Phytochemical Investigation and Pharmacological Evaluation of Solanum xanthocarpum Endowed with their potential Activity
The study was done to assess the in-vitro antibacterial potential of various extracts was studied and compared with ciprofloxacin as the standard and shows significant action against E. coli, B. substilis S. aureus, S. pyrogenes, P. aeruginosa, and S. typhi. Anti-fungal potential of the aqueous extract also studied using miconazole as standard and shows significant action against A. niger and C. albicans. Anthelmintic potential of the aqueous and ethanolic extracts was also studied on earthworms, Eudrillus eugeniae using albendazole as standard and shows moderate activity. In the present study in-vitro free radical scavenging activity of whole plant material performed. Various crude extracts of S. xanthocarpum was prepared by successive maceration process using various solvents such as; chloroform, petroleum ether (60-80o), acetone, ethanol and distilled water. Each one extract have been chosen to study the free radical inhibitory activity by DPPH radical scavenging method. The preliminary phytochemical screening of extracts showed that sterols, alkaloids, glycosides, tannins, saponins, phenolic compounds, carbohydrates and proteins were present in the plant. Petroleum ether, chloroform, acetone, ethanol and distilled water extracts showed 52.69, 46.15, 21.08, 52.72 and 44.35 % respectively compared to standard ascorbic acid. Acetone extract showed poor inhibition of DPPH radical compared to standard and other extracts also.
Indian Herbal Pharmacopoeia (1998). Ministry of Health & Family Welfare, Department of Health, Govt. of India, New Delhi. Vol-I. 139.
The Ayurvedic Pharmacopoeia of India (1989). Ministry of Health & Family Welfare, Department of Health, Government of India, Civil Lines, New Delhi, Vol-I. 1st edition. 59.
The Wealth of India (Raw Material) (1972). Publication and Information Directorate, CSIR, New Delhi. Vol-IX. 393.
Govindan, S., Vishwanathan, S., Vijayasekaran, V., Alagappa, R. A Pilot study on the clinical efficacy of Solanum xanthocarpum and Solanum trilobatum in bronchial asthma. J Ethnopharm. 66(2), 205 (1999). https://doi.org/10.1016/S0378-8741(98)00160-3
Bector, N. P. & Puri, A. S.. Solanum xanthocarpum (Kanthkari) in chronic bronchitis, bronchial asthma, and non-specific unproductive cough (an experimental and pre-clinical co-relatiion). J Assoc physician India. 19(10), 741 (1971).
Jain, J. P. A clinical trial of kantkari (Solanum xanthocarpum) in case of tamak swasa (some respiratory diseases). J Res Ayur Siddh. 1, 447–460 (1980).
Williamson, E. M (1998). Major Herbs of Ayurveda. 1st edition. New York: Elsevier Health Sciences Publications. 271–273.
Kanwar, U., Batla, A., Sanyal, S. N. and Ranga, A. Glycolytic enzyme activities of human and bovine spermatozoa treated in vitro with solasodine. J Ethnopharmacol. 28(2), 249–254 (1990). https://doi.org/10.1016/0378-8741(90)90035-R
Mali, P. C. & Chaturvedi, M. Antispermatogenic activity of Solanum xanthocarpum (50 percent EtOH-extract) in rats. J phytologic Res. 9(1), 13 (1996).
Singh, K. V. and Bansal, S. K. Larvicidal properties of a perennial herb Solanum xanthocarpum against vectors of malaria and dengue/DHF, Current Science. 84(6), 749–751 (2003).
Nadkarni, K. M. (1995). Indian Materia Medica2nd edition. Vol-I. Mumbai: Popular Prakashan, 1156.
Kirtikar, K. R. & Basu, B. D. (1988). Indian Medicinal Plants 2nd edition, VolIII, Allahabad: Lalit Mohan Basu, 1759.
Kurup, P. N. V. (1977). Handbook of Medicinal Plants, Vol-II. New Delhi: CCRIMH, 48.
Karnick, C. R. (1994). Pharmacopoeial Standards of Herbal Plants. New Delhi: Sri Satguru Publications.
Sharma, P. C., Yelane, M. P. and Dennis, T. J. (2002). Data base on Medicinal Plants used in Ayurveda Vol-I. New Delhi: Central Council for Research in Ayurveda and Siddha.
Ali, SS., Kasoju, N., Luthra, A., Singh, A., Sharanabasava, H., Sahu, A., Bora, U. Indian medicinal herbs as sources of antioxidants. Food Res Int, 41(1), 1–15 (2008). https://doi.org/10.1016/j.foodres.2007.10.001
Keshavamurthy, K. R. & Yoganarasimhan, S. N. (1990). Flora of Coorg (Kodagu) Karnataka. Bangalore: Vimsat Publishers.
Gamble, J. S. (1967). The Flora of the Presidency of Madras, Vol-I. Calcutta: BSI Publishers.
Capucino, J. G. & Sherman, N. (1999). Microbiology a laboratory manual, 4th edition, California: Addison Wesley langman Inc., 263.
Gunasekaran, R. Indian J Nat. Pro., 22(1), 11 (2006).
Chhajed, M. R., Khedekar, P. B., Mundhey, A. S.. Synthesis and free radical scavenging activity of some 1, 3, 4-thiazole derivative. Indian J Heterocyc chem., 16, 259–22 (2007).
Chhajed, M. R., Tomar, G. S., Gautam, S. P., Hariharan, A. G. Phytochemical Investigation and Evaluation of In-vitro Free Radical Scavenging Activity of Flickingeria nodosa Lindl. Indian J Pharm. Edu Res., 42(4), 377–380 (2008).
Talesara, G. L., Sharma, R., Nagda, D. P., ARKIVOC. i, 1-12 (2006).
Halliwell, B., Gutteridge, J. M. C. Oxygen toxicity, oxygen radicals, transition metals and diseases. Biochem J., 219, 1–4 (1984). https://doi.org/10.1042/bj2190001
D’Mello, P. M., Jadhav, M. A., Jolly, C. I. Free radical scavenging activity of Syzygium cumini and Ficus bengalensis-plants used in Ayurveda for diabetes mellitus. Indian Drugs, 37(11), 518–520 (2000).
Geronikaki, A., Litina, D. H., Chatziopoulos, C., Soloupis, G. Synthesis and biological evaluation of new 4,5-disubstituted-thiazolyl amides, derivatives of 4-hydroxy-Piperidine or of 4-N-methyl piperazine. Molecules, 8, 472–479 (2003). https://doi.org/10.3390/80600472
Nicholls, D. G., Budd, S. L. Mitochondria and neuronal survival. Physiol Rev, 80, 315–360 (2000). https://doi.org/10.1152/physrev.2000.80.1.315
Thomas M. J. The role of free radicals and antioxidants. Nutrition, 16(7-8), 716 (2000). https://doi.org/10.1016/S0899-9007(00)00343-9
Patil, S., Jolly, C.I., Narayanan, S. Free radical scavenging activity of Acacia catechu and Rotula aquitica : implication in cancer therapy. Indian Drugs, 40(6), 328–332 (2003).
Matill, H. A. Antioxidants. Annu Rev Biochem, 16, 177–192 (1947). https://doi.org/10.1146/annurev.bi.16.070147.001141
Harborne, J. B. (1984). Phytochemical method- A guide to modern technique of plant analysis 2nd edition. New York: Chapman and Hall, 85.
Copyright (c) 2018 Journal of Pharmaceutical Technology, Research and Management
This work is licensed under a Creative Commons Attribution 4.0 International License.
Articles in Journal of Pharmaceutical Technology, Research And Management (J. Pharm. Technol. Res. Manag.) by Chitkara University Publications are Open Access articles that are published with licensed under a Creative Commons Attribution- CC-BY 4.0 International License. Based on a work at https://jptrm.chitkara.edu.in. This license permits one to use, remix, tweak and reproduction in any medium, even commercially provided one give credit for the original creation.
View Legal Code of the above mentioned license, https://creativecommons.org/licenses/by/4.0/legalcode
View Licence Deed here https://creativecommons.org/licenses/by/4.0/
|Journal of Pharmaceutical Technology, Research And Management by Chitkara University Publications is licensed under a Creative Commons Attribution 4.0 International License.
Based on a work at https://jptrm.chitkara.edu.in