53a7bb0819fc9ef4713-57e1 20260804040702991 chitu:chitu chitkarauniversitypublications@chitkara.edu.in WEB-FORM Journal of Pharmaceutical Technology, Research and Management JPTRM 23212217 23212225 10.15415/jptrm https://jptrm.chitkara.edu.in/ 01 29 2026 01 29 2026 13 2 10.15415/jptrm.2025.132 https://jptrm.chitkara.edu.in/2025/vol-13-no-02/ Lacidipine: Beyond Hypertension-Cardiovascular, Neuroprotective, and Renoprotective Effects Soumarshi Das Chitkara College of Pharmacy, Chitkara University, 140401, Punjab, India. https://orcid.org/0009-0004-9479-0345 Prabir Maity Chitkara College of Pharmacy, Chitkara University, 140401, Punjab, India. https://orcid.org/0009-0007-2054-344X Anjali Sharma Chitkara College of Pharmacy, Chitkara University, 140401, Punjab, India. https://orcid.org/0009-0007-3637-3692 Sarita Jangra Chitkara College of Pharmacy, Chitkara University, 140401, Punjab, India. https://orcid.org/0000-0002-9193-4057 Background: Hypertension remains a leading contributor to cardiovascular, cerebrovascular, and renal disease worldwide. While calcium channel blockers are well established for blood pressure management, growing attention is being given to agents that provide organ protection beyond hemodynamic control. Lacidipine, a highly lipophilic dihydropyridine calcium channel blocker, shows strong membrane affinity and antioxidant properties, suggesting potential benefits that extend beyond its antihypertensive role. Purpose: This review critically examines lacidipine’s therapeutic profile by integrating evidence of its vascular, cardiovascular, neurovascular, and renal protective effects alongside its established clinical use. Methods: A comprehensive analysis of preclinical studies, clinical trials, and mechanistic reports was conducted to examine lacidipine’s pharmacological properties, antioxidant activity, and vasoprotective roles beyond blood pressure control. Results: Lacidipine exhibits pronounced vascular selectivity and sustained activity with good tolerability in clinical use. Experimental studies demonstrate antioxidant and anti-inflammatory effects that mitigate endothelial dysfunction, vascular remodeling, and oxidative injury. Clinical evidence supports its efficacy is comparable to other major antihypertensive classes. Emerging data further indicate neuroprotective effects in models of stroke and neurodegeneration, renoprotective actions through improved microvascular and glomerular function, and cardioprotective benefits including attenuation of left ventricular hypertrophy and atherosclerotic progression. Conclusions: Beyond effective blood pressure management, lacidipine shows multi organ protective properties that may enhance long term outcomes in hypertension associated disorders. Further studies are warranted to validate these benefits in clinical settings and to explore repositioning strategies that leverage its pleiotropic therapeutic potential. 01 29 2026 01 29 2026 1 21 10.15415/jptrm.2025.132001 https://jptrm.chitkara.edu.in/2025/lacidipine-beyond-hypertension-cardiovascular-neuroprotective-and-renoprotective-effects/