Development and Optimization of Fast Dissolving Tablets of Losartan Potassium Using Natural Gum Mucilage

Authors

  • Rohit Goyal Chitkara College of Pharmacy, Chitkara University, Rajpura, Punjab-140401
  • Manju Nagpal Chitkara College of Pharmacy, Chitkara University, Rajpura, Punjab-140401
  • Sandeep Arora Chitkara College of Pharmacy, Chitkara University, Rajpura, Punjab-140401
  • Gitika Arora Dhingra NCRD’s Sterling Institute of Pharmacy, Nerul, Navi Mumbai, India

DOI:

https://doi.org/10.15415/jptrm.2013.12009

Keywords:

Disintegration time, wetting time, factorial design, plantago ovata, lepidium sativum

Abstract

Current research work involves preparation of fast dissolving tablets of Losartan Potassium by direct compression method using different concentrations of Plantago ovata and Lepidium sativum mucilage as natural superdisintegrants. A two factor three level (32) factorial design is being used to optimize the formulation. Nine formulation batches (A1-A9) were prepared by taking two factors as independent variables (X1- amount of Plantago ovata mucilage and X2- amount of Lepidium sativum mucilage)
were taken with three levels (+1, 0, -1). All the active blends were evaluated for precompression parameters (angle of repose, bulk density, carr’s index, hausner’s ratio) and formulated tablets were evaluated for post compression parameters (hardness, friability, weight variation, wetting time, disintegration time, water absorption ratio). In vitro drug release studies were carried out using USP II dissolution apparatus for 30 min. The software Design Expert (8.0.7.1) was used for generating experimental design, modeling the response surface and calculating the statistical evaluation. Tablet parametric tests of formulation batches (A1-A9) of FDT were found within prescribed limits.
DT was observed in the range from 12±2 to 58.7±2.52 sec and WT from 10.3±1.52 to 49.7±5.13 sec for formulation batches (A1-A9). More than 87% drug release was observed in all formulation batches (A1-A9) within 15 minutes. Polynomial mathematical models, generated for various response variables using multiple linear regression analysis, were found to be statistically significant (P < 0.05). Formulation A7 was selected by the design expert software which exhibited DT (22.15sec), WT (17.31sec) and in vitro
drug release (100%) within 15 minutes.

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References

Avulapati, S., Roy, A.K., Shashidhar, K.R., Reddy, T. & Reddy, U. (2011). Formulation and evaluation of taste masked and fast disintegrating losartan potassium tablets. International Journal of Drug Delivery Research, 3 (1), 45-51

Baveja, S.K., Rao, K.V. & Arora, J. (1989). Examination of natural gums and mucilages as sustaining materials in tablet dosage forms-II. Indian Journal of Pharmaceutical Sciences, 51,115-118

Bhowmik, D., Chiranjib, B., Krishnakanth, P. & Chandira, R.M. (2009). Fast dissolving tablet: an overview. Journal of Chemistry and Pharmacy Research, 1(1), 163-177

Charkraborthy, S., Khandai, M., Singh, S.P. & Patra, N. (2008). Comparative study on effect of natural and synthetic superdisintegrants in formulation of fast dissolving tablets International Journal of Green Pharmacy, 2, 22-25. http://dx.doi.org/10.4103/0973-8258.39158

Hasegawa, K., Mizutani, J., Kosemura, S. & Yamamura, S. (1992). Isolation and identification of lepidiomoide, a new allelopathic substance from mucilage of germinated cress seeds. Plant Physiology, 100, 1059-61. http://dx.doi.org/10.1104/pp.100.2.1059

Malik, K., Arora, G. & Singh, I. (2012). Ocimum sanctum seeds, a natural superdisintegrant: Formulation and evaluation of fast melt tablets of nimesulide. Polimery w Medycynie, 42(1): 49-59

Patel, D.M., Prajapati, D.G. & Patel, N.M. (2007). ‘Seed mucilage from OCIMUM americanum linn. as disintegrant in tablets: separation and evaluation. Indian Journal of Pharmaceutical Sciences, 69, 431-435. http://dx.doi.org/10.4103/0250-474X.34556

Sharma, J., Kaur, L., Kanuja, N., Nagpal, M. & Bala, R. (2013). Natural polymers- Promising Potential in Drug Delivery. International Journal of Pharm Tech Research, 5 (2), 684-699

Shirsand, S.B., Suresh, S., Kusumdevi, V. & Swamy, P.V. (2006). Formulation design and optimization of fast dissolving clonazepam tablets by sublimation method. Indian Journal of Pharmaceutical Sciences, 73(5), 491-496

Shirsand, S.B., Suresh, S., Para M.S., Swamy, P.V. & Kumar, D.N. (2009).Plantago ovata mucilage in the design of fast disintegrating tablets. Indian Journal of Pharmaceutical Sciences, 71(1), 41-45. http://dx.doi.org/10.4103/0250-474X.51952

Washi, S.P., Sharma, V.D., Jain, V.K. & Sinha, P. (1985). Palntago ovata: genetic diversity, cultivation, utilization and chemistry. Indian Journal of Natural Products, 1, 3-6

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Published

2013-11-11

How to Cite

Rohit Goyal, Manju Nagpal, Sandeep Arora, & Gitika Arora Dhingra. (2013). Development and Optimization of Fast Dissolving Tablets of Losartan Potassium Using Natural Gum Mucilage. Journal of Pharmaceutical Technology, Research and Management, 1(2), 153–169. https://doi.org/10.15415/jptrm.2013.12009

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