Receptor Identification: Advances in Ligands and Transmitters Discovery

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Published: May 20, 2014
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Authors

  • Sandeep AroraChitkara College of Pharmacy, Chitkara University, Rajpura, Punjab-140401
  • Govindrajan RaghavanDabur International, Dubai
  • Avaneesh KumarChitkara College of Pharmacy, Chitkara University, Rajpura, Punjab-140401
DOI Number
https://doi.org/10.15415/jptrm.2014.21005
Keywords
Orphan G-protein-coupled receptors, Hybridisation, PCR, cysteinyl leukotriene CysLT1 and Cys T2, hepatointestinal leukotriene B4, motilin, Ghrelin, Growth hormone-releasing peptide

Abstract

Receptor identification is an integral part of drug discovery and development. By the beginning of the next millennium, the search for the natural ligands of the orphan G-protein-coupled receptors will lead to the discovery of so many new peptides that it may well double their present number. It has recently become evident that all types of chemical messengers, hormones and transmitters act through membrane receptors which constitute our largest superfamily of proteins, i.e. the G protein-coupled receptors. The development of targeted therapies has revolutionized the treatment of various chronic diseases. Receptors have well-conserved regions that are recognized and activated by hormones and neurotransmitters. These ligands are peptides, lipids or biogenic amines, and act as transmitter molecules. Identification of orphan receptors include screening, binding and reverse engineering that help to find out cysteinyl leukotriene CysLT1 and Cys T2, hepatointestinal leukotriene B4, motilin, Ghrelin, Growth hormone-releasing peptide and growth hormone secretagogue receptor and many more. Techniques involved in screening of receptors include low stringency hybridization followed by PCR-derived approaches helps to discover various orphan g protein couple recptors (oGPCR). The discovery of the oGPCR represents a hallmark in neuroscience research, and the exploitation of its numerous physiological and pathophysiological functions is a promising avenue for therapeutic applications.

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How to Cite

Sandeep Arora, Govindrajan Raghavan, Avaneesh Kumar. Receptor Identification: Advances in Ligands and Transmitters Discovery. J. Pharm. Technol. Res. Manag.. 2014, 02, 61-75
Receptor Identification: Advances in Ligands and Transmitters Discovery

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