Pharmaceutical Analysis of Eptifibatide via Simple, Rapid, Economical UV-Spectrophotometric Methods

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Published: May 20, 2015

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Authors

Sushant S. Patil R.C. Patel Institute of Pharmaceutical Education and Research, Shirpur, Dist. Dhule, India
Saurabh B. Ganorkar R.C. Patel Institute of Pharmaceutical Education and Research, Shirpur, Dist. Dhule, India
Atul A. Shirkhedkar R.C. Patel Institute of Pharmaceutical Education and Research, Shirpur, Dist. Dhule, India

DOI Number
https://doi.org/10.15415/jptrm.2015.31004

Keywords
Eptifibatide, UV-Spectrophotometry, First Order Derivative-AUC

Abstract

Eptifibatide is an antiplatelet drug of the glycoprotein IIb/IIIa inhibitor class. Pharmaceutically it is applied to reduce the risk of acute cardiac ischemic events. The present work reveals two simple, rapid and economical UuV-Spectrophotometric methods for pharmaceutical analysis of Eeptifibatide bulk and in parenteral formulation. The ‘Method I’ is based on the Zero Order Spectrophotometric determination of drug at its wavelength maximum 218.20 nm and ‘Method II’ employed First Order Derivative – Aarea Uunder Curve (AUauC) technique in which the area has been integrated between two wavelengths 220.20 to 237.20 nm. The drug obeyed linearity in the concentration range of 3 – 18 μg/mLl with coefficient of correlation; greater than 0.999 in both methods. The amounts of drug determined by both methods are in conformity with label claim. These methods are validated for accuracy, precision and ruggedness with % RSD value less than 2.0.

References

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How to Cite

Sushant S. Patil, Saurabh B. Ganorkar, Atul A. Shirkhedkar. Pharmaceutical Analysis of Eptifibatide via Simple, Rapid, Economical UV-Spectrophotometric Methods. J. Pharm. Technol. Res. Manag.. 2015, 03, 49-55

Pharmaceutical Analysis of Eptifibatide via Simple, Rapid, Economical UV-Spectrophotometric Methods

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