J. Pharm. Technol. Res. Manag.

Evaluation of Polyherbal Anticancer Tablets: A Review

Ishan Dubey, Manmeet Singh Saluja, Ritu M Gilhotra and Mahavir Chhajed

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  • DOI Number
    https://doi.org/10.15415/jptrm.2018.61006
KEYWORDS
PUBLISHED DATE May 2018
PUBLISHER The Author(s) 2018. This article is published with open access at www.chitkara.edu.in/publications
ABSTRACT

Cancer is a malignant abnormal growth of cells, one of the most dreaded and complex diseases. It concerns with several tempo spatial changes in cell composition, which finally lead to neoplasia. Various types of cancers have been reported. Chemotherapy, radiation, and/or surgery may cure them. Herbal remedies are supposed to be harmless as they cause fewer complications and are less likely to habitual. Antioxidant compositions of therapeutic plants show the anticancer activity and therefore, use of different proportions of the active components to formulate various standardized preparation with single or multiple components for their synergistic effects play a crucial role in curing cancer. Evaluation parameters to assess the in vitro anticancer activity includes Caspase-3, Caspase-9, alamar blue, LDH assay, XTT assay, sulforhodamine-B assay, MTT assay, DNA fragmentation assay, neutral red uptake cytotoxic assay, tryphan blue assay. Evaluation of dried extract or granules includes bulk density, tapped density, Carr’s index, Hausner’s ratio, angle of repose while the tablets evaluated by drug-excipient compatibility study by FT-IR, stability studies, hardness, thickness, weight variation, friability, disintegration time and dissolution test.

Page(s) 67–79
URL http://dspace.chitkara.edu.in/jspui/bitstream/123456789/723/1/JPTRM_6_Dubey.pdf
ISSN Print : 2321-2217, Online : 2321-2225
DOI https://doi.org/10.15415/jptrm.2018.61006
REFERENCES
  • Abdullaev, F.I., R.R. Luna, B.V. Roitenburd, A.J. (2000). Espinosa, Pattern of childhood cancer mortality in Mexico. Arch. Med. Res., 31, 526–31. https://doi.org/10.1016/S0188-4409(00)00094-1
  • Abdullaev, F.I., (2001). Plant-derived agents against cancer. In: Pharmacology andTherapeutics in the New Millennium, New Delhi. 345–354.
  • Balunas MJ, Kinghorn AD (2005). Drug discovery from medicinal plants. Life Sci. 78, 431–441. https://doi.org/10.1016/j.lfs.2005.09.012
  • Carter SJ (1986). Powder Flow and Compaction: In: Cooper and Gun’s Tutorial Pharmacy. 2nd Ed. CBS Publishers and Distributors, India. 186–232.
  • Cragg GM, Newman DJ (2003). Plants as a source of anti-cancer and anti-HIV agents. Ann. Appl. Biol. 143, 127–133. https://doi.org/10.1111/j.1744-7348.2003.tb00278.x
  • Duan H et al.,(1996). ICE-LAP3, a novel mammalian homologue of the Caenorhabditis eleganscell death protein Ced-3 is activated during Fas- and tumor necrosis factor-induced apoptosis. Journal Biochemistry 271, 1621–1625.
  • Economou MA et al., (2008).Oral picropodophyllin (PPP) is well tolerated in vivo and inhibits IGF-1R expression and growth of uveal melanoma. Acta Ophthalmologica; 86, 35–41. https://doi.org/10.1111/j.1755-3768.2008.01184.x
  • Edeoga HO, Okwu DE, Mbaebie BO (2005). Phytochemical constituents of some Nigerian medicinal plants. Af.r. J Biotechnol. 4, 685–688. https://doi.org/10.5897/AJB2005.000-3127
  • ICH harmonised tripartite guideline stability testing of New drug substances and products. Q1A(R2). Current Step 4 version, 2003.
  • Khandelwal KR (2009). Practical Pharmacognosy,19th ed: Nirali Prakashan, Pune, 146–165.
  • Kokate CK (2008). Practical Pharmacognosy, 4th ed, Nirali Prakashan,Pune, India. 10–27
  • Lin CW et al., (1991). Lysosomal localization and mechanism of uptake of Nile blue photosensitizers in tumor cells. Cancer Res. 51, 2710–2719.
  • Margret C, Jayakar B (2010). Formulation and evaluation of herbal tablets containing ipomoea digitata linn. Extract. International Journal of Pharmaceutical Sciences Review and Research. 3(1), 101–110.
  • Mishra S U, Murthy P N, Pasa G, Mishra D (2011). Formulation development and evaluation of herbal tablet containing methanolic extract of butea frondosa. International journal of Institutional Pharmacy and life sciences. 1(3), 1–15.
  • Mossman T (1983). Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods; 65, 55–63. https://doi.org/10.1016/0022-1759(83)90303-4
  • Nicholson DW, Ali A and Thornberry NA. (1995). Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis. Nature 376, 37–43. https://doi.org/10.1038/376037a0
  • Nostro A et al.,(2000). Extraction methods and bioautography for evaluation of medicinal plant antimicrobial activity. Lett. Appl. Microbiol. 30, 379–384. https://doi.org/10.1046/j.1472-765x.2000.00731.x
  • O’Brien J, Wilson I, Orton T, Pognan F (2000). Investigation of the Alamar (resazurin) fluorescent dye for the assessment of mammalian cell cytotoxicity. Eur. J. Biochem. 267, 5421–5426. https://doi.org/10.1046/j.1432-1327.2000.01606.x
  • Paronen P, Ikka J (1995). Porosity-pressure functions. In: Pharmaceutical powder compaction technology. Alderborn G, Nystrum C. (Eds), Marcel Dekker, New York 71, 55–75. https://doi.org/10.1201/b14207-4
  • Pezzuto JM (1997). Plant-Derived Anticancer Agents. Biochem.Pharmacol. 53, 121–133. https://doi.org/10.1016/S0006-2952(96)00654-5
  • Petty RD (1995). Comparison of MTT and ATP-based assays for the measurement of viable cell number. Journal of Biolumin. Chemilumin. 10, 29–34. https://doi.org/10.1002/bio.1170100105
  • Porter AG and Janicke RU (1999). Emerging roles of caspase-3 in apoptosis. Cell Death Differentation 6, 99–104. https://doi.org/10.1038/sj.cdd.4400476
  • Reddy L, Odhav B, Bhoola KD (2003). Natural products for cancer prevention: a global perspective. Pharmacology & Therapeutics. 99, 1–13. https://doi.org/10.1016/S0163-7258(03)00042-1
  • Russo A et al., (2006). Pannarin inhibits cell growth and induces cell death in human prostate carcinoma DU- 145 cells. Anti-Cancer Drugs; 17, 1163–1169. https://doi.org/10.1097/01.cad.0000236310.66080.ed
  • Sakahira H, Enari M and Nagata S (1998) Cleavage of CAD inhibitor in CAD activation and DNA degradation during apoptosis. Nature 391, 96−99. https://doi.org/10.1038/34214
  • Sirimal GK (2015). In vitro cytotoxic studies of various formulations of Indian medicinal plants. Indian Journal of Research in Pharmacy and Biotechnology. 3(3), 210–217.
  • Skehan P et al., (1990) New colorimetric cytotoxicity assay for anticancer drug screening. J Natl Cancer Inst; 82, 1107–1112. https://doi.org/10.1093/jnci/82.13.1107
  • Thornberry NA et al., (1997). A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis. Journal of Biochemistry 272, 17907–17911. https://doi.org/10.1074/jbc.272.29.17907
  • Thornberry NA and Littlewood Y (1998).Caspases Enemies Within. Science 281, 1312–1316. https://doi.org/10.1126/science.281.5381.1312
  • United States Pharmacopoaeia (2003). Bulk Density and Tapped Density. Asian Ed.; 26, 2125.
  • Unnikrishnan MC, Ramadasan K(1998). Cytotoxicity of extracts of spices to cultured cells. Nutr Cancer; 11, 251–257. https://doi.org/10.1080/01635588809513995
  • Wiseman, LR, Spencer CM (1998). Drugs Aging 12, 305–334. https://doi.org/10.2165/00002512-199812040-00005
  • Wolf BB, Schuler M, Echeverri F, Green DR (1999). Caspase-3 is the primary activator of apoptotic DNA fragmentation via DNA fragmentation factor-45/ inhibitor of caspase-activated DNase inactivation. Journal Biochemistry 274, 30651–30656. https://doi.org/10.1074/jbc.274.43.30651