Molecular Docking Evaluation of Some Natural Phenolic Compounds as Aldose Reductase Inhibitors for Diabetic Complications

Ajmer Singh Grewal; Neelam Sharma; Sukhbir Singh; Sandeep Arora

doi:10.15415/jptrm.2017.52009

Authors

Ajmer Singh Grewal Chitkara College of Pharmacy, Chitkara University,Rajpura, Patiala,140401, Punjab, India
Neelam Sharma Chitkara College of Pharmacy, Chitkara University, Rajpura, Punjab-140401
Sukhbir Singh Chitkara College of Pharmacy, Chitkara University, Rajpura, Punjab-140401
Sandeep Arora Chitkara College of Pharmacy, Chitkara University, Rajpura, Punjab-140401

DOI:

https://doi.org/10.15415/jptrm.2017.52009

Keywords:

Aldose Reductase, AR Inhibitors, Diabetic Complications, Flavonoids, Molecular Docking, Phenolic compounds, Polyol Pathway

Abstract

The enzyme aldose reductase (AR) is a member of aldoketoreductase super-family which catalyzes the formation of sorbitol from glucose through polyol pathway of glucose catabolism. Reduced sorbitol production via polyol pathway due to AR inhibition is a target of choice for controlling major complications of diabetes. Epalrestat is the only commercially available inhibitor of AR till date,thus, there is a great need to search for more economical, nontoxic and safer inhibitors of AR enzyme. Flavonoids,
the polyphenol compounds in plants have been reported for inhibitory effects against AR. The objective of this study is to explore the binding modes of natural
phenolic compounds with AR to design safer natural drugs as alternatives to synthetic drugs. We conducted a molecular docking study on some natural
phenolic compounds with AR enzyme in complex with the synthetic inhibitor. The overlay of the docked pose of the selected natural phenols with the ARreference inhibitor complex showed that the selected natural compounds have the similar binding pattern with the active site residues of the enzyme as that of co-crystallized inhibitor. The results of docking study showed the best binding affinity of AR with that of 2-(4-hydroxy-3-methoxyphenyl) ethanoic acid and butein, having the lowest binding free energy of –9.8 kcal/mol and–9.7 kcal/mol, respectively. This information can be utilized to design potent, economical and non-toxic natural AR inhibitors from natural phenols for the therapeutics of diabetic complications.

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