In Silico Evaluation of Reserpine as Potential Anti-Candidal Agent

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Published: May 7, 2021

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Authors

Nidhi Rani
Rajwinder Kaur
Prerna Sharma
Praveen Kumar

DOI Number
https://doi.org/10.15415/jptrm.2021.91001

Keywords
Antifungals, Indole alkaloids, Reserpine, Rauwolfiaserpentina, Molecular docking

Abstract

Background: Candida albicans is a fungus that can cause mortality if not treated properly. Lanosterol 14α-demethylase produces Ergosterol, the main sterol in the fungal cell membrane, when the enzyme Lanosterol-demethylase is present (Cytochrome P450DM). This enzyme is a target enzyme for azole antifungal medications.

Purpose: In silico evaluation of reserpine as Potential Anti-Candidal agent.

Method: The target enzyme was chosen and modelled as part of the project. Molecular docking studies were used to investigate Reserpine’s inhibitory impact on Cytochrome P450. MolegroVirtual Docker was used to conduct molecular docking and Chem sketch was utilised to build compound structures.

Result and conclusion: According to the docking research, reserpine exhibited interactions with the demethylase enzyme.

References

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How to Cite

Nidhi Rani, Rajwinder Kaur, Prerna Sharma and Praveen Kumar. In Silico Evaluation of Reserpine as Potential Anti-Candidal Agent. J. Pharm. Technol. Res. Manag.. 2021, 09, 1-5

In Silico Evaluation of Reserpine as Potential Anti-Candidal Agent

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