Mannich Bases of 2-Substituted Benzimidazoles - A Review

Ritchu Sethi; Sandeep Arora; Neelam Jain; Sandeep Jain

doi:10.15415/jptrm.2015.32008

Authors

Ritchu Sethi Chitkara College of Pharmacy, Chitkara University, Rajpura, Punjab-140401
Sandeep Arora Chitkara College of Pharmacy, Chitkara University, Rajpura, Punjab-140401
Neelam Jain School of Pharmaceutical Education and Research, BPS Women University, Khanpur Kalan, Sonepat, Haryana, India
Sandeep Jain Department of Pharmaceutical Sciences, Guru Jambheshwar University, Haryana India

DOI:

https://doi.org/10.15415/jptrm.2015.32008

Keywords:

Mannich Bases, Substituted Benzimidazoles, Pharmacological Activities

Abstract

Mannich bases are the end products of mannich reaction and are known as beta amino ketone carrying compounds. Mannich reaction is a carbon carbon bond forming nucleophilic addition reaction which helps in synthesizing N-methyl derivatives and many other drug molecules. Mannich base derivatives of benzimidazoles possess many pharmacological properties such as anti-oxidant, anti-inflammatory, anticancer, antiviral, anthelmintic and play an important role in medical field. As these drugs are clinically useful in treatment of microbial infections and exhibit other therapeutic activities also, so this encouraged the development of more potent, novel and clinically significant compounds. In this review synthesis and various biological activities of new mannich bases of benzimidazole derivatives reported is discussed.

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