Journal of Pharmaceutical Technology, Research and Management 2019-05-29T15:40:27+0530 Dr. Sandeep Arora Open Journal Systems <div class="col-sm-9"> <div class="archives"> <h4>Welcome to Journal of Pharmaceutical Technology, Research And Management</h4> </div> <div class="about_jorunal_content"> <p>I would like to invite you to submit your research/review papers for possible publication in "Journal of Pharmaceutical Technology, Research and Management (J. Pharm. Technol. Res. Manag.)". It provides a rapid forum for the dissemination of original research articles as well as review articles related to Pharmaceutical Sciences.</p> <p>"Journal of Pharmaceutical Technology, Research and Management (J. Pharm. Technol. Res. Manag.)" is published using an open access publication model, meaning that all interested readers are able to freely access the journal online at . It is a peer reviewed, open access Journal with an International editorial board.</p> <p>The distinguished editorial board with extensive academic qualifications, ensures that journal maintains high scientific standards and focus on the areas of Drug design, Discovery, Development, Formulation, Drug Manufacturing Technologies, Quality Management Systems, Pharmaceutical Regulations, Product &amp; Project Planning and Promotional Strategies in Pharmaceutical Sciences. The probable contributors may ensure that the manuscripts are formatted according to the Athor's Instructions.</p> <p><strong>Licensing Policy</strong></p> <p>Articles in Journal of Pharmaceutical Technology, Research And Management (J. Pharm. Technol. Res. Manag.) by Chitkara University Publications are Open Access articles that are published with licensed under a Creative Commons Attribution- CC-BY 4.0 International License. Based on a work at <a href=""></a>. This license permits one to use, remix, tweak and reproduction in any medium, even commercially provided one give credit for the original creation.</p> <p>View Legal Code of the above mentioned license, <a href=""></a></p> <p>View Licence Deed here <a href=""></a></p> </div> </div> Neuropharmacological Profile of Fractions of Actaea acuminata H. Hara Roots 2019-05-29T15:37:05+0530 Deepak Kumar Suresh Kumar <p>The methanol extract of Actaea acuminata roots have beenpreviously reported to exhibit significant antianxiety, anticonvulsant andantidepressant activities. In present study fractionation of crude bioactivemethanol extract was carried out using different solvents employing standardprocedure. Various fractions were evaluated for antianxiety, anticonvulsantand antidepressant activities using elevated plus maze model (EPM), maximalelectroshock-induced convulsions model (MES) and forced / despair swim test(FST) respectively. Successive partitioning of bioactive methanol extract wasdone with ethyl acetate and 1-butanol. The ethyl acetate fraction (EAF; 100mg/kg), 1-butanol fraction (BF; 25 mg/kg) and remaining methanol extract(RME; 70 mg/kg) were subjected to neuropharmacological activities. TheEAF significantly enhanced entries and average time spent in open arms;significantly decreased duration of MES-induced tonic extension phase andsignificantly decreased duration of immobility time of rats in comparisonto control. BF and RME did not exhibit any neuropharmacological activity.Qualitative chemical tests confirmed presence of alkaloids and polyphenolsin EAF. It is finally concluded that alkaloids and/or polyphenols are bioactiveconstituents of A. acuminata which are responsible for neuropharmacologicalactivities.</p> 2018-05-02T00:00:00+0530 Copyright (c) 2018 Journal of Pharmaceutical Technology, Research and Management Development and Validation of UV Spectrophotometric Method for Simultaneous Estimation of Quinfamide and Mebendazole in in-house Pharmaceutical Formulation 2019-05-29T15:38:08+0530 Ajinkya G. Dhandar Saurabh B. Ganorkar Amod S. Patil Atul A. Shirkhedkar <p>The present work described the development of two simple, accurate, rapid, cost effective and reproducible UV-Spectrophotometric methods for the simultaneous estimation of Quinfamide and Mebendazole in bulk and in laboratory mixture using 0.01M methanolic HCl as a solvent. The absorption maximum for Quinfamide and Mebendazole were found to be at 260.00 nm and 232.40 nm respectively. Beer’s - lamberts was followed in concentration ranges of 1 - 6 μg/mL for Quinfamide and 2- 12 μg/mL for Mebendazole. The percentage recovery of Quinfamide and mebendazole ranged from 98.48 to 99.08 and 98.83 to 99.62 (Method I); from 98.14 to 98.93 and 99.16 to 99.35 (Method II) for Quinfamide and Mebendazole. The established methods were sensible for simultaneous quantitative determination of both these drugs in fixed dose combinations. Validation of both these methods was performed as per ICH guidelines. The developed methods can routinely be used for estimation of both these drugs in their combined dosage form.</p> 2018-05-02T00:00:00+0530 Copyright (c) 2018 Journal of Pharmaceutical Technology, Research and Management Protective Role of Herbal Drugs in Diabetic Neuropathy: An Updated Review 2019-05-29T15:38:56+0530 Eshita Sharma Tapan Behl Monika Sachdeva Rashita Makkar Sandeep Arora <p>Medicinal plants play a beneficial role in health care and are commonly used in preventing and testing diseases and specific ailments. The advantage associated with herbals plants are numerous and cannot be ignored as they have less adherence issues and are accepted widely by the population due to greater belief in Ayurveda since ancient times. Neuropathic pain has immersed as a serious threat to patient that occurs by damaging the blood vessels leading to morbidity and mortality. The present review paper aims in providing an account of various herbal plants that could be employed in treatment of neuropathic pain.</p> 2018-05-02T00:00:00+0530 Copyright (c) 2018 Journal of Pharmaceutical Technology, Research and Management Traditional and Novel Herbal Drugs Emerging as Potent Novel Combinations for Managing Morbidities by Pharmacological and Mechanistic Studies 2019-05-29T15:39:31+0530 Tapan Behl Chanchal Kumar Roshan Kumar Singh Taruna Katyal Arora Sandeep Arora <p>Background: Herbal drugs are used in treatment of diseases since decades. Major contributing factor for their use is easy availability, less expensive and more belief of common population because of relatively less side effects compared to allopathic medicines. Medicines of natural origin or functional foods in the prevention of disease are the need of hour. Hence, the present review focused on activity of four drugs viz. Withania somnifera,Allium sativum,Curcuma longa andAzadirachta indica and role in different clinical complications.<br>Methods: A thorough review of all the articles, research as well as reviews available regarding the concerned topic was performed. MEDLINE database was searched and English language articles were preferably selected.<br>Results: Withania somnifera, Allium sativum, Curcuma longa andAzadirachta indicahave shown alleviation in inflammation, diabetes and cancer states. The herbal drugs have shown beneficial effects in the prevention and treatment of these disorders. Conclusion from these facts:Utilizing this concept, it can be assumed that herbal drugs play an intricate role in safeguarding the health of individuals from life-threatening complications. However, validation and reproducibility of results in clinical trails should be there in order to confirm the safety and<br>efficacy of these herbal drugs.</p> 2018-05-02T00:00:00+0530 Copyright (c) 2018 Journal of Pharmaceutical Technology, Research and Management Phytochemical Investigation and Pharmacological Evaluation of Solanum xanthocarpum Endowed with their potential Activity 2019-05-29T15:40:02+0530 Mahavir Chhajed Atika Jain Sourabh Gupta Ishan Dubey A. K. Shrivastava <p>The study was done to assess the in-vitro antibacterial potential of various extracts was studied and compared with ciprofloxacin as the standard and shows significant action against E. coli, B. substilis S. aureus, S. pyrogenes, P. aeruginosa, and S. typhi. Anti-fungal potential of the aqueous extract also studied using miconazole as standard and shows significant action against A. niger and C. albicans. Anthelmintic potential of the aqueous and ethanolic extracts was also studied on earthworms, Eudrillus eugeniae using albendazole as standard and shows moderate activity. In the present study in-vitro free radical scavenging activity of whole plant material performed. Various crude extracts of S. xanthocarpum was prepared by successive maceration process using various solvents such as; chloroform, petroleum ether (60-80o), acetone, ethanol and distilled water. Each one extract have been chosen to study the free radical inhibitory activity by DPPH radical scavenging method. The preliminary phytochemical screening of extracts showed that sterols, alkaloids, glycosides, tannins, saponins, phenolic compounds, carbohydrates and proteins were present in the plant. Petroleum ether, chloroform, acetone, ethanol and distilled water extracts showed 52.69, 46.15, 21.08, 52.72 and 44.35 % respectively compared to standard ascorbic acid. Acetone extract showed poor inhibition of DPPH radical compared to standard and other extracts also.</p> 2018-05-02T00:00:00+0530 Copyright (c) 2018 Journal of Pharmaceutical Technology, Research and Management Evaluation of Polyherbal Anticancer Tablets: A Review 2019-05-29T15:40:27+0530 Ishan Dubey Manmeet Singh Saluja Ritu M Gilhotra Mahavir Chhajed <p>Cancer is a malignant abnormal growth of cells, one of the most dreaded and complex diseases. It concerns with several tempo spatial changes in cell composition, which finally lead to neoplasia. Various types of cancers have been reported. Chemotherapy, radiation, and/or surgery may cure them. Herbal remedies are supposed to be harmless as they cause fewer complications and are less likely to habitual. Antioxidant compositions of therapeutic plants show the anticancer activity and therefore, use of different proportions of the active components to formulate various standardized preparation with single or multiple components for their synergistic effects play a crucial role in curing cancer. Evaluation parameters to assess the in vitro anticancer activity includes Caspase-3, Caspase-9, alamar blue, LDH assay, XTT assay, sulforhodamine-B assay, MTT assay, DNA fragmentation assay, neutral red uptake cytotoxic assay, tryphan blue assay. Evaluation of dried extract or granules includes bulk density, tapped density, Carr’s index, Hausner’s ratio, angle of repose while the tablets evaluated by drug-excipient compatibility study by FT-IR, stability studies, hardness, thickness, weight variation, friability, disintegration time and dissolution test.</p> 2018-05-02T00:00:00+0530 Copyright (c) 2018 Journal of Pharmaceutical Technology, Research and Management