Tapping the Potential of Probiotics: An Insight on Probiotic Delivery Systems, Their Quantification, and Assessment

References

• Abishad, P., Vergis, J., Unni, V., Ram, V. P., Niveditha, P., Yasur, J., John, L., Byrappa, K., Nambiar, P., Kurkure, N.V., Barbuddhe, S.B., & Rawool, D. B. (2022). Green synthesized silver nanoparticles using Lactobacillus acidophilus as an antioxidant, antimicrobial, and antibiofilm agent against multi-drug resistant enteroaggregative Escherichia coli. Probiotics and antimicrobial proteins, 14(5), 904-914. https://doi.org/10.1007/s12602-022-09961-1
• Aceti, A., Beghetti, I., Maggio, L., Martini, S., Faldella, G., & Corvaglia, L. (2018). Filling the gaps: Current research directions for a rational use of probiotics in preterm infants. Nutrients, 10(10), 1472. https://doi.org/10.3390/nu10101472
• Akgül, T., & Karakan, T. (2018). The role of probiotics in women with recurrent urinary tract infections. Turkish journal of urology, 44(5), 377. https://doi.org/10.5152/tud.2018.48742
• Albadran, H. A., Chatzifragkou, A., Khutoryanskiy, V. V., & Charalampopoulos, D. (2015). Stability of probiotic Lactobacillus plantarum in dry microcapsules under accelerated storage conditions. Food Research International, 74, 208-216. https://doi.org/10.1016/j.foodres.2015.05.016
• Allain, T., Chaouch, S., Thomas, M., Vallée, I., Buret, A. G., Langella, P., Grellier, P., Polack, B., Bermúdez-Humarán, L.G., & Florent, I. (2018). Bile-salt-hydrolases from the probiotic strain Lactobacillus johnsonii La1 mediate anti-giardial activity in vitro and in vivo. Frontiers in Microbiology, 8, 2707. https://doi.org/10.3389/fmicb.2017.02707
• Altamirano‐Ríos, A. V., Guadarrama‐Lezama, A. Y., Arroyo‐Maya, I. J., Hernández‐Álvarez, A. J., & Orozco‐Villafuerte, J. (2022). Effect of encapsulation methods and materials on the survival and viability of Lactobacillus acidophilus: A review. International Journal of Food Science & Technology, 57(7), 4027-4040. https://doi.org/10.1111/ijfs.15779
• Anjum, M., Laitila, A., Ouwehand, A. C., & Forssten, S. D. (2022). Current perspectives on gastrointestinal models to assess probiotic-pathogen interactions. Frontiers in Microbiology, 13. https://doi.org/10.3389/fmicb.2022.831455
• Anselmo, A. C., McHugh, K. J., Webster, J., Langer, R., & Jaklenec, A. (2016). Layer-by-layer encapsulation of probiotics for delivery to the microbiome. Advanced Materials (Deerfield Beach, Fla.), 28(43), 9486. https://doi.org/10.1002%2Fadma.201603270
• Arciero, J. C., Ermentrout, G. B., Upperman, J. S., Vodovotz, Y., & Rubin, J. E. (2010). Using a mathematical model to analyze the role of probiotics and inflammation in necrotizing enterocolitis. PLoS One, 5(4), e10066. https://doi.org/10.1371/journal.pone.0010066
• Aron-Wisnewsky, J., Vigliotti, C., Witjes, J., Le, P., Holleboom, A. G., Verheij, J., Nieuwdorp, M., & Clément, K. (2020). Gut microbiota and human NAFLD: disentangling microbial signatures from metabolic disorders. Nature Reviews Gastroenterology & Hepatology, 17(5), 279-297. https://doi.org/10.1038/s41575-020-0269-9
• Asgari, S., Pourjavadi, A., Licht, T. R., Boisen, A., & Ajalloueian, F. (2020). Polymeric carriers for enhanced delivery of probiotics. Advanced drug delivery reviews, 161, 1-21. https://doi.org/10.1016/j.addr.2020.07.014
• Atassi, F., Pho Viet Ahn, D. L., & Lievin-Le Moal, V. (2019). Diverse expression of antimicrobial activities against bacterial vaginosis and urinary tract infection pathogens by cervicovaginal microbiota strains of Lactobacillus gasseri and Lactobacillus crispatus. Frontiers in microbiology, 10, 2900. https://doi.org/10.3389/fmicb.2019.02900
• Ballini, A., Gnoni, A., De Vito, D., Dipalma, G., Cantore, S., Santacroce, L., Scacco, S., & Inchingolo, F. (2019). Effect of probiotics on the occurrence of nutrition absorption capacities in healthy children: A randomized double-blinded placebo-controlled pilot study. European Review for Medical and Pharmacological Sciences, 23(19), 8645-8657. https://doi. org/10.26355/eurrev_201910_19182
• Barbier, M., Bevere, J., & Damron, F. H. (2018). In vivo bacterial imaging using bioluminescence. Reporter Gene Imaging: Methods and Protocols, 87-97. https://doi.org/10.1007/978-1-4939-7860-1_7
• Bermúdez-Humarán, L. G., Salinas, E., Ortiz, G. G., Ramirez-Jirano, L. J., Morales, J. A., & Bitzer-Quintero, O. K. (2019). From probiotics to psychobiotics: live beneficial bacteria which act on the brain-gut axis. Nutrients, 11(4), 890. https://doi.org/10.3390/nu11040890
• Bevilacqua, A., Speranza, B., Santillo, A., Albenzio, M., Gallo, M., Sinigaglia, M., & Corbo, M. R. (2019). Alginate-microencapsulation of Lactobacillus casei and Bifidobacterium bifidum: Performances of encapsulated microorganisms and bead-validation in lamb rennet. LWT, 113, 108349. https://doi.org/10.1016/j.lwt.2019.108349
• Bron, P. A., Kleerebezem, M., Brummer, R. J., Cani, P. D., Mercenier, A., MacDonald, T. T., Garcia-Ródenas, C. L., & Wells, J. M. (2017). Can probiotics modulate human disease by impacting intestinal barrier function? British Journal of Nutrition, 117(1), 93-107. https://doi.org/10.1017/S0007114516004037
• Bullok, K. E., Gammon, S. T., Violini, S., Prantner, A. M., Villalobos, V. M., Sharma, V., & Piwnica-Worms, D. (2006). Permeation peptide conjugates for in vivo molecular imaging applications. Molecular Imaging, 5(1), 7290-2006. https://doi.org/10.2310/7290.2006.00001
• Chandel, D., Sharma, M., Chawla, V., Sachdeva, N., & Shukla, G. (2019). Isolation, characterization and identification of antigenotoxic and anticancerous indigenous probiotics and their prophylactic potential in experimental colon carcinogenesis. Scientific Reports, 9(1), 14769. https://doi.org/ 10.1038/s41598-019-51361-z
• Chen, H. J., Lin, D. A., Liu, F., Zhou, L., Liu, D., Lin, Z., Yang, C., Jin, Q., Hang, T., & Xie, X. (2018). Transdermal delivery of living and biofunctional probiotics through dissolvable microneedle patches. ACS Applied Bio Materials, 1(2), 374-381. https://pubs.acs.org/doi/abs/10.1021/acsabm.8b00102
• Chen, J., Feng, S., Chen, M., Li, P., Yang, Y., Zhang, J., Li, Y., Chen, S., & Chen, S. (2020). In Vivo Dynamic Monitoring of Bacterial Infection by NIR‐II Fluorescence Imaging. Small, 16(34), 2002054. https://doi.org/10.1002/smll.202002054
• Chen, Y. H., Tsai, W. H., Wu, H. Y., Chen, C. Y., Yeh, W. L., Chen, Y. H., ... & Lai, C. H. (2019). Probiotic Lactobacillus spp. act against Helicobacter pylori-induced inflammation. Journal of clinical medicine, 8(1), 90.  https://doi.org/10.3390/jcm8010090
• Chi, H., Qiu, Y., Ye, X., Shi, J., & Li, Z. (2023). Preparation strategy of hydrogel microsphere and its application in skin repair. Frontiers in Bioengineering and Biotechnology, 11, 1239183.
• Choi, Y. M., Lee, Y. Q., Song, H. S., & Lee, D. Y. (2020). Genome scale metabolic models and analysis for evaluating probiotic potentials. Biochemical Society Transactions, 48(4), 1309-1321. https://doi.org/10.1042/BST20190668
• Choudhary, R., & Mahadevan, R. (2020). Toward a systematic design of smart probiotics. Current Opinion in Biotechnology, 64, 199-209. https://doi.org/10.1016/j.copbio.2020.05.003
• Cizeikiene, D., & Jagelaviciute, J. (2021). Investigation of antibacterial activity and probiotic properties of strains belonging to Lactobacillus and Bifidobacterium genera for their potential application in functional food and feed products. Probiotics and Antimicrobial Proteins, 1-17. https://doi.org/10.1007/s12602-021-09777-5
• Clua, P., Kanmani, P., Zelaya, H., Tada, A., Kober, A. H., Salva, S., Alvarez, S., Kitazawa, H., & Villena, J. (2017). Peptidoglycan from immunobiotic Lactobacillus rhamnosus improves resistance of infant mice to respiratory syncytial viral infection and secondary pneumococcal pneumonia. Frontiers in immunology, 8, 948. https://doi.org/ 10.3389/fmmu.2017.00948
• CNIPA. (2021). CN Patent No. 110321924 B. https://patents.google.com/patent/CN110321924B/en
• Cook, M. T., Tzortzis, G., Khutoryanskiy, V. V., & Charalampopoulos, D. (2013). Layer-by-layer coating of alginate matrices with chitosan–alginate for the improved survival and targeted delivery of probiotic bacteria after oral administration. Journal of Materials Chemistry B, 1(1), 52-60. https://doi.org/10.1039/C2TB00126H
• Costanzo, M., Cesi, V., Palone, F., Pierdomenico, M., Colantoni, E., Leter, B., Vitali, R., Negroni, A., Cucchiara, S., & Stronati, L. (2018). Krill oil, vitamin D and Lactobacillus reuteri cooperate to reduce gut inflammation. Beneficial microbes, 9(3), 389-399. https://doi.org/10.3920/BM2017.0078
• Dalile, B., Van Oudenhove, L., Vervliet, B., & Verbeke, K. (2019). The role of short-chain fatty acids in microbiota–gut–brain communication. Nature reviews Gastroenterology & hepatology, 16(8), 461-478. https://doi. org/10.1038/s41575-019-0157-3
• De Barros, J. M., Lechner, T., Charalampopoulos, D., Khutoryanskiy, V. V., & Edwards, A. D. (2015). Enteric coated spheres produced by extrusion/spheronization provide effective gastric protection and efficient release of live therapeutic bacteria. International journal of pharmaceutics, 493(1-2), 483-494. https://doi.org/10.1016/j.ijpharm.2015.06.051
• De Gregorio, V., Sgambato, C., Urciuolo, F., Vecchione, R., Netti, P. A., & Imparato, G. (2022). Immunoresponsive microbiota-gut-on-chip reproduces barrier dysfunction, stromal reshaping and probiotics translocation under inflammation. Biomaterials, 286, 121573. https://doi.org/10.1016/j.biomaterials.2022.121573
• Devani, P., Ruparelia, A., Garcia-Larsen, V., Cunha, S., Chivenge, J., Robinson, Z., & Boyle, R. (2017). Optimal mode of delivery for using probiotics or prebiotics to prevent eczema: A systematic review and meta-analysis. Clinical and Experimental Allergy, 47(12).
• Dodoo, C. C., Wang, J., Basit, A. W., Stapleton, P., & Gaisford, S. (2017). Targeted delivery of probiotics to enhance gastrointestinal stability and intestinal colonisation. International Journal of Pharmaceutics, 530(1-2), 224-229. https://doi.org/10.1016/j.ijpharm.2017.07.068
• Donaldson, G. P., Lee, S. M., & Mazmanian, S. K. (2016). Gut biogeography of the bacterial microbiota. Nature Reviews Microbiology, 14(1), 20-32. https://doi.org/10.1038/nrmicro3552
• Drago, L., Nicola, L., Iemoli, E., Banfi, G., & De Vecchi, E. (2010). Strain-dependent release of cytokines modulated by Lactobacillus salivarius human isolates in an in vitro model. BMC Research Notes, 3, 1-5.https://doi.org/ 10.1186/1756-0500-3-44
• Dronkers, T. M., Ouwehand, A. C., & Rijkers, G. T. (2020). Global analysis of clinical trials with probiotics. Heliyon, 6(7).
• Dubey, M. R., & Patel, V. P. (2018). Probiotics: A promising tool for calcium absorption. The open nutrition journal, 12(1). https://doi.org/10. 2174/1874288201812010059
• Duque, A. L. R. F., Demarqui, F. M., Santoni, M. M., Zanelli, C. F., Adorno, M. A. T., Milenkovic, D., Mesa, V., & Sivieri, K. (2021). Effect of probiotic, prebiotic, and synbiotic on the gut microbiota of autistic children using an in vitro gut microbiome model. Food Research International, 149, 110657. https://doi.org/10.1016/j.foodres.2021.110657
• Eguchi, K., Fujitani, N., Nakagawa, H., & Miyazaki, T. (2019). Prevention of respiratory syncytial virus infection with probiotic lactic acid bacterium Lactobacillus gasseri SBT2055. Scientific reports, 9(1), 4812. https://doi.org/10.1038/s41598-019-39602-7
• El-Sayed, H. S., El-Sayed, S. M., Mabrouk, A. M., Nawwar, G. A., & Youssef, A. M. (2021). Development of eco-friendly probiotic edible coatings based on chitosan, alginate and carboxymethyl cellulose for improving the shelf life of UF soft cheese. Journal of Polymers and the Environment, 29, 1941-1953. https://doi.org/10.1007/s10924-020-02003-3
• Engevik, M. A., Ruan, W., Esparza, M., Fultz, R., Shi, Z., Engevik, K. A., & Versalovic, J. (2021). Immunomodulation of dendritic cells by Lactobacillus reuteri surface components and metabolites. Physiological reports, 9(2), e14719. https://doi.org/10.14814/phy2.14719
• EPO. (2021). EP Patent No. 3,381,601. https://worldwide.espacenet.com/patent/EP3381601
• Faber, F., Tran, L., Byndloss, M. X., Lopez, C. A., Velazquez, E. M., Kerrinnes, T., & Bäumler, A. J. (2016). Host-mediated sugar oxidation promotes post-antibiotic pathogen expansion. Nature, 534(7609), 697-699. https://doi.org/10.1038/nature18597
• Ferrer-González, E., Fujita, J., Yoshizawa, T., Nelson, J. M., Pilch, A. J., Hillman, E., & Pilch, D. S. (2019). Structure-guided design of a fluorescent probe for the visualization of FtsZ in clinically important gram-positive and gram-negative bacterial pathogens. Scientific reports, 9(1), 20092. https://doi.org/10.1038/s41598-019-56557-x
• Gan, B. H., Siriwardena, T. N., Javor, S., Darbre, T., & Reymond, J. L. (2019). Fluorescence imaging of bacterial killing by antimicrobial peptide dendrimer G3KL. ACS infectious diseases, 5(12), 2164-2173.
• Gani, A., Shah, A., Ahmad, M., Ashwar, B. A., & Masoodi, F. A. (2018). β-d-glucan as an enteric delivery vehicle for probiotics. International journal of biological macromolecules, 106, 864-869. https://doi.org/10.1016/j.ijbiomac.2017.08.093
• Garcia-Brand, A. J., Quezada, V., Gonzalez-Melo, C., Bolaños-Barbosa, A. D., Cruz, J. C., & Reyes, L. H. (2022). Novel developments on stimuli-responsive probiotic encapsulates: from smart hydrogels to nanostructured platforms. Fermentation, 8(3), 117.  https://doi.org/10.3390/fermentation8030117
• Ghadimi, D., Nielsen, A., Hassan, M. F., Fölster-Holst, R., Ebsen, M., Frahm, S. O., Christoph, R., Michael, D.V., & Heller, K. J. (2021). Modulation of proinflammatory bacteria-and lipid-coupled intracellular signaling pathways in a Transwell triple co-culture model by commensal Bifidobacterium animalis R101-8. Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry-Anti-Inflammatory and Anti-Allergy Agents), 20(2), 161-181. https://doi.org/10.2174/1871523019999201029115618
• Gheorghita, R., Anchidin-Norocel, L., Filip, R., Dimian, M., & Covasa, M. (2021). Applications of biopolymers for drugs and probiotics delivery. Polymers, 13(16), 2729. https://doi.org/10.3390/polym13162729
• González-Ferrero, C., Irache, J. M., & González-Navarro, C. J. (2018). Soybean protein-based microparticles for oral delivery of probiotics with improved stability during storage and gut resistance. Food chemistry, 239, 879-888. https://doi.org/10.1016/j.foodchem.2017.07.022
• Górska, A., Przystupski, D., Niemczura, M. J., & Kulbacka, J. (2019). Probiotic bacteria: a promising tool in cancer prevention and therapy. Current microbiology, 76, 939-949. https://doi.org/10.1007/ s00284-019-01679-8
• Gościniak, A., Eder, P., Walkowiak, J., & Cielecka-Piontek, J. (2022). Artificial gastrointestinal models for nutraceuticals research—achievements and challenges: a practical review. Nutrients, 14(13), 2560.  https://doi.org/10.3390/nu14132560
• Gou, H. Z., Zhang, Y. L., Ren, L. F., Li, Z. J., & Zhang, L. (2022). How do intestinal probiotics restore the intestinal barrier? Frontiers in microbiology, 13, 929346. https://doi.org/10.3389/fmicb.2022.929346.
• Gu, Q., & Li, P. (2016). Biosynthesis of vitamins by probiotic bacteria. Probiotics and prebiotics in human nutrition and health, 135-48. https://doi.org/10.5772/63117
• Guan, C., Yang, Y., Tian, D., Jiang, Z., Zhang, H., Li, Y., & Wang, T. (2022). Evaluation of an Ussing chamber system equipped with rat intestinal tissues to predict intestinal absorption and metabolism in humans. European Journal of Drug Metabolism and Pharmacokinetics, 47(5), 639-652. https://doi.org/10.1007/s13318-022-00780-x
• Guevarra, R. B., & Barraquio, V. L. (2015). Viable counts of lactic acid bacteria in Philippine commercial yogurts. Int J Dairy Sci Process, 2(5), 24-28.
• Gulzar, N., Saleem, I. M., Rafiq, S., & Nadeem, M. (2019). Therapeutic potential of probiotics and prebiotics. Oral Health by Using Probiotic Products. https:// doi.org/10.5772/intechopen.86762
• Haque, A., Bowe, F., Fitzhenry, R. J., Frankel, G., Thomson, M., Heuschkel, R., & Dougan, G. (2004). Early interactions of Salmonella enterica serovar typhimurium with human small intestinal epithelial explants. Gut, 53(10), 1424-1430. https://doi.org/10.1136/gut.2003.037382
• Hendijani, F., & Akbari, V. (2018). Probiotic supplementation for management of cardiovascular risk factors in adults with type II diabetes: a systematic review and meta-analysis. Clinical Nutrition, 37(2), 532-541. https://doi.org/10.1016/j.clnu.2017.02.015
• Hill, C., Guarner, F., Reid, G., Gibson, G. R., Merenstein, D. J., Pot, B., & Sanders, M. E. (2014). The International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic. Nature reviews Gastroenterology & hepatology, 11(8), 506-514.
• Hoppe, M., Önning, G., Berggren, A., & Hulthén, L. (2015). Probiotic strain Lactobacillus plantarum 299v increases iron absorption from an iron-supplemented fruit drink: a double-isotope cross-over single-blind study in women of reproductive age. British Journal of Nutrition, 114(8), 1195-1202. https://doi.org/10.1017/S000711451500241X
• Hu, F., Qi, G., Kenry, Mao, D., Zhou, S., Wu, M., & Liu, B. (2020). Visualization and in situ ablation of intracellular bacterial pathogens through metabolic labeling. Angewandte Chemie International Edition, 59(24), 9288-9292. https://doi.org/10.1002/anie.201910187
• Hu, L., Zhou, M., Young, A., Zhao, W., & Yan, Z. (2019). In vivo effectiveness and safety of probiotics on prophylaxis and treatment of oral candidiasis: a systematic review and meta-analysis. BMC Oral Health, 19, 1-12. https://doi.org/10.1186/s12903-019-0841-2
• Imai, Y., Meyer, K. J., Iinishi, A., Favre-Godal, Q., Green, R., Manuse, S., & Lewis, K. (2019). A new antibiotic selectively kills Gram-negative pathogens. Nature, 576(7787), 459-464. https://doi.org/10.1038/s41586-019-1791-1
• Jan, T., Negi, R., Sharma, B., Kumar, S., Singh, S., Rai, A. K., & Ahmed, N. (2024). Next generation probiotics for human health: An emerging perspective. Heliyon.
• Johansson, M. E., & Hansson, G. C. (2012). Preservation of mucus in histological sections, immunostaining of mucins in fixed tissue, and localization of bacteria with FISH. Mucins: Methods and protocols, 229-235. https://doi.org/10.1007/978-1-61779-513-8_13
• Juturu, V., & Wu, J. C. (2018). Microbial production of bacteriocins: Latest research development and applications. Biotechnology advances, 36(8), 2187-2200. https://doi.org/10.1016/j.biotechadv.2018.10.007
• Khorasani, A. C., & Shojaosadati, S. A. (2016). Bacterial nanocellulose-pectin bionanocomposites as prebiotics against drying and gastrointestinal condition. International journal of biological macromolecules, 83, 9-18. https://doi.org/10.1016/j.ijbiomac.2015.11.041
• Khorasani, A. C., & Shojaosadati, S. A. (2017). Starch-and carboxymethylcellulose-coated bacterial nanocellulose-pectin bionanocomposite as novel protective prebiotic matrices. Food Hydrocolloids, 63, 273-285. https://doi.org/10.1016/j.foodhyd.2016.09.002
• Kim, C. S., & Shin, D. M. (2019). Probiotic food consumption is associated with lower severity and prevalence of depression: a nationwide cross-sectional study. Nutrition, 63, 169-174. https://doi.org/ 10.1016/j.nut.2019.02.007
• Kim, J., Hlaing, S. P., Lee, J., Saparbayeva, A., Kim, S., Hwang, D. S., & Yoo, J. W. (2021). Exfoliated bentonite/alginate nanocomposite hydrogel enhances intestinal delivery of probiotics by resistance to gastric pH and on-demand disintegration. Carbohydrate Polymers, 272, 118462. https://doi.org/10.1016/j.carbpol.2021.118462
• Konishi, H., Fujiya, M., Tanaka, H., Ueno, N., Moriichi, K., Sasajima, J., & Kohgo, Y. (2016). Probiotic-derived ferrichrome inhibits colon cancer progression via JNK-mediated apoptosis. Nature communications, 7(1), 12365. https://doi.org/10.1016/j.tifs.2020.02.021
• Lavelle, A., & Sokol, H. (2020). Gut microbiota-derived metabolites as key actors in inflammatory bowel disease. Nature reviews Gastroenterology & hepatology, 17(4), 223-237. https://doi.org/10.1038/s41575-019-0258-z
• Leevy, W. M., Gammon, S. T., Johnson, J. R., Lampkins, A. J., Jiang, H., Marquez, M., & Smith, B. D. (2008). Noninvasive optical imaging of staphylococcus aureus bacterial infection in living mice using a Bis-dipicolylamine-Zinc (II) affinity group conjugated to a near-infrared fluorophore. Bioconjugate chemistry, 19(3), 686-692.
• Li-Juan, L.I., School, S.F., (2013). Effects of dietary chitosan and probiotics on growth and non-specific immunity of Pelteobagrusfulvidraco. Journal of Anhui Agri. Ences. 26(6), 2614–2619.
• Li, Y., Liu, F., Zhang, J., Liu, X., Xiao, P., Bai, H., & Tang, B. Z. (2021). Efficient killing of multidrug‐resistant internalized bacteria by AIEgens in vivo. Advanced Science, 8(9), 2001750.  https://doi.org/10.1002/advs.202001750
• Lim, B., Zimmermann, M., Barry, N. A., & Goodman, A. L. (2017). Engineered regulatory systems modulate gene expression of human commensals in the gut. Cell, 169(3), 547-558.
• Liu, H., Xie, M., & Nie, S. (2020). Recent trends and applications of polysaccharides for microencapsulation of probiotics. Food frontiers, 1(1), 45-59. https://doi.org/10.1002/fft2.11
• Maftei, N. M., Raileanu, C. R., Balta, A. A., Ambrose, L., Boev, M., Marin, D. B., & Lisa, E. L. (2024). The Potential Impact of Probiotics on Human Health: An Update on Their Health-Promoting Properties. Microorganisms, 12(2), 234. https://doi.org/10.3390/microorganisms12020234
• Maldonado Galdeano, C., Cazorla, S. I., Lemme Dumit, J. M., Vélez, E., & Perdigón, G. (2019). Beneficial effects of probiotic consumption on the immune system. Annals of Nutrition and Metabolism, 74(2), 115-124. https://doi.org/10.1159/000496426
• Markowiak, P., & Śliżewska, K. (2017). Effects of probiotics, prebiotics, and synbiotics on human health. Nutrients, 9(9), 1021. https://doi.org/10.3390/nu9091021
• Marx, U., Accastelli, E., David, R., Erfurth, H., Koenig, L., Lauster, R., & Dehne, E. M. (2021). An Individual Patient's “Body” on Chips—How Organismoid Theory Can Translate Into Your Personal Precision Therapy Approach. Frontiers in Medicine, 8, 728866. https://doi.org/10.3389/fmed.2021.728866
• Marzorati, M., Van den Abbeele, P., Bubeck, S., Bayne, T., Krishnan, K., & Young, A. (2021). Treatment with a spore-based probiotic containing five strains of Bacillus induced changes in the metabolic activity and community composition of the gut microbiota in a SHIME® model of the human gastrointestinal system. Food Research International, 149, 110676.
• Maslov, I., Bogorodskiy, A., Mishin, A., Okhrimenko, I., Gushchin, I., Kalenov, S., & Borshchevskiy, V. (2018). Efficient non-cytotoxic fluorescent staining of halophiles. Scientific reports, 8(1), 2549. https://doi.org/10.1038/s41598-018-20839-7
• McFarland, L. V. (2010). Systematic review and meta-analysis of Saccharomyces boulardii in adult patients. World journal of gastroenterology: WJG, 16(18), 2202. https://doi.org/10.3748/wjg.v16.i18.2202
• Michael, D. R., Davies, T. S., Moss, J. W. E., Calvente, D. L., Ramji, D. P., Marchesi, J. R., & Hughes, T. R. (2017). The anti-cholesterolaemic effect of a consortium of probiotics: An acute study in C57BL/6J mice. Scientific reports, 7(1), 2883. https://doi.org/10. 1038/s41598-017-02889-5
• Mishra, S., Wang, S., Nagpal, R., Miller, B., Singh, R., Taraphder, S., & Yadav, H. (2019). Probiotics and prebiotics for the amelioration of type 1 diabetes: present and future perspectives. Microorganisms, 7(3), 67. https://doi.org/10.3390/ microorganisms7030067
• Molska, M., & Reguła, J. (2019). Potential mechanisms of probiotics action in the prevention and treatment of colorectal cancer. Nutrients, 11(10), 2453. https://doi.org/10.3390/nu11102453
• Monteagudo-Mera, A., Rastall, R. A., Gibson, G. R., Charalampopoulos, D., & Chatzifragkou, A. (2019). Adhesion mechanisms mediated by probiotics and prebiotics and their potential impact on human health. Applied microbiology and biotechnology, 103, 6463-6472. https://doi.org/10.1007/s00253-019-09978-7
• National Institutes of Health (NIH). Human Microbiome Project defnes normal bacterial makeup of the body. https://www.nih.gov/news-events/news-releases/nih-human-microbiome-project-defines-normal-bacterial-makeup-body
• Nazir, Y., Hussain, S. A., Abdul Hamid, A., & Song, Y. (2018). Probiotics and their potential preventive and therapeutic role for cancer, high serum cholesterol, and allergic and HIV diseases. BioMed research international, 2018(1), 3428437.  https://doi.org/10.1155/2018/3428437
• Neil, K., Allard, N., Roy, P., Grenier, F., Menendez, A., Burrus, V., & Rodrigue, S. (2021). High‐efficiency delivery of CRISPR‐Cas9 by engineered probiotics enables precise microbiome editing. Molecular systems biology, 17(10), e10335. https://doi.org/10.15252/msb.202110335
• Nekhotiaeva, N., Elmquist, A., Rajarao, G. K., Hällbrink, M., Langel, Ü., & Good, L. (2004). Cell entry and antimicrobial properties of eukaryotic cell‐penetrating peptides. The FASEB Journal, 18(2), 1-15. https://doi.org/10.1096/fj.03-0449fje
• Nyvad, B., & Takahashi, N. (2020). Integrated hypothesis of dental caries and periodontal diseases. Journal of oral microbiology, 12(1), 1710953. https://doi.org/10.1080/20002297.2019.1710953
• Obayomi, O. V., Olaniran, A. F., & Owa, S. O. (2024). Unveiling the role of functional foods with emphasis on prebiotics and probiotics in human health: A review. Journal of Functional Foods, 119, 106337. https://doi.org/10.1016/j.jff.2024.106337
• Odila Pereira, J., Soares, J., Costa, E., Silva, S., Gomes, A., & Pintado, M. (2019). Characterization of edible films based on alginate or whey protein incorporated with Bifidobacterium animalis subsp. lactis BB-12 and prebiotics. Coatings, 9(8), 493.  https://doi.org/10.3390/coatings9080493
• Olnood, C. G., Beski, S. S., Iji, P. A., & Choct, M. (2015). Delivery routes for probiotics: Effects on broiler performance, intestinal morphology and gut microflora. Animal Nutrition, 1(3), 192-202. https://doi.org/10.1016/j.aninu.2015.07.002
• Padhmavathi, V., Shruthy, R., & Preetha, R. (2023). Chitosan coated skim milk-alginate microspheres for better survival of probiotics during gastrointestinal transit. Journal of Food Science and Technology, 60(3), 889-895. https://doi.org/10.1007/s13197-021-05179-1
• Panigrahi, P., Parida, S., Nanda, N. C., Satpathy, R., Pradhan, L., Chandel, D. S., & Gewolb, I. H. (2017). A randomized synbiotic trial to prevent sepsis among infants in rural India. Nature, 548(7668), 407-412. https://doi.org/10.1038/nature23480
• Park, S., Kang, J., Choi, S., Park, H., Hwang, E., Kang, Y., & Ji, Y. (2018). Cholesterol-lowering effect of Lactobacillus rhamnosus BFE5264 and its influence on the gut microbiome and propionate level in a murine model. PLoS One, 13(8), e0203150. https://doi.org/10.1371/journal.pone.0203150
• Pasquina-Lemonche, L., Burns, J., Turner, R. D., Kumar, S., Tank, R., Mullin, N., & Hobbs, J. K. (2020). The architecture of the Gram-positive bacterial cell wall. Nature, 582(7811), 294-297. https://doi.org/10.1038/s41586-020-2236-6
• Percopo, C. M., Rice, T. A., Brenner, T. A., Dyer, K. D., Luo, J. L., Kanakabandi, K., & Rosenberg, H. F. (2015). Immunobiotic Lactobacillus administered post-exposure averts the lethal sequelae of respiratory virus infection. Antiviral research, 121, 109-119. https://doi.org/10.1016/j.antiviral.2015.07.001
• Picard, C., Fioramonti, J., Francois, A., Robinson, T., Neant, F., & Matuchansky, C. (2005). bifidobacteria as probiotic agents–physiological effects and clinical benefits. Alimentary pharmacology & therapeutics, 22(6), 495-512. https://doi.org/10.1111/j.1365-2036.2005.02615.x
• Plaza-Diaz, J., Ruiz-Ojeda, F. J., Gil-Campos, M., & Gil, A. (2019). Mechanisms of action of probiotics. Advances in nutrition, 10, S49-S66. https://doi. org/10.1093/advances/nmy063
• Priya, A. J., Vijayalakshmi, S. P., & Raichur, A. M. (2011). Enhanced survival of probiotic Lactobacillus acidophilus by encapsulation with nanostructured polyelectrolyte layers through layer-by-layer approach. Journal of agricultural and food chemistry, 59(21), 11838-11845.
• Qin, J., Li, R., Raes, J., Arumugam, M., Burgdorf, K. S., Manichanh, C., & Wang, J. (2010). A human gut microbial gene catalogue established by metagenomic sequencing. Nature, 464(7285), 59-65. https://doi.org/10.1038/nature08821
• Razavi, S., Janfaza, S., Tasnim, N., Gibson, D. L., & Hoorfar, M. (2021). Microencapsulating polymers for probiotics delivery systems: Preparation, characterization, and applications. Food Hydrocolloids, 120, 106882. https://doi.org/10.1016/j.foodhyd.2021.106882
• Rivera-Chávez, F., Zhang, L. F., Faber, F., Lopez, C. A., Byndloss, M. X., Olsan, E. E., & Bäumler, A. J. (2016). Depletion of butyrate-producing Clostridia from the gut microbiota drives an aerobic luminal expansion of Salmonella. Cell host & microbe, 19(4), 443-454.
• Rodgers, B., Kirley, K., & Mounsey, A. (2013). Prescribing an antibiotic? Pair it with probiotics. The Journal of family practice, 62(3), 148.
• Ruiz, L., Flórez, A. B., Sánchez, B., Moreno-Muñoz, J. A., Rodriguez-Palmero, M., Jiménez, J., & Margolles, A. (2020). Bifidobacterium longum subsp. infantis CECT7210 (B. infantis IM-1®) displays in vitro activity against some intestinal pathogens. Nutrients, 12(11), 3259. https://doi.org/10.3390/nu12113259
• Sadeghi-Bojd, S., Naghshizadian, R., Mazaheri, M., Ghane Sharbaf, F., & Assadi, F. (2020). Efficacy of probiotic prophylaxis after the first febrile urinary tract infection in children with normal urinary tracts. Journal of the Pediatric Infectious Diseases Society, 9(3), 305-310. https://doi.org/10.1093/jpids/piz025
• Sanders, M. E., Merenstein, D., Merrifield, C. A., & Hutkins, R. (2018). Probiotics for human use. Nutrition bulletin, 43(3), 212-225. https://doi.org/ 10.1111/nbu.12334
• Scalfaro, C., Iacobino, A., Nardis, C., & Franciosa, G. (2017). Galleria mellonella as an in vivo model for assessing the protective activity of probiotics against gastrointestinal bacterial pathogens. FEMS microbiology letters, 364(7), 064. https://doi.org/10.1093/femsle/fnx064
• Shen, H., Zhao, Z., Zhao, Z., Chen, Y., & Zhang, L. (2022). Native and engineered probiotics: promising agents against related systemic and intestinal diseases. International Journal of Molecular Sciences, 23(2), 594. https://doi.org/10.3390/ijms23020594
• Shu, Z., Li, P., Yu, B., Huang, S., & Chen, Y. (2020). The effectiveness of probiotics in prevention and treatment of cancer therapy-induced oral mucositis: A systematic review and meta-analysis. Oral oncology, 102, 104559. https://doi.org/10.1016/j.oraloncology.2019.104559
• Singh, I., Kumar, P., & Pillay, V. (2018). Site-specific delivery of polymeric encapsulated microorganisms: a patent evaluation of US20170165201A1. Expert Opinion on Therapeutic Patents, 28(9), 703-708. https://doi.org/10.1080/13543776.2018.1516752
• Singh, P., Medronho, B., Alves, L., Da Silva, G. J., Miguel, M. G., & Lindman, B. (2017). Development of carboxymethyl cellulose-chitosan hybrid micro-and macroparticles for encapsulation of probiotic bacteria. Carbohydrate Polymers, 175, 87-95.
• Skrypnik, K., Bogdański, P., Schmidt, M., & Suliburska, J. (2019). The effect of multispecies probiotic supplementation on iron status in rats. Biological trace element research, 192, 234-243. https://doi.org/10.1007/ s12011-019-1658-1
• Spencer, N. J., & Hu, H. (2020). Enteric nervous system: sensory transduction, neural circuits and gastrointestinal motility. Nature reviews Gastroenterology & hepatology, 17(6), 338-351. https://doi.org/10.1038/ s41575-020-0271-2
• Sudo, N. (2019). Role of gut microbiota in brain function and stress-related pathology. Bioscience of microbiota, food and health, 38(3), 75-80. https://doi.org/10.12938/bmfh.19-006
• Suez, J., Zmora, N., Segal, E., & Elinav, E. (2019). The pros, cons, and many unknowns of probiotics. Nature medicine, 25(5), 716-729. https:// doi.org/10.1038/s41591-019-0439-x
• Sun, Q., Yin, S., He, Y., Cao, Y., & Jiang, C. (2023). Biomaterials and encapsulation techniques for probiotics: Current status and future prospects in biomedical applications. Nanomaterials, 13(15), 2185. https://doi.org/10.3390/nano13152185
• Ta, L. P., Bujna, E., Kun, S., Charalampopoulos, D., & Khutoryanskiy, V. V. (2021). Electrosprayed mucoadhesive alginate-chitosan microcapsules for gastrointestinal delivery of probiotics. International Journal of Pharmaceutics, 597, 120342. https://doi.org/10.1016/j.ijpharm.2021.120342
• Thomas, R. M., & Jobin, C. (2020). Microbiota in pancreatic health and disease: the next frontier in microbiome research. Nature Reviews Gastroenterology & Hepatology, 17(1), 53-64. https://doi.org/10.1038/ s41575-019-0242-7
• Tropini, C., Earle, K. A., Huang, K. C., & Sonnenburg, J. L. (2017). The gut microbiome: connecting spatial organization to function. Cell host & microbe, 21(4), 433-442.
• Tungland, B. (2018). Human microbiota in health and disease: From pathogenesis to therapy. https://doi.org/10.1016/B978-0-12-814649-1. 00002-8
• USPTO. (2019a). US Patent No. 10,166,198. https://patents.google.com/patent/US10166198B2/en
• USPTO. (2019b). US Patent No. 10,485,921. https://patents.google.com/patent/US10485921B2/en
• USPTO. (2020). US Patent No. 10,857,104. https://patents.google.com/patent/US10857104B2/en
• USPTO. (2021). US Patent No. 11,103,514. https://patents.google.com/patent/US11103514B2/en
• USPTO. (2022). US Patent No. 11,282,921. https://patents.google.com/patent/US11282921B2/en
• Van de Wijgert, J. H., & Verwijs, M. C. (2020). Lactobacilli‐containing vaginal probiotics to cure or prevent bacterial or fungal vaginal dysbiosis: a systematic review and recommendations for future trial designs. BJOG: An International Journal of Obstetrics & Gynaecology, 127(2), 287-299. https://doi.org/10.1111/1471-0528.15870
• Vanhatalo, A., Blackwell, J. R., L’Heureux, J. E., Williams, D. W., Smith, A., van der Giezen, M., & Jones, A. M. (2018). Nitrate-responsive oral microbiome modulates nitric oxide homeostasis and blood pressure in humans. Free Radical Biology and Medicine, 124, 21-30. https://doi.org/10.1016/j.freeradbiomed.2018.05.078
• Vasquez, E. C., Pereira, T. M., Peotta, V. A., Baldo, M. P., & Campos-Toimil, M. (2019). Probiotics as beneficial dietary supplements to prevent and treat cardiovascular diseases: uncovering their impact on oxidative stress. Oxidative medicine and cellular longevity, 2019(1), 3086270. https://doi.org/10.1155/2019/3086270
• Versalovic, J., & Wilson, M. (2008). Therapeutic microbiology: probiotics and related strategies.
• Villena, M. J. M., Lara-Villoslada, F., Martínez, M. A. R., & Hernández, M. E. M. (2015). Development of gastro-resistant tablets for the protection and intestinal delivery of Lactobacillus fermentum CECT 5716. International journal of pharmaceutics, 487(1-2), 314-319.
• Wang, W., & Chen, X. (2018). Antibiotics-based fluorescent probes for selective labeling of Gram-negative and Gram-positive bacteria in living microbiotas. Science China Chemistry, 61, 792-796.
• Wang, W., Lin, L., Du, Y., Song, Y., Peng, X., Chen, X., & Yang, C. J. (2019). Assessing the viability of transplanted gut microbiota by sequential tagging with D-amino acid-based metabolic probes. Nature communications, 10(1), 1317.
• Wang, W., Zhu, Y., & Chen, X. (2017). Selective imaging of Gram-negative and Gram-positive microbiotas in the mouse gut. Biochemistry, 56(30), 3889-3893.
• Wei, Y., Yang, F., Wu, Q., Gao, J., Liu, W., Liu, C., & Tang, R. (2018). Protective effects of bifidobacterial strains against toxigenic Clostridium difficile. Frontiers in microbiology, 9, 888. https://doi.org/10.3389/fmicb.2018.00888
• Wells, J. M., & Mercenier, A. (2008). Mucosal delivery of therapeutic and prophylactic molecules using lactic acid bacteria. Nature Reviews Microbiology, 6(5), 349-362. https://doi.org/10.1038/nrmicro1840
• Whitaker, W. R., Shepherd, E. S., & Sonnenburg, J. L. (2017). Tunable expression tools enable single-cell strain distinction in the gut microbiome. Cell, 169(3), 538-546.
• WIPO. (2020). WO Patent No. 2020/045638. https://patentscope.wipo.int/search/en/detail.jsf?docId=WO2020045638
• Wong, S. H., & Yu, J. (2019). Gut microbiota in colorectal cancer: mechanisms of action and clinical applications. Nature reviews Gastroenterology & hepatology, 16(11), 690-704. https://doi.org/10.1038/ s41575-019-0209-8
• Yan, S., Tian, Z., Li, M., Li, B., & Cui, W. (2019). Effects of probiotic supplementation on the regulation of blood lipid levels in overweight or obese subjects: a meta-analysis. Food & function, 10(3), 1747-1759. https://doi.org/10.1039/C8FO02163E 5
• Yeung, T. W. (2016). Encapsulation of Probiotic Microorganisms in Food-Grade Hydrogel Microbeads for Improving Long-Term Storage and Oral Delivery.
• Zaib, S., Hayat, A., & Khan, I. (2024). Probiotics and their beneficial health effects. Mini Reviews in Medicinal Chemistry, 24(1), 110-125. https://doi.org/10.2174/1389557523666230608163823
• Zanjani, M. A. K., Tarzi, B. G., Sharifan, A., & Mohammadi, N. (2014). Microencapsulation of probiotics by calcium alginate-gelatinized starch with chitosan coating and evaluation of survival in simulated human gastro-intestinal condition. Iranian journal of pharmaceutical research: IJPR, 13(3), 843.
• Zhang, Z., Tang, H., Chen, P., Xie, H., & Tao, Y. (2019). Demystifying the manipulation of host immunity, metabolism, and extraintestinal tumors by the gut microbiome. Signal transduction and targeted therapy, 4(1), 41. https://doi.org/10.1038/s41392-019-0074-5
• Zhao, Z., Xu, S., Zhang, W., Wu, D., & Yang, G. (2022). Probiotic Escherichia coli NISSLE 1917 for inflammatory bowel disease applications. Food & Function, 13(11), 5914-5924.