Synthesis,Characterization and Biological studies on Mannich Bases of 2-Substituted Benzimidazole Derivatives
Home >
2015,
Vol. 3 No. 1 > Synthesis,Characterization and Biological studies on Mannich Bases of 2-Substituted Benzimidazole Derivatives
Authors
- Ritchu Sethi Chitkara College of Pharmacy, Chitkara University, Rajpura, Punjab-140401
- Sandeep Arora Chitkara College of Pharmacy, Chitkara University, Rajpura, Punjab-140401
- Sandeep Jain
Department of Pharmaceutical Sciences, Guru Jambheshwar University, Hissar –125001, India
- Neelam Jain
School of Pharmaceutical Education and Research, BPS Women University,Khanpur, Kalan, Sonepat, Haryana, India
Keywords
Mannich Bases, antimicrobial activity, antioxidant activity
Abstract
In the present study novel derivatives of 2-substituted benzimidazoles were prepared via Mannich reaction and evaluated for their in vitro antimicrobial activity against two gram negative strains (Escherichia coli and Pseudomonas aeruginosa), two gram positive strains (Bacillus subtilis and Staphylococcus aureus) and fungal strains (Candida albicans and Aspergillus niger).The synthesized compounds were also screened for antioxidant activity.The newly synthesized compounds were characterized by spectral and analytical techniques.The results revealed that all the synthesized compounds have a significant antioxidant and biological activity against the tested microorganisms.
References
- A Ashok, M., Holla, B.S., and Poojary, B.C. (2007) Convenient one pot synthesis and antimicrobial evaluation of some new Mannich bases carrying 4-methylthiobenzyl moiety. European Journal of Medicinal Chemistry, 42(8): 1095-1101. http://dx.doi.org/10.1016/j.ejmech.2007.01.015
- Barlin, G.B., and Jiravinya, C. (1990) Potential antimalarials.X.Di-mannich bases of 4-(7’-trifluoromethyl-1’,5’-naphthyridin-4’-ylamino)phenol and N-(4’-Diethylamino-1’-methylbutyl)-7-trifluoromethyl-1,5-naphthyridin-4-amine. Australian Journal of Chemistry, 43(7): 1175-1181. http://dx.doi.org/10.1071/CH 9901175
- Bennet-Jenlins, E., and Baryant, C. (1996) Novel sources of anthelmintics. International Journal for Paracitology. 26(8-9): 937-947. http://dx.doi.org/10.1016/S0020-7519(96)80068-3
- E Edwards, M.L., Ritter,H.W., Stemeric, D.M., and Stewart, K.T. (1983) Mannich bases of 4-phenyl-3-buten-2-one:a new class of antiherpes agent. Journal of Medicinal Chemistry. 26(3): 431-436. http://dx.doi.org/10.1021/jm00357a020
- E Evans B.E., Rittle K.E.,Bock, M.G., Hirshfield, J. (1988) Methods for drug discovery, development of potent selective, orally effective cholecystokinin antagonist. Journal of Med. Chem. 31: 2235-2246. http://dx.doi.org/10.1021/jm00120a002
- Gul, H.I.,Vepsalainen, J., Gul, M., Erciyas, E., and Hanninen, O. (2000) Cytotoxic activities of mono and bis mannich bases derived from acetophenone against Renca and Jurkat cells. Pharmaceutica Acta Helvetiae.74(4): 393-398. http://dx.doi.org/10.1016/S0031-6865(00)00022-4
- Ivanova, Y., Momekov, G., Petrov, O., Karaivanova M., and Kalcheva, V. (2007) Cytotoxic Mannich bases of 6-(3-aryl-2-propenoyl)-2-(3H)-benzoxazolones.European Journal of Medicinal Chemistry. 52(11-12): 1382-1387. http://dx.doi.org/10.1016/j.ejmech.2007.02.019
- Kalluraya,B.,Chimbalkar,R.M., and Hedge J.C. (2005) Anticonvulsant activity of nicotinyl/isonicotinyl substituted 1,2,4-triazol-5-thione Mannich bases. Indian Journal of Heterocyclic Chemistry.15(1): 15-18.
- Kamil, A., Akhtar, S., Jahan, S., Karim, A., Rafik, A., Hassan, S. (2013) Synthesis and antioxidant activity of albendazole derivatives. International Journal of Scientific & Engineering Research. 4(8): 1674-1685.
- Koksal,M., Gokhan, N., Kupeli, E.,Yesilada, E.,Erdogan, H. (2007) Analgesic and antiinflammatory activities of some new mannich bases of 5- nitro-2 benzoxazolinones.Archives of Pharmacal Research. 30(4): 419-424. http://dx.doi.org/10.1007/BF02980214
- Malinka, W., Swiatek, P., Filipek, B., Sapa, J., Jezierska A., and Koll A. (2005) Synthesis, analgesic activity and computational study of new isothiazolopyridines of mannich base type. Farmaco, 60(11-12): 961-968. http://dx.doi.org/10.1016/j.farmac.2005.08.005
- Mandal, S., Yadav, S., Yadav, S., Kumar Nema, R. (2009) Antioxidants- A review. Journal of Chemical and Pharmaceutical Research, 1(1): 102-104.
- Mason, J.S., Morize, I., Menard, P.R. (1999) New 4-point pharmacophore method for molecular similarity and diversity applications: Overview of the method and applications including a novel approach to the design of combinatorial libraries containing privileged sub-structures. Journal of Medicinal Chemistry. 42: 3251-3264. http://dx.doi.org/10.1021/jm9806998
- Pandeya, S.N., Sriram, D., Nath, G., and De Clercq, E. (2000) Synthesis,antibacterial, antifungal and anti-HIV activities of norfloxacin Mannich bases. European Journal of Medicinal Chemistry, 35(2): 249-255. http://dx.doi.org/10.1016/S0223-5234(00)00125-2
- Scott, M.K., Martin, G.E., Distefano D.L. et al, (1992) Pyrrole Mannich bases as potential antipsychotic agents. Journal of Medicinal Chemistry. 35(3): 552-558. http://dx.doi.org/10.1021/jm00081a018
- Singh, B.N., Shukla, S.K., and Singh, M. (2007) Synthesis and biological activity of sulphadiazine schiff’s bases of isatin and their N-Mannich bases. Asian Journal of Chemistry. 19(7): 5013-5018.
- Vasishtha, S.C.,Zello, G.A., Nienaber, K.H.et al, (2004) Cytotoxic and anticonvulsant aryloxy aryl mannich bases and related compounds.European Journal of Medicinal Chemistry. 39(1): 27-35. http://dx.doi.org/10.1016/j.ejmech.2003.09.011
- White, A.W., Almassy, R., Calvert, A.H., Golding, B.T. (2000) Resistance modifying agents, Synthesis and Biological properties of Benzimidazole inhibitors of DNA repair enzyme Poly(ADP Ribose) polymerase. Journal of Med.Chem, 43: 4084-4097. http://dx.doi.org/10.1021/jm000950v
- Zhu, Z., Lippa, B., Drach, J.C.(2000) Design Synthesis and biological evaluation of tricyclic nucleosides(Dimensional probes)as analogues of certain antiviral polyhalogenated Benzimidazole Ribonucleosides. Journal of Med. Chemistry, 43: 2430-2437. http://dx.doi.org/10.1021/jm990290y
How to Cite
Ritchu Sethi, Sandeep Arora, Sandeep Jain, Neelam Jain. Synthesis,Characterization and Biological studies on Mannich Bases of 2-Substituted Benzimidazole Derivatives.
J. Pharm. Technol. Res. Manag.. 2015, 03, 57-64
