Natural occurring phenolic compounds play an important role in cancer prevention and shows antimitotic activity. Number of active constituents like phenolic acid, curcuminoids, coumarine, ligans, quinones, etc. is showing antimitotic activity of Momordica dioica. The present work is on phytochemical investigation and examines antimitotic activity of aqueous extract of fruits Momordica dioica at concentration of 15 mg/ml on Allium cepa root meristamatic cells.
The fruits are air dried and extracted with solvents like water by maceration method. The evaluation of antimitotic activity is done by using Allium cepa root meristamatic cells parameters where and methotrexate was used as a standard drugs.
In Allium assay, aqueous extract of fruits of Momordica diocia(15 mg/ml) and methotrexate act against cells of allium roots and lesser the growth of root and mitotic index when compared with distilled water as control group. The result indicated that cytotoxic property is due to presence of phenolic, alkaloids and flavonoids compounds in 15 mg/ml concentration of aqueous extract of Momordica diocia fruits extract.
On the basis of result, we concluded that, 15 mg/ml concentration of Momordica dioica fruits shows good antimitotic activity on the Allium cepa root tip assay.
Abhang, R. Y., Joglekar, P. P. and Kulkarni, P.H. (1991). Preliminary study on the effect of T. cordifoliaon mitosis.
Anc. Sci. Life., 11(1-2), 7-8.
Abhang, R. Y., Joglekar, P. P. and Kulkarni, P. H.(1999). Preliminary study on the effect of T. Cordifolia on mitosis.
Ancient Science, 1(7), PMC3336579.
Ahirrao, R. A. (2019). Anticancer activity of Fruits of Momordica Dioica by using MTT assay.
Madridge J. Immunol. 3(2), 89-92. https://doi.org/10.18689/mjim-1000120
Bhattacharya, S. and Haldar, P.K. (2012). Evaluation of antimitotic and genotoxic effects of the triterpenoid enriched
extract from Trichosanthes dioica root. American-Eurasian Journal of Toxicological Sciences, 4(1), 20-23.
https://doi.org/10.5829/idosi.aejts.2012.4.1.56310
Chopra, R. N., Nayar, S. L. and Chopra, I. C. (1996). In Glossary of Indianmedicinal plants, National Institute of Science
Communication, New Delhi, India, 169.
Cragg, G. M. and Newman, D. J. (2005). Plants as a source of anticancer agents. J
Ethnopharmacology, 100(1-2), 72-79. https://doi.org/10.1016/j.jep.2005.05.011
Fiskesjo, G. (1985). The Allium test as a standard in environmental monitoring. Hereditas, 102(1), 99-112.
https://doi.org/10.1111/j.1601-5223.1985.tb00471.x
Gonzales, G. F. and Valerio, L. G. (2006). Medicinal plants from Peru: a review of plants as potential agents against cancer.
Antican. Agents Med. Chem., 6(5), 429-444. https://doi.org/10.2174/187152006778226486
Harborne, J. B. (1988). Phytochemical methods: A guide to modern techniques of plant analysis. London:
Champan and Hall Publishing House. https://doi.org/10.1016/0031-9422(88)84139-6
Kartika, K. R. and Basu, B. D. (1987), In; Indian medicinal plants II, Ed: International book distributors, Dehradun, India, 1133.
Kokate, C. K., Purohit, A. P. and Gokhale, S. B. (1999). Textbook of Pharmacognosy. 11th Edition, Nirali Prakashan, Pune, 225-226.
Kulkarni, S. K. (1993). Handbook of experimental pharmacology, 2nd Edition, Vallabh Prakashan, Mumbai, 172-189.
Latha, P. G., Chandralekha, C. T., Vilasini, G. and Panikkar , K. R. (1998). Effects of the flower extract of Ixora coccinea Linn. on the meristamatic cells Allium cepa. Anc. Sci. Life, 17(4), 262-267.
Lee, K. H. (2010). Discovery and development of natural product derived chemotherapeutic agents based on a medicinal chemistry approach. J. Nat. Prod., 73(3), 500-516. https://doi.org/10.1021/np900821e
Li, J. W. and Vederas, J. C. (2009). Drug discovery and natural products: end of an era or an endless frontier? Science, 325(5937), 161-165. https://doi.org/10.1126/science.1168243
Luo- L, Li- Z and Zhang- Y, Huang- R.(1998). Triterpenes and steroidal compounds from Momordica dioica. Yao-Xue-Xue-Bao., 33(11), 839-842.
Newman, D. J., Cragg, G. M. and Snader, K. M.(2003). Natural products as sources of new drugs over the period 1981-2002. J. Nat Prod., 66(7), 1022-1037. https://doi.org/10.1021/np0300961
Patil, N. S., Patil, K. B., Patil, M. R. and Ahirrao, R. A.(2018). Antimitotic activity of fruits of momordica dioica by using Allium cepa root tip assay. Asian J. Pharm. Res., 8(4), 221-224.
https://doi.org/10.5958/2231-5691.2018.00037.0
Periyanayagam, K., Kasirajan, B., Karthikeyan, V., Indumathi, R. andKumuda, T. (2013). Vitisvinifera. L (Vitaceae) fruits towards antimitotic and antiproliferative activity in anticancer drug discovery. Innovare J. Health Sci., 1(3), 32-35.
The useful plants of India (1992), Ed: Publication and Information Directorate, CSIR, New Delhi, India, 379.
The wealth of India (1962), A dictionary of Indian Raw materials and Industrial products VI, Ed: Publication and Information Directorate, CSIR, New Delhi, India, 408.
Willams, G. O. and Omoh, L. E. (1996). Mitotic effects of aqueous leaf extract of Cymbopogoncitratus in Allium cepa roots. Cytobis, 87, 161-164.
| Periodicity | Biannually |
| Issue-1 | May |
| Issue-2 | November |
| ISSN Print | 2321-2217 |
| ISSN Online | 2321-2225 |
| RNI No. | CHAENG/2013/50088 |
Publisher's policy of the journal at Sherpa UK for the submitted, accepted, and published articles. Click OAPolicy
Plan-S ComplianceTo check compliance, one has to use the Journal Check Tool (JCT). This tool provided by cOAlition S (European funders) for the researchers (fundee) to check the compliance with the journal.
Recommend journal to your libraryYou can recommend the journal being a researcher or faculty member to your library. We will post a copy of the Journal to your library on your behalf at free of cost.
Click here: Recommend Journal
The authors are encouraged to submit the author’s copy (preprint) to appropriate preprint archives e.g. https://arxiv.org and/or on https://indiarxiv.org or institutional repositories (e.g., D Space) before paper acceptance by the editor of Journal. After publications of the paper author(s) should mention the citation information, title and abstract along with DOI number of the publication carefully on the required page of the depository(ies).
Contact: Phone: +91-172-2741000, +91-172-4691800
Email : editor.jptrm@chitkara.edu.in;
This work is licensed under a Creative Commons Attribution 4.0 International License.
View Legal Code of the above-mentioned license, https://creativecommons.org/licenses/by/4.0/legalcode
View Licence Deed here https://creativecommons.org/licenses/by/4.0/
Journal of Pharmaceutical Technology, Research and Management by Chitkara University Publications is licensed under a Creative Commons Attribution 4.0 International License.
Based on a work at https://jptrm.chitkara.edu.in//
Chandigarh-Patiala National Highway, Punjab 140 401
Chandigarh Information Center SCO 160-161, Sector 9-C, Chandigarh 160 009
