Phytoconstituents in Breast Cancer Prevention

Abstract

Background: In today's developing nations, breast cancer (BC) is among the foremost risk factor for women. The causes of mortality are still unclear, yet they are frequently related to socioeconomic level and way of life. Numerous clinical therapies have been employed up to this point, i.e.,radiotherapy, hormonal treatment, targeted treatment,mastectomy, and treatment with drugs etc.

Purpose: However, resistance development to chemotherapeutic drugs, radiation and hormonal therapy is one of the common problems for many of the patients with BC.Numerous studies have looked at the anti-cancer potential of natural products due to the fact that they are generally safe.Researchers' interest is being drawn by phytochemicals from plants that are thought to be bioactive. In this review the formation and progression of breast cancer were also studied, along with the mode’s of activity and regulatory function of these phytoconstituents in major signalling networks within the cell.

Conclusion:Phytoconstituents in Breast Cancer Prevention have potential future as well as the difficulties. So, need more study and instructions for experimental animals, medical research, and experimental in vitro and in vivo methods are critically evaluated.

  • Page Number : 37-45
  • Keywords
    Breast cancer, Plethora, Calendula officinalis, Tacca integrifolia, Flax seed
  • DOI Number
    10.15415/jptrm.2022.101005
  • Authors
    • Shreya Sood
    • Sushma Devi
    • Thakur Gurjeet Singh
    • Amarjot Kaur
    • Vinita Singh
    • Prinsi Sahpuriya

References

  • Ahmad, A. (2019). Breast cancer statistics: Recent trends. Advances in Experimental Medicine and Biology, 1152, 1–7. https://doi.org/10.1007/978-3-030-20301-6_1
  • Bozkurt, E., Atmaca, H., Kisim, A., Uzunoglu, S., Uslu, R., &Karaca, B. (2012). Effects of Thymus serpyllum extract on cell proliferation, apoptosis and epigenetic events in human breast cancer cells. Nutrition and Cancer, 64(8), 1245–1250. doi:10.1080/01635581.2012.719658
  • Brooks, J. D., Ward, W. E., Lewis, J. E., Hilditch, J., Nickell, L., Wong, E., &Thompson, L. U. (2004). Supplementation with flaxseed alters estrogen metabolism in postmenopausal women to a greater extent than does supplementation with an equal amount of soy. American Journal of Clinical Nutrition, 79(2), 318–325. doi:10.1093/ajcn/79.2.318
  • Burotto, M., Chiou, V. L., Lee, J. M., &Kohn, E. C. (2014). The MAPK pathway across different malignancies: A new perspective. Cancer120(22), 3446–3456. doi:10.1002/cncr.28864
  • Chavez, K. J., Garimella, S. V., &Lipkowitz, S. (2010). Triple negative breast cancer cell lines: One tool in the search for better treatment of triple negative breast cancer. Breast Disease32(1–2), 35–48. doi:10.3233/BD-2010-0307 
  • Choudhari, A. S., Mandave, P. C., Deshpande, M., Ranjekar, P., &Prakash, O. (2019). Phytochemicals in cancer treatment: From preclinical studies to clinical practice. Frontiers in Pharmacology, 10, 1614. doi:10.3389/fphar.2019.01614
  • Cohen, S. M., &Arnold, L. L. (2011). Chemical carcinogenesis. Toxicological Sciences120 Suppl. 1(suppl_1), S76–S92. doi:10.1093/toxsci/kfq365
  • Craig, W. J. (1999). Health-promoting properties of common herbs. American Journal of Clinical Nutrition70(3) Suppl., 491S–499S. doi:10.1093/ajcn/70.3.491s
  • Cruceriu, D., Diaconeasa, Z., Socaci, S., Socaciu, C., Rakosy-Tican, E., &Balacescu, O. (2020). Biochemical profile, selective cytotoxicity and molecular effects of Calendula officinalis extracts on breast cancer cell lines. NotulaeBotanicae Horti Agrobotanici Cluj-Napoca, 48(1), 24-39. https://doi.org/10.15835/nbha48111778
  • Dar, P. A., Mir, S. A., Bhat, J. A., Hamid, A., Singh, L. R., Malik, F., &Dar, T. A. (2019). An anti-cancerous protein fraction from Withaniasomnifera induces ROS-dependent mitochondria-mediated apoptosis in human MDA-MB-231 breast cancer cells. International Journal of Biological Macromolecules, 135, 77–87. doi:10.1016/j.ijbiomac.2019.05.120 
  • Di, Y., De Silva, F., Krol, E. S., &Alcorn, J. (2018). Flaxseed lignans enhance the cytotoxicity of chemotherapeutic agents against breast cancer cell lines MDA-MB-231 and SKBR3. Nutrition and Cancer70(2), 306–315. doi:10.1080/01635581.2018.1421677
  • Dubey, I., Saluja, M. S., Gilhotra, R. M., &Chhajed, M. (2018). Evaluation of polyherbal anticancer tablets: A review. Journal of Pharmaceutical Technology, 6(1), 67–79. doi:10.15415/jptrm.2018.61006
  • Ferlay, J., Soerjomataram, I., Dikshit, R., Eser, S., Mathers, C., Rebelo, M., &Bray, F. (2015). Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012. International Journal of Cancer, 136(5), E359–E386. https://doi.org/10.1002/ijc.29210
  • Garcia-Oliveira, P., Otero, P., Pereira, A. G., Chamorro, F., Carpena, M., Echave, J., and Prieto, M. A. (2021). Status and challenges of plant-anticancer compounds in cancer treatment. Pharmaceuticals14(2), 157. doi:10.3390/ph14020157
  • Garg, N., Baishnab, S., Das, R., Kaur, K., Gupta, S., &Arora, S. (2019). Insights of breast cancer and barriers to its therapy. Journal of Pharmaceutical Technology, 7(2), 73–86. doi:10.15415/jptrm.2019.72010
  • Ge, X., Chen, S., Liu, X., Wang, Q., Gao, L., Zhao, C., & Liu, Z. (2019). Ferrocene-appended iridium (III) complexes: Configuration regulation, anticancer application, and mechanism research. Inorganic Chemistry58(20), 14175–14184. doi:10.1021/acs.inorgchem.9b02227
  • George, B. P., Chandran, R., &Abrahamse, H. (2021). Role of phytochemicals in cancer chemoprevention: Insights. Antioxidants, 10(9), 1455. doi:10.3390/antiox10091455
  • Goodarzi, S., Tabatabaei, M. J., Mohammad Jafari, R., Shemirani, F., Tavakoli, S., Mofasseri, M., &Tofighi, Z. (2020). Cuminum cyminum fruits as source of luteolin-7-O-glucoside, potent cytotoxic flavonoid against breast cancer cell lines. Natural Product Research, 34(11), 1602–1606. doi:10.1080/14786419.2018.1519824
  • Hahm, E. R., Moura, M. B., Kelley, E. E., Van Houten, B., Shiva, S., &Singh, S. V. (2011).Withaferin A-induced apoptosis in human breast cancer cells is mediated by reactive oxygen species. PLOS ONE, 6(8), e23354. doi:10.1371/journal.pone.0023354
  • Huyen, C. T. T., Luyen, B. T. T., Khan, G. J., Oanh, H. V., Hung, T. M., Li, H. J., &Li, P. (2018). Chemical constituents from Cimicifuga dahurica and their anti-proliferative effects on MCF-7 breast cancer cells. Molecules, 23(5), 1083. doi:10.3390/molecules23051083
  • Iqbal, J., Abbasi, B. A., Mahmood, T., Kanwal, S., Ali, B., Shah, S. A., &Khalil, A. T. (2017). Plant-derived anticancer agents: A green anticancer approachAsian Pacific Journal of Tropical Biomedicine7(12), 1129–1150. https://doi.org/10.1016/j.apjtb.2017.10.016
  • Iqbal, J., Ginsburg, O., Giannakeas, V., Rochon, P. A., Semple, J. L., &Narod, S. A. (2017). The impact of nodal micrometastasis on mortality among women with early-stage breast cancer. Breast Cancer Research and Treatment161(1), 103–115. doi:10.1007/s10549-016-4015-5
  • Jafri, A., Amjad, S., Bano, S., Kumar, S., Serajuddin, M., &Arshad, M. (2020). Efficacy of nano-phytochemicals over pure phytochemicals against various cancers: Current trends and future prospects. In. Nanotechnology in the Life Sciences.Cham, Germany: Springer, 407–424. doi:10.1007/978-3-030-34544-0_20 
  • Kim, D. H., Park, K. W., Chae, I. G., Kundu, J., Kim, E. H., Kundu, J. K., &Chun, K. S. (2016). Carnosic acid inhibits STAT3 signaling and induces apoptosis through generation of ROS in human colon cancer HCT116 cells. Molecular Carcinogenesis55(6), 1096–1110. doi:10.1002/mc.22353 
  • Kubatka, P., Uramova, S., Kello, M., Kajo, K., Kruzliak, P., Mojzis, J., &Busselberg, D. (2017). Antineoplastic effects of clove buds (Syzygium aromaticum L.) in the model of breast carcinoma. Journal of Cellular and Molecular Medicine21(11), 2837–2851. doi:10.1111/jcmm.13197
  • Lee, D., Park, S., Choi, S., Kim, S. H., &Kang, K. S. (2018). In vitro estrogenic and breast cancer inhibitory activities of chemical constituents isolated from Rheum undulatum L. Molecules, 23(5), 1215. doi:10.3390/molecules23051215
  • Liu, J. L., Pan, Y. Y., Chen, O., Luan, Y., Xue, X., Zhao, J. J., &Jia, H. Y. (2017). Curcumin inhibits MCF7 cells by modulating the NF-κB signaling pathway. Oncology Letters14(5), 5581–5584. doi:10.3892/ol.2017.6860
  • Maughan, K. L., Lutterbie, M. A., &Ham, P. S. (2010). Treatment of breast cancer. American Family Physician, 81(11), 1339–1346.
  • Moulder, S., &Hortobagyi, G. N. (2008). Advances in the treatment of breast cancer. Clinical Pharmacology and Therapeutics, 83(1), 26–36. doi:10.1038/sj.clpt.6100449
  • Pledgie-Tracy, A., Sobolewski, M. D., &Davidson, N. E. (2007). Sulforaphane induces cell type–specific apoptosis in human breast cancer cell lines. Molecular Cancer Therapeutics6(3), 1013–1021. doi:10.1158/1535-7163.MCT-06-0494
  • Pons, D. G., Nadal‐Serrano, M., Blanquer‐Rossello, M. M., Sastre‐Serra, J., Oliver, J., &Roca, P. (2014). Genistein modulates proliferation and mitochondrial functionality in breast cancer cells depending on ERalpha/ERbeta ratio. Journal of Cellular Biochemistry115(5), 949–958. doi:10.1002/jcb.24737
  • Reddy, K. B. (2011). Triple-negative breast cancers: An updated review on treatment options. Current Oncology, 18(4), e173–e179. doi:10.3747/co.v18i4.738
  • Santis, C., De, C., Bryan, L., Ma, J., &Jemal, A. (2014).Cancer. Journal of Clinical Medicine, 64(1), 52–62. doi:10.3322/caac.21203
  • Sun, Z. J., Chen, G., Hu, X., Zhang, W., Liu, Y., Zhu, L. X., . . . and Zhao, Y. F. (2010). Activation of PI3K/Akt/IKK-α/NF-κB signaling pathway is required for the apoptosis-evasion in human salivary adenoid cystic carcinoma: Its inhibition by quercetin. Apoptosis15(7), 850–863. doi:10.1007/s10495-010-0497-5 
  • Tesfaye, T., &Ravichadran, Y. D. (2018). Traditional Uses, Pharmacological Action and Phytochemical Analysis of Carissa carandas Linn:A Review.Natural Products Chemistry and Research, 06(5), 334. doi:10.4172/2329-6836.1000334
  • Torre, L. A., Bray, F., Siegel, R. L., Ferlay, J., Lortet‐Tieulent, J., &Jemal., Iqbal, J., Abbasi, B. A., Mahmood, T., Kanwal,,A. (2015). Global cancer statistics, 2012CA: a Cancer Journal for Clinicians, 65(2), 87–108. https://doi.org/10.3322/caac.21492
  • Tyagi, T., Treas, J. N., Mahalingaiah, P. K. S., &Singh, K. P. (2015). Potentiation of growth inhibition and epigenetic modulation by combination of green tea polyphenol and 5-aza-2′-deoxycytidine in human breast cancer cells. Breast Cancer Research and Treatment149(3), 655–668. doi:10.1007/s10549-015-3295-5
  • Uramova, S., Kubatka, P., Dankova, Z., Kapinova, A., Zolakova, B., Samec, M., & Danko, J. (2018). Plant natural modulators in breast cancer prevention: Status quo and future perspectives reinforced by predictive, preventive, and personalized medical approach. EPMA Journal, 9(4), 403–419. https://doi.org/10.1007/s13167-018-0154-6
  • Wang, B., Xing, Z., Wang, F., Yuan, X., &Zhang, Y. (2017). Fangchinoline inhibits migration and causes apoptosis of human breast cancer MDA-MB-231 cells. Oncology Letters, 14(5), 5307–5312. doi:10.3892/ol.2017.6831
  • Wang, N., Wang, Z., Peng, C., You, J., Shen, J., Han, S., &Chen, J. (2014). Dietary compound isoliquiritigenin targets GRP78 to chemosensitize breast cancer stem cells via β-catenin/ABCG2 signaling. Carcinogenesis35(11), 2544–2554. doi:10.1093/carcin/bgu187
  • Wu, X. C., Hotes, J. L., Fulton, J. P., Chen, V. W., Howe, H. L., &Correa, C. (2002). Cancer in North America, 1995–1999. NAACCR Combined Cancer Incidence Rates.Springfield, IL: North American Publishing Association of Central Cancer Registries. doi:10.3390/molecules23051083
  • Yu, H., Lee, H., Herrmann, A., Buettner, R., &Jove, R. (2014). Revisiting STAT3 signalling in cancer: New and unexpected biological functions. Nature Reviews Cancer, 14(11), 736-746.https://doi.org/10.1038/nrc3818
  • Zainurin, N. A. A., Hashim, Y. Z. H. Y., Azmin, N. F. M., &Abbas, P. (2018). Agarwood Leaf essential oil characterization and effects on MCF-7 breast cancer cells. International Journal on Advanced Science, Engineering and Information Technology8(4–2), 1604–1609. doi:10.18517/ijaseit.8.4-2.7034
  • Zheng, J., Zhou, Y., Li, Y., Xu, D. P., Li, S., &Li, H. B. (2016). Spices for prevention and treatment of cancers. Nutrients8(8), 495. doi:10.3390/nu8080495

  • Published Date : 2022-05-07