Formulation and Evaluation of Moxifloxacin Hydrochloride Niosomes for Controlled Ophthalmic Drug Delivery

Abstract

The objective of present invesigation was to formulate and evaluate a niosomal delivery system of moxifloxacin hydrchloride for the treatment of ocular infections. Moxifloxacin-loaded niosomes were prepared by using thin film hydration technique and were investigated for surface pH, morphology, entrapment, in-vitro release, TEeM (transmission electron microscopy), physical stability & ocular irritancy test. The release study profile was subjected to release kinetics models. Aall the vesicles were uniform and spherical in size. The drug relaese pattern of all formulation follows decreasing order: MN3 > MN6 > MN9 > MN5 > MN2 > MN1 > MN8 > MN4 > MN7. The formulation MN3 (span 60: cholesterol) molar ratio produce faster release of drug i.e. 77.98% after 12 hours, concluded less sustained action. The study concluded that the moxifloxacin loaded niosomes to be effective in sustaining the drug release leading to decreased side effects and increased patient compliance

  • Page Number : 11-28
  • Keywords
    Moxifoxacin, Niosomes, Film Hydration Technique, sustianed release
  • DOI Number
    10.15415/jptrm.2015.31002
  • Authors
    • Varinder Kaur Chitkara College of Pharmacy, Chitkara University, Rajpura, Punjab-140401
    • Pravin Pawar Gourishankar Institute of Pharmaceutical Education & Research, Limb, Satara, Maharashtra, India

References

  • Abdel-Mottaleb MMA, Lamprecht A. (2011). Standardized in vitro drug release test for colloidal drug carriers using modified USP dissolution apparatus. Drug Development and Industrial Pharmacy, 37, 178-184. http://dx.doi.org/10.3109/03639045.2010.502534
  • Abdelkader H, Ismail S, Kamal A, Alany RG.(2011). Design and evaluation of controlled-release niosomes and discomes for naltrexone hydrochloride ocular delivery. Journal of Pharmaceuical Sciences,100(5), 1833-46. http://dx.doi.org/10.1002/jps.22422
  • Achouri D, Alhanout K, Piccerelle P, Andrieu V. (2013). Recent advances in ocular drug delivery. Drug Development and Industrial Pharmacy, 39 (11), 1599-1617. http://dx.doi.org/10.3109/03639045.2012.736515
  • Aggarwal D, Garg A, Kaur IP. (2004). Development of a topical niosomal preparation of acetazolamide: preparation and evaluation. Journal of Pharmacy and Pharmacology, 56, 1509–17. http://dx.doi.org/10.1211/0022357044896
  • Aggarwal D, Kaur IP. (2005). Improved pharmacodynamics of timolol maleate from a mucoadhesive niosomal ophthalmic drug delivery system. International Journal of Pharmaceutics, 290(1-2), 155-159. http://dx.doi.org/10.1016/j.ijpharm.2004.10.026
  • Carafa M, Santucci E, Alhaique F, Coviello T, Murtas E, Riccieri FM, Lucaniab G, Torrissi MR. (1998). Preparation and properties of new unilamellar non-ionic/ionic surfactant vesicles. International Journal of Pharmaceutics, 160(1), 51–9. http://dx.doi.org/10.1016/S0378-5173(97)00294-9
  • Chengjiu H, David Rhodes G. (1991). Proniosomes: A Novel Drug Carrier Preparation. International Journal of Pharmaceutics, 185, 23-35.
  • Dajcs JJ, Thibodeaux BA, Marquart ME, Girgis DO, Traiedj M, O’Callaghan RJ. (2004). Effectiveness of ciprofloxacin, levofloxacin or moxifloxacin for treatment of experimental Staphylococcus aureus keratitis. Antimicrobial Agents and Chemotherpy, 48, 1948–1952. http://dx.doi.org/10.1128/AAC.48.6.1948-1952.2004
  • Habib FS, Fouad EA, Abdel-Rhaman MS, Fathalla D. (2010). Liposomes as an ocular delivery system of fluconazole: in-vitro studies. Acta ophthalmolgia, 88(8), 901-4. http://dx.doi.org/10.1111/j.1755-3768.2009.01584.x
  • Hardman JG, Limbird LE.(2001). Goodman & Gilman’s the pharmacological basis of therapeutics. Mc Graw Hill, New York. pp.
  • Junyaprasert VB, Teeranachaideekul V, Supaperm T. (2008). Effect of Charged and Nonionic Membrane Additives on Physicochemical Properties and Stability of Niosomes. AAPS PharmSciTech, 9, 851-859. http://dx.doi.org/10.1208/s12249-008-9121-1
  • Kaur IP, Aggarwal D, Singh H, Kakkar S. (2010). Improved ocular absorption kinetics of timolol maleate loaded into a bioadhesive niosomal delivery system. Graefe’s Archive for Clinical Experimental Ophthalmology, 248(10), 1467-72. http://dx.doi.org/10.1007/s00417-010-1383-0
  • Kumar M, Kulkarni GT. (2012). Recent advances in ophthalmic drug delivery system. Int Journal of Pharmacy and Pharmceutical Sciences, 4 (1), 387-394.
  • Malviya R, Kumar A, Sharma PK. (2011). Recent trends in ocular drug delivery: A short review. European Journal of Applied Science, 3 (3), 86-92.
  • Maurice DM, Mishima S.(1984).Ocular pharmacokinetics. In: Sears, M.L., (Eds.), Handbook of Experimental Pharmacology. Berlin-Heidelberg: Springer Verlag, pp. 116-119. http://dx.doi.org/10.1007/978-3-642-69222-2_2
  • Muzzalupo R, Tavano L, Trombino S, Cassano R, Picci N, Mesa CL. (2008). Niosomes from α, ω-trioxyethylene-bis (sodium2-dodecyloxy-propylenesulfonate): Preparation and characterization. Colloids and Surface B: Biointerfaces, 64, 200-207. http://dx.doi.org/10.1016/j.colsurfb.2008.01.026
  • Patel HA, Patel JK, Patel NK, Patel RR. (2010). Ophthalmic drug delivery system -A review. Der Pharmacia Lettre, 2(4), 100-115.
  • Patel FM, Patel AN, Rathore KS. (2011). Release of metformin hydrochloride from ispaghula sodium alginate beads adhered cock intestinal mucosa. International journal of Current Pharmaceutical Research, 3, 52-55.
  • Pestova E, Millichap JJ, Noskin GA, Peterson LR. (2000). Intracellular targets of moxacifloxacin: a comparison with other fluoroquinolones. Journal of Antimicrobial Chemotherpy, 45, 583–590. http://dx.doi.org/10.1093/jac/45.5.583
  • Shahiwala A, Misra A. (2002). Studies in topical application of niosomally entrapped nimuslide. Journal of Pharmacy and Pharmaceutical Sciences, 5, 220-225.
  • Singh G, Dwivedi H, Saraf SK, Saraf SA. (2011). Niosomal Delivery of Isoniazid - Development and Characterization. Tropical Journal of Pharmaceuitical Research, 10, 203-210. http://dx.doi.org/10.4314/tjpr.v10i2.66564
  • Srinivas S, Kumar YA, Hemanth A, Anitha M. (2010). Preparation and evaluation of niosomes containing Aceclofenac. Digest Journal of Nanomaterials and Biostructures, 5, 249-254.
  • Tangri P, Khurana S. (2011). Basics of ocular drug delivery systems. International Journal of pharmaceutical Biomedical Research, 2(4), 1541-1552.
  • Yagci R, Oflu Y, Dincel A, Kaya E, Yagci S, Bayer B, Duman S, Bozkurt A. (2007), Penetration of second-, third-, and fourth generation topical fluroroquinolone into aqueous and vitrous humor in a rabbit endophtalmitis model. Eye (Lond), 21, 990–994. http://dx.doi.org/10.1038/sj.eye.6702414
  • Yoshioka T, Sternberg B, Florence AT. (1994). Preparation and properties of vesicles (niosomes) of sorbitan monoesters (Span 20, 40, 60 and 80) and a sorbitan triester (Span 85). International Journal of Pharmaceutics, 105(1), 1-6. http://dx.doi.org/10.1016/0378-5173(94)90228-3

  • Published Date : 2015-05-20