Synthesis, antimicrobial evaluation and QSAR studies of p-amino benzoic acid derivatives

  • Meeta Faculty of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak-124001, India
  • Pradeep Kumar Faculty of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak-124001, India
  • Balasubramanian Narasimhan Faculty of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak-124001, India
Keywords: PABA, Synthesis, Antimicrobial, mt-QSAR, LOO method


A series of Schiff bases (1-16) and esters (17-27) of p-amino benzoic acid (PABA) was synthesized and its in vitro antimicrobial potential was evaluated by using tube dilution method. Compound 11 was found to be most promising antibacterial agent (pMICbs = 2.11 μM/ml) having antibacterial potential comparable to standard drug norfloxacin (pMICbs = 2.61 μM/ml) and may be taken as a lead compound for the development of novel antibacterial agents. QSAR analysis indicated that electronic parameters, total energy (Te) and energy of lowest unoccupied molecular orbital (LUMO) were found dominant in explaining the antimicrobial activity of synthesized compounds.


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How to Cite
Meeta, Pradeep Kumar, & Balasubramanian Narasimhan. (2014). Synthesis, antimicrobial evaluation and QSAR studies of p-amino benzoic acid derivatives. Journal of Pharmaceutical Technology, Research and Management, 2(1), 87-104.