Annona Muricata: Unveiling its Potential as a Complementary and Alternative Cancer Therapy

Published: November 10, 2023

Authors

Shinam Bakshi, Abhinav Yadav, Sanchit Dhankhar, Samrat Chauhan, Shushank Mahajan and Deepak Singla

Keywords
Annona muricata, chemotherapy, phytochemical, antioxidant, anticancer, phytochemical

Abstract

Background: Soursop (Annona muricata) is a tropical fruit that has recently been under scrutiny for its supposedly appreciable health benefits. The plant is rich in phytochemicals and the medicinal value of the fruit has been under study in treating cancer, diabetes, oxidative stress, hypertension, haemorrhagic disease, and reduction of bad cholesterol.

Purpose: The review serves to discuss the potential use of the Annona muricata in nutraceutical and pharmaceutical development. The discussion below is based on the use of soursop pulp, seeds, and leaf extracts as functional ingredients in food products and their implications for pharmaceutical industries.

Methods: Recent literatures have been surveyed from PUBMED, GOOGLE SCHOLAR, etc. like search engines, for summarising detailed ongoing research on Annona muricata, which could be used in complementary and alternative cancer therapy.

Conclusion: The high nutritional value and pharmacological potential of Annona muricata turn it into a very good candidate for different health-related applications. There exist promising benefits of phytochemicals present in soursop for the treatment and prevention of a number of health conditions, underscoring its importance in functional foods and medicines development.

References

  • Ahmed, M. S., Khan, I. J., Aman, S., Chauhan, S., Kaur, N., Shriwastav, S., Goel, K., Saini, M., Dhankar, S., Singh, T. G., Dev, J., & Mujwar, S. (2023). Phytochemical investigations, in-vitro antioxidant, antimicrobial potential, and in-silico computational docking analysis of Euphorbia milii Des Moul. Journal of Experimental Biology and Agricultural Sciences, 11(2), 380-393. https://doi.org/10.18006/2023.11(2).380.393
  • Badrie, N., & Schauss, A. G. (2010). Soursop (Annona muricata L.): composition, nutritional value, medicinal uses, and toxicology. Bioactive foods in promoting health, 621-643. Academic Press.https://doi.org/10.1016/B978-0-12-374628-3.00039-6
  • Bhattacharya, T., Soares, G. A. B. E., Chopra, H., Rahman, M. M., Hasan, Z., Swain, S. S., & Cavalu, S. (2022). Applications of phyto-nanotechnology for the treatment of neurodegenerative disorders. Materials15(3), 804. https://doi.org/10.3390/ma15030804
  • Dhankhar, S., Chauhan, S., Mehta, D. K., Nitika, Saini, K., Saini, M., Das, R., Gupta, S., & Gautam, V. (2023). Novel targets for potential therapeutic use in Diabetes mellitus. Diabetology & Metabolic Syndrome, 15(1), 17. https://doi.org/10.1186/s13098-023-00983-5
  • Dhankar, S., Garg, N., Chauhan, S., & Saini, M. (2024a). A Bird View on the Role of Graphene Oxide Nanosystems in Therapeutic Delivery. Current Nanoscience, 20, 1-11. https://doi.org/10.2174/0115734137299120240312044808
  • Dhankhar, S., Garg, N., Chauhan, S., & Saini, M. (2024b). Role of Artificial Intelligence in Diabetic Wound Screening and Early Detection. Current Biotechnology, 13, 1-14.  https://doi.org/10.2174/0122115501303253240408072559
  • Dhankhar, S., Garg, N., Chauhan, S., Saini, M., Singh, T. G., & Singh, R. (2024c). Unravelling the Microbiome’s Role in Healing Diabetic Wounds. Current Pharmaceutical Biotechnology, 25, 1-13. https://doi.org/10.2174/0113892010307032240530071003
  • Dhankar, S., Mujwar, S., Garg, N., Chauhan, S., Sharma, P., Kumar Sharma, S., Kamal, M. A., Rani, D. N., Kumar, S., & Saini, M. (2024d). Artificial Intelligence in The Management of Neurodegenerative Disorders. CNS & Neurological Disorders – Drug Targets, 23, 1-10. https://doi.org/10.2174/0118715273266095231009092603
  • El Tawiil, G. A., Noaman, E. A., Askar, M. A., El Fatih, N. M., & Mohamed, H. E. (2020). Anticancer and apoptogenic effect of graviola and low-dose radiation in tumor xenograft in mice. Integrative Cancer Therapies, 19. https://doi.org/10.1177/1534735419900930
  • Fidianingsih, I., & Handayani, E. S. (2014). Annona muricata aqueous extract suppresses T47D breast cancer cell proliferation. Universa medicina33(1), 19-26. https://doi.org/10.18051/UnivMed.2014.v33.19-26
  • Gavamukulya, Y., Wamunyokoli, F., & El-Shemy, H. A. (2017). Annona muricata: Is the natural therapy to most disease conditions including cancer growing in our backyard? A systematic review of its research history and future prospects. Asian Pacific journal of tropical medicine, 10(9), 835-848. https://doi.org/10.1016/j.apjtm.2017.08.009
  • Goodman, M. (1989). Managing the side effects of chemotherapy. Seminars in oncology nursing, 5(2), 29-52. https://doi.org/10.1016/0749-2081(89)90080-6s
  • Goyal, S., Gupta, N., Chatterjee, S., & Nimesh, S. (2017). Natural plant extracts as potential therapeutic agents for the treatment of cancer. Current topics in medicinal chemistry, 17(2), 96-106. https://doi.org/10.2174/1568026616666160530154407
  • Hadisaputri, Y. E., Habibah, U., Abdullah, F. F., Halimah, E., Mutakin, M., Megantara, S., Abdulah, R., & Diantini, A. (2021). Antiproliferation activity and apoptotic mechanism of soursop (Annona muricata l.) leaves extract and fractions on mcf7 breast cancer cells. Breast Cancer: Targets and Therapy, 13, 447. https://doi.org/10.2147/BCTT.S317682
  • Hasan, A. E. Z., Julistiono, H., Bermawie, N., Riyanti, E. I., & Arifni, F. R. (2022). Soursop leaves (Annona muricata L.) endophytic fungi anticancer activity against HeLa cells. Saudi Journal of Biological Sciences, 29(8), 103354.
  • Hasmila, I., Natsir, H., & Soekamto, N. H. (2019). Phytochemical analysis and antioxidant activity of soursop leaf extract (Annona muricata Linn.). Journal of physics: conference series, 1341(3), 032027.https://doi.org/10.1088/1742-6596/1341/3/032027
  • Kciuk, M., Garg, A., Rohilla, M., Chaudhary, R., Dhankhar, S., Dhiman, S., Bansal, S., Saini, M., Singh, T. G., Chauhan, S.& Kontek, R. (2024a). Therapeutic Potential of Plant-Derived Compounds and Plant Extracts in Rheumatoid Arthritis—Comprehensive Review. Antioxidants13(7), 775.https://doi.org/10.3390/antiox13070775
  • Kciuk, M., Garg, N., Dhankhar, S., Saini, M., Mujwar, S., Devi, S., Chauhan, S., Singh, T. G., Singh, R., Marciniak, B., Gielecińska, A., & Kontek, R. (2024b). Exploring the Comprehensive Neuroprotective and Anticancer Potential of Afzelin. Pharmaceuticals17(6), 701. https://doi.org/10.3390/ph17060701
  • Kumar, A., Behl, T., & Chadha, S. (2020). Synthesis of physically crosslinked PVA/Chitosan loaded silver nanoparticles hydrogels with tunable mechanical properties and antibacterial effects. International journal of biological macromolecules, 149, 1262-1274. https://doi.org/10.1016/j.ijbiomac.2020.02.048
  • Kishore, L., Kaur, N., Chauhan, S., & Singh, R. (2014). Phyto-pharmacological review of Coccinia indica. World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS), 3(2), 1734-1745. https://cabidigitallibrary.org/doi/full/10.5555/20143096249
  • Mattiuzzi, C., & Lippi, G. (2019). Current cancer epidemiology. Journal of epidemiology and global health9(4), 217-222.https://doi.org/10.2991/jegh.k.191008.001
  • Mittal, P., Dhankhar, S., Chauhan, S., Garg, N., Bhattacharya, T., Ali, M., Chaudhary, A. A., Rudayni, H. A., Al-Zharani, M., & Ahmad, W. (2023). A Review on Natural Antioxidants for Their Role in the Treatment of Parkinson’s Disease. Pharmaceuticals, 16(7), 908. https://doi.org/10.3390/ph16070908
  • Moghadamtousi, S. Z., Fadaeinasab, M., Nikzad, S., Mohan, G., Ali, H. M., & Kadir, H. A. (2015). Annona muricata (Annonaceae): a review of its traditional uses, isolated acetogenins and biological activities. International journal of molecular sciences, 16(7), 15625-15658. https://doi.org/10.3390/ijms160715625
  • Naik, A. V., & Sellappan, K. (2020). In vitro evaluation of Annona muricata L.(Soursop) leaf methanol extracts on inhibition of tumorigenicity and metastasis of breast cancer cells. Biomarkers, 25(8), 701-710. https://doi.org/10.1080/1354750X.2020.1836025
  • Narwal, S., Dhanda, T., Sharma, P., Sharma, V., Dhankhar, S., Garg, N., Ghosh, S. N., & Rani, N. (2023). Current Therapeutic Strategies for Chagas Disease. Anti-Infective Agents, 21, 1-11. https://doi.org/10.2174/2211352521666230823122601
  • Nayak, A., & Hegde, K. (2021). A comprehensive review on the miracle nature of Annona muricata Linn. RGUHS Journal of Pharmaceutical Sciences, 11(1). https://doi.org/10.26463/rjps.11_1_6
  • Panchal, M., Rana, P., Garg, N., Dhankhar, S., Chauhan, S., & Sharma, H. (2024). A Comprehensive Review of Alternative Therapeutic Approaches for Nausea and Vomiting Relief in Pregnancy. New Emirates Medical Journal, 5, 1-8. https://doi.org/10.2174/0102506882282929231212074538
  • Prasad, S. K., Varsha, V., & Devananda, D. (2019). Anti-cancer properties of Annona muricata (L.): A Review. Medicinal Plants-International Journal of Phytomedicines and Related Industries11(2), 123-134.https://doi.org/10.5958/0975-6892.2019.00016.9
  • Rehni, A. K., Singh, T. G., Jaggi, A. S., & Singh, N. (2008). Pharmacological preconditioning of the brain: a possible interplay between opioid and calcitonin gene related peptide transduction systems. Pharmacological Reports, 60(6), 904.
  • Rehni, A. K., Singh, T. G., Singh, N., & Arora, S. (2010). Tramadol-induced seizurogenic effect: a possible role of opioid-dependent histamine (H 1) receptor activation-linked mechanism. Naunyn-Schmiedeberg’s archives of pharmacology381, 11-19.
  • Rethinam, P., & Sundararaj, P. (2016). Annona muricata l., soursop (graviola)-nature’s gift to mankind with amazing medicinal benefits. International Journal of Innovative Horticulture5(2), 73-80. https://doi.org/10.1007/s00210-009-0476-y
  • Rohilla, M., Bansal, S., Garg, A., Dhiman, S., Dhankhar, S., Saini, M., Chauhan, S., Alsubaie, N., Batiha, G. E.-S., & Albezrah, N. K. A. (2023). Discussing pathologic mechanisms of Diabetic retinopathy & therapeutic potentials of curcumin and β-glucogallin in the management of Diabetic retinopathy. Biomedicine & Pharmacotherapy, 169, 115881. https://doi.org/10.1016/j.biopha.2023.115881
  • Rubio-Melgarejo, A., Balois-Morales, R., Palomino-Hermosillo, Y. A., López-Guzmán, G. G., Ramírez-Ramírez, J. C., Cervantes-García, E., Villalobos-Rosario, B. J., & Bautista-Rosales, P. U. (2020). Phytochemical and Antioxidant Dynamics of the Soursop Fruit (Annona muricata L.) in response to Colletotrichum spp. Journal of Food Quality, 2020.  https://doi.org/10.1155/2020/3180634
  • Saharan, R., Kaur, J., Dhankhar, S., Garg, N., Chauhan, S., Kumar, S., & Sharma, H. (2024). Hydrogel-based Drug Delivery System in Diabetes Management. Pharmaceutical Nanotechnology, 12, 1-11.  https://doi.org/10.2174/0122117385266276230928064235
  • Samrat Chauhan, L. K., Navpreet Kaur, Randhir Singh. (2015). Potential Anti-Arthritic Agents From Indian Medicinal Plants. Research and Reviews: Journal of Pharmacy and Pharmaceutical Sciences, 4(3), 10-22.
  • Sawant, T. P., & Dongre, R. S. (2014). Bio-chemical compositional analysis of Annona muricata: a miracle fruit’s review. International Journal of Universal Pharmacy and Bio Sciences, 3(2), 82-104. https://doi.org/10.1007/s13205-016-0520-9
  • Tejasari, M., Sastramihardja, H., Abdurachman, S. A., & Prasetyo, D. (2018). Anticancer activity of novel soursop leaves active compound (SF-1603) through apoptotic induction in liver cancer. MJFAS, 14(2), 226-234. https://doi.org/10.11113/mjfas.v14n2.1064
  • Zugazagoitia, J., Guedes, C., Ponce, S., Ferrer, I., Molina-Pinelo, S., & Paz-Ares, L. (2016). Current challenges in cancer treatment. Clinical therapeutics38(7), 1551-1566. https://doi.org/10.1016/j.clinthera.2016.03.026

How to Cite

Shinam Bakshi, Abhinav Yadav, Sanchit Dhankhar, Samrat Chauhan, Shushank Mahajan and Deepak Singla. Annona Muricata: Unveiling its Potential as a Complementary and Alternative Cancer Therapy. J. Pharm. Technol. Res. Manag.. 2023, 11, 107–113
Annona Muricata: Unveiling its Potential as a Complementary and Alternative Cancer Therapy

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