Synthesis,Characterization and Biological studies on Mannich Bases of 2-Substituted Benzimidazole Derivatives
Keywords:Mannich Bases, antimicrobial activity, antioxidant activity
In the present study novel derivatives of 2-substituted benzimidazoles were prepared via Mannich reaction and evaluated for their in vitro antimicrobial activity against two gram negative strains (Escherichia coli and Pseudomonas aeruginosa), two gram positive strains (Bacillus subtilis and Staphylococcus aureus) and fungal strains (Candida albicans and Aspergillus niger).The synthesized compounds were also screened for antioxidant activity.The newly synthesized compounds were characterized by spectral and analytical techniques.The results revealed that all the synthesized compounds have a significant antioxidant and biological activity against the tested microorganisms.
A Ashok, M., Holla, B.S., and Poojary, B.C. (2007) Convenient one pot synthesis and antimicrobial evaluation of some new Mannich bases carrying 4-methylthiobenzyl moiety. European Journal of Medicinal Chemistry, 42(8): 1095-1101. http://dx.doi.org/10.1016/j.ejmech.2007.01.015
Barlin, G.B., and Jiravinya, C. (1990) Potential antimalarials.X.Di-mannich bases of 4-(7’-trifluoromethyl-1’,5’-naphthyridin-4’-ylamino)phenol and N-(4’-Diethylamino-1’-
methylbutyl)-7-trifluoromethyl-1,5-naphthyridin-4-amine. Australian Journal of Chemistry, 43(7): 1175-1181. http://dx.doi.org/10.1071/CH 9901175
Bennet-Jenlins, E., and Baryant, C. (1996) Novel sources of anthelmintics. International Journal for Paracitology. 26(8-9): 937-947. http://dx.doi.org/10.1016/S0020-7519(96)80068-3
E Edwards, M.L., Ritter,H.W., Stemeric, D.M., and Stewart, K.T. (1983) Mannich bases of 4-phenyl-3-buten-2-one:a new class of antiherpes agent. Journal of Medicinal Chemistry. 26(3): 431-436. http://dx.doi.org/10.1021/jm00357a020
E Evans B.E., Rittle K.E.,Bock, M.G., Hirshfield, J. (1988) Methods for drug discovery, development of potent selective, orally effective cholecystokinin antagonist. Journal of Med. Chem. 31: 2235-2246. http://dx.doi.org/10.1021/jm00120a002
Gul, H.I.,Vepsalainen, J., Gul, M., Erciyas, E., and Hanninen, O. (2000) Cytotoxic activities of mono and bis mannich bases derived from acetophenone against Renca and Jurkat cells. Pharmaceutica Acta Helvetiae.74(4): 393-398. http://dx.doi.org/10.1016/S0031-6865(00)00022-4
Ivanova, Y., Momekov, G., Petrov, O., Karaivanova M., and Kalcheva, V. (2007) Cytotoxic Mannich bases of 6-(3-aryl-2-propenoyl)-2-(3H)-benzoxazolones.European Journal of Medicinal Chemistry. 52(11-12): 1382-1387. http://dx.doi.org/10.1016/j.ejmech.2007.02.019
Kalluraya,B.,Chimbalkar,R.M., and Hedge J.C. (2005) Anticonvulsant activity of nicotinyl/isonicotinyl substituted 1,2,4-triazol-5-thione Mannich bases. Indian Journal of Heterocyclic Chemistry.15(1): 15-18.
Kamil, A., Akhtar, S., Jahan, S., Karim, A., Rafik, A., Hassan, S. (2013) Synthesis and antioxidant activity of albendazole derivatives. International Journal of Scientific & Engineering Research. 4(8): 1674-1685.
Koksal,M., Gokhan, N., Kupeli, E.,Yesilada, E.,Erdogan, H. (2007) Analgesic and antiinflammatory activities of some new mannich bases of 5- nitro-2 benzoxazolinones.Archives of Pharmacal Research. 30(4): 419-424. http://dx.doi.org/10.1007/BF02980214
Malinka, W., Swiatek, P., Filipek, B., Sapa, J., Jezierska A., and Koll A. (2005) Synthesis, analgesic activity and computational study of new isothiazolopyridines of mannich base type. Farmaco, 60(11-12): 961-968. http://dx.doi.org/10.1016/j.farmac.2005.08.005
Mandal, S., Yadav, S., Yadav, S., Kumar Nema, R. (2009) Antioxidants- A review. Journal of Chemical and Pharmaceutical Research, 1(1): 102-104.
Mason, J.S., Morize, I., Menard, P.R. (1999) New 4-point pharmacophore method for molecular similarity and diversity applications: Overview of the method and applications including a novel approach to the design of combinatorial libraries containing privileged sub-structures. Journal of Medicinal Chemistry. 42: 3251-3264. http://dx.doi.org/10.1021/jm9806998
Pandeya, S.N., Sriram, D., Nath, G., and De Clercq, E. (2000) Synthesis,antibacterial, antifungal and anti-HIV activities of norfloxacin Mannich bases. European Journal of Medicinal Chemistry, 35(2): 249-255. http://dx.doi.org/10.1016/S0223-5234(00)00125-2
Scott, M.K., Martin, G.E., Distefano D.L. et al, (1992) Pyrrole Mannich bases as potential antipsychotic agents. Journal of Medicinal Chemistry. 35(3): 552-558. http://dx.doi.org/10.1021/jm00081a018
Singh, B.N., Shukla, S.K., and Singh, M. (2007) Synthesis and biological activity of sulphadiazine schiff’s bases of isatin and their N-Mannich bases. Asian Journal of Chemistry. 19(7): 5013-5018.
Vasishtha, S.C.,Zello, G.A., Nienaber, K.H.et al, (2004) Cytotoxic and anticonvulsant aryloxy aryl mannich bases and related compounds.European Journal of Medicinal Chemistry. 39(1): 27-35. http://dx.doi.org/10.1016/j.ejmech.2003.09.011
White, A.W., Almassy, R., Calvert, A.H., Golding, B.T. (2000) Resistance modifying agents, Synthesis and Biological properties of Benzimidazole inhibitors of DNA repair enzyme Poly(ADP Ribose) polymerase. Journal of Med.Chem, 43: 4084-4097. http://dx.doi.org/10.1021/jm000950v
Zhu, Z., Lippa, B., Drach, J.C.(2000) Design Synthesis and biological evaluation of tricyclic nucleosides(Dimensional probes)as analogues of certain antiviral polyhalogenated Benzimidazole Ribonucleosides. Journal of Med. Chemistry, 43: 2430-2437. http://dx.doi.org/10.1021/jm990290y
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Based on a work at https://jptrm.chitkara.edu.in