J. Pharm. Technol. Res. Manag.

Phytochemical Investigation and Pharmacological Evaluation of Solanum xanthocarpum Endowed with their potential Activity

Mahavir Chhajed, Atika Jain, Sourabh Gupta, Ishan Dubey and A. K. Shrivastava

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  • DOI Number
    https://doi.org/10.15415/jptrm.2018.61005
KEYWORDS

S. xanthocarpum, antibacterial, antifungal, DPPH free radical, phytochemical screening.

PUBLISHED DATE May 2018
PUBLISHER The Author(s) 2018. This article is published with open access at www.chitkara.edu.in/publications
ABSTRACT

The study was done to assess the in-vitro antibacterial potential of various extracts was studied and compared with ciprofloxacin as the standard and shows significant action against E. coli, B. substilis S. aureus, S. pyrogenes, P. aeruginosa, and S. typhi. Anti-fungal potential of the aqueous extract also studied using miconazole as standard and shows significant action against A. niger and C. albicans. Anthelmintic potential of the aqueous and ethanolic extracts was also studied on earthworms, Eudrillus eugeniae using albendazole as standard and shows moderate activity. In the present study in-vitro free radical scavenging activity of whole plant material performed. Various crude extracts of S. xanthocarpum was prepared by successive maceration process using various solvents such as; chloroform, petroleum ether (60-80o), acetone, ethanol and distilled water. Each one extract have been chosen to study the free radical inhibitory activity by DPPH radical scavenging method. The preliminary phytochemical screening of extracts showed that sterols, alkaloids, glycosides, tannins, saponins, phenolic compounds, carbohydrates and proteins were present in the plant. Petroleum ether, chloroform, acetone, ethanol and distilled water extracts showed 52.69, 46.15, 21.08, 52.72 and 44.35 % respectively compared to standard ascorbic acid. Acetone extract showed poor inhibition of DPPH radical compared to standard and other extracts also.

Page(s) 55–65
URL http://dspace.chitkara.edu.in/jspui/bitstream/123456789/722/1/JPTRM_5_Chhajed.pdf
ISSN Print : 2321-2217, Online : 2321-2225
DOI https://doi.org/10.15415/jptrm.2018.61005
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