Inhibition of Formalin Induced Paw Edema in Rats by Various Fractions/Extracts of Bryophyllum pinnatum
Keywords:Anti-inflammatory, Formalin, Bryophyllum, pinnatum
Traditionally, Bryophyllum pinnatum is used in the management of arthritis and inflammatory diseases. However, B. pinnatum has not been analysed previously for anti-inflammatory activity. Hence, this study is designed to determine the anti-inflammatory effects of various fractions of B. pinnatum leaf extract using rat model of formalin-induced paw edema. Treatment with various fractions showed marked decrease in formalin-induced paw volume and edema in rats. The results of BPAAF treatment were comparable to standard drug, diclofenac. These results indicate that B. pinnatum could be developed as ant-inflammatory drug after further studies.
Anti-inflammatory, Formalin, Bryophyllum Anonymus (1998). Wealth of India, Raw materials, NIS, CSIR, New Delhi, vol. 10, 588-590.
Anonymous, the Ayurvedic Pharmacopoeia of India, vol 1, Government of India Ministry of Family Welfare, 1998-b:306.
Greenwald, R. A. (1991). Animal models for evaluation of arthritic drugs. Method Find Clin. Pharmacol, 13, 75-83.
Hosseinzadeh, H., & Younesi, H. M. (2002). Antinociceptive and anti-inflammatory effects of Crocus sativus L. stigma and petal extracts in mice. BMC pharmacology, 2, 7. https://doi.org/10.1186/1471-2210-2-7
Kirtikar, K. R. and Basu, B. D. (1935). Indian Medicinal Plants, 2nd ed, I, 311.
Sofowora, A. (1993). Medicinal plants and traditional medicine in Africa 2nd ed. Ibadan. Polygraphic Ventures. Ltd, 207-9.
Zimmerman, M. (1989). Pain mechanism and mediators in osteoarthritis. Semin. Arth. Rheum, 18, 22-29. https://doi.org/10.1016/0049-0172(89)90012-7
How to Cite
Articles in Journal of Pharmaceutical Technology, Research And Management (J. Pharm. Technol. Res. Manag.) by Chitkara University Publications are Open Access articles that are published with licensed under a Creative Commons Attribution- CC-BY 4.0 International License. Based on a work at https://jptrm.chitkara.edu.in. This license permits one to use, remix, tweak and reproduction in any medium, even commercially provided one give credit for the original creation.
View Legal Code of the above mentioned license, https://creativecommons.org/licenses/by/4.0/legalcode
View Licence Deed here https://creativecommons.org/licenses/by/4.0/
|Journal of Pharmaceutical Technology, Research And Management by Chitkara University Publications is licensed under a Creative Commons Attribution 4.0 International License.
Based on a work at https://jptrm.chitkara.edu.in