Traditional and Novel Herbal Drugs Emerging as Potent Novel Combinations for Managing Morbidities by Pharmacological and Mechanistic Studies
Background: Herbal drugs are used in treatment of diseases since decades. Major contributing factor for their use is easy availability, less expensive and more belief of common population because of relatively less side effects compared to allopathic medicines. Medicines of natural origin or functional foods in the prevention of disease are the need of hour. Hence, the present review focused on activity of four drugs viz. Withania somnifera,Allium sativum,Curcuma longa andAzadirachta indica and role in different clinical complications.
Methods: A thorough review of all the articles, research as well as reviews available regarding the concerned topic was performed. MEDLINE database was searched and English language articles were preferably selected.
Results: Withania somnifera, Allium sativum, Curcuma longa andAzadirachta indicahave shown alleviation in inflammation, diabetes and cancer states. The herbal drugs have shown beneficial effects in the prevention and treatment of these disorders. Conclusion from these facts:Utilizing this concept, it can be assumed that herbal drugs play an intricate role in safeguarding the health of individuals from life-threatening complications. However, validation and reproducibility of results in clinical trails should be there in order to confirm the safety and
efficacy of these herbal drugs.
Abiy, E., Berhe, A. (2016) Anti-Bacterial Effect of Garlic (Allium sativum) against Clinical Isolates of Staphylococcus aureus and Escherichia coli from Patients Attending Hawassa Referral Hospital, Ethiopia. Journal of Infectious Diseases and Treatment,2, 2. https://doi.org/10.21767/2472-1093.100023
Agita A, Alsagaff MT. (2017) Inflammation, Immunity, and Hypertension. Acta Med Indones,49,158-165. https://doi.org/10.1161/HYPERTENSIONAHA.110.16357641
Akter, R., Mahabub-Uz-Zaman, M., Rahman, MS., Khatun, MA, Abdullah AM, Ahmed, NU., Islam, F. (2013) Comparative studies on antidiabetic effect with a phytochemical screening of Azadirachta indicia and Andrographis paniculata. IOSR Journal of Pharmacy and Biological Sciences, 5, 122–128. e-ISSN:2278–3008.
Akuri, M. C., Barbalho, S. M., Val, R. M., & Guiguer, E. L. (2017). Reflections about Osteoarthritis and Curcuma longa. Pharmacognosy Reviews, 11, 8–12. https://doi.org/10.4103/phrev.phrev_54_16
Andallu, B., Radhika, B. (2000) Hypoglycemic, diuretic and hypocholesterolemic effect of winter cherry (Withania somnifaria, Dunal) root. Indian Jour Exp Bio, 38, 607–609. PMID: 11116534.
Aneesh, T., Hisham, M., Sekhar, M., Madhu, M., Deepa, T. (2009) International market scenario of traditional Indian herbal drugs-India declining. International Journal of Green Pharmacy, 3, 184–190.https://doi.org/10.4103/0973-8258.5627
Anjali, K., Ritesh, K., Sudarshan, M., Jaipal, S. C., Kumar, S. (2013) Antifungal efficacy of aqueous extracts of neem cake, karanj cake and vermicompost against some phytopathogenic fungi. The Bioscan, 8, 671–674.
Anushka, S., Rajendran, P., Vedha, V., Ashok, G., Kannan M., and Karthikeyan, M. (2011) A study on the anti-viral properties of Azadirachta indica (A.Juss, Neem) against HBV, HIV, HSV-I, Vaccinia and Varicella zoster viruses and Coscinium fenestratum (Gaertn.) Colebr, Tree turmeric) against HBV and HIV. Biomedicine, 31, 482–486.
Badam, L., Joshi, SP., Bedekar, SS. (1999) In vitro’ antiviral activity of neem (Azadirachta indica. A. Juss) leaf extract against group B Coxsackieviruses. J Commun Dis, 31, 79–90. PMID: 10810594
Banerjee, S. K., Mukherjee, P. K., Maulik, S. K. (2003) Garlic as an antioxidant: the good, the bad and the ugly. Phytotherapy Research, 17, 97–106.https://doi.org/10.1002/ptr.1281
Barbara, G., Stanghellini, V., De Giorgio, R., Cremon, C., Cottrell, GS., Santini, D., Pasquinelli, G., Morselli-Labate, AM., Grady, EF., Bunnett, NW., et al. (2004) Activated mast cells in proximity to colonic nerves correlate with abdominal pain in irritable bowel syndrome. Gastroenterology,126, 693–702. PMID: 14988823
Benavides, G. A., Squadrito, G. L., Mills, R. W., Patel, H. D., Isbell, T. S., Patel, R. P., DarleyUsmar, V. M., Doeller, J. E., Kraus, D. W. (2007) Hydrogen sulfide mediates the vasoactivity of garlic. PNAS, 104, 17977–17982. https://doi.org/10.1073/pnas.0705710104
Bhattacharya, S. K., Muruganandam, A. V. (2003) Adaptogenic activity of Withania somnifera: an experimental study using a rat model of chronic stress. Pharmacol Biochem Behav, 75, 547–55. PMID: 12895672
Borek, C. (2006) Garlic reduces dementia and heart-disease risk. J. Nutr,136,810–812. https://doi.org/10.1093/jn/136.3.810S
Cancer Research UK. (2018)http://www.cancerresearchuk.org/health-professional/cancer-statistics/worldwide-cancer
Cerella, C., Dicato, M., Jacob, C., Diederich, M. (2011) Chemical properties and mechanisms determining the anti-cancer action of garlic-derived organic sulfur compounds. Anti-Cancer Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry-Anti-Cancer Agents),11, 267–71.https://doi.org/10.2174/187152011795347522
Chatterjee, A., Pakrashi, S. C. (1995) The Treatise on Indian Medicinal Plants. New Delhi, Publication and Information Directorate, 4, 208–212.http://www.niscair.res.in/ActivitiesandServices/Products/products.htm
Chopra, I. C., Gupta, K. C., Nazir, B. N. (1952) Preliminary study of antibacterial substances from Melia azidirachta. Indian. J Med Res, 40, 511–515. PMID: 13061059
Chung, L. Y. (2006). The antioxidant properties of garlic compounds: allyl cysteine, alliin, allicin, and allyl disulfide. J Med Food, 9, 205–13.https://doi.org/10.1089/jmf.2006.9.205.
Daka, D. (2011) Antibacterial effect of garlic (Allium sativum) on Staphyloccus aureus: An in vitro study. African Journal of Biotechnology, 10, 666–669.https://doi.org/10.5897/AJB09.553
Das, K. K., Das, S. N., and Dasgupta, S. (2001) The influence of ascorbic acid on nickel induced hepatic lipid peroxidation in rats. J. Basic Clin. Physiol Pharmacol,12, 187–194. PMID: 11762690
Debella, A. (2004) Procedures in preparation of Medicine from plants. Aartistic Printing Press, Addis Ababa.
Eidi, A., Eidi, M., Esmaeili, E. (2006) Antidiabetic effect of garlic (Allium sativum L.) in normal and streptozotocin-induced diabetic rats. Phytomedicine, 13, 624–9. https://doi.org/10.1016/j.phymed.2005.09.010
Eltaweel, M. A. (2014) Antibacterial Effect of Garlic (Allium Sativum) On Staphylococcus Aureus: An In Vitro Study. In International Conference on Advances in Environment, Agriculture & Medical Sciences (ICAEAM’14).
Gannon, J. M., Forrest, P. E. Roy, Chengappa, K. N. (2014) Subtle changes in thyroid indices during a placebo-controlled study of an extract of Withania somnifera in persons with bipolar disorder. Journal of Ayurveda and Integrative Medicine, 5, 241–245. https://doi.org/10.4103/0975-9476.146566
Gauttam, V. K., Kalia, A. N. (2013) Development of polyherbal antidiabetic formulation encapsulated in the phospholipids vesicle system. Journal of Advanced Pharmaceutical Technology & Research, 4, 108–117.https://doi.org/10.4103/2231-4040.111527
Gbotolorun, S., Osinubi, A., Noronha, C., & Okanlawon, A. (2008) Antifertility potential of Neem flower extract on adult female Sprague-Dawley rats. African Health Sciences, 8, 168–173.PMID: 19357745
Ghonmode, W. N., Balsaraf, O. D., Tambe, V. H., Saujanya, K. P., Patil, A. K., Kakde, D. D. (2013) Comparison of the antibacterial efficiency of neem leaf extracts, grape seed extracts and 3% sodium hypochlorite against E. feacalis—an in vitro study. Journal of International Oral Health, 5, 61–66.PMID: 24453446
Ghorbani, Z., Hekmatdoost, A., Mirmiran, P. (2014) Anti-hyperglycemic and insulin sensitizer effects of turmeric and its principle constituent curcumin. International journal of endocrinology and metabolism, 12, e18081.https://doi.org/10.5812/ijem.18081
Goel, A., Aggarwal, B. B. (2010) Curcumin, the golden spice from Indian saffron, is a chemosensitizer and radiosensitizer for tumors and chemoprotector and radioprotector for normal organs. Nutrition and Cancer, 62, 919–30.https://doi.org/10.1080/01635581.2010.509835
Gorelick, J., Rosenberg, R., Smotrich, A., Hanus, L., Bernstein, N. (2015) Hypoglycemic activity of withanolides and elicitated Withania somnifera. Phytochemistry,116, 283–289. https://doi.org/.10.1016/j.phytochem.2015.02.029
Govindachari, T.R., Suresh, G., Gopalakrishnan, G., Banumathy, B., Masilamani, S. (1998) Identification of antifungal compounds from the seed oil of Azadirachta indica . Phytoparasitica, 26, 109–116. https://doi.org/10.1007/BF02980677
Grandhi, A., Mujumdar, A.M., Patwardhan, B.A. (1994) Comparative pharmacological investigation of Ashwagandha and Ginseng. J Ethnopharmacol, 44, 131–135.PMID: 7898119
Gupta, A., Singh, S. (2014) Evaluation of anti-inflammatory effect of Withania somniferaroot on collagen-induced arthritis in rats. Pharm Biol, 52, 308–20. https://doi.org10.3109/13880209.2013.835325
Gupta, S. C., Reuter, S., Phromnoi, K., Park, B., Hema, P. S., Nair, M., Aggarwal, B. B. (2011) Nimbolide sensitizes human colon cancer cells to TRAIL through reactive oxygen species-and ERK-dependent up-regulation of death receptors, p53, and Bax. Journal of Biological Chemistry, 286, 1134–46.https://doi.org/10.1074/jbc.M110.191379
Hendrick, V., Altshuler, L., Whybrow, P. (1998) Psychoneuroendocrinology of mood disorders: The hypothalamic-pituitary-thyroid axis. Psychiatr Clin North Am, 21, 277–92. PMID: 9670226
Henrotin, Y., Priem, F., & Mobasheri, A. (2013). Curcumin: a new paradigm and therapeutic opportunity for the treatment of osteoarthritis: curcumin for osteoarthritis management. SpringerPlus,2, 56.https://doi.org/10.1186/2193-1801-2-56
Hodge, G., Hodge, S., Han, P. (2002) Allium sativum (garlic) suppresses leukocyte inflammatory cytokine production in vitro: potential therapeutic use in the treatment of inflammatory bowel disease. Cytometry, 48, 209–215.https://doi.org/10.1002/cyto.10133
Hornícková, J., Kubec, R., Cejpek, K., Velíšek, J., Ovesná, J., Stavelíková, H. (2010) Profiles of S-alk (en) ylcysteine sulfoxides in various garlic genotypes. Czech Journal of Food Sciences, 28, 298–308. https://doi.org/20103329663
Islam, M. S., Kusumoto, Y., Al-Mamun, M. A. (2011) Cytotoxicity and cancer (HeLa) cell killing efficacy of aqueous garlic (Allium sativum) extract. Journal of Scientific Research, 3, 375–382. https://doi.org/210.3329/jsr.v3i2.6557
Jackson, R., McNeil, B., Taylor, C., Holl, G., Ruff, D., Gwebu, E. T. (2002) Effect of aged garlic extract n caspase-3 activity in vitro. Nutritional Neuroscience, 5,287–290. https://doi.org/10.1080/10284150290032012
Jalil, A., Ashfaq, U. A., Shahzadi, S., Javed, M. R., Rasul, I., Rehman, S. U., Shah, M., Masoud, M. S. (2013) Screening and design of anti-diabetic compounds sourced from the leaves of neem (Azadirachta indica). Bioinformation, 9,1031–1035. https://doi.org/10.6026/97320630091031
Janan, M., Sakih, Alaa, T., Monawer, Ismaeil, M., Abdulikhar. (2016) Antibacterial activity of garlic against multidrug resistance Staphylococcus Aureus and Enterococcus faecalis. In Duhok City Journal of University of Duhok.Pure and Eng. Sciences, 19, 114–122.
Jang, G.H., Ha, J.H., Huh, T.L., and Lee, Y.M. (2008) Effect of proton beam on blood vessel formation in early developing zebrafish (Danio rerio) embryos.Archives of Pharmacal Research, 31, 779–785.https://doi.org/10.1007/s12272-001-1226-1
Julie, S., Jurenka, M. T. (2009) Anti-inflammatory properties of curcumin, a major constituent. Altern Med Rev, 14, 141–53. PMID: 19594223
Kalinowska, A., Orlinska, B., Panasiuk, M., Jamiolkowska, M., Zasim, A., Florys, B., Wojtkielewicz, K., Luczynski, W., Glowinska-Olszewska, B., Bossowski, A. (2017) Assessment of preservation of beta-cell function in children with long-standing type 1 diabetes with “ultrasensitive c-peptide” method. Pediatr Endocrinol Diabetes Metab, 23, 130–138. https://doi.org/10.18544/pedm-23.03.0084
Kalogeris, T., Baines, C. P., Krenz, M., Korthuis, R. J. (2012) Cell Biology of Ischemia/Reperfusion Injury. International review of cell and molecular biology,298, 229-317. https://doi.org/10.1016/B978-0-12-394309-5.00006-7
Khajehdehi, P. (2012) Turmeric: Reemerging of a neglected Asian traditional remedy.J Nephropathol,1, 17–22. https://doi.org/10.5812/jnp.5
Koley, K. M., Lal, J. (1994) Pharmacological effects of Azadirachta indica(neem) leaf extract on the ECG and blood pressure of rat. Indian journal of physiology and Pharmacology, 38, 223–-5. PMID:7814089
Le Marchand, L. (2002) Cancer preventive effects of flavonoids—a review. Biomedicine and Pharmacotherapy, 56, 296–301. PMID: 12224601
Lee, D.Y., Li, H., Lim, H. J., Lee, H. J., Jeon, R., Ryu, J. H. (2012) Anti-inflammatory activity of sulfur-containing compounds from garlic. Journal of medicinal food, 15, 992–9. https://doi.org/10.1089/jmf.2012.2275
Lee, J. W., Ryu, H. W., Park, S. Y., Park, H. A., Kwon, O. K., Yuk, H. J., Shrestha, K. K., Park, M., Kim, J. H., Lee, S., Oh, S. R., Ahn, K. S. (2017) Protective effects of neem (Azadirachta indica A. Juss.) leaf extract against cigarette smoke- and lipopolysaccharide-induced pulmonary inflammation. Int J Mol Med, 40,1932-1940. https://doi.org/10.3892/ijmm.2017.3178
Mrudula, T., Suryanarayana, P., Srinivas, P. N., Reddy, G.B. (2007) Effect of curcumin on hyperglycemia-induced vascular endothelial growth factor expression in streptozotocin-induced diabetic rat retina. Biochemical and biophysical research communications, 361, 528–32. https://doi.org/10.1016/j.bbrc.2007.07.059
Nagpal, M., Sood, S. (2013) Role of curcumin in systematic and oral health: An overview. Journal of natural science, biology and medicine, 4, 3–7. https://doi.org/10.4103/0976-9668.107253
Naik, M. R., Bhattacharya, A., Behera, R., Agrawal, D., Dehury, S., Kumar, S. (2014) Study of anti-inflammatory effect of neem seed oil (Azadirachta indica) on infected albino rats. Journal of Health Research and Reviews, 1, 66–69. https://doi.org/10.4103/2394-2010.153880
Othman, F. G. M., Peng, S. L., Rahmat, A., Basri, R., Pei, C. P. (2012) Effect of neem leaf extract (Azadirachta indica) on c-Myc oncogene expression in 4T1 breast cancer cells of BALB/c mice. Cell Journal (Yakhteh), 14, 53–60. PMID: 23626938
Padiya, R., Khatua, T. N., Bagul, P. K., Kuncha, M., Banerjee, S. K. (2011) Garlic improves insulin sensitivity and associated metabolic syndromes in fructose fed rats. Nutrition & Metabolism, 8, 53–60. https://doi.org/10.1186/1743-7075-8-53
Patel, B. B., Majumdar, A. P. (2009) Synergistic role of curcumin with current therapeutics in colorectal cancer: minireview. Nutr Cancer,61, 842–846.https://doi.org/10.1080/01635580903285106
Patil, P., Patil, S., Mane, A., Verma, S. (2013) Antidiabetic activity of alcoholic extract of Neem (Azadirachta indica) root bark. National Journal of Physiology, Pharmacy and Pharmacology, 3, 142–6. https://doi.org/10.5455/njppp.2013.3.134-138
Queiroz, A. C., Gagliardi, J. F., Forjaz, C. L., Rezk, C. C. (2009) Clinic and ambulatory blood pressure responses after resistance exercise. J Strength Cond Res, Champaign, 23, 571–578. https://doi.org/10.1519/JSC.0b013e318196b637
Rachel, W., Lily, S., and Kamal, A. (2013) Priority Medicines for Europe and the World. www.who.int/medicines/areas/priority_medicines/BP6_12Osteo.pdf
Rahmani, A. H., Alzohairy, M. A., Khan, M. A., Aly, S. M. (2014) Therapeutic implications of black seed and its constituent thymoquinone in the prevention of cancer through inactivation and activation of molecular pathways. Evidence-Based Complementary and Alternative Medicine, 18, 2014. https://doi.org/10.1155/2014/724658
Rai, M., Jogee, P. S., Agarkar, G., dos Santos C. A. (2016) Anticancer activities of Withania somnifaria: Current research, formulations, and future perspectives. Pharm Biol, 54, 189–97. https://doi.org/10.3109/13880209.2015.1027778
Rajeev, N., Sarita, K., Alka, P. (2014) Anticancer activity of Allium sativum (Bulb) polyphenolic compound.Int. J. Pharm. Sci. Rev. Res, 29, 131–134. ISSN 0976 – 044X.
Reuland, D. J., Khademi, S., Castle, C. J., Irwin, D. C., McCord, J. M., Miller, B. F., Hamilton, K. L. (2013) Upregulation of phase II enzymes through phytochemical activation of Nrf2 protects cardiomyocytes against oxidant stress. Free Radic Biol Med, 56, 102–11. https://doi.org/10.1016/j.freeradbiomed.2012.11.016
Riar, S. S., Devakuma, C., Ilavazhagam, G., Kain, A. K., Bardham, J. (1991) Antifertility activities of volatile fraction of Neem oil.Contraception, 44,319–326. https://doi.org/10.1016/0010-7824(91)90021-7
Sangita, C., Priyanka, C., Protapaditya, D., Sanjib, B. (2012) Evaluation of Anti-inflammatory Effect of Ashwagandha: A Preliminary Study in vitro. Pharmacognosy Journal, 4, 47–49. https://doi.org/10.5530/pj.2012.29.7
Satarupa, P., Aparna, L. I., Priyanka, P. (2015) Anti-inflammatory activity of aquesh extract of Allium sativum leaves. Asian J Pharm Clin Res, 8, 78–80. Online ISSN: 2455–3891
Satyavati, G. V., Raina, M. K., Sharma, M., editors. (1976) Medicinal Plants of India Volume 1. New Delhi: Indian Council of Medical Research.
Scarpignato, C., Lanas, A., Blandizzi, C., Lems, W.F., Hermann, M., Hunt, R. H., International, NSAID, Consensus, Group. (2015) Safe prescribing of non-steroidal anti-inflammatory drugs in patients with osteoarthritis – An expert consensus addressing benefits as well as gastrointestinal and cardiovascular risks. BMC Med, 13, 55. https://doi.org/10.1186/s12916-015-0285-8
Setty Balakrishnan, A., Nathan, A. A., Kumar, M., Ramamoorthy, S., & Ramia Mothilal, S. K. (2017) Withania somnifera targets interleukin-8 and cyclooxygenase-2 in human prostate cancer progression. Prostate International, 5, 75–83. http://doi.org/10.1016/j.prnil.2017.03.002
Shah, N. C. (2014) Allium sativum (Garlic): The Folk and Modern uses- Part II. The Scitech Journal, 1, 31–36. ISSN 2348-2311
Sharma, A.K., Basu, I., Singh, S. (2017) Efficacy and Safety of Ashwagandha Root Extract in Subclinical Hypothyroid Patients: A Double-Blind, Randomized Placebo-Controlled Trial. J Altern Complement Med, 24, 243–248. https://doi.org/10.1089/acm.2017.0183
Shehzad, A., Lee, Y. S. (2010) Curcumin: Multiple molecular targets mediate multiple pharmacological actions. Drugs of the future, 35, 113–30. https://doi.org/10.4236/jct.2015.63029
Sogani, R. K., Katoch, K. (1981) Correlation of Serum cholesterol levels and incidence of myocardial infarction with dietary onion and garlic eating habits. J. Assoc. Physicians India, 29, 443–446. PMID: 7319999
Srinath, R. K., Shah, B., Varghese, C., Ramadoss, A. (2005) Responding to the threat of chronic diseases in India. Lancet, 366, 1744–1749.
Subapriya, R., Kumaraguruparan, R., Nagini, S. (2006) Expression of PCNA, cytokeratin, Bcl-2 and p53 during chemoprevention of hamster buccal pouch carcinogenesis by ethanolic neem (Azadirachta indica) leaf extract. Clinical Biochemistry, 39, 1080–7. https://doi.org/10.1016/j.clinbiochem.2006.06.013
Tiwari, V., Darmani, N. A., Yue, B. Y. J. T., Shukla D. (2010) In vitro antiviral activity of neem (Azardirachta indica L.) bark extract against herpes simplex virus type-1 infection. Phytotherapy Research, 24, 1132–1140. https://doi.org/10.1002/ptr.3085
Upadhyay, S. N., Dhawan, S., Talwar, G. P. (1993) Antifertility Effects of Neem (Azadirachta indica) Oil in Male Rats by Single Intra-Vas Administration: An Alternate Approach to Vasectomy. Journal of Andrology, 14, 275–281.PMID: 8226307
Updhyay, S., Kaushi, C., Talwar, G. P. (1990) Antifertility effects of Neem oil by single intrauterine administration: A novel method of contraception. Proc The Royal Soc Lond, 242, 175–179. https://doi.org/10.1098/rspb.1990.0121
Wang, J., Zhang, X., Lan, H., Wang, W. (2017) Effect of garlic supplement in the management of type 2 diabetes mellitus (T2DM): a meta-analysis of randomized controlled trials. Food & nutrition research, 61, 1377571. https://doi.org/10.1080/16546628.2017.137757
WHO traditional medicine strategy: 2014-2023, 2014.
World health organization (WHO) (2003) Fifth-sixth world health assembly, A56/18.
Yadav, B., Bajaj, A., Saxena, M., Saxena, A. K. (2010) In Vitro Anticancer Activity of the Root, Stem and Leaves of Withania somnifera against Various Human Cancer Cell Lines. Indian Journal of Pharmaceutical Sciences, 72,659–663. https://doi.org/10.4103/0250-474X.78543
Yeh, G. Y., Davis, R.B., Phillips, R.S. (2006) Use of Complementary Therapies in Patients with Cardiovascular Disease. Am. J. Card, 98, 673–680. https://doi.org/10.1016/j.amjcard.2006.03.051
Zhi, L., Dong, L., Kong, D., Sun, B., Sun, Q., Grundy, D., Zhang, G., Rong, W. (2013) Curcumin acts via transient receptor potential vanilloid-1 receptors to inhibit gut nociception and reverses visceral hyperalgesia. Neurogastroenterol Motil, 25, e429–e440. https://doi.org/10.1111/nmo.12145
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