A Brief Review of Pharmacoeconomics and Its Importance in Healthcare
Abstract
Background: Assessing health interventions today requires the use of economic knowledge due to the growing complexity and high cost of healthcare. Pharmacoeconomics, a branch of health economics, assesses the value of pharmaceutical goods and services by weighing their costs and benefits. Pharmacoeconomic analysis plays a critical role in supporting evidence-based decision-making and policy-making as healthcare expenditures throughout the globe continue to grow.
Purpose: The objective of this study is to provide a concise overview of pharmacoeconomics, its primary methodologies, and its growing significance within healthcare systems.
Methods: This literature review, covering publications from 2014 to 2025, analyzed peer-reviewed articles, policy documents, and textbooks on pharmacoeconomics. The review employed comparative frameworks such as cost minimization, cost-effectiveness, cost-utility, and cost-benefit analyses.
Results: Pharmacoeconomic analysis is increasingly being included in national and international healthcare systems to ensure efficient resource management. It significantly influences the evaluation of rival treatment options and the judgments about medication reimbursement. Common methodologies encompass cost-effectiveness and cost-utility evaluations, among others. Countries such as the UK, Canada, and Australia have institutionalized pharmacoeconomic evaluations through the establishment of organizations like the National Institute for Health and Care Excellence (NICE), the Canadian Agency for Drugs and Technologies in Health (CADTH), and the Pharmaceutical Benefits Advisory Committee (PBAC).
Conclusion: Pharmacoeconomics is a crucial component of the modern healthcare landscape, facilitating the optimal allocation of limited financial resources to enhance health outcomes. It assists policymakers, physicians, and payers in making decisions informed by costs and clinical outcomes. As healthcare costs continue to rise, the role of pharmacoeconomics in policymaking and practice will become increasingly essential.
- Page Number : 58-68
-
Published Date : 2025-10-20
- Keywords
Cost-effectiveness, Drugs, Expenses, Health economics, Pharmacoeconomics - DOI Number
10.15415/jptrm.2025.131005 -
Authors
Arti Saini and Shivam Sharma
References
- Ahmad, A., Chang, J., Chung, H., Mohanta, G., Parimilakrishnan, S., & Patel, I. (2013). The role of pharmacoeconomics in current Indian healthcare system. Journal of Research in Pharmacy Practice, 2(1), 3. https://doi.org/10.4103/2279-042X.114081
- Al Meslamani, A. Z. (2024). Barriers to digital endpoints in data collection in low- and middle-income countries. Expert Review of Pharmacoeconomics & Outcomes Research, 24(6), 701–703. https://doi.org/10.1080/14737167.2024.2331047
- Alzarea, A. I., Khan, Y. H., Alanazi, A. S., Butt, M. H., Almalki, Z. S., Alahmari, A. K., Alsahali, S., & Mallhi, T. H. (2022). Barriers and facilitators of pharmacoeconomic studies: A review of evidence from the Middle Eastern countries. International Journal of Environmental Research and Public Health, 19(13), 7862. https://doi.org/10.3390/ijerph19137862
- Angello, J. T., Voytovich, R. M., & Jan, S. A. (1997). A cost/efficacy analysis of oral antifungals indicated for the treatment of onychomycosis: Griseofulvin, itraconazole, and terbinafine. The American Journal of Managed Care, 3(3), 443–450.
- Antibacterial prescribing for RTIs varies widely across Europe. (2013). PharmacoEconomics & Outcomes News, 401(1), 7. https://doi.org/10.1007/BF03275904
- Arenas-Guzman, R., Tosti, A., Hay, R., & Haneke, E. (2005). Pharmacoeconomics—An aid to better decision-making. Journal of the European Academy of Dermatology and Venereology, 19(Suppl. 1), 34–39. https://doi.org/10.1111/j.1468-3083.2005.01285.x
- Asher, I., & Pearce, N. (2014). Global burden of asthma among children. The International Journal of Tuberculosis and Lung Disease, 18(11), 1269–1278. https://doi.org/10.5588/ijtld.14.0170
- Augustine, N. R., Madhavan, G., & Nass, S. J. (2017). Making medicines affordable: A national imperative (Vol. 1, pp. 1–234). National Academies Press. https://doi.org/10.17226/24946
- Bodrogi, J., & Kaló, Z. (2010). Principles of pharmacoeconomics and their impact on strategic imperatives of pharmaceutical research and development. British Journal of Pharmacology, 159(7), 1367–1373. https://doi.org/10.1111/j.1476-5381.2009.00550.x
- Buyx, A. M., Friedrich, D. R., & Schöne-Seifert, B. (2011). Ethics and effectiveness: Rationing healthcare by thresholds of minimum effectiveness. BMJ, 342, d54. https://doi.org/10.1136/bmj.d54
- Choi, J. S., Lee, W. B., & Rhee, P. L. (2013). Cost-benefit analysis of electronic medical record system at a tertiary care hospital. Healthcare Informatics Research, 19(3), 205–211. https://doi.org/10.4258/hir.2013.19.3.205
- Di Bona, D., Bilancia, M., Albanesi, M., Caiaffa, M. F., & Macchia, L. (2020). Cost-effectiveness of grass pollen allergen immunotherapy in adults. Allergy, 75(9), 2319–2329. https://doi.org/10.1111/all.14246
- Di Bona, D., Plaia, A., Leto-Barone, M. S., La Piana, S., & Di Lorenzo, G. (2012). Efficacy of subcutaneous and sublingual immunotherapy with grass allergens for seasonal allergic rhinitis: A meta-analysis-based comparison. Journal of Allergy and Clinical Immunology, 130(5), 1097–1107. https://doi.org/10.1016/j.jaci.2012.08.012
- Doron, S., & Davidson, L. E. (2011). Antimicrobial stewardship. Mayo Clinic Proceedings, 86(11), 1113–1123. https://doi.org/10.4065/mcp.2011.0358
- Dranitsaris, G., & Ellis, A. K. (2014). Sublingual or subcutaneous immunotherapy for seasonal allergic rhinitis: An indirect analysis of efficacy, safety, and cost. Journal of Evaluation in Clinical Practice, 20(3), 225–238. https://doi.org/10.1111/jep.12112
- Ekanayake, P., Hupfeld, C., & Mudaliar, S. (2020). Sodium-glucose cotransporter type 2 (SGLT-2) inhibitors and ketogenesis: The good and the bad. Current Diabetes Reports, 20(12), 72. https://doi.org/10.1007/s11892-020-01359-z
- Ellis, C. N., Reiter, K. L., Wheeler, J. R. C., & Fendrick, A. M. (2002). Economic analysis in dermatology. Journal of the American Academy of Dermatology, 46(2), 271–283. https://doi.org/10.1067/mjd.2002.119566
- Ghinea, N., Lipworth, W., & Kerridge, I. (2016). Propaganda or the cost of innovation? Challenging the high price of new drugs. BMJ, 352, i1284. https://doi.org/10.1136/bmj.i1284
- Gold, M. R., Stevenson, D., & Fryback, D. G. (2002). HALYs and QALYs and DALYs, oh my: Similarities and differences in summary measures of population health. Annual Review of Public Health, 23, 115–134. https://doi.org/10.1146/annurev.publhealth.23.100901.140513
- Guerin, P. J., Singh-Phulgenda, S., & Strub-Wourgaft, N. (2020). The consequence of COVID-19 on the global supply of medical products: Why Indian generics matter for the world. F1000Research, 9, 225. https://doi.org/10.12688/f1000research.23057.1
- Hayduchok, I. G., Shapovalova, V. O., Ishcheikin, K. E., Chopyak, V. V., Jr., S. V. V., & Shapovalov, V. V. (2021). Pharmacoeconomic approaches for pharmacotherapy of rheumatoid arthritis. Likars’ka Sprava, 1–2, 70–79. https://doi.org/10.31640/jvd.1-2.2021(11)
- Hlatky, M. A., Owens, D. K., & Sanders, G. D. (2006). Cost-effectiveness as an outcome in randomized clinical trials. Clinical Trials, 3(6), 543–551. https://doi.org/10.1177/1740774506073105
- Hu, J., & Mossialos, E. (2016). Pharmaceutical pricing and reimbursement in China: When the whole is less than the sum of its parts. Health Policy, 120(5), 519–534. https://doi.org/10.1016/j.healthpol.2016.03.014
- Humphrey, K. M., Cork, M. J., & Haycox, A. (1998). A retrospective cost-effectiveness analysis of the treatment of onychomycosis in general practice. The British Journal of Dermatology, 139(4), 660–664. https://doi.org/10.1046/j.1365-2133.1998.02463.x
- India Pharmaceutical Market Size, Share and Growth, 2033. (n.d.). IMARC Group. Retrieved September 27, 2025, from https://www.imarcgroup.com/india-pharmaceutical-market
- Indian Pharmaceutical Industry: Creating global impact. (2025). Pharmaceutical Engineering. Retrieved September 24, 2025, from https://ispe.org/pharmaceutical-engineering/march-april-2025/indian-pharmaceutical-industry-creating-global-impact
- John, N. N., Krishnan, A., Midhun, J. V., & Juan, R. (2020). A study to evaluate pharmacoeconomics of antihypertensive drugs in a tertiary care teaching hospital. Journal of Drug Delivery and Therapeutics, 10(4-S), 176–180. https://doi.org/10.22270/jddt.v10i4-s.4227
- Joshi, S. S., Shetty, Y. C., & Karande, S. (2019). Generic drugs: The Indian scenario. Journal of Postgraduate Medicine, 65(2), 67–70. https://doi.org/10.4103/jpgm.jpgm_420_18
- Kawauchi, H., Yanai, K., Wang, D. Y., Itahashi, K., & Okubo, K. (2019). Antihistamines for allergic rhinitis treatment from the viewpoint of nonsedative properties. International Journal of Molecular Sciences, 20(1), 213. https://doi.org/10.3390/ijms20010213
- Kruk, M. E., Gage, A. D., Arsenault, C., Jordan, K., Leslie, H. H., Roder-DeWan, S., Adeyi, O., Barker, P., Daelmans, B., Doubova, S. V., English, M., Elorrio, E. G., Guanais, F., Gureje, O., Hirschhorn, L. R., Jiang, L., Kelley, E., Lemango, E. T., Liljestrand, J., … Pate, M. (2018). High-quality health systems in the Sustainable Development Goals era: Time for a revolution. The Lancet Global Health, 6(11), e1196–e1252. https://doi.org/10.1016/s2214-109x(18)30386-3
- Kumar, S., & Preetha, G. S. (2012). Health promotion: An effective tool for global health. Indian Journal of Community Medicine, 37(1), 5–12. https://doi.org/10.4103/0970-0218.94009
- Lam, W. Y., & Fresco, P. (2015). Medication adherence measures: An overview. BioMed Research International, 2015, 217047. https://doi.org/10.1155/2015/217047
- McInnes, I. B., & Schett, G. (2011). The pathogenesis of rheumatoid arthritis. The New England Journal of Medicine, 365(23), 2205–2219. https://doi.org/10.1056/nejmra1004965
- Meena, D. K., & Mathaiyan, J. (2025). Assessment of drug inventory using ABC–VED matrix analysis in selected public health facilities of Puducherry, India. Journal of Family Medicine and Primary Care, 14(4), 1389–1395. https://doi.org/10.4103/jfmpc.jfmpc_1544_24
- NHA | Official website Ayushman Bharat Digital Mission. (n.d.). Government of India. Retrieved September 27, 2025, from https://abdm.gov.in/
- Pereira, M., Lunet, N., Azevedo, A., & Barros, H. (2009). Differences in prevalence, awareness, treatment, and control of hypertension between developing and developed countries. Journal of Hypertension, 27(5), 963–975. https://doi.org/10.1097/hjh.0b013e3283282f65
- Pharmacoeconomics and its impact on Ayushman Bharat projects in rural India. (n.d.). World Journal of Pharmaceutical Research. Retrieved September 24, 2025, from https://www.wisdomlib.org/science/journal/world-journal-of-pharmaceutical-research/d/doc1380340.html
- Rahman, W., Solinsky, P. J., Munir, K. M., & Lamos, E. M. (2019). Pharmacoeconomic evaluation of sodium-glucose transporter-2 (SGLT2) inhibitors for the treatment of type 2 diabetes. Expert Opinion on Pharmacotherapy, 20(2), 151–161. https://doi.org/10.1080/14656566.2018.1543408
- Ramezani, M., Bakhtiari, A., Daroudi, R., Mobinizadeh, M., Fazaeli, A. A., Olyaeemanesh, A., Rabiee, H. R., Mostafavi, H., Sazgarnejad, S., Bordbar, S., & Takian, A. (2025). Applications of artificial intelligence and the challenges in health technology assessment: A scoping review and framework with a focus on economic dimensions. Health Economics Review, 15(1), 1–11. https://doi.org/10.1186/s13561-025-00645-4
- Rawal, L. B., Tapp, R. J., Williams, E. D., Chan, C., Yasin, S., & Oldenburg, B. (2012). Prevention of type 2 diabetes and its complications in developing countries: A review. International Journal of Behavioral Medicine, 19(2), 121–133. https://doi.org/10.1007/s12529-011-9162-9
- Strategy document on National Medical Devices Policy, 2023. (n.d.). Department of Pharmaceuticals, Government of India. Retrieved September 24, 2025, from https://pharma-dept.gov.in/policy/strategy-document-national-medical-devices-policy-2023
- Tannoury, M., & Attieh, Z. (2017). The influence of emerging markets on the pharmaceutical industry. Current Therapeutic Research, 86, 19–24. https://doi.org/10.1016/j.curtheres.2017.04.005
- Thokala, P., Srivastava, T., Smith, R., Ren, S., Whittington, M. D., Elvidge, J., Wong, R., & Uttley, L. (2023). Living health technology assessment: Issues, challenges, and opportunities. PharmacoEconomics, 41(3), 227–237. https://doi.org/10.1007/s40273-022-01229-4