Traditional and Novel Herbal Drugs Emerging as Potent Novel Combinations for Managing Morbidities by Pharmacological and Mechanistic Studies

References

• Abiy, E., Berhe, A. (2016) Anti-Bacterial Effect of Garlic (Allium sativum) against Clinical Isolates of Staphylococcus aureus and Escherichia coli from Patients Attending Hawassa Referral Hospital, Ethiopia. Journal of Infectious Diseases and Treatment,2, 2. https://doi.org/10.21767/2472-1093.100023
• Agita A, Alsagaff MT. (2017) Inflammation, Immunity, and Hypertension. Acta Med Indones,49,158-165. https://doi.org/10.1161/HYPERTENSIONAHA.110.16357641
• Akter, R., Mahabub-Uz-Zaman, M., Rahman, MS., Khatun, MA, Abdullah AM, Ahmed, NU., Islam, F. (2013) Comparative studies on antidiabetic effect with a phytochemical screening of Azadirachta indicia and Andrographis paniculata. IOSR Journal of Pharmacy and Biological Sciences, 5, 122–128. e-ISSN:2278–3008.
• Akuri, M. C., Barbalho, S. M., Val, R. M., & Guiguer, E. L. (2017). Reflections about Osteoarthritis and Curcuma longa. Pharmacognosy Reviews, 11, 8–12. https://doi.org/10.4103/phrev.phrev_54_16
• Andallu, B., Radhika, B. (2000) Hypoglycemic, diuretic and hypocholesterolemic effect of winter cherry (Withania somnifaria, Dunal) root. Indian Jour Exp Bio, 38, 607–609. PMID: 11116534.
• Aneesh, T., Hisham, M., Sekhar, M., Madhu, M., Deepa, T. (2009) International market scenario of traditional Indian herbal drugs-India declining. International Journal of Green Pharmacy, 3, 184–190.https://doi.org/10.4103/0973-8258.5627
• Anjali, K., Ritesh, K., Sudarshan, M., Jaipal, S. C., Kumar, S. (2013) Antifungal efficacy of aqueous extracts of neem cake, karanj cake and vermicompost against some phytopathogenic fungi. The Bioscan, 8, 671–674.
• Anushka, S., Rajendran, P., Vedha, V., Ashok, G., Kannan M., and Karthikeyan, M. (2011) A study on the anti-viral properties of Azadirachta indica (A.Juss, Neem) against HBV, HIV, HSV-I, Vaccinia and Varicella zoster viruses and Coscinium fenestratum (Gaertn.) Colebr, Tree turmeric) against HBV and HIV. Biomedicine, 31, 482–486.
• Badam, L., Joshi, SP., Bedekar, SS. (1999) In vitro’ antiviral activity of neem (Azadirachta indica. A. Juss) leaf extract against group B Coxsackieviruses. J Commun Dis, 31, 79–90. PMID: 10810594
• Banerjee, S. K., Mukherjee, P. K., Maulik, S. K. (2003) Garlic as an antioxidant: the good, the bad and the ugly. Phytotherapy Research, 17, 97–106.https://doi.org/10.1002/ptr.1281
• Barbara, G., Stanghellini, V., De Giorgio, R., Cremon, C., Cottrell, GS., Santini, D., Pasquinelli, G., Morselli-Labate, AM., Grady, EF., Bunnett, NW., et al. (2004) Activated mast cells in proximity to colonic nerves correlate with abdominal pain in irritable bowel syndrome. Gastroenterology,126, 693–702. PMID: 14988823
• Benavides, G. A., Squadrito, G. L., Mills, R. W., Patel, H. D., Isbell, T. S., Patel, R. P., DarleyUsmar, V. M., Doeller, J. E., Kraus, D. W. (2007) Hydrogen sulfide mediates the vasoactivity of garlic. PNAS, 104, 17977–17982. https://doi.org/10.1073/pnas.0705710104
• Bhattacharya, S. K., Muruganandam, A. V. (2003) Adaptogenic activity of Withania somnifera: an experimental study using a rat model of chronic stress. Pharmacol Biochem Behav, 75, 547–55. PMID: 12895672
• Borek, C. (2006) Garlic reduces dementia and heart-disease risk. J. Nutr,136,810–812. https://doi.org/10.1093/jn/136.3.810S
• Cancer Research UK. (2018)http://www.cancerresearchuk.org/health-professional/cancer-statistics/worldwide-cancer
• Cerella, C., Dicato, M., Jacob, C., Diederich, M. (2011) Chemical properties and mechanisms determining the anti-cancer action of garlic-derived organic sulfur compounds. Anti-Cancer Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry-Anti-Cancer Agents),11, 267–71.https://doi.org/10.2174/187152011795347522
• Chatterjee, A., Pakrashi, S. C. (1995) The Treatise on Indian Medicinal Plants. New Delhi, Publication and Information Directorate, 4, 208–212.http://www.niscair.res.in/ActivitiesandServices/Products/products.htm
• Chopra, I. C., Gupta, K. C., Nazir, B. N. (1952) Preliminary study of antibacterial substances from Melia azidirachta. Indian. J Med Res, 40, 511–515. PMID: 13061059
• Chung, L. Y. (2006). The antioxidant properties of garlic compounds: allyl cysteine, alliin, allicin, and allyl disulfide. J Med Food, 9, 205–13.https://doi.org/10.1089/jmf.2006.9.205.
• Daka, D. (2011) Antibacterial effect of garlic (Allium sativum) on Staphyloccus aureus: An in vitro study. African Journal of Biotechnology, 10, 666–669.https://doi.org/10.5897/AJB09.553
• Das, K. K., Das, S. N., and Dasgupta, S. (2001) The influence of ascorbic acid on nickel induced hepatic lipid peroxidation in rats. J. Basic Clin. Physiol Pharmacol,12, 187–194. PMID: 11762690
• Debella, A. (2004) Procedures in preparation of Medicine from plants. Aartistic Printing Press, Addis Ababa.
• Eidi, A., Eidi, M., Esmaeili, E. (2006) Antidiabetic effect of garlic (Allium sativum L.) in normal and streptozotocin-induced diabetic rats. Phytomedicine, 13, 624–9. https://doi.org/10.1016/j.phymed.2005.09.010
• Eltaweel, M. A. (2014) Antibacterial Effect of Garlic (Allium Sativum) On Staphylococcus Aureus: An In Vitro Study. In International Conference on Advances in Environment, Agriculture & Medical Sciences (ICAEAM’14).
• Gannon, J. M., Forrest, P. E. Roy, Chengappa, K. N. (2014) Subtle changes in thyroid indices during a placebo-controlled study of an extract of Withania somnifera in persons with bipolar disorder. Journal of Ayurveda and Integrative Medicine, 5, 241–245. https://doi.org/10.4103/0975-9476.146566
• Gauttam, V. K., Kalia, A. N. (2013) Development of polyherbal antidiabetic formulation encapsulated in the phospholipids vesicle system. Journal of Advanced Pharmaceutical Technology & Research, 4, 108–117.https://doi.org/10.4103/2231-4040.111527
• Gbotolorun, S., Osinubi, A., Noronha, C., & Okanlawon, A. (2008) Antifertility potential of Neem flower extract on adult female Sprague-Dawley rats. African Health Sciences, 8, 168–173.PMID: 19357745
• Ghonmode, W. N., Balsaraf, O. D., Tambe, V. H., Saujanya, K. P., Patil, A. K., Kakde, D. D. (2013) Comparison of the antibacterial efficiency of neem leaf extracts, grape seed extracts and 3% sodium hypochlorite against E. feacalis—an in vitro study. Journal of International Oral Health, 5, 61–66.PMID: 24453446
• Ghorbani, Z., Hekmatdoost, A., Mirmiran, P. (2014) Anti-hyperglycemic and insulin sensitizer effects of turmeric and its principle constituent curcumin. International journal of endocrinology and metabolism, 12, e18081.https://doi.org/10.5812/ijem.18081
• Goel, A., Aggarwal, B. B. (2010) Curcumin, the golden spice from Indian saffron, is a chemosensitizer and radiosensitizer for tumors and chemoprotector and radioprotector for normal organs. Nutrition and Cancer, 62, 919–30.https://doi.org/10.1080/01635581.2010.509835
• Gorelick, J., Rosenberg, R., Smotrich, A., Hanus, L., Bernstein, N. (2015) Hypoglycemic activity of withanolides and elicitated Withania somnifera. Phytochemistry,116, 283–289. https://doi.org/.10.1016/j.phytochem.2015.02.029
• Govindachari, T.R., Suresh, G., Gopalakrishnan, G., Banumathy, B., Masilamani, S. (1998) Identification of antifungal compounds from the seed oil of Azadirachta indica . Phytoparasitica, 26, 109–116. https://doi.org/10.1007/BF02980677
• Grandhi, A., Mujumdar, A.M., Patwardhan, B.A. (1994) Comparative pharmacological investigation of Ashwagandha and Ginseng. J Ethnopharmacol, 44, 131–135.PMID: 7898119
• Gupta, A., Singh, S. (2014) Evaluation of anti-inflammatory effect of Withania somniferaroot on collagen-induced arthritis in rats. Pharm Biol, 52, 308–20. https://doi.org10.3109/13880209.2013.835325
• Gupta, S. C., Reuter, S., Phromnoi, K., Park, B., Hema, P. S., Nair, M., Aggarwal, B. B. (2011) Nimbolide sensitizes human colon cancer cells to TRAIL through reactive oxygen species-and ERK-dependent up-regulation of death receptors, p53, and Bax. Journal of Biological Chemistry, 286, 1134–46.https://doi.org/10.1074/jbc.M110.191379
• Hendrick, V., Altshuler, L., Whybrow, P. (1998) Psychoneuroendocrinology of mood disorders: The hypothalamic-pituitary-thyroid axis. Psychiatr Clin North Am, 21, 277–92. PMID: 9670226
• Henrotin, Y., Priem, F., & Mobasheri, A. (2013). Curcumin: a new paradigm and therapeutic opportunity for the treatment of osteoarthritis: curcumin for osteoarthritis management. SpringerPlus,2, 56.https://doi.org/10.1186/2193-1801-2-56
• Hodge, G., Hodge, S., Han, P. (2002) Allium sativum (garlic) suppresses leukocyte inflammatory cytokine production in vitro: potential therapeutic use in the treatment of inflammatory bowel disease. Cytometry, 48, 209–215.https://doi.org/10.1002/cyto.10133
• Hornícková, J., Kubec, R., Cejpek, K., Velíšek, J., Ovesná, J., Stavelíková, H. (2010) Profiles of S-alk (en) ylcysteine sulfoxides in various garlic genotypes. Czech Journal of Food Sciences, 28, 298–308. https://doi.org/20103329663
• IDF. (2018) https://www.idf.org/our-activities/congress/hyderabad-2018.html
• Islam, M. S., Kusumoto, Y., Al-Mamun, M. A. (2011) Cytotoxicity and cancer (HeLa) cell killing efficacy of aqueous garlic (Allium sativum) extract. Journal of Scientific Research, 3, 375–382. https://doi.org/210.3329/jsr.v3i2.6557
• Jackson, R., McNeil, B., Taylor, C., Holl, G., Ruff, D., Gwebu, E. T. (2002) Effect of aged garlic extract n caspase-3 activity in vitro. Nutritional Neuroscience, 5,287–290. https://doi.org/10.1080/10284150290032012
• Jalil, A., Ashfaq, U. A., Shahzadi, S., Javed, M. R., Rasul, I., Rehman, S. U., Shah, M., Masoud, M. S. (2013) Screening and design of anti-diabetic compounds sourced from the leaves of neem (Azadirachta indica). Bioinformation, 9,1031–1035. https://doi.org/10.6026/97320630091031
• Janan, M., Sakih, Alaa, T., Monawer, Ismaeil, M., Abdulikhar. (2016) Antibacterial activity of garlic against multidrug resistance Staphylococcus Aureus and Enterococcus faecalis. In Duhok City Journal of University of Duhok.Pure and Eng. Sciences, 19, 114–122.
• Jang, G.H., Ha, J.H., Huh, T.L., and Lee, Y.M. (2008) Effect of proton beam on blood vessel formation in early developing zebrafish (Danio rerio) embryos.Archives of Pharmacal Research, 31, 779–785.https://doi.org/10.1007/s12272-001-1226-1
• Julie, S., Jurenka, M. T. (2009) Anti-inflammatory properties of curcumin, a major constituent. Altern Med Rev, 14, 141–53. PMID: 19594223
• Kalinowska, A., Orlinska, B., Panasiuk, M., Jamiolkowska, M., Zasim, A., Florys, B., Wojtkielewicz, K., Luczynski, W., Glowinska-Olszewska, B., Bossowski, A. (2017) Assessment of preservation of beta-cell function in children with long-standing type 1 diabetes with “ultrasensitive c-peptide” method. Pediatr Endocrinol Diabetes Metab, 23, 130–138. https://doi.org/10.18544/pedm-23.03.0084
• Kalogeris, T., Baines, C. P., Krenz, M., Korthuis, R. J. (2012) Cell Biology of Ischemia/Reperfusion Injury. International review of cell and molecular biology,298, 229-317. https://doi.org/10.1016/B978-0-12-394309-5.00006-7
• Khajehdehi, P. (2012) Turmeric: Reemerging of a neglected Asian traditional remedy.J Nephropathol,1, 17–22. https://doi.org/10.5812/jnp.5
• Koley, K. M., Lal, J. (1994) Pharmacological effects of Azadirachta indica(neem) leaf extract on the ECG and blood pressure of rat. Indian journal of physiology and Pharmacology, 38, 223–-5. PMID:7814089
• Le Marchand, L. (2002) Cancer preventive effects of flavonoids—a review. Biomedicine and Pharmacotherapy, 56, 296–301. PMID: 12224601
• Lee, D.Y., Li, H., Lim, H. J., Lee, H. J., Jeon, R., Ryu, J. H. (2012) Anti-inflammatory activity of sulfur-containing compounds from garlic. Journal of medicinal food, 15, 992–9. https://doi.org/10.1089/jmf.2012.2275
• Lee, J. W., Ryu, H. W., Park, S. Y., Park, H. A., Kwon, O. K., Yuk, H. J., Shrestha, K. K., Park, M., Kim, J. H., Lee, S., Oh, S. R., Ahn, K. S. (2017) Protective effects of neem (Azadirachta indica A. Juss.) leaf extract against cigarette smoke- and lipopolysaccharide-induced pulmonary inflammation. Int J Mol Med, 40,1932-1940. https://doi.org/10.3892/ijmm.2017.3178
• Mrudula, T., Suryanarayana, P., Srinivas, P. N., Reddy, G.B. (2007) Effect of curcumin on hyperglycemia-induced vascular endothelial growth factor expression in streptozotocin-induced diabetic rat retina. Biochemical and biophysical research communications, 361, 528–32. https://doi.org/10.1016/j.bbrc.2007.07.059
• Nagpal, M., Sood, S. (2013) Role of curcumin in systematic and oral health: An overview. Journal of natural science, biology and medicine, 4, 3–7. https://doi.org/10.4103/0976-9668.107253
• Naik, M. R., Bhattacharya, A., Behera, R., Agrawal, D., Dehury, S., Kumar, S. (2014) Study of anti-inflammatory effect of neem seed oil (Azadirachta indica) on infected albino rats. Journal of Health Research and Reviews, 1, 66–69. https://doi.org/10.4103/2394-2010.153880
• Othman, F. G. M., Peng, S. L., Rahmat, A., Basri, R., Pei, C. P. (2012) Effect of neem leaf extract (Azadirachta indica) on c-Myc oncogene expression in 4T1 breast cancer cells of BALB/c mice. Cell Journal (Yakhteh), 14, 53–60. PMID: 23626938
• Padiya, R., Khatua, T. N., Bagul, P. K., Kuncha, M., Banerjee, S. K. (2011) Garlic improves insulin sensitivity and associated metabolic syndromes in fructose fed rats. Nutrition & Metabolism, 8, 53–60. https://doi.org/10.1186/1743-7075-8-53
• Patel, B. B., Majumdar, A. P. (2009) Synergistic role of curcumin with current therapeutics in colorectal cancer: minireview. Nutr Cancer,61, 842–846.https://doi.org/10.1080/01635580903285106
• Patil, P., Patil, S., Mane, A., Verma, S. (2013) Antidiabetic activity of alcoholic extract of Neem (Azadirachta indica) root bark. National Journal of Physiology, Pharmacy and Pharmacology, 3, 142–6. https://doi.org/10.5455/njppp.2013.3.134-138
• Queiroz, A. C., Gagliardi, J. F., Forjaz, C. L., Rezk, C. C. (2009) Clinic and ambulatory blood pressure responses after resistance exercise. J Strength Cond Res, Champaign, 23, 571–578. https://doi.org/10.1519/JSC.0b013e318196b637
• Rachel, W., Lily, S., and Kamal, A. (2013) Priority Medicines for Europe and the World. www.who.int/medicines/areas/priority_medicines/BP6_12Osteo.pdf
• Rahmani, A. H., Alzohairy, M. A., Khan, M. A., Aly, S. M. (2014) Therapeutic implications of black seed and its constituent thymoquinone in the prevention of cancer through inactivation and activation of molecular pathways. Evidence-Based Complementary and Alternative Medicine, 18, 2014. https://doi.org/10.1155/2014/724658
• Rai, M., Jogee, P. S., Agarkar, G., dos Santos C. A. (2016) Anticancer activities of Withania somnifaria: Current research, formulations, and future perspectives. Pharm Biol, 54, 189–97. https://doi.org/10.3109/13880209.2015.1027778
• Rajeev, N., Sarita, K., Alka, P. (2014) Anticancer activity of Allium sativum (Bulb) polyphenolic compound.Int. J. Pharm. Sci. Rev. Res, 29, 131–134. ISSN 0976 – 044X.
• Reuland, D. J., Khademi, S., Castle, C. J., Irwin, D. C., McCord, J. M., Miller, B. F., Hamilton, K. L. (2013) Upregulation of phase II enzymes through phytochemical activation of Nrf2 protects cardiomyocytes against oxidant stress. Free Radic Biol Med, 56, 102–11. https://doi.org/10.1016/j.freeradbiomed.2012.11.016
• Riar, S. S., Devakuma, C., Ilavazhagam, G., Kain, A. K., Bardham, J. (1991) Antifertility activities of volatile fraction of Neem oil.Contraception, 44,319–326. https://doi.org/10.1016/0010-7824(91)90021-7
• Sangita, C., Priyanka, C., Protapaditya, D., Sanjib, B. (2012) Evaluation of Anti-inflammatory Effect of Ashwagandha: A Preliminary Study in vitro. Pharmacognosy Journal, 4, 47–49. https://doi.org/10.5530/pj.2012.29.7
• Satarupa, P., Aparna, L. I., Priyanka, P. (2015) Anti-inflammatory activity of aquesh extract of Allium sativum leaves. Asian J Pharm Clin Res, 8, 78–80. Online ISSN: 2455–3891
• Satyavati, G. V., Raina, M. K., Sharma, M., editors. (1976) Medicinal Plants of India Volume 1. New Delhi: Indian Council of Medical Research.
• Scarpignato, C., Lanas, A., Blandizzi, C., Lems, W.F., Hermann, M., Hunt, R. H., International, NSAID, Consensus, Group. (2015) Safe prescribing of non-steroidal anti-inflammatory drugs in patients with osteoarthritis – An expert consensus addressing benefits as well as gastrointestinal and cardiovascular risks. BMC Med, 13, 55. https://doi.org/10.1186/s12916-015-0285-8
• Setty Balakrishnan, A., Nathan, A. A., Kumar, M., Ramamoorthy, S., & Ramia Mothilal, S. K. (2017) Withania somnifera targets interleukin-8 and cyclooxygenase-2 in human prostate cancer progression. Prostate International, 5, 75–83. http://doi.org/10.1016/j.prnil.2017.03.002
• Shah, N. C. (2014) Allium sativum (Garlic): The Folk and Modern uses- Part II. The Scitech Journal, 1, 31–36. ISSN 2348-2311
• Sharma, A.K., Basu, I., Singh, S. (2017) Efficacy and Safety of Ashwagandha Root Extract in Subclinical Hypothyroid Patients: A Double-Blind, Randomized Placebo-Controlled Trial. J Altern Complement Med, 24, 243–248. https://doi.org/10.1089/acm.2017.0183
• Shehzad, A., Lee, Y. S. (2010) Curcumin: Multiple molecular targets mediate multiple pharmacological actions. Drugs of the future, 35, 113–30. https://doi.org/10.4236/jct.2015.63029
• Sogani, R. K., Katoch, K. (1981) Correlation of Serum cholesterol levels and incidence of myocardial infarction with dietary onion and garlic eating habits. J. Assoc. Physicians India, 29, 443–446. PMID: 7319999
• Srinath, R. K., Shah, B., Varghese, C., Ramadoss, A. (2005) Responding to the threat of chronic diseases in India. Lancet, 366, 1744–1749. https://doi.org/10.1016/S0140-6736(05)67343-6.
• Subapriya, R., Kumaraguruparan, R., Nagini, S. (2006) Expression of PCNA, cytokeratin, Bcl-2 and p53 during chemoprevention of hamster buccal pouch carcinogenesis by ethanolic neem (Azadirachta indica) leaf extract. Clinical Biochemistry, 39, 1080–7. https://doi.org/10.1016/j.clinbiochem.2006.06.013
• Tiwari, V., Darmani, N. A., Yue, B. Y. J. T., Shukla D. (2010) In vitro antiviral activity of neem (Azardirachta indica L.) bark extract against herpes simplex virus type-1 infection. Phytotherapy Research, 24, 1132–1140. https://doi.org/10.1002/ptr.3085
• Upadhyay, S. N., Dhawan, S., Talwar, G. P. (1993) Antifertility Effects of Neem (Azadirachta indica) Oil in Male Rats by Single Intra-Vas Administration: An Alternate Approach to Vasectomy. Journal of Andrology, 14, 275–281.PMID: 8226307
• Updhyay, S., Kaushi, C., Talwar, G. P. (1990) Antifertility effects of Neem oil by single intrauterine administration: A novel method of contraception. Proc The Royal Soc Lond, 242, 175–179. https://doi.org/10.1098/rspb.1990.0121
• Wang, J., Zhang, X., Lan, H., Wang, W. (2017) Effect of garlic supplement in the management of type 2 diabetes mellitus (T2DM): a meta-analysis of randomized controlled trials. Food & nutrition research, 61, 1377571. https://doi.org/10.1080/16546628.2017.137757
• WHO traditional medicine strategy: 2014-2023, 2014.
• World health organization (WHO) (2003) Fifth-sixth world health assembly, A56/18.
• Yadav, B., Bajaj, A., Saxena, M., Saxena, A. K. (2010) In Vitro Anticancer Activity of the Root, Stem and Leaves of Withania somnifera against Various Human Cancer Cell Lines. Indian Journal of Pharmaceutical Sciences, 72,659–663. https://doi.org/10.4103/0250-474X.78543
• Yeh, G. Y., Davis, R.B., Phillips, R.S. (2006) Use of Complementary Therapies in Patients with Cardiovascular Disease. Am. J. Card, 98, 673–680. https://doi.org/10.1016/j.amjcard.2006.03.051
• Zhi, L., Dong, L., Kong, D., Sun, B., Sun, Q., Grundy, D., Zhang, G., Rong, W. (2013) Curcumin acts via transient receptor potential vanilloid-1 receptors to inhibit gut nociception and reverses visceral hyperalgesia. Neurogastroenterol Motil, 25, e429–e440. https://doi.org/10.1111/nmo.12145