53a7bb081a02e9f8a533d3f 20260824101724680 chitu:chitu chitkarauniversitypublications@chitkara.edu.in WEB-FORM Journal of Pharmaceutical Technology, Research and Management JPTRM 23212217 23212225 10.15415/jptrm https://jptrm.chitkara.edu.in/ 8 4 2026 8 4 2026 13 2 10.15415/jptrm.2025.132 https://jptrm.chitkara.edu.in/2025/vol-13-no-02/ Comprehensive Insights into Lipid Nanocarriers: Preparation, Characterization and Applications Ravi Goyal Herbovive Private Limited, Hisar, Haryana, India. Gurpreet Kaur Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala, Punjab, India. Sumit Sharma School of Pharmaceutical Sciences, Delhi Pharmaceutical Sciences and Research University, New Delhi, India. Deepika Raina School of Pharmacy, Graphic Era Hill University, Dehradun, Uttarakhand, India. Nitin Chitranshi School of Biomedical Science, University of New England, Australia. Background: Lipid nanocarriers have emerged as a novel alternative to traditional drug delivery systems such as emulsions, liposomes, and microparticulate systems. These are spherical nano-sized (1–1000 nm) colloidal carriers dispersed in an aqueous surfactant solution. Their biodegradable, biocompatible, and non-toxic nature has led to extensive exploration in clinical medicine for multiple routes of administration, including oral, parenteral, and topical delivery. They offer high stability, large drug-loading capacity, and the ability to deliver both hydrophilic and lipophilic drugs in a targeted and controlled manner. Purpose: The purpose of this review is to provide a comprehensive overview of lipid nanocarriers, focusing on their fundamental principles, advantages, limitations, preparation methods, and characterization techniques. Methods: The review compiles and analyzes literature from relevant publications from the last 15 years on lipid nanocarriers, covering their formulation approaches, different preparation techniques, and evaluation parameters used to assess their physicochemical and functional properties. Results: Lipid nanocarriers demonstrate significant advantages, including enhanced stability, improved drug loading, controlled and targeted drug release, and adaptability to various formulation requirements. Their versatility makes them suitable for applications in pharmaceuticals, vaccines, nutraceuticals, and diagnostic systems. Conclusions: A comprehensive understanding of lipid nanocarriers can open new avenues in the treatment of multifactorial disorders. Their safety, efficacy, and flexibility position them as promising candidates for advanced drug delivery systems and future therapeutic innovations. 08 04 2026 08 04 2026 88 107 10.15415/jptrm.2025.132006 https://jptrm.chitkara.edu.in/2025/comprehensive-insights-into-lipid-nanocarriers-preparation-characterization-and-applications/