J. Pharm. Technol. Res. Manag.

Systemic Review: Sexual Dysfunction in Women with type 2 Diabetes Mellitus

Mr. Ravinder Kumar, Diksha Gera, Govind Arora, Ms. Pratima K. Syal


Diabetes; hyperglycaemia; sexual dysfunction

PUBLISHER The Author(s) 2018. This article is published with open access at www.chitkara.edu.in/publications.

Diabetes would not just have a high blood glucose level in the individual body, yet these days diabetes likewise goes with numerous other organic issues like hypertension, feeble the myocardial layer working, sexual broke, and so on. These are some real issue which is these days joined by diabetes to a person’s body. Guys are for the most part being determined to have the sexual broke issue, guys, as well as experience a sexual broke issue. As similarly we may see less clinical examinations, including sexual broke issues looked for the sort two diabetic ladies. The primary goal of this article is to illuminate the situation that females proceed with much trouble with regards to the sexual broke Complication that might be physiological or neurotic if there should arise an occurrence of sorting two diabetes in ladies. It chiefly involves the useful extent of females like sexual drive, excitement, vaginal grease, Orgasm and general fulfilment space. Talking about the treatmentaccess of the ailment in the analytic way for it, Diabetes essentially hinders the sexual execution of Diabetic Women. Determinants of sexual ability incorporate age and extent of diabetes.


Diabetes mellitus is the most frequently occurring chronic disease worldwide and is characterized by hyperglycaemia. It is known to rise speedily with over 550 million to be affected by 2030 [1] among all the countries in the world. The prevalence of the disease is also rising with agrowing population, aging, urbanization, physical inactivity and obesity, which will further worsen the situation of disease [2]. In diabetes mellitus is an outcome of impaired metabolism of fats, lipids, carbohydrates and proteins as well. It is found to be responsible for several organfailurelike renal failure, heart failure, and sexual dysfunction[3]. However, most of the patients with diabetes die due to cardiovascular diseases like stroke. It occurs at a stage when diabetes becomes chronic. Diabetes Mellitusacting an imperative role in the pathogenesis of sexual dysfunction among both females and males. Many studies have been accomplish to study sexual dysfunction in diabetic males, but there are lesser data available in diabetic females due to a number of reasons like a small sample size. According to a study conducted by Pontiroli et al. [4] and Enzlin et al. [5] The prevalence rate for females lies between 25-71% and 27% respectively. Moreover, large epidemiological studies suggested that the prevalence of sexual dysfunction ranges from 40-60% with higher rates found in postmenopausal women. There are many factors that are responsible for the etiology of sexual dysfunction among females such as neurological, psychological as well as vascular factors [6-10]. Although, the data available for neurological factors areless. Yet some neurological disorders like multiple sclerosis, lumbar radiculopathy etc. Can result in dysfunction of female genital organs [7-10].

The most common and the most useful observation is the Prevalence of diabetes in Asia people mainly it lowers the BMI of the diabetic people.

The main reason is that the Asians are recorded as the most prominent race by the IOTF to be prone to the diabetic nature due to the high adiposity content.

Page(s) 143-151
URL http://dspace.chitkara.edu.in/jspui/bitstream/123456789/792/1/JPTRM%206-2-5.pdf
ISSN Print : 2321-2217, Online : 2321-2225
DOI 10.15415/jptrm.2018.62011

Diabetes mellitus is a leading public health concern across worldwide, which are growing at a faster rate affecting half of the population due to age, urbanization, physical inactivity, obesity, etc. Diabetes also affects the cardiovascular system, psychological and sexual dysfunction to a great extent. The prevalence rate of erectile dysfunction approaches to 50% among males, but the data for females are less conclusive due to a small sample size. There are many risk factors that are responsible for sexual impairment in females out of which psychological issues are considered to be as the main determinant of female sexual dysfunction. Depression plays a major role in the pathogenesis of FSD and interpersonal relationships and may result in poor quality of life.Recent studies indicate that diabetic women are at higher risk for developing sexual dysfunction as compared to women without diabetes. The adoption of a healthy lifestyle and exercise can help in preventing and treating these disorders and also lowering the burden of chronic diseases. However, depression can be treated with some antidepressants. By adopting all of these can help improve sexual activity and well being of an individual.

  • Wild, S., Roglic, G., Green, A., Sicree, R., & King, H. (2004). Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Diabetes care, 27(5), 1047–1053. https://doi.org/10.2337/diacare.27.5.1047
  • Dennerstein, L., Randolph, J., Taffe, J., Dudley, E., & Burger, H. (2002). Hormones, mood, sexuality, and the menopausal transition. Fertility and Sterility, 77, 42–48. https://doi.org/10.1016/S0015-0282(02)03001-7
  • Pontiroli, A. E., Cortelazzi, D., & Morabito, A. (2013). Female sexual dysfunction and diabetes: A systematic review and meta?analysis. The journal of sexual medicine, 10(4), 1044–1051. https://doi.org/10.1111/jsm.12065
  • Enzlin, P., Mathieu, C., Van den Bruel, A., Vanderschueren, D., & Demyttenaere, K. (2003). Prevalence and predictors of sexual dysfunction in patients with type 1 diabetes. Diabetes care, 26(2), 409–414. https://doi.org/10.2337/diacare.26.2.409
  • Lehman PT, Jacobs JA. (2006). Etiology of diabetic impotence. J Urol 129, 291–294. Lehman, T. P., & Jacobs, J. A. (1983). Etiology of diabetic impotence. The Journal of urology, 129(2), 291–294. https://doi.org/10.1016/S0022-5347(17)52057-1
  • Li, H., Qi, T., Huang, Z. S., Ying, Y., Zhang, Y., Wang, B., ... & Chen, J. (2017). Relationship between gut microbiota and type 2 diabetic erectile dysfunction in Sprague-Dawley rats. Journal of Huazhong University of Science and Technology [Medical Sciences], 37(4), 523–530. https://doi.org/10.1007/s11596-017-1767-z
  • Buvat, J., Lemaire, A., Buvat-Herbaut, M., Guieu, J. D., Bailleul, J. P., & Fossati, P. (1985). Comparative investigations in 26 impotent and 26 nonimpotent diabetic patients. The Journal of urology, 133(1), 34–38. https://doi.org/10.1016/S0022-5347(17)48773-8
  • Kim, B. H., & Son, S. M. (2006). Mechanism of developing diabetic vascular complication by oxidative stress. Journal of Korean Endocrine Society, 21(6), 448–459. https://doi.org/10.3803/jkes.2006.21.6.448
  • Skrha, J. (2003). Pathogenesis of angiopathy in diabetes. Acta diabetologica, 40(2), s324–s329. https://doi.org/10.1007/s00592-003-0113-z
  • Orasanu, G., & Plutzky, J. (2009). The pathologic continuum of diabetic vascular disease. Journal of the American College of Cardiology, 53(5 Supplement), S35–S42. https://doi.org/10.1016/j.jacc.2008.09.055
  • Doumas, M., Tsiodras, S., Tsakiris, A., Douma, S., Chounta, A., Papadopoulos, A., & Giamarellou, H. (2006). Female sexual dysfunction in essential hypertension: a common problem being uncovered. Journal of hypertension, 24(12), 2387–2392. https://doi.org/10.1097/01.hjh.0000251898.40002.5b
  • International Diabetes Federation (2012) Diabetes Atlas. Brussels, Belgium: International Diabetes Federation, 5th ed.
  • Owiredu, W. K., Amidu, N., Alidu, H., Sarpong, C., & Gyasi-Sarpong, C. K. (2011). Determinants of sexual dysfunction among clinically diagnosed diabetic patients. Reproductive Biology and Endocrinology, 9(1), 70. https://doi.org/10.1186/1477-7827-9-70
  • Basson, R., Berman, J., Burnett, A., Derogatis, L., Ferguson, D., Fourcroy, J.,& Leiblum, S. (2000). Report of the international consensus development conference on female sexual dysfunction: definitions and classifications. The Journal of urology, 163(3), 888–893. https://doi.org/10.1016/S0022-5347(05)67828-7 https://doi.org/10.1097/00005392-200003000-00043
  • American Psychiatric Association (2013).Highlights of changes from DSM-IV to DSM-5. In: Diagnostic and Statistical Manual of Mental Disorders. 5th ed. Arlington, VA: American Psychiatric Association.
  • Veronelli, A., Mauri, C., Zecchini, B., Peca, M. G., Turri, O., Valitutti, M. T.,& Pontiroli, A. E. (2009). Sexual dysfunction is frequent in premenopausal women with diabetes, obesity, and hypothyroidism, and correlates with markers of increased cardiovascular risk. A preliminary report. The journal of sexual medicine, 6(6), 1561–1568. https://doi.org/10.1111/j.1743-6109.2009.01242.x
  • Khalilzadeh, E. M. A. D., Hazrati, R. E. Z. A., Vafaie Sayah, G., & Hasannejad, H. A. M. I. D. E. H. (2015). Opioidergic and cholinergic but not nitric oxide pathways are involved in antinociceptive activity of Vitex agnus-castus essential oil in the acute trigeminal model of pain in rat. Asian J Pharm Clin Res, 8(1), 283–286.
  • Esposito, K., Ciotola, M., Marfella, R., Di Tommaso, D., Cobellis, L., & Giugliano, D. (2005). Sexual dysfunction in women with the metabolic syndrome. Diabetes care, 28(3), 756–756. https://doi.org/10.2337/diacare.28.3.756
  • Martelli, V., Valisella, S., Moscatiello, S., Matteucci, C., Lantadilla, C., Costantino, A., & Meriggiola, M. C. (2012). Prevalence of sexual dysfunction among postmenopausal women with and without metabolic syndrome. The journal of sexual medicine, 9(2), 434–441. https://doi.org/10.1111/j.1743-6109.2011.02517.x
  • Enzlin, P., Mathieu, C., Van den Bruel, A., Bosteels, J., Vanderschueren, D., & Demyttenaere, K. (2002). Sexual dysfunction in women with type 1 diabetes: a controlled study. Diabetes care, 25(4), 672–677. https://doi.org/10.2337/diacare.25.4.672
  • Mezones-Holguin, E., Blümel, J. E., Huezo, M., Vargas, R., Castro, J., Córdova, W., & CasteloBranco, C. (2008). Impact of diabetes mellitus on the sexuality of Peruvian postmenopausal. Gynecological Endocrinology, 24(8), 470–474. https://doi.org/10.1080/09513590802273749
  • Konuru, V., Sangam, K., Mohammed, A.,Kanneganti, S. (2017). Evaluation of Pharmacoeconomic Direct Cost In Diabetes Patients. Ashian journal od pharmaceutical and clinical research, 10(4), 38–40. https://doi.org/10.22159/ajpcr.2017.v10i4.8510
  • Leedom, L., Feldman, M., Procci, W., & Zeidler, A. (1991). Symptoms of sexual dysfunction and depression in diabetic women. Journal of Diabetic Complications, 5(1), 38–41. https://doi.org/10.1016/0891-6632(91)90009-E
  • Newman, A. S., & Bertelson, A. D. (1986). Sexual dysfunction in diabetic women. Journal of behavioral medicine, 9(3), 261–270. https://doi.org/10.1007/BF00844773
  • Bitzer, J., & Alder, J. (2009). Diabetes and female sexual health. Women’s Health, 5(6), 629–636. https://doi.org/10.2217/WHE.09.58
  • Bond, D. S., Vithiananthan, S., Leahey, T. M., Thomas, J. G., Sax, H. C., Pohl, D., ... & Wing, R. R. (2009). Prevalence and degree of sexual dysfunction in a sample of women seeking bariatric surgery. Surgery for Obesity and Related Diseases, 5(6), 698–704. https://doi.org/10.1016/j.soard.2009.07.004
  • Basson, R., Berman, J., Burnett, A., Derogatis, L., Ferguson, D., Fourcroy, J., ... & Leiblum, S. (2000). Report of the international consensus development conference on female sexual dysfunction: definitions and classifications. The Journal of urology, 163(3), 888–893. https://doi.org/10.1016/S0022-5347(05)67828-7 https://doi.org/10.1097/00005392-200003000-00043
  • Lindau, S. T., Schumm, L. P., Laumann, E. O., Levinson, W., O’muircheartaigh, C. A., & Waite, L. J. (2007). A study of sexuality and health among older adults in the United States. New England Journal of Medicine, 357(8), 762–774. https://doi.org/10.1056/NEJMoa067423
  • Eyada, M., & Atwa, M. (2007). Sexual function in female patients with unstable angina or non-STelevation myocardial infarction. The journal of sexual medicine, 4(5), 1373–1380. https://doi.org/10.1111/j.1743-6109.2007.00473.x
  • Muharam, R., Budiman, B., Rachman, IA., Nirmalasari, RA. (2016). Effect of daidzen 120 mg supllimentation to menopausal symptoms and quality of life in non- equal producers women. Asian journal clin Res, 9(3), 37–40. https://doi.org/10.22159/ajpcr.2016.v9s3.14023
  • Lewis, R. W., Fugl?Meyer, K. S., Corona, G., Hayes, R. D., Laumann, E. O., Moreira Jr, E. D., & Segraves, T. (2010). Definitions/epidemiology/risk factors for sexual dysfunction. The journal of sexual medicine, 7(4pt2), 1598–1607. https://doi.org/10.1111/j.1743-6109.2010.01778.x
  • Peng, Y. S., Chiang, C. K., Kao, T. W., Hung, K. Y., Lu, C. S., Chiang, S. S., ... & Lien, Y. R. (2005). Sexual dysfunction in female hemodialysis patients: a multicenter study. Kidney international, 68(2), 760–765. https://doi.org/10.1016/S0085-2538(15)50896-X
  • Bhasin, S., Enzlin, P., Coviello, A., & Basson, R. (2007). Sexual dysfunction in men and women with endocrine disorders. The Lancet, 369(9561), 597–611. https://doi.org/10.1016/S0140-6736(07)60280-3
  • Maiorino, M. I., Bellastella, G., & Esposito, K. (2014). Diabetes and sexual dysfunction: current perspectives. Diabetes, metabolic syndrome and obesity: targets and therapy, 7, 95.
  • Park, K., Ahn, K., Chang, J. S., Lee, S. E., Ryu, S. B., & Park, Y. I. (2002). Diabetes induced alteration of clitoral hemodynamics and structure in the rabbit. The Journal of urology, 168(3), 1269–1272. https://doi.org/10.1016/S0022-5347(05)64638-1 https://doi.org/10.1097/00005392-200209000-00101
  • Feldhaus-Dahir, M. (2009). The causes and prevalence of hypoactive sexual desire disorder: part I. Urologic nursing, 29(4), 259.
  • Patil S, V., Mandare A, P.,Pandurang G,B.(2017). Study Of Total Cholesterol (Tc), Triacylglycerols (Tg), High Density Lipoprotein Cholesterol (Hdl-C) In Type II Diabetes Mellitus. Asian j Pharma clin Res, 10(2),116–118. https://doi.org/10.22159/ajpcr.2017.v10i2.14535
  • Bargiota, A. , Dimitropoulos, K. , Tzortzis, V. , Koukoulis, GN. (2011). Sexual dysfunction in diabetic women. HORMONES, 10(3), 196–06 https://doi.org/10.14310/horm.2002.1309
  • Duby, J. J., Campbell, R. K., Setter, S. M., & Rasmussen, K. A. (2004). Diabetic neuropathy: an intensive review. American Journal of Health-System Pharmacy, 61(2), 160–173.
  • Brown, J. S., Wessells, H., Chancellor, M. B., Howards, S. S., Stamm, W. E., Stapleton, A. E., ... & McVary, K. T. (2005). Urologic complications of diabetes. Diabetes care, 28(1), 177–185. https://doi.org/10.2337/diacare.28.1.177
  • Schram, M. T., Baan, C. A., & Pouwer, F. (2009). Depression and quality of life in patients with diabetes: a systematic review from the European depression in diabetes (EDID) research consortium. Current diabetes reviews, 5(2), 112–119. https://doi.org/10.2174/157339909788166828
  • Enzlin, P., Rosen, R., Wiegel, M., Brown, J., Wessells, H., Gatcomb, P., & Cleary, P. A. (2009). Sexual dysfunction in women with type 1 diabetes: longterm findings from the DCCT/EDIC study cohort. Diabetes care, 32(5), 780–785. https://doi.org/10.2337/dc08-1164
  • Enzlin, P., Mathieu, C., Van den Bruel, A., Vanderschueren, D., & Demyttenaere, K. (2003). Prevalence and predictors of sexual dysfunction in patients with type 1 diabetes. Diabetes care, 26(2), 409–414. https://doi.org/10.2337/diacare.26.2.409
  • Kumar Patnaik, S., Haritha, P., Rao P R. (2017). Erectile Dysfunaction and its pharmacology y: An overview, Asian J Pharma clin Res, 10(2), 17–23.
  • Rockliffe-Fidler, C., & Kiemle, G. (2003). Sexual function in diabetic women: A psychological perspective. Sexual and Relationship Therapy, 18(2), 143–159. https://doi.org/10.1080/1468199031000099415
  • Ogbera, A. O., Chinenye, S., Akinlade, A., Eregie, A., & Awobusuyi, J. (2009). Frequency and correlates of sexual dysfunction in women with diabetes mellitus. The journal of sexual medicine, 6(12), 3401–3406. https://doi.org/10.1111/j.1743-6109.2009.01396.x
  • Fugl-Meyer, A., & Sjogren, K. (1999). Sexual disabilities, problems and satisfaction in 18-74 year old Swedes. Scand J Sexol, 2, 79.
  • B Basson, R. (2005). Women’s sexual dysfunction: revised and expanded definitions. Canadian Medical Association Journal, 172(10), 1327–1333. https://doi.org/10.1503/cmaj.1020174 49. B?k, E., Marcisz, C., Krzemi?ska, S., DobrzynMatusiak, D., Foltyn, A., & Drosdzol-Cop, A. (2017). Relationships of sexual dysfunction with depression and acceptance of illness in women and men with type 2 diabetes mellitus. International journal of environmental research and public health, 14(9), 1073. https://doi.org/10.3390/ijerph14091073
  • Elyasi, F., Kashi, Z., Tasfieh, B., Bahar, A., & Khademloo, M. (2015). Sexual dysfunction in women with type 2 diabetes mellitus. Iranian journal of medical sciences, 40(3), 206.