Histone Deacetylase Inhibitors As Potential Therapeutic Agents For Various Disorders

Home > 2017, Vol. 5 No. 2 > Histone Deacetylase Inhibitors As Potential Therapeutic Agents For Various Disorders
Published: November 2, 2017
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Authors

  • Kajal ThapaChitkara College of Pharmacy, Chitkara University, Rajpura, Punjab-140401
  • Savir KumarChitkara College of Pharmacy, Chitkara University, Rajpura, Punjab-140401
  • Anurag SharmaChitkara College of Pharmacy, Chitkara University, Rajpura, Punjab-140401
  • Sandeep AroraChitkara College of Pharmacy, Chitkara University, Rajpura, Punjab-140401
  • Amarjot Kaur GrewalChitkara College of Pharmacy, Chitkara University, Rajpura, Punjab-140401
  • Thakur Gurjeet SinghChitkara College of Pharmacy, Chitkara University, Rajpura, Punjab-140401
DOI Number
https://doi.org/10.15415/jptrm.2017.52014
Keywords
Epigenetic, Histone, Acetylation, Deacetylation, Lysine, Histone deacetylases inhibitors

Abstract

Epigenetic modification acetylation or deacetylation of histone considered as an important element in various disorders. Histone acetyltransferases (HATs) and histone deacetylases (HDACs) are the enzymes which catalyse the acetylation and deacetylation of histone respectively. It helps in regulating the condensation of chromatin and transcription of genes. Lysine acetylation and deacetylation present on the nucleosomal array of histone is the key factor for gene expression and regulation in a normal working living cell. Modification in histone protein will lead to the development of cancer and can cause various neurodegenerative disorders. To safeguard the cells or histone proteins from these diseases histone deacetylase inhibitors are used. In this review, the main focus is upon the role of histone deacetylases inhibitors in various diseases.

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How to Cite

Kajal Thapa, Savir Kumar, Anurag Sharma, Sandeep Arora, Amarjot Kaur Grewal , Thakur Gurjeet Singh. Histone Deacetylase Inhibitors As Potential Therapeutic Agents For Various Disorders. J. Pharm. Technol. Res. Manag.. 2017, 05, 235-253
Histone Deacetylase Inhibitors As Potential Therapeutic Agents For Various Disorders

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