Stiff Person Syndrome Misdiagnosed as Oxaliplatin Induced Neurotoxicity

Home > 2021, Vol. 9 No. 01 > Stiff Person Syndrome Misdiagnosed as Oxaliplatin Induced Neurotoxicity

Published: May 7, 2021

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Authors

K A Shaima
D Meghana
K Rooha
J Sarita

DOI Number
https://doi.org/10.15415/jptrm.2021.91005

Keywords
Stiff-person syndrome (SPS), Autoimmune Disorder, Methylprednisolone, Bevacizumab, Oxaliplatin

Abstract

Introduction: Stiff person syndrome is characterized by muscle rigidity that waxes and wanes along with concurrent spasms. The symptoms of the stiff-person syndrome were identical to those of oxaliplatin side effects.

Methods: This was a case report of a 65-year-old man who was diagnosed with stiff-person syndrome. He experienced pain with bleeding from the rectum. Screening tests were used to check foramphiphysin antibodies and electromyography. FNAC was done from the government hospital which was conclusive of metastasis. He was initiated on Capecitabine and Oxaliplatin protocol.

Results: During the hospital stay, he was treated with 1gm Methylprednisolone for 5 days and sequentially with immunoglobulin 2gm per day for 5 days, concomitantly Benzodiazepam was given 10mg three times a day for 3 days but later withdrawn as the patient started experiencing dizziness. He achieved no clinical benefit in neurological status. Eventually developed aspiration pneumonia and succumbed to death after one month of diagnosis of SPS.

Conclusion: Further studies should carry out to develop an evidence-based approach to diagnosing and treating SPS patients.

References

Balint, B., P, Kailash. (2016).Stiff person syndrome and other immune-mediated movement disorders – new insights. current opinions in neurology,29(4),496-506.Doi: 10.1097/WCO.0000000000000351
Corina, R., Radu, D., Aurelian, U., &Deaconu, A. (2013). Stiff person syndrome with negative anti-GAD antibodies: A case report. Romanian Journal of Neurology,12(3), 156-159. Doi: 10.37897/RJN.2013.3.10
Dekker, M., Urasa, S., Maro, V., Kinabo, G., &Howlett,W. (2013). Clinical hallmarks and epidemiology of stiff person syndrome in Tanzania. Journal of Neurological Sciences, 333(1),118. Doi:10.1016/j.jns.2013.07.397
James, A,G, C., Dylan, T,P., Willis, W. (2018). Inpatient care for stiff person syndrome in the United states: a nationwide readmission study. Journal of clinical Movement Disorders, 5.
Joe, S., Hayley, S. (2019). Stiff Person Syndrome: A case report and review of literature.British and Irish Orthoptic Journal, 15(1), 64-71. Doi: 10.22599/bioj.150
Jonathan, G., John, G., M. Paz Soldan, M, P. (2016).Epidemiology of Stiff Person Syndrome in the United States Veterans Health Administration Database. American Academy of Neurology, 86(16), 356.
Sasa B., Vladimir M., Juraj P., Irma G., Hilda G., Ervina B., Domina K., Niksa L., Stjepko P.(2013). Paraneoplastic stiff person syndrome associated with colon cancer misdiagnosed as idiopathic Parkinson’s disease worsened after capacitabine therapy. World Journal of Surgical Oncology.11, 224. Doi: 10.1186/1477-7819-11-224

How to Cite

K A Shaima, D Meghana, K Rooha and J Sarita. Stiff Person Syndrome Misdiagnosed as Oxaliplatin Induced Neurotoxicity. J. Pharm. Technol. Res. Manag.. 2021, 09, 43-45

Stiff Person Syndrome Misdiagnosed as Oxaliplatin Induced Neurotoxicity

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