Acupuncture: A Potential Therapy for Neurological and Psychiatric Disorders

Home > 2023, Vol. 11 No. 02 > Acupuncture: A Potential Therapy for Neurological and Psychiatric Disorders

Published: November 10, 2023

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Authors

Deepak Kajla, Maneesh Mohan, and Kenneth C. Ugoeze

DOI Number
https://doi.org/10.15415/jprtm.2023.112002

Keywords
Neurology, Acupuncture, Psychological, Psychiatric disorders, Neuroprotection

Abstract

Background: Acupuncture, a practice rooted in traditional Chinese medicine for thousands of years, is increasingly recognized as a complementary therapy for neurological and psychiatric disorders.

Purpose: This review aims to explore recent advancements in acupuncture’s application for treating specific neurological and psychiatric conditions and to highlight its therapeutic potential and underlying mechanisms.

Methods: The review synthesizes findings from extensive research and scientific studies, incorporating insights from modern neuroimaging techniques like functional magnetic resonance imaging (fMRI) and positron emission tomography (PET). It also examines the efficacy of combined modalities, such as laser and electroacupuncture.

Results: Acupuncture has demonstrated efficacy in managing neurological conditions such as stroke, neuropathic pain, and neurodegenerative diseases by enhancing cerebral blood flow, promoting neuroplasticity, and providing neuroprotection. Its application in psychiatric disorders, including anxiety, depression, and post-traumatic stress disorder (PTSD), has shown promising outcomes. These therapeutic effects are mediated through mechanisms involving the autonomic nervous system, decreased inflammation, and neurotransmitter regulation. Combining acupuncture with modalities like laser and electroacupuncture has expanded treatment options and enhanced efficacy.

Conclusion: Recent advancements underscore acupuncture’s promise as an effective adjuvant therapy for neurological and psychiatric conditions. However, challenges remain in standardizing procedures and refining study designs to better define specific mechanisms and optimize therapeutic parameters. Continued research is essential to establish acupuncture as a reliable treatment option for improving patient outcomes.

References

Alaee, E., Pachenari, N., Khani, F., Semnanian, S., Shojaei, A., & Azizi, H. (2023). Enhancement of neuronal excitability in the medial prefrontal cortex following prenatal morphine exposure. Brain Research Bulletin, 204, 110803. https://doi.org/10.1016/j.brainresbull.2023.110803
Anderson, B. J., Jurawanichkul, S., Kligler, B. E., Marantz, P. R., & Evans, R. (2019). Interdisciplinary Relationship Models for Complementary and Integrative Health: Perspectives of Chinese Medicine Practitioners in the United States. Journal of Alternative and Complementary Medicine (New York, N.Y.), 25(3), 288–295. https://doi.org/10.1089/acm.2018.0268
Barreto, G., White, R. E., Ouyang, Y., Xu, L., & Giffard, R. G. (2011). Astrocytes: Targets for Neuroprotection in Stroke. Central Nervous System Agents in Medicinal Chemistry, 11(2), 164–173.
Bing, Z., Villanueva, L., & Le Bars, D. (1991). Acupuncture-evoked responses of subnucleus reticularis dorsalis neurons in the rat medulla. Neuroscience, 44(3), 693–703. https://doi.org/10.1016/0306-4522(91)90088-6
Bouhassira, D., Le Bars, D., & Villanueva, L. (1987). Heterotopic activation of A delta and C fibres triggers inhibition of trigeminal and spinal convergent neurones in the rat. The journal of physiology, 389(1), 301-317. https://doi.org/10.1113/jphysiol.1987.sp016658
Bussell, J. (2013). The Effect of Acupuncture on Working Memory and Anxiety. 6(5), 241–246. https://doi.org/10.1016/j.jams.2012.12.006
Chang, K., Bai, S., Lee, H., & Lee, B. (2014). Effects of Acupuncture Stimulation at Different Acupoints on Formalin-Induced Pain in Rats. The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology, 18, 121–127. https://doi.org/10.4196/kjpp.2014.18.2.121
Chavez, L. M., Huang, S. S., MacDonald, I., Lin, J. G., Lee, Y. C., & Chen, Y. H. (2017). Mechanisms of Acupuncture Therapy in Ischemic Stroke Rehabilitation: A Literature Review of Basic Studies. International Journal of Molecular Sciences, 18(11), 2270. https://doi.org/10.3390/ijms18112270
Chen, H., Wu, C., Lv, Q., Li, M., & Ren, L. (2023). Targeting Mitochondrial Homeostasis: The Role of Acupuncture in Depression Treatment. Neuropsychiatric Disease and Treatment, 19, 1741–1753. https://doi.org/10.2147/NDT.S421540
Chen, J., Xie, Y., Lin, Q., Qian, Z., Feng, J., Zhang, J., & Guo, Z. (2022). Investigating Acupoint Selection and Combinations of Acupuncture for Tic Disorders: An Association Rule Mining and Network Analysis Study. Frontiers in Neurology, 13. https://doi.org/10.3389/fneur.2022.894951
Cherkin, D. C., Sherman, K. J., Avins, A. L., Erro, J. H., Ichikawa, L., Barlow, W. E., & Deyo, R. A. (2009). A Randomized Trial Comparing Acupuncture, Simulated Acupuncture, and Usual Care for Chronic Low Back Pain. Archives of Internal Medicine, 169(9), 858–866. https://doi.org/10.1001/archinternmed.2009.65
Chiang, C. Y. (1973). Peripheral afferent pathway for acupuncture analgesia. Scientia Sinica, 1973(16), 210-216.
Cummings, M. (2009). Modellvorhaben Akupunktur—A summary of the ART, ARC and GERAC trials. Acupuncture in Medicine: Journal of the British Medical Acupuncture Society, 27(1), 26–30. https://doi.org/10.1136/aim.2008.000281
Ernst, E., Lee, M. S., & Choi, T. Y. (2011). Acupuncture for depression? A systematic review of systematic reviews. Evaluation & the Health Professions, 34(4), 403–412. https://doi.org/10.1177/0163278710386109
Ernst, E., & White, A. R. (2001). Prospective studies of the safety of acupuncture: A systematic review. The American Journal of Medicine, 110(6), 481–485. https://doi.org/10.1016/s0002-9343(01)00651-9
Haake, M., Müller, H. H., Schade-Brittinger, C., Basler, H. D., Schäfer, H., Maier, C., & Molsberger, A. (2007). German Acupuncture Trials (GERAC) for chronic low back pain: randomized, multicenter, blinded, parallel-group trial with 3 groups. Archives of internal medicine, 167(17), 1892-1898. https://doi.org/10.1001/archinte.167.17.1892
Han, J. S. (2003). Acupuncture: Neuropeptide release produced by electrical stimulation of different frequencies. Trends in Neurosciences, 26(1), 17–22. https://doi.org/10.1016/s0166-2236(02)00006-1
He, W., Rong, P. J., Li, L., Ben, H., Zhu, B., & Litscher, G. (2012). Auricular Acupuncture May Suppress Epileptic Seizures via Activating the Parasympathetic Nervous System: A Hypothesis Based on Innovative Methods. Evidence-Based Complementary and Alternative Medicine : eCAM, 2012, 615476. https://doi.org/10.1155/2012/615476
Ho, L. F., Guo, Y., Ching, J. Y. L., Chan, K. L., Tsang, P. H., Wong, M. H., & Lin, Z. X. (2019). Efficacy and safety of electroacupuncture plus warm needling therapy for heel pain: Study protocol for a randomized controlled trial. Trials, 20, 480. https://doi.org/10.1186/s13063-019-3572-4
Hopper, D., Bajaj, Y., Kei Choi, C., Jan, O., Hall, T., Robinson, K., & Briffa, K. (2013). A pilot study to investigate the short-term effects of specific soft tissue massage on upper cervical movement impairment in patients with cervicogenic headache. Journal of Manual & Manipulative Therapy, 21(1), 18-23. https://doi.org/10.1179/2042618612Y.0000000018
Huang, L., Tang, Y., & Sperlagh, B. (2022). Glial Purinergic Signaling-Mediated Oxidative Stress (GPOS) in Neuropsychiatric Disorders. Oxidative Medicine and Cellular Longevity, 2022(1), 1075440. https://doi.org/10.1155/2022/1075440
Huang, W., Johnson, T. M., Kutner, N. G., Halpin, S. N., Weiss, P., Griffiths, P. C., & Bliwise, D. L. (2018). Acupuncture for Treatment of Persistent Disturbed Sleep: A Randomized Clinical Trial in Veterans With Mild Traumatic Brain Injury and Posttraumatic Stress Disorder. The Journal of Clinical Psychiatry, 80(1). https://doi.org/10.4088/JCP.18m12235
Itoh, K., Okada, K., & Kawakita, K. (2004). A proposed experimental model of myofascial trigger points in human muscle after slow eccentric exercise. Acupuncture in Medicine: Journal of the British Medical Acupuncture Society, 22(1), 2–12. https://doi.org/10.1136/aim.22.1.2
Kawakita, K., & Gotoh, K. (1996). Role of polymodal receptors in the acupuncture-mediated endogenous pain inhibitory systems. Progress in Brain Research, 113, 507–523. https://doi.org/10.1016/s0079-6123(08)61105-x
Kawakita, K., Itoh, K., & Okada, K. (2002). The polymodal receptor hypothesis of acupuncture and moxibustion, and its rational explanation of acupuncture points. International Congress Series, 1238, 63-68. https://doi.org/10.1016/S0531-5131(02)00411-9
Kawakita, K., Okada, K., & Kawamura, H. (2005). Analysis of a questionnaire on the characteristics of palpable hardenings: a survey of experienced Japanese acupuncturists. JAM (Online Journal of JSAM), 1, 1-8. https://www.jsam.jp/onlineJournal/pdf2/20.pdf
Kawakita, K., & Okada, K. (2014). Acupuncture therapy: mechanism of action, efficacy, and safety: a potential intervention for psychogenic disorders?. BioPsychoSocial medicine, 8, 1-7. https://doi.org/10.1186/1751-0759-8-4
Kawakita, K., Shinbara, H., Imai, K., Fukuda, F., Yano, T., & Kuriyama, K. (2006). How do acupuncture and moxibustion act? Focusing on the progress in Japanese acupuncture research. Journal of pharmacological sciences, 100(5), 443-459. https://doi.org/10.1254/jphs.crj06004x
Kim, S. N., Doo, A. R., Park, J. Y., Bae, H., Chae, Y., Shim, I., & Park, H. J. (2011). Acupuncture enhances the synaptic dopamine availability to improve motor function in a mouse model of Parkinson’s disease. PLoS One, 6(11), e27566. https://doi.org/10.1371/journal.pone.0027566
Kim, Y. D., Heo, I., Shin, B. C., Crawford, C., Kang, H. W., & Lim, J. H. (2013). Acupuncture for posttraumatic stress disorder: a systematic review of randomized controlled trials and prospective clinical trials. Evidence‐Based Complementary and Alternative Medicine, 2013(1), 615857. https://doi.org/10.1155/2013/615857
Lao, L., Hamilton, G. R., Fu, J., & Berman, B. M. (2003). Is acupuncture safe? A systematic review of case reports. Alternative Therapies in Health and Medicine, 9(1), 72–83. https://www.ncbi.nlm.nih.gov/books/NBK69580/
Le Bars, D., Dickenson, A. H., & Besson, J. M. (1979). Diffuse noxious inhibitory controls (DNIC). I. Effects on dorsal horn convergent neurones in the rat. Pain, 6(3), 283–304. https://doi.org/10.1016/0304-3959(79)90049-6
Lee, B., Kim, S. N., Park, H. J., & Lee, H. (2014). Research advances in treatment of neurological and psychological diseases by acupuncture at the Acupuncture Meridian Science Research Center. Integrative Medicine Research, 3(2), 41–48. https://doi.org/10.1016/j.imr.2014.03.003
Lee, B., Sur, B., Shim, J., Hahm, D.-H., & Lee, H. (2014). Acupuncture stimulation improves scopolamine-induced cognitive impairment via activation of cholinergic system and regulation of BDNF and CREB expressions in rats. BMC Complementary and Alternative Medicine, 14, 338. https://doi.org/10.1186/1472-6882-14-338
Lee, J. H., Choi, T. Y., Lee, M. S., Lee, H., Shin, B. C., & Lee, H. (2013). Acupuncture for acute low back pain: a systematic review. The Clinical journal of pain, 29(2), 172-185. https://doi.org/10.1097/AJP.0b013e31824909f9
Liao, E. T., Tang, N. Y., Lin, Y. W., & Liang. H. C. (2017). Long-term electrical stimulation at ear and electro-acupuncture at ST36-ST37 attenuated COX-2 in the CA1 of hippocampus in kainic acid-induced epileptic seizure rats. Scientific Reports, 7(1), 472. https://doi.org/10.1038/s41598-017-00601-1
Linde, K., Streng, A., Jürgens, S., Hoppe, A., Brinkhaus, B., Witt, C., & Melchart, D. (2005). Acupuncture for patients with migraine: A randomized controlled trial. JAMA, 293(17), 2118–2125. https://doi.org/10.1001/jama.293.17.2118
MacPherson, H., Thomas, K., Walters, S., & Fitter, M. (2001). The York acupuncture safety study: prospective survey of 34 000 treatments by traditional acupuncturists. Bmj, 323(7311), 486-487. https://doi.org/10.1136/bmj.323.7311.486
Manheimer, E., Cheng, K., Linde, K., Lao, L., Yoo, J., Wieland, S., & Bouter, L. M. (2010). Acupuncture for peripheral joint osteoarthritis. The Cochrane Database of Systematic Reviews, 2010(1), CD001977. https://doi.org/10.1002/14651858.CD001977.pub2
Manheimer, E., White, A., Berman, B., Forys, K., & Ernst, E. (2005). Meta-analysis: Acupuncture for low back pain. Annals of Internal Medicine, 142(8), 651–663. https://doi.org/10.7326/0003-4819-142-8-200504190-00014
Mayhew, E., & Ernst, E. (2007). Acupuncture for fibromyalgia: A systematic review of randomized clinical trials. In Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet]. Centre for Reviews and Dissemination (UK). https://www.ncbi.nlm.nih.gov/books/NBK73525/
Melchart, D., Weidenhammer, W., Streng, A., Reitmayr, S., Hoppe, A., Ernst, E., & Linde, K. (2004). Prospective investigation of adverse effects of acupuncture in 97 733 patients. Archives of Internal Medicine, 164(1), 104–105. https://doi.org/10.1001/archinte.164.1.104
Melzack, R., Stillwell, D. M., & Fox, E. J. (1977). Trigger points and acupuncture points for pain: Correlations and implications. Pain, 3(1), 3–23. https://doi.org/10.1016/0304-3959(77)90032-X
Mohammadzadeh, N., Mehri, S., & Hosseinzadeh, H. (2017). Berberis vulgaris and its constituent berberine as antidotes and protective agents against natural or chemical toxicities. Iranian Journal of Basic Medical Sciences, 20(5), 538–551. https://doi.org/10.22038/IJBMS.2017.8678
Mudimela, S., Vishwanath, N. K., Pillai, A., Morales, R., Marrelli, S. P., Barichello, T., & Giridharan, V. V. (2022). Clinical significance and potential role of trimethylamine N-oxide in neurological and neuropsychiatric disorders. Drug Discovery Today, 27(11), 103334. https://doi.org/10.1016/j.drudis.2022.08.002
Peplow, P. V., & Martinez, B. (2016). Prevention and protection against cerebral ischemic injury using acupuncture. Neural Regeneration Research, 11(4), 559–560. https://doi.org/10.4103/1673-5374.180735
Pilkington, K., Kirkwood, G., Rampes, H., Cummings, M., & Richardson, J. (2007). Acupuncture for anxiety and anxiety disorders—A systematic literature review. Acupuncture in Medicine: Journal of the British Medical Acupuncture Society, 25(1–2), 1–10. https://doi.org/10.1136/aim.25.1-2.1
Polatin, P. B., Kinney, R. K., Gatchel, R. J., Lillo, E., & Mayer, T. G. (1993). Psychiatric illness and chronic low-back pain. The mind and the spine—Which goes first? Spine, 18(1), 66–71. https://doi.org/10.1097/00007632-199301000-00011
Pomeranz, B., & Chiu, D. (1976). Naloxone blockade of acupuncture analgesia: Endorphin implicated. Life Sciences, 19(11), 1757–1762. https://doi.org/10.1016/0024-3205(76)90084-9
Scharf, H. P., Mansmann, U., Streitberger, K., Witte, S., Krämer, J., Maier, C., & Victor, N. (2006). Acupuncture and knee osteoarthritis: A three-armed randomized trial. Annals of Internal Medicine, 145(1), 12–20. https://doi.org/10.7326/0003-4819-145-1-200607040-00005
Shah, J. P., Phillips, T. M., Danoff, J. V., & Gerber, L. H. (2005). An in vivo microanalytical technique for measuring the local biochemical milieu of human skeletal muscle. Journal of Applied Physiology (Bethesda, Md.: 1985), 99(5), 1977–1984. https://doi.org/10.1152/japplphysiol.00419.2005
Shah, J. P., Thaker, N., Heimur, J., Aredo, J. V., Sikdar, S., & Gerber, L. H. (2015). Myofascial Trigger Points Then and Now: A Historical and Scientific Perspective. PM & R : The Journal of Injury, Function, and Rehabilitation, 7(7), 746–761. https://doi.org/10.1016/j.pmrj.2015.01.024
Sjölund, B., Terenius, L., & Eriksson, M. (1977). Increased cerebrospinal fluid levels of endorphins after electro-acupuncture. Acta Physiologica Scandinavica, 100(3), 382–384. https://doi.org/10.1111/j.1748-1716.1977.tb05964.x
Song, A., Zhang, Y., Chen, R., & Liang, F. (2018). Is Acupuncture Effective for Improving Insulin Resistance? A Systematic Review and Meta-analysis. Current Medical Science, 38(6), 1109–1116. https://doi.org/10.1007/s11596-018-1991-1
Sun, X., Liu, H., Sun, Z., Zhang, B., Wang, X., Liu, T., & Li, H. (2020). Acupuncture protects against cerebral ischemia-reperfusion injury via suppressing endoplasmic reticulum stress-mediated autophagy and apoptosis. Molecular Medicine (Cambridge, Mass.), 26(1), 105. https://doi.org/10.1186/s10020-020-00236-5
Taguchi, R. (2008). Acupuncture Anesthesia and Analgesia for Clinical Acute Pain in Japan. Evidence-Based Complementary and Alternative Medicine : eCAM, 5(2), 153–158. https://doi.org/10.1093/ecam/nem056
Tan, S., Xue, S., Behnood-Rod, A., Chellian, R., Wilson, R., Knight, P., & Bruijnzeel, A. W. (2019). Sex differences in the reward deficit and somatic signs associated with precipitated nicotine withdrawal in rats. Neuropharmacology, 160, 107756. https://doi.org/10.1016/j.neuropharm.2019.107756
Toyama, P. M., & Nishizawa, M. (1972). The physiological basis of acupuncture therapy. Journal of the National Medical Association, 64(5), 397–402. https://pmc.ncbi.nlm.nih.gov/articles/PMC2608746/
Tramèr, M. R., Moore, R. A., Reynolds, D. J., & McQuay, H. J. (2000). Quantitative estimation of rare adverse events which follow a biological progression: A new model applied to chronic NSAID use. Pain, 85(1–2), 169–182. https://doi.org/10.1016/s0304-3959(99)00267-5
Waddell, G. (1987). 1987 Volvo award in clinical sciences. A new clinical model for the treatment of low-back pain. Spine, 12(7), 632–644. https://doi.org/10.1097/00007632-198709000-00002
Wei, T. H., & Hsieh, C. L. (2020). Effect of Acupuncture on the p38 Signaling Pathway in Several Nervous System Diseases: A Systematic Review. International Journal of Molecular Sciences, 21(13), 4693. https://doi.org/10.3390/ijms21134693
White, A., Hayhoe, S., Hart, A., & Ernst, E. (2001). Adverse events following acupuncture: prospective survey of 32 000 consultations with doctors and physiotherapists. Bmj, 323(7311), 485-486. https://doi.org/10.1136/bmj.323.7311.485
Witt, C. M., Pach, D., Brinkhaus, B., Wruck, K., Tag, B., Mank, S., & Willich, S. N. (2009). Safety of acupuncture: Results of a prospective observational study with 229, 230 patients and introduction of a medical information and consent form. Forschende Komplementarmedizin (2006), 16(2), 91–97. https://doi.org/10.1159/000209315
Wolf, W. (1964). Acupuncture, The Ancient Chinese Art of Healing. American Journal of Psychotherapy, 18(4), 698–699. https://doi.org/10.1176/appi.psychotherapy.1964.18.4.698
Xue, H., Zeng, L., He, H., Xu, D., & Ren, K. (2023). Effectiveness of acupuncture as auxiliary combined with Western medicine for epilepsy: A systematic review and meta-analysis. Frontiers in Neuroscience, 17. https://doi.org/10.3389/fnins.2023.1203231
Yamashita, H., & Tsukayama, H. (2008). Safety of Acupuncture Practice in Japan: Patient Reactions, Therapist Negligence and Error Reduction Strategies. Evidence-Based Complementary and Alternative Medicine : eCAM, 5(4), 391–398. https://doi.org/10.1093/ecam/nem086
Yoshida, K., & Kato, S. (2011). Cases of Low Back Pain in Psychiatry and Their Diagnostic Problems. 54(2). https://www.med.or.jp/english/activities/pdf/2011_02/112_116.pdf
Yunus, M., Masi, A. T., Calabro, J. J., Miller, K. A., & Feigenbaum, S. L. (1981). Primary fibromyalgia (fibrositis): Clinical study of 50 patients with matched normal controls. Seminars in Arthritis and Rheumatism, 11(1), 151–171. https://doi.org/10.1016/0049-0172(81)90096-2
Zhang, Y., Zhao, M., Zhang, B., Zhang, K., & Zhou, Z. (2021). Acupuncture as an Adjunctive Treatment for Post-stroke Epilepsy: Protocol for a Randomized Controlled Trial. Frontiers in Neurology, 12, 711390. https://doi.org/10.3389/fneur.2021.711390
Zhang, Z. J., Chen, H. Y., Yip, K., Ng, R., & Wong, V. T. (2010). The effectiveness and safety of acupuncture therapy in depressive disorders: Systematic review and meta-analysis. Journal of Affective Disorders, 124(1–2), 9–21. https://doi.org/10.1016/j.jad.2009.07.005

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Deepak Kajla, Maneesh Mohan, and Kenneth C. Ugoeze. Acupuncture: A Potential Therapy for Neurological and Psychiatric Disorders. J. Pharm. Technol. Res. Manag.. 2023, 11, 93-105

Acupuncture: A Potential Therapy for Neurological and Psychiatric Disorders

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