Role of Protein Kinase C in Diabetic Complications

  • Simran Chitkara College of Pharmacy, Chitkara University, Punjab, India
  • Amarjot Kaur Grewal Chitkara College of Pharmacy, Chitkara University, Punjab, India
  • Sandeep Arora Chitkara College of Pharmacy, Chitkara University, Punjab, India
  • Thakur Gurjeet Singh Chitkara College of Pharmacy, Chitkara University, Punjab, India
Keywords: Diabetes mellitus, Hyperglycemia, PKC, Microvascular complications, PKC inhibitors


Diabetes is the most common and systemic disorder associated with hyperglycemia which is the significant factor in the development of micro- and macrovascular changes. Many mechanistic approaches i.e. activation of Protein kinase C, glycation end products production, hexosamine pathway and polyol pathway induce cellular damage and lead to the development of diabetic complications like nephropathy, neuropathy, retinopathy, and myopathy. One of the adverse effects of long-lasting hyperglycemia is activation of PKC (intracellular signaling enzyme) and has become a field of great research interest. Hence, in this review special emphasis is placed on microvascular complications which are due to activation of PKC. Clinical trials have also been conducted using selective PKC inhibitors and have shown positive results against hyperglycemia.


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How to Cite
Simran, Amarjot Kaur Grewal, Sandeep Arora, & Thakur Gurjeet Singh. (2019). Role of Protein Kinase C in Diabetic Complications. Journal of Pharmaceutical Technology, Research and Management, 7(2), 87-95.