Journal of Pharmaceutical Technology, Research and Management 2020-12-02T14:35:04+0530 Dr. Sandeep Arora Open Journal Systems <div class="col-sm-9"> <div class="archives"> <h4>Welcome to Journal of Pharmaceutical Technology, Research And Management</h4> </div> <div class="about_jorunal_content"> <p>I would like to invite you to submit your research/review papers for possible publication in "Journal of Pharmaceutical Technology, Research and Management (J. Pharm. Technol. Res. Manag.)". It provides a rapid forum for the dissemination of original research articles as well as review articles related to Pharmaceutical Sciences.</p> <p>"Journal of Pharmaceutical Technology, Research and Management (J. Pharm. Technol. Res. Manag.)" is published using an open access publication model, meaning that all interested readers are able to freely access the journal online at <a href=""></a> It is a peer reviewed, open access Journal with an International editorial board.</p> <p>The distinguished editorial board with extensive academic qualifications, ensures that journal maintains high scientific standards and focus on the areas of Drug design, Discovery, Development, Formulation, Drug Manufacturing Technologies, Quality Management Systems, Pharmaceutical Regulations, Product &amp; Project Planning and Promotional Strategies in Pharmaceutical Sciences. The probable contributors may ensure that the manuscripts are formatted according to the Athor's Instructions.</p> <p><strong>Licensing Policy</strong></p> <p>Articles in Journal of Pharmaceutical Technology, Research And Management (J. Pharm. Technol. Res. Manag.) by Chitkara University Publications are Open Access articles that are published with licensed under a Creative Commons Attribution- CC-BY 4.0 International License. Based on a work at <a href=""></a>. This license permits one to use, remix, tweak and reproduction in any medium, even commercially provided one give credit for the original creation.</p> <p>View Legal Code of the above mentioned license, <a href=""></a></p> <p>View Licence Deed here <a href=""></a></p> </div> </div> Phytoalexins: Sources and Their Pharmacological Potential 2020-12-02T14:27:22+0530 Rakesh K Sindhu Bhavika Arora Sandeep Arora <p><strong>Background:</strong> Plants are easily prone towards microbial infections on exposure to microorganisms and pathogens. In order to defense, plants produce low molecular weight secondary metabolites which were later known as “Phytoalexins”. These molecules have vast therapeutic potential also. <br /><strong>Purpose:</strong> The purpose of this review is to explore the phytoalexins and their pharmacological effects.<br /><strong>Methods:</strong> The data included from the articles were published from Web of Science, PubMed, Medline, Scopus, and Embase by using relevant keywords including plants possessing phytoalexins and their specific biological applications.<br /><strong>Results:</strong> The review insights the potential of phytoalexins in various diseases and to explore phytoalexins applications in human health and disease control. <br /><strong>Conclusions:</strong> On the basis of this review it may be concluded that phytoalexins have tremendous potential in the treatment and prevention of various life-threatening diseases like diabetes mellitus, cancer, brain damage, and heart attack.</p> 2020-05-20T00:00:00+0530 Copyright (c) 2020 Bhavika Arora, Rakesh K Sindhu and Sandeep Arora Antioxidant Potential of Glycyrrhiza glabra L. roots: In-Vitro Evidences 2020-12-02T14:28:08+0530 Varinder Singh Amit Kumar <p><strong>Background:</strong> The study was aimed to determine the mechanism of antioxidant effects of Glycyrrhiza glabra L. (GG) roots using in-vitro assays.<br /><strong>Methods:</strong> The various extracts of GG roots were prepared and evaluated for DPPH scavenging, reducing effects and nitric oxide inhibiting activities. Prepared extracts were screened for the presence of various phytochemicals and quantified on the basis of phytochemical present therein.<br /><strong>Results:</strong> The results showed that all the prepared extracts contained phenolic compounds. Also, extract showed appreciable antioxidant effects in all three assays employed. However, among prepared extracts, ethylacetate extract was found to have strong free radical inhibition, ferric reducing potential and nitric oxide inhibitory effects. The reason for high antioxidant activity in ethylacetate extract could be attributed to the significant amount of phenol compounds present in it. <br /><strong>Conclusion:</strong> Evidently, GG’s capacity to scavenge free radicals, reducing potential and inhibit nitric oxide contributes to its antioxidant effects and thus, could be a strong candidate for developing antioxidant based drug therapy.</p> 2020-05-20T00:00:00+0530 Copyright (c) 2020 Varinder Singh and Amit Kumar Pharmaceutical Applications of Xanthan Gum in Ophthalmic Delivery Systems 2020-12-02T14:30:34+0530 Shiveena Bhatia Tarun Kumar Sonali Batra Sumit Sharma <p><strong>Introduction:</strong> Ophthalmic delivery system is one of the challenging domains of formulation and development due to tear dilutions, drug loss due to lacrimal drainage, limited volume and pre-corneal barriers. Several pharmaceutical technologies are exploited in order to counter the challenges posed by ocular route such as emulsions and suspensions. But all these technologies have stability issues which lead to their limited use.<br /><strong>Background:</strong> Among polysaccharides, xanthan gum, a natural occurring biodegradable exopolysaccharide extracted from bacterium <em>Xanthomonas campestris</em> is widely accepted as one of the potential polysaccharide in ophthalmic delivery systems.<br /><strong>Review Results:</strong> Xanthan gum is commonly used as an additive to various ophthalmic formulations due to its mucoadhesive property and imparting stability to various novel pharmaceutical technologies for ophthalmic. Xanthan gum also allows chemical modifications with various ligands which consequently allow controlled release, modified dissolution rate and viscoelasticity. <br /><strong>Conclusion:</strong> In this review we are providing an insight over potential of pharmaceutical applications of xanthan gum. Also, we have discussed the scope of chemical modifications in xanthan gum with modified physicochemical properties.</p> 2020-05-20T00:00:00+0530 Copyright (c) 2020 Shiveena Bhatia et al. A Comprehensive Review on Therapeutic Potential of Benzimidazole: A Miracle Scaffold 2020-12-02T14:31:50+0530 Ritchu Babbar Swikriti Sandeep Arora <p><strong>Background:</strong> Benzimidazole is a category of heterocyclic aromatic compounds formed from the fusion of six membered benzene with five membered imidazolering. The moiety possesses diverse biological and clinical applications. A number of studies have shown that a varied substituent around the benzimidazole nucleus results in pharmacologically active compounds of therapeutic interest. <br><strong>Purpose:</strong> Owing to its number of pharmacological properties, this moiety is of choice of interest in designing and synthesis of new therapeutic compounds. The existence of the benzimidazole core in numerous groups of biological agents like antimicrobial, antiviral, antiparasitic, antihypertensive, anticancer, CNS stimulant as well as depressants has made important scaffold for development of many newer therapeutic agents. There is utmost need to understand the synthesis and associated role of benzimidazole derived compounds in different diseases. Therefore, in the present review, we attempt to discuss various derivatives of benzimidazole nucleus with different pharmacological activities. <br><strong>Conclusion:</strong> Benzimidazoles have played a great role in discovery of drug and development. Huge attempt has been made towards benzimidazole heterocyclic-based organic compounds with great excellence that resulted in drugs with enormous biological activity. Therapeutic drugs containing benzimidazole nucleus are used in building drugs that serve to be an active area of research. This article becomes a source that will lead to discovery of new opportunities for all researchers interested in benzimidazole-based heterocyclic medicinal chemistry.</p> 2020-05-20T00:00:00+0530 Copyright (c) 2020 Swikriti, Sandeep Arora and Ritchu Babbar Improving Physicochemical Properties of Repaglinide Through Pharmaceutical Adduct Formation 2020-12-02T14:34:02+0530 Sharen Gill Poonam Arora <p><strong>Background:</strong> Many formulation strategies are presently in development in pharmaceutical industry. However, the formation of pharmaceutical adducts is considered to be the most appropriate technique for improving the drug solubility and dissolution as no chemical bond changes are involved in this technique.<br><strong>Purpose:</strong> This technique is highly used for compounds which are not able to give viable formulation products with standard techniques such as salt formation and polymorph generation. In the present study, this method is applied to repaglinide, which is an hypoglycemic agent, with compromised solubility. <br><strong>Methods:</strong> The adducts were prepared by slow evaporation method and characterized using DSC, FTIR and PXRD studies. The solubility and dissolution studies were carried out to determine the increased solubility of drug in adducts. The drug amount interacted with coformers has also been determined. <br><strong>Results:</strong> The present study demonstrates the improvement in solubility and thus dissolution of repaglinide in adducts.<br><strong>Conclusion:</strong> The adducts formed in the present study can be further exploited to prepare formulation of repaglinide adducts with better physicochemical characteristics.</p> 2020-12-01T00:00:00+0530 Copyright (c) 2020 Sharen Gill and Poonam Arora Ranitidine Induced Hepatotoxicity: A Review 2020-12-02T14:35:04+0530 Onkar Bedi Amit Bandyopadhyay Banerjee Thakur Gurjeet Singh Sandeep Arora Manisha Gupta <p><strong>Background:</strong> Ranitidine (RAN) is one of the common drugs associated with idiosyncratic adverse drug reactions (IADRs) in humans. It was found to be associated with severe adverse drug reactions due to the presence of contaminants such as N-Nitrosodimethylamine (NDMA) which is claimed to be carcinogenic. As a consequence, on April 1, 2020, United States Food and Drug Administration (USFDA) had decided to call off all the RAN products from the market. The exact cause of RAN associated idiosyncratic hepatotoxicity is not clear yet. <br><strong>Purpose:</strong> To summarize and analyze the reason behind the withdrawal of RAN products from the market and whether ranitidine will be available again in future or will FDA withdraw approvals of ranitidine National Drug Authority (NDA) and an abbreviated new drug application (ANDA)? <br><strong>Methods:</strong> We performed a systematic PubMed/MEDLINE search of studies investigating the reason behind the withdrawal of RAN products and explored the possible mechanism associated with RAN induced hepatotoxicity.<br><strong>Conclusion:</strong> RAN induced liver injury is difficult to diagnose and study because of its relative rarity and unpredictive occurrence. Recent studies suggest that most of the RAN associated idiosyncratic reactions may lead to hepatocyte damage, followed by a series of events, such as activation of specific T- and B-cells, release of proinflammatory mediators like TNFα, interleukins, various cytokines and chemokines. The exact cause of RAN associated idiosyncratic hepatotoxicity is not clear yet. More studies must be carried out on this to know about the exact reason behind RAN associated hepatotoxicity.</p> 2020-05-20T00:00:00+0530 Copyright (c) 2020 Amit Bandyopadhyay Banerjee et al.