linn. fruit peel. Chron Young Sci, 3, 204-208.

Duarte, A., Fernandes, M. J., Bernardes, J. P., & Miguel, M. G. (2016). Citrus as a component of the Mediterranean diet. Journal of Spatial and Organizational Dynamics, 4(4), 289–304.

El-Alfy, T., Hetta, M., Yassin, N., Rahman, R., & Kadry, E. (2012). Estrogenic activity of Citrus medica L. leaves growing in Egypt. J Appl Pharm Sci, 2, 180-185.

Eslami, M., Bayat, M., MozaffariNejad, A. S., Sabokbar, A., & Anvar, A. A. (2016). Effect of polymer/nanosilver composite packaging on long-term microbiological status of Iranian saffron (Crocus sativus L.). Saudi Journal of Biological Sciences, 23(3), 341-347.https://doi.org/10.1016/j.sjbs.2015.07.004

Gaur, V., Aggarwal, A., & Kumar, A. (2011). Possible nitric oxide mechanism in the protective effect of hesperidin against ischemic reperfusion cerebral injury in rats. Indian J ExpBiol, 49, 609-618.PMID: 21870429

Grosso, G., Bei, R., Mistretta, A., Marventano, S., Calabrese, G., Masuelli, L., et al. (2013). Effects of vitamin C on health: A review of evidence. Frontiers in Bioscience, 18, 1017-1029.https://doi.org/10.2741/4160

Guerra, F., Mendes, J., Oliveira, W., Souza, F., Trajano, V., Coutinho, H., et al. (2013). Antibacterial activity of the essential oil of Citrus limon against multi drug resistant Acinetobacter strains. Rev Bras Farm, 94, 142-147.

Guillon, F., & Champ, M. (2000). Structural and physical properties of dietary fibres, and consequences of processing on human physiology. Food Research International, 33(3-4), 233-245.

Heiss, E., Herhaus, C., Klimo, K., Bartsch, H., & Gerhäuser, C. (2001). Nuclear factor κB is a molecular target for sulforaphane-mediated anti-inflammatory mechanisms. The Journal of Biological Chemistry, 276(34), 32008-32015. https://doi.org/10.1074/jbc.M104794200

Huang, S. M., Tsai, S. Y., Lin, J. A., Wu, C. H., & Yen, G. C. (2012). Cytoprotective effects of hesperetin and hesperidin against amyloid beta-induced impairment of glucose transport through downregulation of neuronal autophagy. Mol Nutr Food Res, 56, 601-609. https://doi.org/10.1002/mnfr.201100682
Hwang, S. L., Shih, P. H., & Yen, G. C. (2012). Neuroprotective effects of citrus flavonoids. J Agric Food Chem, 60(4), 877-885.https://doi.org/10.1021/jf204452y

Jannati, M., Fotouhi, R., Abad, A. P., &Salehi, Z. (2009). Genetic diversity analysis of Iranian citrus varieties using microsatellite (SSR) based markers. Journal of Horticulture and Forestry, 1(7), 120-125.

Jomaa, S., Rahmo, A., Alnori, A., & Chatty, M. (2012). The cytotoxic effect of essential oil of Syrian Citrus limon peel on human colorectal carcinoma cell line (Lim1863). Middle East J Cancer, 3, 15-21.

Kangralkar, V., Gavimath, C., Jadhav, N., & Burli, S. (2000). Potential hypoglycemic effect of essential oil of Citrus reticulata in Wistar rats. Int J Pharm Appl, 1, 6-9.

Katcher, H. I., Hill, A. M., Lanford, J. L., Yoo, J. S., & Kris-Etherton, P. M. (2009). Lifestyle approaches and dietary strategies to lower LDL cholesterol and triglycerides and raise HDL-cholesterol. Endocrinol Metab Clin North Am, 38, 45-78.https://doi.org/10.1016/j.ecl.2008.11.010

Kharjul, M., Gali, V., & Kharjul, A. (2014). Antidiabetic potential of ethanolic extracts of Citrus maxima fruit peel and Anvilleagarcinii. Int J Pharm Innov, 4, 8-18.

Kulkarni, T. R., Kothekar, M. A., & Mateenuddin, M. (2005). Study of antifertility effect of lemon seeds (Citrus limonum) in female albino mice. Indian J Physiol Pharmacol, 49, 305-312.

Kulkarni, T., Mateenuddin, M., Bodhankar, S., & Saharabudhe, R. (2012). Reversible anti-fertility effect of lemon seeds (Citrus limonum) in Male Albino Rats. IJRPBS, 3, 545-550.

Kumar, A., Lalitha, S., & Mishra, J. (2013). Possible nitric oxide mechanism in the protective effect of hesperidin against pentylenetetrazole (PTZ)-induced kindling and associated cognitive dysfunction in mice. Epilepsy and Behavior, 29, 103–111.https://doi.org/10.1016/j.yebeh.2013.06.007

Mabberley, D. J. (2004). Citrus (Rutaceae): a review of recent advances in etymology, systematics and medical applications. Blumea-Biodiversity, Evolution and Biogeography of Plants, 49(2-3), 481-498.

Madhuri, S., Hegde, A., Srilakshmi, N., & Prashitha, K. (2014). Antimicrobial activity of Citrus sinensis and Citrus aurantium peel extracts. JPSI, 3, 366-368.

Mahato, N., Sharma, K., Sinha, M., & Cho, M. H. (2018). Citrus waste-derived nutra-pharmaceuticals for health benefits: current trends and future perspectives. Journal of Functional Foods, 40, 307–316.

Malhi, B. S., & Trivedi, V. P. (1972). Vegetable antifertility drugs of India. Q J Crude Drug Res, 12, 19-22.

Maurya, R., Srivastava, S., Kulshreshta, D. K., & Gupta, C. M. (2004). Traditional remedies for fertility regulation. Curr Med Chem, 11, 1431-1450.

Miranda, R. F., de Paula, M. M., da Costa, G. M., Barão, C. E., da Silva, A. C. R., Raices, R. S. L., et al. (2019). Orange juice added with L. casei: is there an impact of the probiotic addition methodology on the quality parameters? LWT, 106, 186–193. Doi: 10.1016/j.lwt.2019.02.047

Moon, S. H., Lee, J. H., Kim, K. T., et al. (2013). Antimicrobial effect of 7-O-butylnaringenin, a novel flavonoid, and various natural flavonoids against Helicobacter pylori strains. Int J Environ Res Public Health, 10(11), 5459-5469.https://doi.org/10.3390/ijerph10115459

Moore, G. A. (2001). Oranges and lemons: clues to the taxonomy of Citrus from molecular markers. Trends in Genetics, 17(9), 536-540.https://doi.org/10.1016/s0168-9525(01)02442-8

Muhammad, N., Omoniwa, O., Usman, L., & Omoniwa, B. (2013). Antihyperglycemic activity of leaf essential oil of Citrus sinensis (L.) Osbeck on alloxan–Induced Diabetic Rats. Ann Rev Res Biol, 3, 825-834.

Mulder, G. J., &Ouwerkerk-Mahadevan, S. (1997). Modulation of glutathione conjugation in vivo: how to decrease glutathione conjugation in vivo or in intact cellular systems in vitro. Chemico-Biological Interactions, 105(1), 17-34.

Nada, K., & Zainab, A. (2013). Antimicrobial activity of different aqueous lemon extracts. J Appl Pharm Sci, 3, 74-78.

Nalini, A., & Chimmad, B. (2003). Morphological and nutritional characteristics of selected citrus fruits of Uttara Kannada District. Karnataka J Agric Sci, 16, 533-538.

Negi, S., &Anand, B. (2010). Analgesic activity of fruit decoction of Citrus medica Linn. J Pharm Res, 3, 2119.

Nicolosi, E., Deng, Z. N., Gentile, A., La Malfa, S., Continella, G., & Tribulato, E. (2000). Citrus phylogeny and genetic origin of important species as investigated by molecular markers. Feoretical and Applied Genetics, 100(8), 1155-1166.

Okwu, D. (2008). Citrus fruits: A rich source of phytochemicals and their roles in human health. Int J Chem Sci, 6, 451-471.

Osfor, M., Hegazy, A., El-moaty, M., Elmadbouly, M., Afify, A., & Elbahnasawy, A. (2013). Hypo-cholesterolemic and hypoglycemic effects of orange albedo powder (Citrus aurantium L.) on male albino rats. Int J Nutr Food Sci, 2, 70-76.

Oyedepo, A., & Babarinde, S. (2013). Effects of Shaddock (Citrus maxima) fruit juice on glucose tolerance and lipid profile in type-II Diabetic Rats. Chem Sci Trans, 2, 19-24.

Padilla-Camberos, E., Lazcano-Díaz, E., Flores-Fernandez, J. M., Owolabi, M. S., Allen, K., & Villanueva-Rodríguez, S. (2014). Evaluation of the inhibition of carbohydrate hydrolyzing enzymes, the antioxidant activity, and the polyphenolic content of Citrus limetta peel extract. Scientific World Journal, 2014, 1-4. https://doi.org/10.1155/2014/121760

Patil, J., Jayaprakasha, G., Chidambara, K., Tichy, S., Chetti, M., Patil, B., et al. (2009). Apoptosis-mediated proliferation inhibition of human colon cancer cells by volatile principles of Citrus aurantifolia. J Food Chem, 114, 1351-1358.

Patil, S. J., & Patil, S. B. (2008). Estrogenic activity of petroleum ether extract of seeds of Citrus medica on immature albino rats. Int J Green Pharm, 2, 91-94.

Pawinee, P., Thirayudh, G., & Aporn, C. (1985). Antifertility effect of Citrus hystrix. J Ethnopharmacol, 13, 105-110.

Pradeep, M., Wadher, T., & Gomashe, A. (2007). Antibacterial activity of Citrus limon fruit juice against clinical isolates of human pathogens. Asian J MicrobiolBiotechnol Environ Sci, 9, 129-132.

Rabiei, Z., & Rafieian-Kopaei, M. (2014). Neuroprotective effect of pretreatment with Lavandulaofficinalisethanolic extract on blood-brain barrier permeability in a rat stroke model. Asian Pac J Trop Med, 7(1), S421-S426.https://doi.org/10.1016/s1995-7645(14)60269-8

Rafiq, S., Kaul, R., Sofi, S. A., Bashir, N., Nazir, F., & Nayik, G. A. (2018). Citrus peel as a source of functional ingredient: a review. J Saudi SocAgricSci, 17(4), 351-358.

Rauf, A., Uddin, G., & Ali, J. (2014). Phytochemical analysis and radical scavenging profile of juices of Citrus sinensis, Citrus anrantifolia, and Citrus limonum. Org Med Chem Lett, 4, 5.https://doi.org/10.1186/2191-2858-4-5

Roger, G. (1999). New Life Style Enjoy It. Editorial Safelie SL. Spain, 75-76.

Roger, G. (2002). Encyclopedia of Medicinal Plants. Vol. 1. Editorial Safeliz S.L. Spain, 153-154.

Rozza, A., Moraes, T., Kushima, H., Tanimoto, A., Bauab, M. (2011). Gastroprotective mechanisms of Citrus lemon (Rutaceae) essential oil and its majority compounds limonene and β-pinene: Involvement of heat-shock protein-70, vasoactive intestinal peptide, glutathione, sulfhydryl compounds, nitric oxide, and prostaglandin E2. Chem Biol Interact, 189, 82-89.https://doi.org/10.1016/j.cbi.2010.09.031

Rudra, S. G., Nishad, J., Jakhar, N., & Kaur, C. (2015). Food industry waste: mine of nutraceuticals. Int J Sci Environ Technol, 4(1), 205-229.
Sarrafchi, A., Bahmani, M., Shirzad, H., & Rafieian-Kopaei, M. (2015). Oxidative stress and Parkinson’s disease: new hopes in treatment with herbal antioxidants. Current Pharmaceutical Design, 22(2), 238–246.https://doi.org/10.2174/1381612822666151112151653

Scora, R. W. (1975). On the history and origin of Citrus. Bull Torrey Bot Club, 102, 369-375.

Selli, S. (2007). Volatile constituents of orange wine obtained from moro oranges (Citrus sinensis [L.] osbeck). J Food Qual, 30, 330-341. doi: 10.1111/j.1745-4557.2007.00124.x

Sen, S., Bala, A., Kar, B., Bhattacharya, S., Mazumder, U., & Gupta, M. (2012). Antitumor potential of Citrus limetta fruit peel in Ehrlich ascites carcinoma-bearing Swiss albino mice. Altern Med Stud, 2, e10.

Sen, S., Gupta, M., Mazumder, U., Haldar, P., Saha, P., Bhattacharya, S., et al. (2011). Antihyperglycemic effect and antioxidant property of Citrus maxima leaf in streptozotocin-induced Diabetic rats. Diabetol Croat, 40-4, 113-120.

Shanmugam, P., Venkataraman, S., &Ariamuthu, S. (2013). Cytoprotective action of Citrus aurantifolia fruit extract against aflatoxin-B1 induced cytotoxicity. Int J Res PharmacolPharmacother, 2, 408-413.

Shinkafi, S., & Ndanusa, H. (2013). Antibacterial activity of Citrus limon on Acne vulgaris (pimples). Int J Sci Invent Today, 2, 397-409.

Silalahi, J. (2002). Anticancer and health protective properties of citrus fruit components. Asia Pac J Clin Nutr, 11, 79-84.https://doi.org/10.1046/j.1440-6047.2002.00271.x

Singh, A., Saini, M. L., &Behl, R. K. (2003). Screening of citrus rootstocks for salt tolerance in semi-arid climates – A review. Tropics, 13(1), 53-66.

Singh, J., Sood, S., &Muthuraman, A. (2014). In-vitro evaluation of bioactive compounds, antioxidant, lipid peroxidation and lipoxygenase inhibitory potential of Citrus karna L. peel extract. J Food Sci Technol, 51(1), 67-74. https://doi.org/10.1007/s13197-011-0479-9

Siskos, E. P., Konstantopoulou, M. A., Mazomenos, B. E., & Jervis, M. (2007). Insecticidal activity of Citrus aurantium fruit, leaf, and shoot extracts against adult olive fruit flies (Diptera: Tephritidae). J Econ Entomol, 100, 1215-1220.https://doi.org/10.1603/0022-0493(2007)100[1215:iaocaf]2.0.co;2
Sivakumar, N., &Venkataraman, R. (2010). Phytochemical and pharmacological studies on plant waste materials. Pharm Sin, 1, 1-6.

Sood, S., Arora, B., Bansal, S., Muthuraman, A., Gill, N. S., Arora, R., et al. (2009). Antioxidant, anti-inflammatory and analgesic potential of the Citrus decumana L. peel extract. Inflammopharmacology, 17, 267-274.https://doi.org/10.1007/s10787-009-0015-y

Sood, S., Bansal, S., Muthuraman, A., Gill, N., & Bali, M. (2009). Therapeutic potential of Citrus medica L. peel extract in carrageenan-induced inflammatory pain in rats. Res J Med Plant, 3, 123-133.

Summer, J. (2000). The Natural History of Medicinal Plants (Vol. 16). Timber Press, London, UK.

Tiwari, B. K., O’ Donnell, C. P., Muthukumarappan, K., & Cullen, P. J. (2009). Ascorbic acid degradation kinetics of sonicated orange juice during storage and comparison with thermally pasteurized juice. LWT – Food SciTechnol, 42, 700-704. doi: 10.1016/j.lwt.2008.10.009

Trovato, A., Monforte, M., Barbera, R., Rossitto, A., Galati, E., &Forestieri, A. (1996). Effects of fruit juices of Citrus sinensis L. and Citrus limon L. on experimental hypercholesterolemia in the rat. Phytomedicine, 2, 221-227.https://doi.org/10.1016/s0944-7113(96)80046-8

Van Horn, L., McCoin, M., Kris-Etherton, P. M., et al. (2008). The evidence for dietary prevention and treatment of cardiovascular disease. J Am Diet Assoc, 108, 287-331.https://doi.org/10.1016/j.jada.2007.10.050

Wu, G. A., Terol, J., Ibanez, V., et al. (2018). Genomics of the origin and evolution of citrus. Nature, 554(7692), 311-316.https://doi.org/10.1038/nature25447

Yamane, H., Konno, K., Sabelis, M., Takabayashi, J., Sassa, T., & Oikawa, H. (2010). In Comprehensive Natural Products II, L. Mander& H. W. Lui (Eds.), 385, p. 339. Elsevier, Oxford, UK.

Yekeen, M., Ajala, O., &Alarape, A. (2014). Antifungal activities of Citrus sinensis seed oil against Lentinussajor-caju. AdvApplSci Res, 5, 109-113.

Yu, Y., Xiao, G., Xu, Y., Wu, J., Fu, M., & Wen, J. (2015). Slight Fermentation with Lactobacillus fermentium improves the taste (Sugar: Acid Ratio) of Citrus (Citrus reticulatacv. chachiensis) Juice. J Food Sci, 80, M2543-M2547. https://doi.org/10.1111/1750-3841.13088

Yuasa, M., Shimada, A., Matsuzaki, A., Eguchi, A., &Tominaga, M. (2021). Chemical composition and sensory properties of fermented citrus juice using probiotic lactic acid bacteria. Food Biosci, 39, 100810. https://doi.org/10.1016/j.fbio.2020.100810

Zhang, Y., Wang, J. F., Dong, J., et al. (2013). Inhibition of α-toxin production by subinhibitory concentrations of naringenin controls Staphylococcus aureus pneumonia. Fitoterapia, 86, 92-99.https://doi.org/10.1016/j.fitote.2013.02.001

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