Evaluation of Polyherbal Anticancer Tablets: A Review
Keywords:Therapeutic, Anticancer, Caspase
Cancer is a malignant abnormal growth of cells, one of the most dreaded and complex diseases. It concerns with several tempo spatial changes in cell composition, which finally lead to neoplasia. Various types of cancers have been reported. Chemotherapy, radiation, and/or surgery may cure them. Herbal remedies are supposed to be harmless as they cause fewer complications and are less likely to habitual. Antioxidant compositions of therapeutic plants show the anticancer activity and therefore, use of different proportions of the active components to formulate various standardized preparation with single or multiple components for their synergistic effects play a crucial role in curing cancer. Evaluation parameters to assess the in vitro anticancer activity includes Caspase-3, Caspase-9, alamar blue, LDH assay, XTT assay, sulforhodamine-B assay, MTT assay, DNA fragmentation assay, neutral red uptake cytotoxic assay, tryphan blue assay. Evaluation of dried extract or granules includes bulk density, tapped density, Carr’s index, Hausner’s ratio, angle of repose while the tablets evaluated by drug-excipient compatibility study by FT-IR, stability studies, hardness, thickness, weight variation, friability, disintegration time and dissolution test.
Abdullaev, F.I., R.R. Luna, B.V. Roitenburd, A.J. (2000). Espinosa, Pattern of childhood cancer mortality in Mexico. Arch. Med. Res., 31, 526–31. https://doi.org/10.1016/S0188-4409(00)00094-1
Abdullaev, F.I., (2001). Plant-derived agents against cancer. In: Pharmacology and Therapeutics in the New Millennium, New Delhi. 345–354.
Balunas MJ, Kinghorn AD (2005). Drug discovery from medicinal plants. Life Sci. 78, 431–441. https://doi.org/10.1016/j.lfs.2005.09.012
Carter SJ (1986). Powder Flow and Compaction: In: Cooper and Gun’s Tutorial Pharmacy. 2nd Ed. CBS Publishers and Distributors, India. 186–232.
Cragg GM, Newman DJ (2003). Plants as a source of anti-cancer and anti-HIV agents. Ann. Appl. Biol. 143, 127–133. https://doi.org/10.1111/j.1744-7348.2003.tb00278.x
Duan H et al.,(1996). ICE-LAP3, a novel mammalian homologue of the Caenorhabditis eleganscell death protein Ced-3 is activated during Fas- and tumor necrosis factor-induced apoptosis. Journal Biochemistry 271, 1621–1625.
Economou MA et al., (2008).Oral picropodophyllin (PPP) is well tolerated in vivo and inhibits IGF-1R expression and growth of uveal melanoma. Acta Ophthalmologica; 86, 35–41. https://doi.org/10.1111/j.1755-3768.2008.01184.x
Edeoga HO, Okwu DE, Mbaebie BO (2005). Phytochemical constituents of some Nigerian medicinal plants. Af.r. J Biotechnol. 4, 685–688. https://doi.org/10.5897/AJB2005.000-3127
ICH harmonised tripartite guideline stability testing of New drug substances and products. Q1A(R2). Current Step 4 version, 2003.
Khandelwal KR (2009). Practical Pharmacognosy,19th ed: Nirali Prakashan, Pune, 146–165.
Kokate CK (2008). Practical Pharmacognosy, 4th ed, Nirali Prakashan,Pune, India. 10–27
Lin CW et al., (1991). Lysosomal localization and mechanism of uptake of Nile blue photosensitizers in tumor cells. Cancer Res. 51, 2710–2719.
Margret C, Jayakar B (2010). Formulation and evaluation of herbal tablets containing ipomoea digitata linn. Extract. International Journal of Pharmaceutical Sciences Review and Research. 3(1), 101–110.
Mishra S U, Murthy P N, Pasa G, Mishra D (2011). Formulation development and evaluation of herbal tablet containing methanolic extract of butea frondosa. International journal of Institutional Pharmacy and life sciences. 1(3), 1–15.
Mossman T (1983). Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods; 65, 55–63. https://doi.org/10.1016/0022-1759(83)90303-4
Nicholson DW, Ali A and Thornberry NA. (1995). Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis. Nature 376, 37–43. https://doi.org/10.1038/376037a0
Nostro A et al.,(2000). Extraction methods and bioautography for evaluation of medicinal plant antimicrobial activity. Lett. Appl. Microbiol. 30, 379–384. https://doi.org/10.1046/j.1472-765x.2000.00731.x
O’Brien J, Wilson I, Orton T, Pognan F (2000). Investigation of the Alamar (resazurin) fluorescent dye for the assessment of mammalian cell cytotoxicity. Eur. J. Biochem. 267, 5421–5426. https://doi.org/10.1046/j.1432-1327.2000.01606.x
Paronen P, Ikka J (1995). Porosity-pressure functions. In: Pharmaceutical powder compaction technology. Alderborn G, Nystrum C. (Eds), Marcel Dekker, New
York 71, 55–75. https://doi.org/10.1201/b14207-4
Pezzuto JM (1997). Plant-Derived Anticancer Agents. Biochem.Pharmacol. 53, 121–133. https://doi.org/10.1016/S0006-2952(96)00654-5
Petty RD (1995). Comparison of MTT and ATP-based assays for the measurement of viable cell number. Journal of Biolumin. Chemilumin. 10, 29–34. https://doi.org/10.1002/bio.1170100105
Porter AG and Janicke RU (1999). Emerging roles of caspase-3 in apoptosis. Cell Death Differentation 6, 99–104. https://doi.org/10.1038/sj.cdd.4400476
Reddy L, Odhav B, Bhoola KD (2003). Natural products for cancer prevention: a global perspective. Pharmacology & Therapeutics. 99, 1–13. https://doi.org/10.1016/S0163-7258(03)00042-1
Russo A et al., (2006). Pannarin inhibits cell growth and induces cell death in human prostate carcinoma DU- 145 cells. Anti-Cancer Drugs; 17, 1163–1169. https://doi.org/10.1097/01.cad.0000236310.66080.ed
Sakahira H, Enari M and Nagata S (1998) Cleavage of CAD inhibitor in CAD activation and DNA degradation during apoptosis. Nature 391, 96−99. https://doi.org/10.1038/34214
Sirimal GK (2015). In vitro cytotoxic studies of various formulations of Indian medicinal plants. Indian Journal of Research in Pharmacy and Biotechnology. 3(3), 210–217.
Skehan P et al., (1990) New colorimetric cytotoxicity assay for anticancer drug screening. J Natl Cancer Inst; 82, 1107–1112. https://doi.org/10.1093/jnci/82.13.1107
Thornberry NA et al., (1997). A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis. Journal of Biochemistry 272, 17907–17911. https://doi.org/10.1074/jbc.272.29.17907
Thornberry NA and Littlewood Y (1998).Caspases Enemies Within. Science 281, 1312–1316. https://doi.org/10.1126/science.281.5381.1312
United States Pharmacopoaeia (2003). Bulk Density and Tapped Density. Asian Ed.; 26, 2125.
Unnikrishnan MC, Ramadasan K(1998). Cytotoxicity of extracts of spices to cultured cells. Nutr Cancer; 11, 251–257. https://doi.org/10.1080/01635588809513995
Wiseman, LR, Spencer CM (1998). Drugs Aging 12, 305–334. https://doi.org/10.2165/00002512-199812040-00005
Wolf BB, Schuler M, Echeverri F, Green DR (1999). Caspase-3 is the primary activator of apoptotic DNA fragmentation via DNA fragmentation factor-45/ inhibitor of caspase-activated DNase inactivation. Journal Biochemistry 274, 30651–30656. https://doi.org/10.1074/jbc.274.43.30651
How to Cite
Articles in Journal of Pharmaceutical Technology, Research And Management (J. Pharm. Technol. Res. Manag.) by Chitkara University Publications are Open Access articles that are published with licensed under a Creative Commons Attribution- CC-BY 4.0 International License. Based on a work at https://jptrm.chitkara.edu.in. This license permits one to use, remix, tweak and reproduction in any medium, even commercially provided one give credit for the original creation.
View Legal Code of the above mentioned license, https://creativecommons.org/licenses/by/4.0/legalcode
View Licence Deed here https://creativecommons.org/licenses/by/4.0/
|Journal of Pharmaceutical Technology, Research And Management by Chitkara University Publications is licensed under a Creative Commons Attribution 4.0 International License.
Based on a work at https://jptrm.chitkara.edu.in