Gastroprotective Effect of Symplocos Racemosa Whole Plant Methanolic Extract Against Experimentally Induced Gastric Ulcer in Rat

  • R. K. Gupta Babu Banarsi Das National Institute of Technology and management, Lukhnow-227108, Uttar Pradesh, India
  • Ravi Vishwakarma Arya Collage of Pharmacy, RIICO Industrial Area, Kukas, Jaipur-302028, Rajasthan, India
  • Yashwant Giri Seemanta Institute of Pharmaceutical Sciences, Jharpokharia-757086, Odisha, India
  • Varinder Singh Chitkara College of Pharmacy, Chitkara University, Punjab
Keywords: Antiulcer, Indomethacin, Ranitidine, Antisecretory, Methanol

Abstract

Peptic ulcer is a condition which results from an imbalance between offensive and defensive factors of gastrointestinal system. The investigation was designed to evaluate the antiulcer activity of Symplocos racemosa whole plant methanol extract (MESR) in rat model of indomethacininduced gastric ulceration. The total acidity, gastric volume, pH and free acidity were measured to determine the anti-ulcer activity of MESR. Pretreatment with MESR (125-500 mg/kg) markedly reduced the indomethacin-induced increase in gastric ulcer index and score. These results revealed that antisecretory effects MESR were responsible for antiulcer activity of MESR.

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Published
2019-11-05
How to Cite
R. K. Gupta, Ravi Vishwakarma, Yashwant Giri, & Varinder Singh. (2019). Gastroprotective Effect of Symplocos Racemosa Whole Plant Methanolic Extract Against Experimentally Induced Gastric Ulcer in Rat. Journal of Pharmaceutical Technology, Research and Management, 7(2), 59-61. https://doi.org/10.15415/jptrm.2019.72007
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Articles