A Review on Role of Advanced Glycation End products (AGEs) in Rheumatoid Arthritis


  • Ravinder Kumar Chitkara College of Pharmacy, Chitkara University, Rajpura, Punjab-140401
  • Sandeep Arora Chitkara College of Pharmacy, Chitkara University, Rajpura, Punjab-140401
  • Pratima Syal Chitkara College of Pharmacy, Chitkara University, Rajpura, Punjab-140401
  • Mayank Sippy Chitkara College of Pharmacy, Chitkara University, Rajpura, Punjab-140401




Advance glycated end products, RAGE, Rheumatoid arthritis


Rheumatoid arthritis (RAa) is a systemic inflammatory connective tissue disease with polyarthritis as a prominent feature; however, extra-articular symptoms and signs are always present. Aadvanced glycation end products with ability of cross-linking of proteins characteristic fluorescence and reaction with AaGEe-specific receptor RAaGEe (receptor for AaGEes). AaGEes action as well as AaGEe formation is directly related to both to inflammation and oxidative stress. RAaGEe is a 35-kDa polypeptide whose gene is located at the junction of the class II and III HLAla regions on chromosome. ligation of RAaGEe has been shown to activate p21ras and mitogen-activated protein (MAaP) kinase, and stimulate nuclear translocation of the transcription factor NF-κB, thereby, resulting in the transcription of target genes thus may induce chronic cellular activation and tissue damage.


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How to Cite

Ravinder Kumar, Sandeep Arora, Pratima Syal, & Mayank Sippy. (2015). A Review on Role of Advanced Glycation End products (AGEs) in Rheumatoid Arthritis. Journal of Pharmaceutical Technology, Research and Management, 3(1), 1–10. https://doi.org/10.15415/jptrm.2015.31001




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